ferrostatin-1 and Polycystic-Kidney--Autosomal-Dominant

Autosomal dominant polycystic kidney disease (ADPKD), the most common inherited kidney disease, is regulated by different forms of cell death, including apoptosis and autophagy. However, the role in ADPKD of ferroptosis, a recently discovered form of cell death mediated by iron and lipid metabolism, remains elusive.. To determine a pathophysiologic role of ferroptosis in ADPKD, we investigated whether the absence of. We found that kidney cells and tissues lacking. These findings indicate that ferroptosis contributes to ADPKD progression and management of ferroptosis may be a novel strategy for ADPKD treatment.

Topics: Animals; Cell Cycle; Cells, Cultured; Cyclohexylamines; Disease Models, Animal; Disease Progression; Epithelial Cells; Female; Ferroptosis; Gene Expression Regulation; Humans; Iron; Lipid Peroxidation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Phenylenediamines; Piperazines; Polycystic Kidney, Autosomal Dominant; RNA Interference; Spheroids, Cellular; Transcriptome; TRPP Cation Channels