ferrostatin-1 and Cardiomyopathy--Hypertrophic

Maintaining iron homeostasis is essential for proper cardiac function. Both iron deficiency and iron overload are associated with cardiomyopathy and heart failure via complex mechanisms. Although ferritin plays a central role in iron metabolism by storing excess cellular iron, the molecular function of ferritin in cardiomyocytes remains unknown.. To characterize the functional role of Fth (ferritin H) in mediating cardiac iron homeostasis and heart disease.. Mice expressing a conditional Fth knockout allele were crossed with 2 distinct Cre recombinase-expressing mouse lines, resulting in offspring that lack. Our findings provide compelling evidence that ferritin plays a major role in protecting against cardiac ferroptosis and subsequent heart failure, thereby providing a possible new therapeutic target for patients at risk of developing cardiomyopathy.

Topics: Aging; Alleles; Amino Acid Transport System y+; Animals; Apoferritins; Cardiomyopathies; Cardiomyopathy, Hypertrophic; Crosses, Genetic; Cyclohexylamines; Ferroptosis; Glutathione; Heart Failure; Homeostasis; Hypertrophy, Left Ventricular; Iron; Iron Deficiencies; Iron Overload; Iron, Dietary; Lipid Peroxidation; Male; Mice; Mice, Transgenic; Myocardium; Myocytes, Cardiac; Oxidative Stress; Phenylenediamines; Reactive Oxygen Species