ferrostatin-1 and Amyotrophic-Lateral-Sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by oxidative stress that triggers motor neurons loss in the brain and spinal cord. However, the mechanisms underlying the exact role of oxidative stress in ALS-associated neural degeneration are not definitively established. Oxidative stress-generated phospholipid peroxides are known to have extensive physiological and pathological consequences to tissues. Here, we discovered that the deficiency of glutathione peroxidase 4 (GPX4), an essential antioxidant peroxidase, led to the accumulation of phospholipid peroxides and resulted in a loss of motor neurons in spinal cords of ALS mice. Mutant human SOD1

Topics: Amyotrophic Lateral Sclerosis; Animals; Glutathione Peroxidase; Humans; Mice; Mice, Transgenic; Motor Neurons; Neurodegenerative Diseases; Peroxides; Phospholipids; Superoxide Dismutase; Superoxide Dismutase-1