ferric-carboxymaltose and Acidosis

Heart failure (HF) is often associated with iron deficiency (ID). Skeletal muscle abnormalities are common in HF, but the potential role of ID in this phenomenon is unclear. In addition to hemopoiesis, iron is essential for muscle bioenergetics. We examined whether energetic abnormalities in skeletal muscle in HF are affected by ID and if they are responsive to intravenous iron.. Forty-four chronic HF subjects and 25 similar healthy volunteers underwent. HF patients display skeletal muscle myopathy that is more severe in those with iron deficiency. The presence of ID is associated with greater acidosis with exercise, which may explain early muscle fatigue. Further study is warranted to identify the strategy to restore iron content in skeletal muscle.

Topics: Acidosis; Administration, Intravenous; Adult; Aged; Biomarkers; Case-Control Studies; Energy Metabolism; Exercise Test; Female; Ferric Compounds; Heart Failure; Humans; Iron; Iron Deficiencies; Isometric Contraction; Leg; Magnetic Resonance Spectroscopy; Male; Maltose; Middle Aged; Muscle, Skeletal; Phosphorus Isotopes; Predictive Value of Tests; Time Factors; Treatment Outcome