ferric-ammonium-citrate and Pulmonary-Disease--Chronic-Obstructive

Iron is a key element for systemic oxygen delivery and cellular energy metabolism. Thus regulation of systemic and local iron metabolism is key for maintaining energy homeostasis. Significant changes in iron levels due to malnutrition or hemorrhage, have been associated with several diseases such as hemochromatosis, liver cirrhosis and COPD. Macrophages are key cells in regulating iron levels in tissues as they sequester excess iron. How iron overload affects macrophage differentiation and function remains a subject of debate. Here we used an

Topics: Humans; Iron; Iron Overload; Macrophages; Monocytes; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Reactive Oxygen Species