ferric-ammonium-citrate and Acinetobacter-Infections

Iron is an essential metal for all organisms, yet disruption of its homeostasis, particularly in labile forms that can contribute to oxidative stress, is connected to diseases ranging from infection to cancer to neurodegeneration. Iron deficiency is also among the most common nutritional deficiencies worldwide. To advance studies of iron in healthy and disease states, we now report the synthesis and characterization of iron-caged luciferin-1 (ICL-1), a bioluminescent probe that enables longitudinal monitoring of labile iron pools (LIPs) in living animals. ICL-1 utilizes a bioinspired endoperoxide trigger to release d-aminoluciferin for selective reactivity-based detection of Fe

Topics: 2,2'-Dipyridyl; Acinetobacter baumannii; Acinetobacter Infections; Anemia, Iron-Deficiency; Animals; Cation Transport Proteins; Cations, Divalent; Disease Models, Animal; Ferric Compounds; Firefly Luciferin; Fluorescent Dyes; Gene Expression Regulation; Hepcidins; Homeostasis; Iron; Iron Overload; Iron Regulatory Protein 1; Iron Regulatory Protein 2; Luminescent Measurements; Mice; Mice, Transgenic; Quaternary Ammonium Compounds; Receptors, Transferrin; Signal Transduction; Transferrin