fentanyl has been researched along with Serotonin Syndrome in 19 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Emerging evidence from case reports suggests that fentanyl may precipitate potentially life-threatening serotonin syndrome in patients taking serotonergic drugs." | 7.83 | Effects of fentanyl on serotonin syndrome-like behaviors in rats. ( Kaminaga, S; Kawano, T; Kitamura, S; Locatelli, FM; Tateiwa, H; Yamanaka, D; Yokoyama, M, 2016) |
| " Although this article focuses on serotonin syndrome as a result of an adverse interaction of selective serotonin reuptake inhibitors (SSRI) and fentanyl, it is important for not only anesthesia professionals, but all clinicians--such as those in emergency medicine and critical care--to be aware of this syndrome and its management." | 7.80 | Serotonin syndrome: fentanyl and selective serotonin reuptake inhibitor interactions. ( Greenier, E; Lukyanova, V; Reede, L, 2014) |
| "To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram, as evidenced by medication history, clinical features and reversal following discontinuation of fentanyl." | 7.74 | Serotonin syndrome caused by interaction between citalopram and fentanyl. ( Ailawadhi, S; Baer, MR; Carlson, LA; Sung, KW, 2007) |
| "On emergence, she had convulsions and was nonresponsive." | 5.91 | Fentanyl-Induced Serotonin Syndrome 5 Days After Cessation of Serotonergic Agents: A Case Report. ( Agrawal, S; Sekhri, N; Siddiqui, A, 2023) |
| "Serotonin syndrome is a syndrome identified by a triad of altered mental status, neuromuscular overactivity, and autonomic instability caused by the overstimulation of serotonin in the central nervous system and periphery." | 5.42 | Serotonin syndrome caused by fentanyl and methadone in a burn injury. ( Gala, G; Hillman, AD; Sultan, SM; Witenko, CJ, 2015) |
| "We report a case of serotonin syndrome developed shortly after the initiation of linezolid in a 63-year-old patient in whom selective serotonin reuptake inhibitor therapy was discontinued for the duration of antibiotic therapy." | 3.96 | Linezolid and fentanyl: An underrecognized drug-to-drug interaction. ( Abu Saleh, O; Barth, D; Corsini Campioli, C; Esquer Garrigos, Z; Sia, IG; Sohail, RM, 2020) |
| "Even small doses of fentanyl administered to patients taking multiple serotonergic medications and herbal supplements may trigger serotonin syndrome." | 3.85 | Serotonergic medications, herbal supplements, and perioperative serotonin syndrome. ( Naranjo, J; Pollard, EM; Sprung, J; Warner, MA; Warner, ME; Weingarten, TN, 2017) |
| "Emerging evidence from case reports suggests that fentanyl may precipitate potentially life-threatening serotonin syndrome in patients taking serotonergic drugs." | 3.83 | Effects of fentanyl on serotonin syndrome-like behaviors in rats. ( Kaminaga, S; Kawano, T; Kitamura, S; Locatelli, FM; Tateiwa, H; Yamanaka, D; Yokoyama, M, 2016) |
| " Although this article focuses on serotonin syndrome as a result of an adverse interaction of selective serotonin reuptake inhibitors (SSRI) and fentanyl, it is important for not only anesthesia professionals, but all clinicians--such as those in emergency medicine and critical care--to be aware of this syndrome and its management." | 3.80 | Serotonin syndrome: fentanyl and selective serotonin reuptake inhibitor interactions. ( Greenier, E; Lukyanova, V; Reede, L, 2014) |
| "We report a case of serotonin syndrome caused by interaction between nasal fentanyl, oxycodone and escitalopram." | 3.76 | [Serotoninergic antidepressants and opiate analgesics: a sometimes-painful association. A case report]. ( Lefebvre-Kuntz, D; Reich, M, 2010) |
| "To report a case of serotonin syndrome associated with interaction between fentanyl and citalopram, as evidenced by medication history, clinical features and reversal following discontinuation of fentanyl." | 3.74 | Serotonin syndrome caused by interaction between citalopram and fentanyl. ( Ailawadhi, S; Baer, MR; Carlson, LA; Sung, KW, 2007) |
| "On emergence, she had convulsions and was nonresponsive." | 1.91 | Fentanyl-Induced Serotonin Syndrome 5 Days After Cessation of Serotonergic Agents: A Case Report. ( Agrawal, S; Sekhri, N; Siddiqui, A, 2023) |
| "Serotonin syndrome is a syndrome identified by a triad of altered mental status, neuromuscular overactivity, and autonomic instability caused by the overstimulation of serotonin in the central nervous system and periphery." | 1.42 | Serotonin syndrome caused by fentanyl and methadone in a burn injury. ( Gala, G; Hillman, AD; Sultan, SM; Witenko, CJ, 2015) |
| "Fentanyl was administered for intraoperative and postoperative analgesia (1 mg intraoperatively, and 2." | 1.35 | Serotonin toxicity caused by an interaction between fentanyl and paroxetine. ( Field, J; Irving, C; Rang, ST, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 11 (57.89) | 24.3611 |
| 2020's | 3 (15.79) | 2.80 |
| Authors | Studies |
|---|---|
| Siddiqui, A | 1 |
| Agrawal, S | 1 |
| Sekhri, N | 1 |
| Al-Khalil, M | 1 |
| Sack, A | 1 |
| Elson, R | 1 |
| Pleat, J | 1 |
| Corsini Campioli, C | 1 |
| Barth, D | 1 |
| Esquer Garrigos, Z | 1 |
| Abu Saleh, O | 1 |
| Sohail, RM | 1 |
| Sia, IG | 1 |
| Warner, ME | 1 |
| Naranjo, J | 1 |
| Pollard, EM | 1 |
| Weingarten, TN | 2 |
| Warner, MA | 1 |
| Sprung, J | 2 |
| Larson, KJ | 1 |
| Wittwer, ED | 1 |
| Nicholson, WT | 1 |
| Price, DL | 1 |
| Hillman, AD | 1 |
| Witenko, CJ | 1 |
| Sultan, SM | 1 |
| Gala, G | 2 |
| Greenier, E | 1 |
| Lukyanova, V | 1 |
| Reede, L | 1 |
| Atkinson, TJ | 1 |
| Fudin, J | 1 |
| Pham, TC | 1 |
| Hillman, A | 1 |
| Witenko, C | 1 |
| Sultan, S | 1 |
| Kitamura, S | 1 |
| Kawano, T | 1 |
| Kaminaga, S | 1 |
| Yamanaka, D | 1 |
| Tateiwa, H | 1 |
| Locatelli, FM | 1 |
| Yokoyama, M | 1 |
| Rang, ST | 1 |
| Field, J | 1 |
| Irving, C | 1 |
| Kirschner, R | 1 |
| Donovan, JW | 1 |
| Alkhatib, AA | 1 |
| Peterson, KA | 1 |
| Tuteja, AK | 1 |
| Reich, M | 1 |
| Lefebvre-Kuntz, D | 1 |
| Rastogi, R | 1 |
| Swarm, RA | 1 |
| Patel, TA | 1 |
| Gollapudy, S | 1 |
| Kumar, V | 1 |
| Dhamee, MS | 1 |
| Ailawadhi, S | 1 |
| Sung, KW | 1 |
| Carlson, LA | 1 |
| Baer, MR | 1 |
| Ozkardesler, S | 1 |
| Gurpinar, T | 1 |
| Akan, M | 1 |
| Koca, U | 1 |
| Sarikaya, H | 1 |
| Olmez, T | 1 |
| Elar, Z | 1 |
| Chambost, M | 1 |
| Liron, L | 1 |
| Peillon, D | 1 |
| Combe, C | 1 |
| Giese, SY | 1 |
| Neborsky, R | 1 |
1 review available for fentanyl and Serotonin Syndrome
| Article | Year |
|---|---|
Case scenario: opioid association with serotonin syndrome: implications to the practitioners.
Topics: Analgesics, Opioid; Antidepressive Agents, Tricyclic; Celecoxib; Chronic Pain; Cyclooxygenase 2 Inhi | 2011 |
18 other studies available for fentanyl and Serotonin Syndrome
| Article | Year |
|---|---|
Fentanyl-Induced Serotonin Syndrome 5 Days After Cessation of Serotonergic Agents: A Case Report.
Topics: Adult; Drug Overdose; Female; Fentanyl; Humans; Seizures; Serotonin Agents; Serotonin Syndrome; Youn | 2023 |
A 5-year single-centre retrospective study of potential drug interactions in burns inpatients with psychiatric comorbidities.
Topics: Adult; Analgesics, Opioid; Antidepressive Agents; Arrhythmias, Cardiac; Burns; Comorbidity; Drug Int | 2020 |
Linezolid and fentanyl: An underrecognized drug-to-drug interaction.
Topics: Drug Interactions; Female; Fentanyl; Humans; Linezolid; Middle Aged; Serotonin Syndrome | 2020 |
Serotonergic medications, herbal supplements, and perioperative serotonin syndrome.
Topics: Aged; Curcuma; Dietary Supplements; Drug Interactions; Fentanyl; Fluoxetine; Humans; Male; Midazolam | 2017 |
Myoclonus in patient on fluoxetine after receiving fentanyl and low-dose methylene blue during sentinel lymph node biopsy.
Topics: Drug Interactions; Fentanyl; Fluoxetine; Humans; Male; Methylene Blue; Middle Aged; Myoclonus; Senti | 2015 |
Serotonin syndrome caused by fentanyl and methadone in a burn injury.
Topics: Adult; Analgesics, Opioid; Burns; Drug Interactions; Drug Therapy, Combination; Fentanyl; Humans; Ma | 2015 |
Serotonin syndrome: fentanyl and selective serotonin reuptake inhibitor interactions.
Topics: Adult; Anesthesia; Back Pain; Carpal Tunnel Syndrome; Depression; Drug Interactions; Female; Fentany | 2014 |
Combined fentanyl and methadone induced serotonin syndrome is called into question.
Topics: Analgesics, Opioid; Burns; Fentanyl; Humans; Male; Methadone; Serotonin Syndrome | 2015 |
Effects of fentanyl on serotonin syndrome-like behaviors in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Fentanyl; Male; Motor Activity; Rats; Rats, Sprague | 2016 |
Serotonin toxicity caused by an interaction between fentanyl and paroxetine.
Topics: Analgesics, Opioid; Drug Interactions; Drug Therapy, Combination; Female; Fentanyl; Humans; Middle A | 2008 |
Serotonin syndrome precipitated by fentanyl during procedural sedation.
Topics: Conscious Sedation; Emergency Service, Hospital; Female; Fentanyl; Humans; Hypnotics and Sedatives; | 2010 |
Serotonin syndrome as a complication of fentanyl sedation during esophagogastroduodenoscopy.
Topics: Adult; Analgesics, Opioid; Conscious Sedation; Endoscopy, Digestive System; Female; Fentanyl; Humans | 2010 |
[Serotoninergic antidepressants and opiate analgesics: a sometimes-painful association. A case report].
Topics: Adenocarcinoma; Administration, Intranasal; Administration, Oral; Aged; Analgesics, Opioid; Antidepr | 2010 |
A case of serotonin syndrome precipitated by fentanyl and ondansetron in a patient receiving paroxetine, duloxetine, and bupropion.
Topics: Aged; Analgesics, Opioid; Anesthesia, General; Bupropion; Drug Therapy, Combination; Duloxetine Hydr | 2012 |
Serotonin syndrome caused by interaction between citalopram and fentanyl.
Topics: Aged; Citalopram; Drug Interactions; Drug Therapy, Combination; Fentanyl; Humans; Myelodysplastic Sy | 2007 |
A possible perianesthetic serotonin syndrome related to intrathecal fentanyl.
Topics: Adult; Analgesics, Opioid; Ephedrine; Ergot Alkaloids; Fentanyl; Humans; Injections, Spinal; Male; M | 2008 |
[Serotonin syndrome during fluoxetine poisoning in a patient taking moclobemide].
Topics: Adult; Anesthetics, Intravenous; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, | 2000 |
Serotonin syndrome: potential consequences of Meridia combined with Demerol or fentanyl.
Topics: Analgesics, Opioid; Antidepressive Agents; Appetite Depressants; Cyclobutanes; Drug Interactions; Fe | 2001 |