fentanyl has been researched along with Sensitivity and Specificity in 73 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The objective of this article is to evaluate the effect of dexmedetomidine on emergence agitation (EA) and recovery profiles in children after sevoflurane anesthesia and its pharmacological mechanisms." | 8.91 | Meta-analysis of dexmedetomidine on emergence agitation and recovery profiles in children after sevoflurane anesthesia: different administration and different dosage. ( Niu, K; Wang, G; Wang, H; Zhu, A; Zhu, M, 2015) |
| "In Fall 2017, we first undertook an assessment of the limits of detection for fentanyl, then tested the three devices' sensitivity and specificity in distinguishing fentanyl in street-acquired drug samples." | 7.96 | An assessment of the limits of detection, sensitivity and specificity of three devices for public health-based drug checking of fentanyl in street-acquired samples. ( Clarke, W; Gilbert, M; Green, TC; Lucas, R; McKenzie, M; Park, JN; Sherman, SG; Struth, E, 2020) |
| " The magnitude of analgesia in the cold pressor model showed some correlation with TDF dosage and comparable effects for the full agonist fentanyl and the partial agonist buprenorphine." | 6.72 | Differential sensitivity of three experimental pain models in detecting the analgesic effects of transdermal fentanyl and buprenorphine. ( Gasser, UE; Koltzenburg, M; Pokorny, R; Richarz, U, 2006) |
| "The objective of this article is to evaluate the effect of dexmedetomidine on emergence agitation (EA) and recovery profiles in children after sevoflurane anesthesia and its pharmacological mechanisms." | 4.91 | Meta-analysis of dexmedetomidine on emergence agitation and recovery profiles in children after sevoflurane anesthesia: different administration and different dosage. ( Niu, K; Wang, G; Wang, H; Zhu, A; Zhu, M, 2015) |
| "In Fall 2017, we first undertook an assessment of the limits of detection for fentanyl, then tested the three devices' sensitivity and specificity in distinguishing fentanyl in street-acquired drug samples." | 3.96 | An assessment of the limits of detection, sensitivity and specificity of three devices for public health-based drug checking of fentanyl in street-acquired samples. ( Clarke, W; Gilbert, M; Green, TC; Lucas, R; McKenzie, M; Park, JN; Sherman, SG; Struth, E, 2020) |
| "The LFA can detect fentanyl and norfentanyl with high clinical sensitivity and specificity in the ED population with rapid fentanyl screening needs." | 3.96 | Development and Clinical Validation of a Sensitive Lateral Flow Assay for Rapid Urine Fentanyl Screening in the Emergency Department. ( Chen, H; Feng, S; Li, Z; Liu, K; Wang, P, 2020) |
| " We designed this observational study to compare the sensitivity and specificity of the PSI with that of the bispectral index (BIS) with respect to their ability to predict the loss of consciousness and emergence from anesthesia, as well as to assess changes in IV (propofol) and inhaled (desflurane) anesthetics during the maintenance period." | 3.71 | A comparison of patient state index and bispectral index values during the perioperative period. ( Chen, X; Kariger, R; Ma, H; Sloninsky, A; Tang, J; Wender, RH; White, PF, 2002) |
| "The relationships between SPI with postoperative pain score and opioid requirement were analysed." | 2.94 | Prediction of postoperative pain and analgesic requirements using surgical pleth index: a observational study. ( Kim, BJ; Kim, GS; Park, M, 2020) |
| " The magnitude of analgesia in the cold pressor model showed some correlation with TDF dosage and comparable effects for the full agonist fentanyl and the partial agonist buprenorphine." | 2.72 | Differential sensitivity of three experimental pain models in detecting the analgesic effects of transdermal fentanyl and buprenorphine. ( Gasser, UE; Koltzenburg, M; Pokorny, R; Richarz, U, 2006) |
| "During fentanyl-induced muscular rigidity BIS recordings reflect EMG variations." | 2.70 | Biasing effect of the electromyogram on BIS: a controlled study during high-dose fentanyl induction. ( Gillbe, C; Mofeez, A; Renna, M; Wigmore, T, 2002) |
| " The evolution in dosing of ITN warrants a re-examination of its usefulness in modern obstetric practice." | 2.44 | Single-dose intrathecal analgesia to control labour pain: is it a useful alternative to epidural analgesia? ( Hammett, DC; Kelly, L; Minty, A; Minty, RG, 2007) |
| " Long-acting oral opioids supply satisfactory analgesia at more convenient dosing intervals." | 2.43 | Advances in opioid therapy and formulations. ( Walsh, D, 2005) |
| "Sensitivity and specificity were lower for heroin (77." | 1.51 | Street fentanyl use: Experiences, preferences, and concordance between self-reports and urine toxicology. ( Carlson, RR; Daniulaityte, R; Juhascik, MP; Sizemore, IE; Strayer, KE, 2019) |
| "Midazolam was administered to all patients." | 1.46 | Bronchoscopic diagnosis of peripheral pulmonary lung cancer employing sedation with fentanyl and midazolam. ( Ando, C; Fujiwara, K; Iwamoto Md, Y; Minami, D; Nakasuka, T; Sato, K; Sato, T; Shibayama, T; Yonei Md PhD, T, 2017) |
| "One hundred sixty consecutive cardiac arrest patients treated with therapeutic hypothermia." | 1.40 | Early bispectral index and sedation requirements during therapeutic hypothermia predict neurologic recovery following cardiac arrest. ( Billings, FT; Burjek, NE; Hollenbeck, RD; McPherson, JA; Wagner, CE; Wang, L; Yu, C, 2014) |
| "Oral Fentanyl was absorbed the slowest (t90~300 min); the absorption of intranasal Fentanyl was relatively rapid (t90~20-40 min); and the various oral transmucosal routes had intermediate absorption rates (t90~160-300 min)." | 1.39 | Physiologically-based pharmacokinetic model for Fentanyl in support of the development of Provisional Advisory Levels. ( Adeshina, F; Shankaran, H; Teeguarden, JG, 2013) |
| "Pleuroscopy is considered a safe procedure with a high diagnostic accuracy but this record is based on studies published by pulmonologists experienced in performing the procedure." | 1.39 | Safety and accuracy of semirigid pleuroscopy performed by pulmonary fellows at a major university hospital: our initial experience. ( Bajwa, AA; Cury, JD; Jones, L; Shujaat, A; Usman, F, 2013) |
| "Fentanyl is an extremely potent synthetic opioid that is widely used for chronic pain treatment; it is highly addictive and prone to abuse." | 1.37 | Development of a homogeneous immunoassay for the detection of fentanyl in urine. ( Barhate, R; Coulter, C; Huynh, K; Moore, C; Rodrigues, W; Soares, J; Vincent, M; Wang, G, 2011) |
| " To facilitate pharmacokinetic studies of fentanyl and its metabolites in neonates and other children, we developed and validated an LC-MS/MS method based on minimally invasive, low blood volume sampling." | 1.37 | A low blood volume LC-MS/MS assay for the quantification of fentanyl and its major metabolites norfentanyl and despropionyl fentanyl in children. ( Christians, U; Clavijo, CF; Cromie, M; Galinkin, JL; Hoffman, KL; Schniedewind, B; Thomas, JJ, 2011) |
| " Moreover, the present method was successfully applied to study pharmacokinetic parameters of FEN after intraperitoneal administration to male Wistar rat." | 1.37 | HPLC-UV method development for fentanyl determination in rat plasma and its application to elucidate pharmacokinetic behavior after i.p. administration to rats. ( Almousa, AA; Hanajiri, RK; Ikeda, R; Kuroda, N; Nakashima, K; Wada, M, 2011) |
| "Fentanyl is a very potent synthetic narcotic analgesic." | 1.34 | Use of single-drop microextraction for determination of fentanyl in water samples. ( Dubey, DK; Ganesan, K; Gupta, PK; Manral, L, 2007) |
| "Fentanyl (m/z 337) was found in each of the six overdose cases by the appearance of the MS-MS daughter ion on both an ion trap and a triple-quadrupole MS resulting from the fragmentation pathway of fentanyl (m/z 337 --> 188)." | 1.34 | Direct-injection mass spectrometric method for the rapid identification of fentanyl and norfentanyl in postmortem urine of six drug-overdose cases. ( Callery, PS; Kraner, JC; Peer, CJ; Shakleya, DM; Younis, IR, 2007) |
| "Fentanyl is an opioid drug widely used as a co-adjuvant in abdominal delivery, a fact that justifies its pharmacokinetic study under these conditions." | 1.33 | Pharmacokinetics and transplacental distribution of fentanyl in epidural anesthesia for normal pregnant women. ( da Cunha, SP; de Barros Duarte, L; de Carvalho Cavalli, R; Duarte, G; Lanchote, VL; Moisés, EC, 2005) |
| " With time the dosing often increases because of tolerance." | 1.32 | Methadone dosage for prevention of opioid withdrawal in children. ( Cimino, M; Fletcher, JE; Heard, AM; Heard, CM; Kielma, D; Siddappa, R, 2003) |
| "Fentanyl is a very strong opioid with analgesic properties that are approximately 80 times stronger than those of morphine and therefore is used in major surgery and treatment of pain in tumor patients." | 1.31 | Comparison of nonradioactive microtiter plate enzyme immunoassays for the sensitive detection of fentanyl. ( Käferstein, H; Sticht, G, 2000) |
| "Sensitivity and specificity were 50% and 97%, respectively." | 1.29 | Factors associated with hypotension and bradycardia after epidural blockade. ( Curatolo, M; Orlando, A; Scaramozzino, P; Venuti, FS; Zbinden, AM, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (15.07) | 18.2507 |
| 2000's | 35 (47.95) | 29.6817 |
| 2010's | 21 (28.77) | 24.3611 |
| 2020's | 6 (8.22) | 2.80 |
| Authors | Studies |
|---|---|
| Vandergrift, GW | 1 |
| Gill, CG | 1 |
| Sapci, I | 1 |
| Aiello, A | 1 |
| Hassab, TH | 1 |
| Gorgun, E | 1 |
| Hull, TL | 1 |
| Champagne, BJ | 1 |
| Steele, SR | 1 |
| Valente, MA | 1 |
| Green, TC | 1 |
| Park, JN | 1 |
| Gilbert, M | 1 |
| McKenzie, M | 1 |
| Struth, E | 1 |
| Lucas, R | 1 |
| Clarke, W | 1 |
| Sherman, SG | 1 |
| Li, Z | 1 |
| Chen, H | 1 |
| Feng, S | 1 |
| Liu, K | 1 |
| Wang, P | 1 |
| Hyun, DG | 1 |
| Huh, JW | 1 |
| Hong, SB | 1 |
| Koh, Y | 1 |
| Lim, CM | 1 |
| Angelini, DJ | 1 |
| Biggs, TD | 1 |
| Prugh, AM | 1 |
| Smith, JA | 1 |
| Hanburger, JA | 1 |
| Llano, B | 1 |
| Avelar, R | 1 |
| Ellis, A | 1 |
| Lusk, B | 1 |
| Malik Naanaa, A | 1 |
| Sisco, E | 1 |
| Sekowski, JW | 1 |
| Tikhomirov, M | 1 |
| Śniegocki, T | 1 |
| Poźniak, B | 1 |
| Minami, D | 1 |
| Nakasuka, T | 1 |
| Ando, C | 1 |
| Iwamoto Md, Y | 1 |
| Sato, K | 1 |
| Fujiwara, K | 1 |
| Shibayama, T | 1 |
| Yonei Md PhD, T | 1 |
| Sato, T | 1 |
| McGowan, CR | 1 |
| Harris, M | 1 |
| Platt, L | 1 |
| Hope, V | 1 |
| Rhodes, T | 1 |
| Daniulaityte, R | 1 |
| Carlson, RR | 1 |
| Juhascik, MP | 1 |
| Strayer, KE | 1 |
| Sizemore, IE | 1 |
| Park, M | 1 |
| Kim, BJ | 1 |
| Kim, GS | 1 |
| Shankaran, H | 1 |
| Adeshina, F | 1 |
| Teeguarden, JG | 1 |
| Shujaat, A | 1 |
| Bajwa, AA | 1 |
| Usman, F | 1 |
| Jones, L | 1 |
| Cury, JD | 1 |
| Sharma, A | 1 |
| Singh, PM | 1 |
| Trikha, A | 1 |
| Rewari, V | 1 |
| Burjek, NE | 1 |
| Wagner, CE | 1 |
| Hollenbeck, RD | 1 |
| Wang, L | 1 |
| Yu, C | 1 |
| McPherson, JA | 1 |
| Billings, FT | 1 |
| Bista, SR | 2 |
| Lobb, M | 1 |
| Haywood, A | 2 |
| Hardy, J | 2 |
| Tapuni, A | 2 |
| Norris, R | 2 |
| Jeyabalan, A | 1 |
| Medford, AR | 1 |
| Heapy, A | 1 |
| Dziura, J | 1 |
| Buta, E | 1 |
| Goulet, J | 1 |
| Kulas, JF | 1 |
| Kerns, RD | 1 |
| Fu, J | 1 |
| Gibbons, K | 1 |
| Good, P | 1 |
| Zhu, M | 1 |
| Wang, H | 1 |
| Zhu, A | 1 |
| Niu, K | 1 |
| Wang, G | 2 |
| Lurie, IS | 1 |
| Iio, R | 1 |
| Leung, JW | 1 |
| Mann, SK | 1 |
| Siao-Salera, R | 1 |
| Ransibrahmanakul, K | 1 |
| Lim, B | 1 |
| Cabrera, H | 1 |
| Canete, W | 1 |
| Barredo, P | 1 |
| Gutierrez, R | 1 |
| Leung, FW | 1 |
| Cooreman, S | 1 |
| Deprez, C | 1 |
| Martens, F | 1 |
| Van Bocxlaer, J | 1 |
| Croes, K | 1 |
| Huynh, K | 1 |
| Barhate, R | 1 |
| Rodrigues, W | 1 |
| Moore, C | 1 |
| Coulter, C | 1 |
| Vincent, M | 1 |
| Soares, J | 1 |
| Clavijo, CF | 1 |
| Thomas, JJ | 1 |
| Cromie, M | 1 |
| Schniedewind, B | 1 |
| Hoffman, KL | 1 |
| Christians, U | 1 |
| Galinkin, JL | 1 |
| Almousa, AA | 1 |
| Ikeda, R | 1 |
| Wada, M | 1 |
| Kuroda, N | 1 |
| Hanajiri, RK | 1 |
| Nakashima, K | 1 |
| Ghassabian, S | 1 |
| Moosavi, SM | 1 |
| Valero, YG | 1 |
| Shekar, K | 1 |
| Fraser, JF | 1 |
| Smith, MT | 1 |
| Niesters, M | 1 |
| Mahajan, R | 1 |
| Olofsen, E | 1 |
| Boom, M | 1 |
| Garcia Del Valle, S | 1 |
| Aarts, L | 1 |
| Dahan, A | 1 |
| Margarido, CB | 1 |
| Dlacic, A | 1 |
| Balki, M | 1 |
| Furtado, L | 1 |
| Carvalho, JC | 1 |
| Villemagne, PS | 1 |
| Dannals, RF | 1 |
| Ravert, HT | 1 |
| Frost, JJ | 2 |
| Frecska, E | 1 |
| Arato, M | 1 |
| Chen, X | 1 |
| Tang, J | 1 |
| White, PF | 1 |
| Wender, RH | 1 |
| Ma, H | 1 |
| Sloninsky, A | 1 |
| Kariger, R | 1 |
| Dominguez, KD | 1 |
| Lomako, DM | 1 |
| Katz, RW | 1 |
| Kelly, HW | 1 |
| Farrar, JT | 1 |
| Berlin, JA | 1 |
| Strom, BL | 1 |
| Renna, M | 1 |
| Wigmore, T | 1 |
| Mofeez, A | 1 |
| Gillbe, C | 1 |
| Hunter, RP | 1 |
| Koch, DE | 1 |
| Mutlow, A | 1 |
| Isaza, R | 1 |
| Day, J | 1 |
| Slawson, M | 1 |
| Lugo, RA | 1 |
| Wilkins, D | 1 |
| Siddappa, R | 1 |
| Fletcher, JE | 1 |
| Heard, AM | 1 |
| Kielma, D | 1 |
| Cimino, M | 1 |
| Heard, CM | 1 |
| Bencherif, B | 1 |
| Stumpf, MJ | 1 |
| Links, JM | 1 |
| Van Nimmen, NF | 2 |
| Poels, KL | 1 |
| Veulemans, HA | 2 |
| Magosso, E | 1 |
| Ursino, M | 1 |
| van Oostrom, JH | 1 |
| Li, YH | 1 |
| Xu, JH | 1 |
| Yang, JJ | 1 |
| Tian, J | 1 |
| Xu, JG | 1 |
| Walsh, D | 1 |
| Ikai, A | 1 |
| Riemer, RK | 1 |
| Ramamoorthy, C | 1 |
| Malhotra, S | 1 |
| Malhatra, S | 1 |
| Cassorla, L | 1 |
| Amir, G | 1 |
| Hanley, FL | 1 |
| Reddy, VM | 1 |
| Pihlainen, K | 1 |
| Grigoras, K | 1 |
| Franssila, S | 1 |
| Ketola, R | 1 |
| Kotiaho, T | 1 |
| Kostiainen, R | 1 |
| Moisés, EC | 1 |
| de Barros Duarte, L | 1 |
| de Carvalho Cavalli, R | 1 |
| Lanchote, VL | 1 |
| Duarte, G | 1 |
| da Cunha, SP | 1 |
| Koltzenburg, M | 1 |
| Pokorny, R | 1 |
| Gasser, UE | 1 |
| Richarz, U | 1 |
| Bagheri, H | 1 |
| Es-haghi, A | 1 |
| Khalilian, F | 1 |
| Rouini, MR | 1 |
| Angst, MS | 1 |
| Clark, DJ | 1 |
| Gupta, PK | 1 |
| Manral, L | 1 |
| Ganesan, K | 1 |
| Dubey, DK | 1 |
| Chang, YW | 1 |
| Yao, HT | 1 |
| Chao, YS | 1 |
| Yeh, TK | 1 |
| Bytzer, P | 1 |
| Lindeberg, B | 1 |
| Skulska, A | 1 |
| Kała, M | 1 |
| Adamowicz, P | 1 |
| Chudzikiewicz, E | 1 |
| Lechowicz, W | 1 |
| Minty, RG | 1 |
| Kelly, L | 1 |
| Minty, A | 1 |
| Hammett, DC | 1 |
| Peer, CJ | 1 |
| Shakleya, DM | 1 |
| Younis, IR | 1 |
| Kraner, JC | 1 |
| Callery, PS | 1 |
| Morris, GF | 1 |
| Gore-Hickman, W | 1 |
| Lang, SA | 1 |
| Yip, RW | 1 |
| Lee, VC | 1 |
| Smart, D | 1 |
| Lambert, DG | 1 |
| Szeitz, A | 1 |
| Riggs, KW | 1 |
| Harvey-Clark, C | 1 |
| Curatolo, M | 1 |
| Scaramozzino, P | 1 |
| Venuti, FS | 1 |
| Orlando, A | 1 |
| Zbinden, AM | 1 |
| Fryirs, B | 1 |
| Woodhouse, A | 1 |
| Huang, JL | 1 |
| Dawson, M | 1 |
| Mather, LE | 1 |
| Fryirsa, B | 1 |
| Valaer, AK | 1 |
| Huber, T | 1 |
| Andurkar, SV | 1 |
| Clark, CR | 1 |
| DeRuiter, J | 1 |
| Willenbring, S | 1 |
| Stevens, CW | 1 |
| Kovoor, A | 1 |
| Celver, JP | 1 |
| Wu, A | 1 |
| Chavkin, C | 1 |
| Portier, EJ | 1 |
| de Blok, K | 1 |
| Butter, JJ | 1 |
| van Boxtel, CJ | 1 |
| Zamparelli, M | 1 |
| Eaton, S | 1 |
| Spitz, L | 1 |
| Pierro, A | 1 |
| Lambropoulos, J | 1 |
| Spanos, GA | 1 |
| Lazaridis, NV | 1 |
| Käferstein, H | 1 |
| Sticht, G | 1 |
| Kotani, N | 1 |
| Hashimoto, H | 1 |
| Kushikata, T | 1 |
| Yoshida, H | 1 |
| Muraoka, M | 1 |
| Takahashi, S | 1 |
| Matsuki, A | 1 |
| Tanaka, M | 1 |
| Sato, M | 1 |
| Kimura, T | 1 |
| Nishikawa, T | 1 |
| Choi, HS | 1 |
| Shin, HC | 1 |
| Khang, G | 1 |
| Rhee, JM | 1 |
| Lee, HB | 1 |
| Drummond, JC | 1 |
| Brann, CA | 1 |
| Perkins, DE | 1 |
| Wolfe, DE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Controlled Trial Comparing Maximal and Half-maximal Suction Pressure Applied During Water Exchange in Colonoscopy[NCT01948284] | 74 participants (Anticipated) | Interventional | 2013-08-31 | Recruiting | |||
| Comparative Efficacy of Water & Indigo Carmine vs Water or Air Method[NCT01607255] | Phase 4 | 480 participants (Actual) | Interventional | 2013-05-16 | Completed | ||
| A Randomized Controlled Comparison of Warm Water Infusion in Lieu of Air Insufflation vs. Air Insufflation for Aiding Colonoscopy Insertion in Sedated Patients Undergoing Colorectal Cancer (CRC) Screening and Surveillance.[NCT00785889] | 56 participants (Actual) | Interventional | 2008-03-31 | Completed | |||
| Comparison of Study Method Versus Conventional Method for Performing Unsedated Colonoscopy for Colorectal Cancer Screening and Surveillance[NCT01383252] | 10 participants (Actual) | Interventional | 2010-02-28 | Completed | |||
| Randomized Controlled Trial (RCT) to Compare Adenoma Detection Rate of Combined Chromoendoscopy (Indigo Carmine) With Water Infusion in Lieu of Air Insufflation (Water Method) vs. Water Method Alone in Screening Colonoscopy[NCT01383265] | 1,177 participants (Actual) | Interventional | 2010-03-31 | Completed | |||
| Water Colonoscopy Versus Air Colonoscopy for Unsedated Patients With Prior Abdominal or Pelvic Surgery: a Prospective Randomized, Controlled Trial[NCT01485133] | 110 participants (Actual) | Observational | 2011-11-30 | Completed | |||
| Comparing Air Insufflation, Water Immersion and Water Exchange Methods During Minimal Sedated Colonoscopy, a Randomized, Controlled Trial[NCT01535326] | 270 participants (Actual) | Interventional | 2012-02-29 | Completed | |||
| Water Infusion and Carbon Dioxide Insufflation Versus Air Insufflation Versus Air Insufflation Techniques in Screening Colonoscopies in the United States: A Comparative Study Evaluating Safety, Efficacy and Adenoma Detection Rate (ADR)[NCT01782014] | Phase 3 | 450 participants (Anticipated) | Interventional | 2013-02-28 | Terminated | ||
| Propofolsleep - A Observational Study on Cardiopulmonary and Pharyngeal Reactions While Drug Induced Sleep Endoscopy in Patients With Obstructive Sleep Apnea Syndrome Under PSI Monitoring[NCT03224936] | 20 participants (Anticipated) | Observational | 2017-08-22 | Active, not recruiting | |||
| Ilioinguinal/Iliohypogastric vs. Quadratus Lumborum Nerve Blockade for Elective Open Inguinal Herniorrhaphy[NCT03007966] | Phase 2 | 60 participants (Actual) | Interventional | 2017-01-30 | Completed | ||
| Randomized Trial Comparing Anchorsure® Suture Anchoring System and the CapioTM Slim Suture Capturing Device for Sacrospinous Ligament Suspension.[NCT03565640] | 48 participants (Actual) | Interventional | 2018-10-29 | Completed | |||
| Evaluation of Ultrasound-Guided Adductor Canal Blockade for Postoperative Analgesia Following Robotic Medial Unicompartmental Knee Replacement[NCT01818531] | Phase 4 | 150 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
| Combined Spinal Epidural Analgesia in Labour: A Comparison of Two Intrathecal Regimens of Single Shot Spinal[NCT03117595] | Phase 4 | 100 participants (Actual) | Interventional | 2017-11-23 | Completed | ||
| Epithelial Healing and Visual Outcomes of Patients Using Omega-3 Supplements as an Adjunct Therapy Before and After Photorefractive Keratectomy (PRK) Surgery[NCT01059019] | 17 participants (Actual) | Interventional | 2010-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Proximal diminutive adenoma detection rate (ADR) in screening colonoscopy performed with the unusual air method, versus the water (exchange) method and with dye added to the water (exchange) method (NCT01607255)
Timeframe: 36 months
| Intervention | participants (Number) | |
|---|---|---|
| Proximal ADR | Serrated Lesion | |
| Air Method | 83 | 18 |
| Water (Exchange) Method | 86 | 38 |
| Water (Exchange) Plus Dye Method | 89 | 42 |
the number of participants with at least one adenoma in each of the study groups. (NCT01535326)
Timeframe: 9 to 12 months
| Intervention | participants (Number) |
|---|---|
| Air Insufflation | 39 |
| Water Immersion | 41 |
| Water Exchange | 51 |
The maximal pain score during insertion phase of colonoscopy was assessed with 0 to 10 scale VAS score (0: no pain; 10: maximal pain) (NCT01535326)
Timeframe: 9 to 12 months
| Intervention | units on a scale (Median) |
|---|---|
| Air Insufflation | 3.5 |
| Water Immersion | 1.8 |
| Water Exchange | 0 |
satisfaction score obtained after colonoscopy 0 = no satisfied; 10 = most satisfied (NCT01535326)
Timeframe: 9 to 12 months
| Intervention | units on a scale (Median) |
|---|---|
| Air Insufflation | 10 |
| Water Immersion | 10 |
| Water Exchange | 10 |
proportion of patients without insertion pain during colonoscopy (NCT01535326)
Timeframe: up to 12 months
| Intervention | participants (Number) |
|---|---|
| Air Insufflation | 27 |
| Water Immersion | 39 |
| Water Exchange | 55 |
(NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 2 |
| Quadratus Lumborum Block | 3 |
(NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 0 |
| Quadratus Lumborum Block | 4 |
(NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 6 |
| Quadratus Lumborum Block | 3 |
(NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 9 |
| Quadratus Lumborum Block | 5 |
(NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 3 |
| Quadratus Lumborum Block | 2 |
(NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | Participants (Count of Participants) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 3 |
| Quadratus Lumborum Block | 3 |
Assessed on an 11 point (0-10) numeric analog scale with a higher score denoting a worse outcome (NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | score on a scale (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 3 |
| Quadratus Lumborum Block | 2.7 |
Assessed on an 11-point (0-10) numeric analog scale with a higher score denoting a worse outcome (NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | score on a scale (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 3.6 |
| Quadratus Lumborum Block | 3.3 |
Assessed on an 11 point (0-10) numeric analog scale with a higher score denoting a worse outcome (NCT03007966)
Timeframe: 24hrs Post Nerve Block
| Intervention | score on a scale (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 4.9 |
| Quadratus Lumborum Block | 5.3 |
Assessed on an 11-point (0-10) numeric analog scale with a higher score denoting a worse outcome. (NCT03007966)
Timeframe: 8 hrs Post Nerve Block
| Intervention | score on a scale (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 5.10 |
| Quadratus Lumborum Block | 5.03 |
When does the patient require their first post operative analgesic dose? (NCT03007966)
Timeframe: 24hrs Post Nerve Block
| Intervention | minutes (Median) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 141 |
| Quadratus Lumborum Block | 91 |
Total opioids consumed during the first 24hrs post operatively. Measured as 24hr Oxycodone Equivalent (NCT03007966)
Timeframe: 24 hrs Post Nerve Block
| Intervention | milligrams (Mean) |
|---|---|
| Ilioinguinal / Iliohypogastric Block | 19.7 |
| Quadratus Lumborum Block | 25.2 |
"Symptomatic success was assessed by the pelvic floor disability index (PFDI-20) questionnaire. The PFDI-20 has 20 items within 3 sub-scales of symptoms (total of 20 items). Each item produces a response of 0 to 4, the average response in each sub-scale is multiplied by 25 to obtain the sub-scale score (range 0 to 100). The total score is the sum of the three sub-scale scores with a range of 0-300. Higher value for a time-point score indicates a greater degree of symptom bother.~The difference in scores across the study time-points was calculated by subtracting the total score at baseline from the score at 12 months post-operation. A negative value for the difference in scores from baseline to 12 months indicates symptom improvement, where the more negative the difference in score is the greater the improvement in symptoms." (NCT03565640)
Timeframe: Baseline and Month 12
| Intervention | score on a scale (Mean) |
|---|---|
| Capio Slim Device | -66.3 |
| Anchorsure Device | -71.0 |
"Symptomatic success will be assessed by the Pelvic Floor Impact Questionnaire - 7 (PFIQ-7). The PFIQ-7 has 7 items for each of 3 sub-scales (total of 21 items). Each item produces a response of 0 to 3, the average response in each sub-scale is multiplied by 100/3 to obtain the total scale score (range 0 to 100). The total score is the sum of the three sub-scale scores with a range of 0-300. Higher value for a time-point score indicates a greater degree of symptom bother.~The difference in scores across the study time-points was calculated by subtracting the total score at baseline from the score at 12 months post-operation. A negative value for the difference in scores from baseline to 12 months indicates symptom improvement, where the more negative the difference in score is the greater the improvement in symptoms." (NCT03565640)
Timeframe: Baseline and Month 12
| Intervention | score on a scale (Mean) |
|---|---|
| Capio Slim Device | -26.4 |
| Anchorsure Device | -40.6 |
The stage is assigned as follows: 0 if there is no prolapse at all, 1 if there is prolapse but the leading point is not within 1cm of the hymen, 2 if the leading point is within 1 cm of the hymen (from 1cm within the hymen to 1cm beyond the hymen), 3 if the leading point is more than 1cm from the hymen but less than 2cm from being completely prolapsed, and 4 if the leading point is within 2cm of being complete prolapsed. Therefore higher POP-Q stages correlate to a worse degree of prolapse than lower POP-Q stages. (NCT03565640)
Timeframe: at 12 MONTHS
| Intervention | Units on a scale (Mean) |
|---|---|
| Capio Slim Device | 0.8 |
| Anchorsure Device | 0.9 |
This will be assessed using the numeric rating scale (NRS). The score is 0-10, with higher scores denoting a greater degree of pain. (NCT03565640)
Timeframe: postoperative 12 month
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Sacrospinous ligament fixation site Pain compared to preop | Worst pain compared to preop | |
| Anchorsure Device | -0.2 | -1.5 |
| Capio Slim Device | -0.5 | -1.8 |
Comparison of quadriceps motor strength at 6 hour post nerve block between two groups: adductor canal block and lumbar plexus block. The score range is 0-5, with higher scores denoting better outcomes. (NCT01818531)
Timeframe: 6 hours
| Intervention | units on a scale (Mean) |
|---|---|
| Adductor Canal Block | 4 |
| Lumbar Plexus Block | 2.5 |
Time to first analgesic between two groups: adductor canal block and lumbar plexus block. (NCT01818531)
Timeframe: 24 hours
| Intervention | minutes (Mean) |
|---|---|
| Adductor Canal Block | 601 |
| Lumbar Plexus Block | 659 |
Comparison of cumulative opioid consumption over 24 hour period between adductor canal block and lumbar plexus block. (NCT01818531)
Timeframe: 6, 12, 18, and 24 hours
| Intervention | mg (Mean) | |||
|---|---|---|---|---|
| 6 hours | 12 hours | 18 hours | 24 hours | |
| Adductor Canal Block | 1.5 | 11 | 20.9 | 27.9 |
| Lumbar Plexus Block | 2.5 | 10.3 | 20.7 | 32.1 |
Occurrence of opioid related side effects (nausea, vomiting and pruritus) between two groups: adductor canal block and lumbar plexus block. (NCT01818531)
Timeframe: 6, 12, 18, and 24 hours
| Intervention | events (Number) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nausea 6 hours | Nausea 12 hours | Nausea 18 hours | Nausea 24 hours | Vomiting 6 hours | Vomiting 12 hours | Vomiting 18 hours | Vomiting 24 hours | Pruritus 6 hours | Pruritus 12 hours | Pruritus 18 hours | Pruritus 24 hours | |
| Adductor Canal Block | 14 | 10 | 5 | 9 | 6 | 6 | 2 | 4 | 11 | 7 | 5 | 10 |
| Lumbar Plexus Block | 15 | 16 | 8 | 15 | 8 | 6 | 3 | 6 | 3 | 4 | 5 | 13 |
Comparison of verbal numerical pain scores at rest and with movement 6 hours following nerve blockade. The score range is 0-10 with higher scores denoting worse outcomes. (NCT01818531)
Timeframe: 6 hours post block.
| Intervention | score on a scale (Mean) | |
|---|---|---|
| rest | movement | |
| Adductor Canal Block | 1 | 1.6 |
| Lumbar Plexus Block | 1.1 | 1.5 |
4 reviews available for fentanyl and Sensitivity and Specificity
| Article | Year |
|---|---|
Paper spray mass spectrometry: A new drug checking tool for harm reduction in the opioid overdose crisis.
Topics: Drug Overdose; Fentanyl; Harm Reduction; High-Throughput Screening Assays; Humans; Illicit Drugs; Li | 2019 |
Meta-analysis of dexmedetomidine on emergence agitation and recovery profiles in children after sevoflurane anesthesia: different administration and different dosage.
Topics: Anesthesia; Anesthesia Recovery Period; Anesthetics, Inhalation; Child; Dexmedetomidine; Fentanyl; H | 2015 |
Advances in opioid therapy and formulations.
Topics: Administration, Cutaneous; Analgesia, Patient-Controlled; Analgesics, Opioid; Chemistry, Pharmaceuti | 2005 |
Single-dose intrathecal analgesia to control labour pain: is it a useful alternative to epidural analgesia?
Topics: Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Dose-Response Relationship, Drug; F | 2007 |
15 trials available for fentanyl and Sensitivity and Specificity
54 other studies available for fentanyl and Sensitivity and Specificity
| Article | Year |
|---|---|
Colorectal Surgery Resident Participation in Screening Colonoscopies: How Does It Impact Quality?
Topics: Aged; Clinical Competence; Colonic Diseases; Colonoscopy; Colorectal Surgery; Female; Fentanyl; Huma | 2019 |
An assessment of the limits of detection, sensitivity and specificity of three devices for public health-based drug checking of fentanyl in street-acquired samples.
Topics: Drug Contamination; Fentanyl; Humans; Illicit Drugs; Limit of Detection; Maryland; Opioid-Related Di | 2020 |
Development and Clinical Validation of a Sensitive Lateral Flow Assay for Rapid Urine Fentanyl Screening in the Emergency Department.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Biological Assay; Chromatography, Liquid; Drug O | 2020 |
Iatrogenic Opioid Withdrawal Syndrome in Critically Ill Patients: a Retrospective Cohort Study.
Topics: Aged; Analgesics, Opioid; Critical Illness; Female; Fentanyl; Humans; Incidence; Male; Middle Aged; | 2020 |
The use of lateral flow immunoassays for the detection of fentanyl in seized drug samples and postmortem urine.
Topics: Fentanyl; Gas Chromatography-Mass Spectrometry; Humans; Illicit Drugs; Immunoassay; Opioid-Related D | 2021 |
Lipemia in the Plasma Sample Affects Fentanyl Measurements by Means of HPLC-MS
Topics: Analgesics, Opioid; Animals; Chromatography, High Pressure Liquid; Fentanyl; Forensic Toxicology; Hy | 2021 |
Bronchoscopic diagnosis of peripheral pulmonary lung cancer employing sedation with fentanyl and midazolam.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Biopsy; Bronchoscopy; Carcinoma, Squamous Cell; Conscious S | 2017 |
Fentanyl self-testing outside supervised injection settings to prevent opioid overdose: Do we know enough to promote it?
Topics: Drug Overdose; Drug Users; Fentanyl; Humans; Opioid-Related Disorders; Reagent Strips; Self Care; Se | 2018 |
Street fentanyl use: Experiences, preferences, and concordance between self-reports and urine toxicology.
Topics: Adult; Chromatography, Liquid; Female; Fentanyl; Health Knowledge, Attitudes, Practice; Heroin Depen | 2019 |
Physiologically-based pharmacokinetic model for Fentanyl in support of the development of Provisional Advisory Levels.
Topics: Absorption; Administration, Inhalation; Administration, Intranasal; Administration, Oral; Adolescent | 2013 |
Safety and accuracy of semirigid pleuroscopy performed by pulmonary fellows at a major university hospital: our initial experience.
Topics: Fellowships and Scholarships; Female; Fentanyl; Hospitals, University; Humans; Male; Midazolam; Midd | 2013 |
Early bispectral index and sedation requirements during therapeutic hypothermia predict neurologic recovery following cardiac arrest.
Topics: Adult; Aged; Central Nervous System; Cohort Studies; Consciousness Monitors; Female; Fentanyl; Heart | 2014 |
Development, validation and application of an HPLC-MS/MS method for the determination of fentanyl and nor-fentanyl in human plasma and saliva.
Topics: Chromatography, High Pressure Liquid; Drug Monitoring; Drug Stability; Fentanyl; Humans; Linear Mode | 2014 |
Endobronchial ultrasound-guided transbronchial needle aspiration: patient satisfaction under light conscious sedation.
Topics: Anesthetics, Intravenous; Bronchoscopy; Carcinoma; Conscious Sedation; Endoscopic Ultrasound-Guided | 2014 |
Use of multiple-reaction monitoring ratios for identifying incompletely resolved fentanyl homologs and analogs via ultra-high-pressure liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, Liquid; Fentanyl; Sensitivity and Specificity; Tandem Mass Spectrometry | 2009 |
A comprehensive LC-MS-based quantitative analysis of fentanyl-like drugs in plasma and urine.
Topics: Analgesics, Opioid; Animals; Cattle; Chromatography, Liquid; Fentanyl; Limit of Detection; Mass Spec | 2010 |
Development of a homogeneous immunoassay for the detection of fentanyl in urine.
Topics: Analgesics, Opioid; Chromatography, Liquid; Drug Stability; Fentanyl; Forensic Toxicology; Humans; I | 2011 |
A low blood volume LC-MS/MS assay for the quantification of fentanyl and its major metabolites norfentanyl and despropionyl fentanyl in children.
Topics: Blood Volume; Child; Chromatography, High Pressure Liquid; Fentanyl; Humans; Sensitivity and Specifi | 2011 |
HPLC-UV method development for fentanyl determination in rat plasma and its application to elucidate pharmacokinetic behavior after i.p. administration to rats.
Topics: Animals; Area Under Curve; Chromatography, High Pressure Liquid; Drug Stability; Fentanyl; Injection | 2011 |
High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS.
Topics: Chromatography, Liquid; Drug Stability; Fentanyl; High-Throughput Screening Assays; Humans; Linear M | 2012 |
Validation of a novel respiratory rate monitor based on exhaled humidity.
Topics: Adolescent; Adult; Anesthetics, Intravenous; Blood Gas Monitoring, Transcutaneous; Electrocardiograp | 2012 |
The epidural electric stimulation test does not predict local anesthetic spread or consumption in labour epidural analgesia.
Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Anesthetics, Loca | 2013 |
Opiate sensitivity test in patients with stereotypic movement disorder and trichotillomania.
Topics: Adult; Analysis of Variance; Dose-Response Relationship, Drug; Female; Fentanyl; Humans; Middle Aged | 2002 |
A comparison of patient state index and bispectral index values during the perioperative period.
Topics: Adult; Aged; Electroencephalography; Female; Fentanyl; Humans; Logistic Models; Male; Middle Aged; P | 2002 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Clinically important changes in acute pain outcome measures: a validation study.
Topics: Acute Disease; Administration, Buccal; Analgesics, Opioid; Fentanyl; Humans; Neoplasms; Outcome Asse | 2003 |
Extraction and quantitation of carfentanil and naltrexone in goat plasma with liquid chromatography-mass spectrometry.
Topics: Analgesics, Opioid; Animals; Chromatography, Liquid; Fentanyl; Goats; Naltrexone; Reproducibility of | 2003 |
Analysis of fentanyl and norfentanyl in human plasma by liquid chromatography-tandem mass spectrometry using electrospray ionization.
Topics: Adolescent; Child; Child, Preschool; Chromatography, High Pressure Liquid; Fentanyl; Humans; Infant; | 2003 |
Methadone dosage for prevention of opioid withdrawal in children.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; F | 2003 |
Highly sensitive gas chromatographic-mass spectrometric screening method for the determination of picogram levels of fentanyl, sufentanil and alfentanil and their major metabolites in urine of opioid exposed workers.
Topics: Adult; Alfentanil; Analgesics, Opioid; Calibration; Fentanyl; Gas Chromatography-Mass Spectrometry; | 2004 |
Development and validation of a highly sensitive gas chromatographic-mass spectrometric screening method for the simultaneous determination of nanogram levels of fentanyl, sufentanil and alfentanil in air and surface contamination wipes.
Topics: Air; Alfentanil; Fentanyl; Gas Chromatography-Mass Spectrometry; Reproducibility of Results; Sensiti | 2004 |
Opioid-induced respiratory depression: a mathematical model for fentanyl.
Topics: Adaptation, Physiological; Analgesics, Opioid; Anesthetics, Intravenous; Computer Simulation; Dose-R | 2004 |
Preliminary results of fetal cardiac bypass in nonhuman primates.
Topics: Anesthesia, General; Anesthetics, Intravenous; Animals; Blood Gas Analysis; Blood Pressure Determina | 2005 |
Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures.
Topics: Amphetamines; Atmospheric Pressure; Fentanyl; Forensic Sciences; Mass Spectrometry; Molecular Struct | 2005 |
Pharmacokinetics and transplacental distribution of fentanyl in epidural anesthesia for normal pregnant women.
Topics: Analgesia, Epidural; Analgesics, Opioid; Female; Fentanyl; Gas Chromatography-Mass Spectrometry; Hum | 2005 |
Determination of fentanyl in human plasma by head-space solid-phase microextraction and gas chromatography-mass spectrometry.
Topics: Analgesics, Opioid; Fentanyl; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentrati | 2007 |
Comment on Koltzenburg et al.: Differential sensitivity of three experimental pain models in detecting the analgesic effects of transdermal fentanyl and buprenorphine. Pain 2006;126:165-74.
Topics: Administration, Cutaneous; Adult; Analgesics, Opioid; Buprenorphine; Cold Temperature; Cross-Over St | 2007 |
Use of single-drop microextraction for determination of fentanyl in water samples.
Topics: Fentanyl; Gas Chromatography-Mass Spectrometry; Hydrogen-Ion Concentration; Illicit Drugs; Microchem | 2007 |
Rapid and sensitive determination of fentanyl in dog plasma by on-line solid-phase extraction integrated with a hydrophilic column coupled to tandem mass spectrometry.
Topics: Animals; Calibration; Chromatography, Liquid; Dogs; Drug Stability; Fentanyl; Male; Online Systems; | 2007 |
[Determination of fentanyl, atropine and scopolamine in biological material using LC-MS/APCI methods].
Topics: Atropine; Calibration; Chromatography, High Pressure Liquid; Chromatography, Liquid; Fentanyl; Foren | 2007 |
Direct-injection mass spectrometric method for the rapid identification of fentanyl and norfentanyl in postmortem urine of six drug-overdose cases.
Topics: Adult; Deuterium; Drug Overdose; Fatal Outcome; Female; Fentanyl; Forensic Medicine; Humans; Male; M | 2007 |
Spinal and cortical evoked potential studies in the ketamine-anesthetized rabbit: fentanyl exerts component-specific, naloxone-reversible changes dependent on stimulus intensity.
Topics: Anesthesia; Animals; Blood Pressure; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interac | 1994 |
Desensitization of the mu-opioid activation of phospholipase C in SH-SY5Y cells: the role of protein kinases C and A and Ca(2+)-activated K+ currents.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Sensitive and selective assay for fentanyl using gas chromatography with mass selective detection.
Topics: Analgesics, Opioid; Animals; Fentanyl; Gas Chromatography-Mass Spectrometry; Reproducibility of Resu | 1996 |
Factors associated with hypotension and bradycardia after epidural blockade.
Topics: Adjuvants, Anesthesia; Adult; Aged; Analgesia, Epidural; Anesthesia, Epidural; Anesthetics, Local; B | 1996 |
Determination of subnanogram concentrations of fentanyl in plasma by gas chromatography-mass spectrometry: comparison with standard radioimmunoassay.
Topics: Analgesics, Opioid; Fentanyl; Gas Chromatography-Mass Spectrometry; Humans; Injections, Intravenous; | 1997 |
Development of a gas chromatographic-mass spectrometric drug screening method for the N-dealkylated metabolites of fentanyl, sufentanil, and alfentanil.
Topics: Alfentanil; Analgesics, Opioid; Drug Residues; Fentanyl; Gas Chromatography-Mass Spectrometry; Human | 1997 |
Spinal mu, delta and kappa opioids alter chemical, mechanical and thermal sensitivities in amphibians.
Topics: Analgesics, Opioid; Animals; Drug Interactions; Enkephalin, Leucine-2-Alanine; Fentanyl; Injections, | 1997 |
Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy.
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; G-Protein-C | 1998 |
Simultaneous determination of fentanyl and midazolam using high-performance liquid chromatography with ultraviolet detection.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Chromatography, High Pressure Liquid; Fentanyl; Humans; M | 1999 |
Amino acids counteract the inhibitory effect of fentanyl on hepatocyte oxidative metabolism.
Topics: Adjuvants, Anesthesia; Amino Acids; Animals; Animals, Newborn; Body Temperature Regulation; Cell Res | 2000 |
Development and validation of an HPLC assay for fentanyl, alfentanil, and sufentanil in swab samples.
Topics: Alfentanil; Analgesics, Opioid; Chromatography, High Pressure Liquid; Fentanyl; Reproducibility of R | 2000 |
Comparison of nonradioactive microtiter plate enzyme immunoassays for the sensitive detection of fentanyl.
Topics: Analgesics, Opioid; Calibration; False Positive Reactions; Fentanyl; Humans; Immunoenzyme Techniques | 2000 |
Quantitative analysis of fentanyl in rat plasma by gas chromatography with nitrogen-phosphorus detection.
Topics: Analgesics, Opioid; Animals; Chromatography, Gas; Fentanyl; Nitrogen; Phosphorus; Rats; Reproducibil | 2001 |
A comparison of median frequency, spectral edge frequency, a frequency band power ratio, total power, and dominance shift in the determination of depth of anesthesia.
Topics: Adult; Aged; Alpha Rhythm; Anesthesia, General; Arousal; Beta Rhythm; Consciousness; Delta Rhythm; E | 1991 |