Page last updated: 2024-10-27

fentanyl and Pain, Procedural

fentanyl has been researched along with Pain, Procedural in 20 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Pain, Procedural: Pain associated with examination, treatment or procedures.

Research Excerpts

ExcerptRelevanceReference
"The addition of gabapentin to moderate sedation during D&E did not result in lower maximum recalled procedural pain."9.69Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023)
"In a small sample of children aged 4 to 18 years undergoing abscess I&D, IN fentanyl was noninferior, and potentially superior, to IV morphine for reducing procedural pain and distress."9.27Randomized Trial of Intranasal Fentanyl Versus Intravenous Morphine for Abscess Incision and Drainage. ( Aponte-Patel, L; Babineau, J; Dayan, PS; Fenster, DB; Tsze, DS, 2018)
"The aim of the study was to evaluate the effectiveness of fentanyl pectin nasal spray (FPNS) in controlling procedural breakthrough cancer pain (BTCP) in advanced cancer patients undergoing radiotherapy."7.91Effectiveness of fentanyl pectin nasal citrate in controlling episodes of breakthrough cancer pain triggered by routine radiotherapy procedures. ( Aymar, N; Jiménez, E; Mena, A; Mestre, F; Ortiz, I; Pardo, J; Roncero, R; Vidal, M, 2019)
"The addition of gabapentin to moderate sedation during D&E did not result in lower maximum recalled procedural pain."5.69Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial. ( Brant, AR; Floyd, S; Lotke, PS; Reeves, MF; Scott, RK; Tefera, E; Ye, PP, 2023)
"  NMDA receptor antagonists versus no treatment, placebo, oral sweet solution, or non-pharmacological intervention One RCT evaluated using oral ketamine (10 mg/kg body weight) versus sugar syrup (66."5.41Non-opioid analgesics for procedural pain in neonates. ( Bruschettini, M; Persad, E; Pizarro, AB, 2023)
" Opioids may result in an increase in episodes of apnea compared to placebo (RR 3."5.41Opioids for procedural pain in neonates. ( Borys, F; Bruschettini, M; Kinoshita, M; Olsson, E, 2023)
" Opioids may result in an increase in episodes of apnea compared to placebo (RR 3."5.41Opioids for procedural pain in neonates. ( Borys, F; Bruschettini, M; Kinoshita, M; Olsson, E, 2023)
"In a small sample of children aged 4 to 18 years undergoing abscess I&D, IN fentanyl was noninferior, and potentially superior, to IV morphine for reducing procedural pain and distress."5.27Randomized Trial of Intranasal Fentanyl Versus Intravenous Morphine for Abscess Incision and Drainage. ( Aponte-Patel, L; Babineau, J; Dayan, PS; Fenster, DB; Tsze, DS, 2018)
"The aim of the study was to evaluate the effectiveness of fentanyl pectin nasal spray (FPNS) in controlling procedural breakthrough cancer pain (BTCP) in advanced cancer patients undergoing radiotherapy."3.91Effectiveness of fentanyl pectin nasal citrate in controlling episodes of breakthrough cancer pain triggered by routine radiotherapy procedures. ( Aymar, N; Jiménez, E; Mena, A; Mestre, F; Ortiz, I; Pardo, J; Roncero, R; Vidal, M, 2019)
" We included any duration of drug treatment and any dosage given continuously or as bolus; we excluded studies that gave opioids to ventilated infants for procedures."2.72Opioids for newborn infants receiving mechanical ventilation. ( Bellù, R; Bruschettini, M; de Waal, KA; Nava, C; Romantsik, O; Zanini, R, 2021)
"Main adverse drug events were nausea and vomiting, somnolence, and confusion."1.72Tolerance of Fentanyl Pectin Nasal Spray for Procedural Pain in Geriatric Patients. ( Baudrant, M; Bedouch, P; Cracowski, JL; Drevet, S; Gavazzi, G; Gibert, P; Grevy, A; Maindet, C; Maljean, L; Mitha, N; Payen, M; Tiffet, T; Zerhouni, N, 2022)
" The primary outcome measures were adverse events and failed laceration repair."1.51Safety and effectiveness of intranasal midazolam and fentanyl used in combination in the pediatric emergency department. ( Cosgrove, P; Kienstra, AJ; Ryan, PM; Vezzetti, R; Wilkinson, M, 2019)
" Vital signs before and after dosing were not significantly different."1.51Intranasal midazolam and fentanyl for procedural sedation and analgesia in infants in the neonatal intensive care unit. ( Bidegain, M; Cotten, CM; Fisher, K; Goldberg, RN; Greenberg, RG; Hornik, CD; Ku, LC; Simmons, C; Smith, PB, 2019)
" Adverse events in CAPS patients were recorded."1.51Computer-Assisted Propofol Sedation for Esophagogastroduodenoscopy Is Effective, Efficient, and Safe. ( Beecher, R; Chiorean, M; Drennan, F; Gluck, M; Koch, J; Kozarek, RA; La Selva, D; Larsen, M; Lin, OS; McCormick, S; Ross, A; Tombs, D; Venu, N; Weigel, W, 2019)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's10 (50.00)24.3611
2020's10 (50.00)2.80

Authors

AuthorsStudies
Maljean, L1
Gavazzi, G1
Gibert, P1
Grevy, A1
Payen, M1
Zerhouni, N1
Tiffet, T1
Cracowski, JL1
Mitha, N1
Maindet, C1
Baudrant, M1
Bedouch, P1
Drevet, S1
Brant, AR1
Reeves, MF1
Ye, PP1
Scott, RK1
Floyd, S1
Tefera, E1
Lotke, PS1
Persad, E1
Pizarro, AB1
Bruschettini, M4
Kinoshita, M2
Olsson, E2
Borys, F2
Cruickshank, A1
Qeadan, F1
Kuttesch, JF1
Agarwal, HS1
Lai, SF1
Lam, MT1
Li, HWR1
Ng, EHY1
Rezniczek, GA1
Hecken, JM1
Rehman, S1
Dogan, A1
Tempfer, CB1
Hilal, Z1
Wang, J1
Yuan, X1
Guo, W1
Xiang, X1
Wu, Q1
Fang, M1
Zhang, W1
Ding, Z1
Xie, K1
Fang, J1
Zhou, H1
Fu, S1
Fihlman, M1
Karru, E1
Varpe, P1
Huhtinen, H1
Hagelberg, N1
Saari, TI1
Olkkola, KT1
Bellù, R1
Romantsik, O1
Nava, C1
de Waal, KA1
Zanini, R1
Mayorga-Buiza, MJ1
Marquez-Rivas, J1
Gomez-Gonzalez, E1
Nusrat, S1
Madhoun, MF1
Tierney, WM1
Ryan, PM1
Kienstra, AJ1
Cosgrove, P1
Vezzetti, R1
Wilkinson, M1
Cabadas Avión, R1
Baluja, A1
Ojea Cendón, M1
Leal Ruiloba, MS1
Vázquez López, S1
Rey Martínez, M1
Magdalena López, P1
Álvarez-Escudero, J1
Ku, LC1
Simmons, C1
Smith, PB1
Greenberg, RG1
Fisher, K1
Hornik, CD1
Cotten, CM1
Goldberg, RN1
Bidegain, M1
Pardo, J1
Mena, A1
Jiménez, E1
Aymar, N1
Ortiz, I1
Roncero, R1
Mestre, F1
Vidal, M1
Lin, OS1
La Selva, D1
Kozarek, RA1
Tombs, D1
Weigel, W1
Beecher, R1
Koch, J1
McCormick, S1
Chiorean, M1
Drennan, F1
Gluck, M1
Venu, N1
Larsen, M1
Ross, A1
Wall, SL1
Clarke, DL1
Allorto, NL1
Fenster, DB1
Dayan, PS1
Babineau, J1
Aponte-Patel, L1
Tsze, DS1

Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Gabapentin as an Adjunct for Pain Management During Dilation and Evacuation: A Double-blind Randomized Controlled Trial[NCT03635905]Phase 4130 participants (Actual)Interventional2017-05-26Completed
Efficacy of Topical Lidocaine/Prilocaine in Pain Management in Pleurocentesis[NCT05984264]Phase 4118 participants (Anticipated)Interventional2023-01-01Recruiting
A Randomized Study on Use of Virtual Reality Technology for Pain Relief in Transvaginal Oocyte Retrieval Under Conscious Sedation[NCT05218382]160 participants (Anticipated)Interventional2022-12-01Recruiting
Large Loop Excision of the Transformation Zone (LLETZ) With Versus Without Intraoperative Application of Lugol's Iodine in Women With Cervical Dysplasia: a Prospective Randomized Trial[NCT05132114]216 participants (Anticipated)Interventional2022-01-17Recruiting
Large Loop Excision of the Transformatione Zone Under General Versus Local Anesthesia: a Randomized Trial.[NCT03494686]229 participants (Actual)Interventional2018-04-03Completed
Dexmedetomidine-esketamine Combined With Oxycodone for Ultrasound-guided Percutaneous Radiofrequency Ablation in Patients With Liver Cancer: a Randomized Controlled Study[NCT06003218]88 participants (Anticipated)Interventional2023-10-16Recruiting
Effect of an Adjunctive Sedative for the Patients With Histories of Paradoxical Reaction to Midazolam During Sedative Endoscopy[NCT03940391]220 participants (Anticipated)Interventional2019-05-01Enrolling by invitation
A Randomized Controlled Trial of Intranasal Fentanyl in Combination With Midazolam Versus Midazolam Alone for Analgesia and Anxiolysis During Pediatric Facial Laceration Repair[NCT04745260]100 participants (Anticipated)Interventional2021-03-01Not yet recruiting
Comparison of Two Methods Using Intranasal Lidocaine to Alleviate Discomfort Associated With Administration of Intranasal Midazolam in Children.[NCT03054844]Phase 255 participants (Actual)Interventional2017-04-03Completed
Efficacy of Intranasal Fentanyl at Reducing Pain During Abscess Incision and Drainage (I&D) in Children[NCT01549002]Phase 320 participants (Actual)Interventional2012-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Parental Satisfaction

If my child needed medications to stay calm for a procedure, I would like to use these same medications again. (NCT03054844)
Timeframe: 1 minute

InterventionParticipants (Count of Participants)
PREMED10
PREMIX12

Procedural Distress, Cry Duration

Cry duration was measured in seconds and defined as the time from onset of crying following administration of an IN medication until the cessation of crying sounds and/or tears. If a patient did not cry, the cry duration was zero (NCT03054844)
Timeframe: 10 minutes

Interventionseconds (Mean)
PREMED84
PREMIX73

Procedural Distress, FLACC

The Faces, Legs, Activity, Cry, Consolability (FLACC) scale is comprised of five criteria (face, legs, activity, cry, consolability), with a possible score of 0 to 2 units on a scale for each criteria and a possible total score of 0 to 10 units on a scale (0 meaning no pain, 10 meaning most pain). (NCT03054844)
Timeframe: 10 minutes

InterventionUnits on a scale (Mean)
PREMED6.7
PREMIX7

Procedural Distress, OSBD-R

The Observational Scale of Behavioral Distress-Revised (OSBD-R) is an observational measure of pain and distress shown to have strong validity in children. The scale is an 8-factor, weighted observational scale used to measure distress associated with medical procedures, which has been validated in children and adults aged 1 to 20 years. The total Observational Scale of Behavioral Distress-Revised score is the sum of the scale scores for each phase, with each phase assigned a score from 0 to 23.5 units on a scale (0=no distress, 23.5=maximum distress), based on the frequency and types of behaviors observed during a predetermined number of 15-second intervals during each phase. There were four phases so the range of scores for the total OSBD-R was 0 to 94 units on a scale, with a higher score indicated a greater degree of distress. (NCT03054844)
Timeframe: 10 minutes

InterventionUnits on a scale (Mean)
PREMED6.4
PREMIX7

Procedural Pain

The Children's Hospital of Eastern Ontario Pain Scale (CHEOPS) utilizes six observational factors (cry, facial, verbal, torso, touch, and legs) to evaluate pain in young children and can be used to monitor the effectiveness of interventions for reducing the pain and discomfort of an intervention. This scale rates each behavior numerically, with a score of 4-6 units on a scale representing no pain, and a maximum score of 13 units on a scale representing (most pain perceived). (NCT03054844)
Timeframe: 10 minutes

InterventionUnits on a scale (Mean)
PREMED10.6
PREMIX10.5

Provider Satisfaction

I would like to use this method of administering intranasal midazolam and lidocaine again in the future (NCT03054844)
Timeframe: 1 minute

InterventionParticipants (Count of Participants)
PREMED8
PREMIX24

Number of Patients Satisfied With Analgesia Administered

"Number of patients satisfied with analgesia administered will be evaluated by determining the number of patients who report a Likert scale response of somewhat satisfied, very satisfied, or extremely satisfied (i.e. any patient who selects any of these three responses will be considered to have been satisfied with analgesia administered). Patients will be asked 10 minutes after procedure completion. If the patient is 8 years of age and older, both the patient and the parent or guardian will complete a satisfaction survey. If the patients is younger than 8 years, their parent or guardian will complete the satisfaction survey." (NCT01549002)
Timeframe: 10 minutes after procedure completion

InterventionParticipants (Count of Participants)
Intranasal Fentanyl10
Intravenous Morphine4

Score on the Observational Scale of Behavioral Distress Revised (OSBD-R)

Our primary outcome is the Observational Scale of Behavioral Distress - Revised (OSBD-R) to assess observed intra-procedural pain. The total OSBD-R score is a summation of the OSBD-R score of each individual phase. The score in each phase can range from 0 to 23.5. There were four phases in our study, so the range of scores for the total OSBD-R was 0 to 94, with a higher score indicating a greater degree of pain and distress. The four phases in the study are (1) before analgesia administration, (2) ten minutes after analgesia administration but before beginning I&D, (3) immediately post I&D procedure (to ascertain the pain perceived during procedure), and (4) ten minutes after procedure completion. The scores documented here are the total OSBD-R scores. (NCT01549002)
Timeframe: Up to 10 minutes after the procedure completion

Interventionunits on a scale (Mean)
Intranasal Fentanyl5.48
Intravenous Morphine18.92

Score on the Faces Pain Scale Revised (FPS-R)

"The Faces Pain Scale - Revised (FPS-R) is a self-report measure of pain has strong validity and reliability in children 4 - 17 years of age undergoing painful procedures, and will be used to assess patients' self reported pain. A score of 0 means no pain, a score of 10 means very much pain. Therefore, a lower score indicates that a patient is experiencing a lower degree of pain intensity.~Patients will complete the FPS-R at four times during their medical encounter: (1) before analgesia administration, (2) ten minutes after analgesia administration but before beginning I&D, (3) immediately post I&D procedure (to ascertain the pain perceived during procedure), and (4) ten minutes after procedure completion." (NCT01549002)
Timeframe: Up to 10 minutes after procedure completion

,
Interventionunits on a scale (Median)
Before analgesia administration10 min after analgesia, before I&DImmediately post-I&D10 min after procedure completion
Intranasal Fentanyl6241
Intravenous Morphine44105

Reviews

4 reviews available for fentanyl and Pain, Procedural

ArticleYear
Non-opioid analgesics for procedural pain in neonates.
    The Cochrane database of systematic reviews, 2023, 04-04, Volume: 4

    Topics: Aged; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Apnea; Body Wei

2023
Opioids for procedural pain in neonates.
    The Cochrane database of systematic reviews, 2023, 04-05, Volume: 4

    Topics: Analgesics; Analgesics, Opioid; Apnea; Bradycardia; Fentanyl; Humans; Hypotension; Infant; Infant, N

2023
Opioids for procedural pain in neonates.
    The Cochrane database of systematic reviews, 2023, 06-23, Volume: 6

    Topics: Analgesics; Analgesics, Opioid; Apnea; Bradycardia; Fentanyl; Humans; Hypotension; Infant, Newborn;

2023
Opioids for newborn infants receiving mechanical ventilation.
    The Cochrane database of systematic reviews, 2021, 03-17, Volume: 3

    Topics: Analgesics, Opioid; Bias; Child Development; Fentanyl; Heroin; Humans; Hypnotics and Sedatives; Infa

2021

Trials

7 trials available for fentanyl and Pain, Procedural

ArticleYear
Gabapentin as an adjunct for pain management during dilation and evacuation: A double-blind randomized controlled trial.
    Contraception, 2023, Volume: 118

    Topics: Dilatation; Double-Blind Method; Female; Fentanyl; Gabapentin; Humans; Midazolam; Nausea; Pain; Pain

2023
A randomized double-blinded non-inferiority trial comparing fentanyl and midazolam with pethidine and diazepam for pain relief during oocyte retrieval.
    Reproductive biomedicine online, 2020, Volume: 40, Issue:5

    Topics: Adult; Analgesics; Conscious Sedation; Diazepam; Double-Blind Method; Drug Therapy, Combination; Fem

2020
Syringe or mask? Loop electrosurgical excision procedure under local or general anesthesia: a randomized trial.
    American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:6

    Topics: Adenocarcinoma in Situ; Adult; Anesthesia, General; Anesthesia, Local; Anesthetics, Inhalation; Anes

2020
Syringe or mask? Loop electrosurgical excision procedure under local or general anesthesia: a randomized trial.
    American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:6

    Topics: Adenocarcinoma in Situ; Adult; Anesthesia, General; Anesthesia, Local; Anesthetics, Inhalation; Anes

2020
Syringe or mask? Loop electrosurgical excision procedure under local or general anesthesia: a randomized trial.
    American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:6

    Topics: Adenocarcinoma in Situ; Adult; Anesthesia, General; Anesthesia, Local; Anesthetics, Inhalation; Anes

2020
Syringe or mask? Loop electrosurgical excision procedure under local or general anesthesia: a randomized trial.
    American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:6

    Topics: Adenocarcinoma in Situ; Adult; Anesthesia, General; Anesthesia, Local; Anesthetics, Inhalation; Anes

2020
Sedation and Analgesia for Liver Cancer Percutaneous Radiofrequency Ablation: Fentanyl and Oxycodone Comparison.
    International journal of medical sciences, 2020, Volume: 17, Issue:14

    Topics: Aged; Analgesia; Analgesics, Opioid; Blood Pressure; Blood Pressure Determination; Conscious Sedatio

2020
Feasibility of a transmucosal sublingual fentanyl tablet as a procedural pain treatment in colonoscopy patients: a prospective placebo-controlled randomized study.
    Scientific reports, 2020, 12-01, Volume: 10, Issue:1

    Topics: Administration, Sublingual; Aged; Analgesics, Opioid; Colonoscopy; Double-Blind Method; Feasibility

2020
Use of diphenhydramine as an adjunctive sedative for colonoscopy in patients on chronic opioid therapy: a randomized controlled trial.
    Gastrointestinal endoscopy, 2018, Volume: 88, Issue:4

    Topics: Aged; Analgesics, Opioid; Anesthetics, Intravenous; Colonoscopy; Deep Sedation; Diphenhydramine; Fem

2018
Randomized Trial of Intranasal Fentanyl Versus Intravenous Morphine for Abscess Incision and Drainage.
    Pediatric emergency care, 2018, Volume: 34, Issue:9

    Topics: Abscess; Administration, Intranasal; Administration, Intravenous; Adolescent; Analgesics, Opioid; Ch

2018
Randomized Trial of Intranasal Fentanyl Versus Intravenous Morphine for Abscess Incision and Drainage.
    Pediatric emergency care, 2018, Volume: 34, Issue:9

    Topics: Abscess; Administration, Intranasal; Administration, Intravenous; Adolescent; Analgesics, Opioid; Ch

2018
Randomized Trial of Intranasal Fentanyl Versus Intravenous Morphine for Abscess Incision and Drainage.
    Pediatric emergency care, 2018, Volume: 34, Issue:9

    Topics: Abscess; Administration, Intranasal; Administration, Intravenous; Adolescent; Analgesics, Opioid; Ch

2018
Randomized Trial of Intranasal Fentanyl Versus Intravenous Morphine for Abscess Incision and Drainage.
    Pediatric emergency care, 2018, Volume: 34, Issue:9

    Topics: Abscess; Administration, Intranasal; Administration, Intravenous; Adolescent; Analgesics, Opioid; Ch

2018

Other Studies

9 other studies available for fentanyl and Pain, Procedural

ArticleYear
Tolerance of Fentanyl Pectin Nasal Spray for Procedural Pain in Geriatric Patients.
    Journal of the American Medical Directors Association, 2022, Volume: 23, Issue:6

    Topics: Aged; Analgesics, Opioid; Drug-Related Side Effects and Adverse Reactions; Fentanyl; Humans; Nasal S

2022
Eutectic mixture of lidocaine and prilocaine versus 1% lidocaine injection for lumbar punctures in pediatric oncology patients.
    Pediatric blood & cancer, 2019, Volume: 66, Issue:11

    Topics: Administration, Cutaneous; Analgesics; Anesthetics, Local; Child; Female; Fentanyl; Humans; Hypnotic

2019
Can fetus feel pain in the second trimester? Lessons learned from a sentinel event.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2018, Volume: 34, Issue:2

    Topics: Adjuvants, Anesthesia; Adrenergic alpha-1 Receptor Agonists; Analgesics, Opioid; Anesthesia, General

2018
Safety and effectiveness of intranasal midazolam and fentanyl used in combination in the pediatric emergency department.
    The American journal of emergency medicine, 2019, Volume: 37, Issue:2

    Topics: Administration, Intranasal; Analgesics, Opioid; Anxiety; Child; Child, Preschool; Drug Therapy, Comb

2019
Effectiveness and safety of gastrointestinal endoscopy during a specific sedation training program for non-anesthesiologists.
    Revista espanola de enfermedades digestivas, 2019, Volume: 111, Issue:3

    Topics: Adult; Aged; Conscious Sedation; Endoscopy, Gastrointestinal; Female; Fentanyl; Gastroenterologists;

2019
Intranasal midazolam and fentanyl for procedural sedation and analgesia in infants in the neonatal intensive care unit.
    Journal of neonatal-perinatal medicine, 2019, Volume: 12, Issue:2

    Topics: Administration, Intranasal; Analgesics, Opioid; Arterial Pressure; Bradycardia; Catheterization, Per

2019
Effectiveness of fentanyl pectin nasal citrate in controlling episodes of breakthrough cancer pain triggered by routine radiotherapy procedures.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2019, Volume: 21, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Breakthrough Pain; Cancer Pain; Female; Fentanyl

2019
Computer-Assisted Propofol Sedation for Esophagogastroduodenoscopy Is Effective, Efficient, and Safe.
    Digestive diseases and sciences, 2019, Volume: 64, Issue:12

    Topics: Adult; Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Anesthetists; Blood Gas Monitorin

2019
Analgesia protocols for burns dressings: Challenges with implementation.
    Burns : journal of the International Society for Burn Injuries, 2019, Volume: 45, Issue:7

    Topics: Academic Medical Centers; Acetaminophen; Analgesics; Anesthetics, Inhalation; Bandages; Burns; Child

2019