fentanyl has been researched along with Neuroblastoma in 20 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have examined the effect of fentanyl on [3H]noradrenaline release in a human neuroblastoma cell preparation, SH-SY5Y." | 7.69 | Fentanyl inhibits the release of [3H]noradrenaline from SH-SY5Y human neuroblastoma cells. ( Atcheson, R; Lambert, DG; Rowbotham, DJ, 1994) |
| "We have examined the effect of fentanyl on [3H]noradrenaline release in a human neuroblastoma cell preparation, SH-SY5Y." | 3.69 | Fentanyl inhibits the release of [3H]noradrenaline from SH-SY5Y human neuroblastoma cells. ( Atcheson, R; Lambert, DG; Rowbotham, DJ, 1994) |
| " Using SH-SY5Y human neuroblastoma cells (expressing both mu- and delta-opioid receptors), we demonstrated that fentanyl, a mu-preferring opioid, caused a dose-dependent (EC50 = 16 nM) monophasic increase in inositol (1,4,5)trisphosphate mass formation that peaked at 15 s and returned to basal within 1-2 min." | 3.69 | mu-Opioid receptor stimulation of inositol (1,4,5)trisphosphate formation via a pertussis toxin-sensitive G protein. ( Lambert, DG; Smart, D; Smith, G, 1994) |
| " We have examined the opiate binding characteristics, effects on cAMP formation and [3H]noradrenaline release of morphine, morphine-6 (M6G) and -3 (M3G)-glucuronides, and fentanyl in SH-SY5Y human neuroblastoma cells." | 3.68 | Effects of morphine and its metabolites on opiate receptor binding, cAMP formation and [3H]noradrenaline release from SH-SY5Y cells. ( Atcheson, R; Hirst, RA; Lambert, DG; Rowbotham, DJ, 1993) |
| "We have examined how fentanyl modulates [3H]noradrenaline uptake in two cultured neuronal cell preparations, the human neuroblastoma SH-SY5Y and the rat phaeochromocytoma PC12." | 3.68 | Fentanyl inhibits the uptake of [3H]noradrenaline in cultured neuronal cells. ( Atcheson, R; Lambert, DG; Rowbotham, DJ, 1993) |
| "Opiate receptors from NG108-15 neuroblastoma-glioma hybrid cell membranes were purified to apparent homogeneity in a form covalently labeled with the opiate affinity ligand 3-methylfentanylisothiocyanate (super-FIT)." | 3.67 | Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells. ( Burke, TR; Jacobson, AE; Klee, WA; Rice, KC; Simonds, WF, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.00) | 18.7374 |
| 1990's | 11 (55.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cohen-Karni, D | 1 |
| Kovaliov, M | 1 |
| Li, S | 1 |
| Jaffee, S | 1 |
| Tomycz, ND | 1 |
| Averick, S | 1 |
| Caputi, FF | 1 |
| Lattanzio, F | 1 |
| Carretta, D | 1 |
| Mercatelli, D | 1 |
| Candeletti, S | 1 |
| Romualdi, P | 1 |
| Wager, TT | 1 |
| Chappie, T | 1 |
| Horton, D | 1 |
| Chandrasekaran, RY | 1 |
| Samas, B | 1 |
| Dunn-Sims, ER | 1 |
| Hsu, C | 1 |
| Nawreen, N | 1 |
| Vanase-Frawley, MA | 1 |
| O'Connor, RE | 1 |
| Schmidt, CJ | 1 |
| Dlugolenski, K | 1 |
| Stratman, NC | 1 |
| Majchrzak, MJ | 1 |
| Kormos, BL | 1 |
| Nguyen, DP | 1 |
| Sawant-Basak, A | 1 |
| Mead, AN | 1 |
| Shiota, M | 1 |
| Oda, Y | 1 |
| Taniguchi, M | 1 |
| Hamabata, T | 1 |
| Mizumoto, H | 1 |
| Hata, D | 1 |
| Moulédous, L | 1 |
| Diaz, MF | 1 |
| Gutstein, HB | 1 |
| Burke, TR | 2 |
| Bajwa, BS | 1 |
| Jacobson, AE | 3 |
| Rice, KC | 3 |
| Streaty, RA | 2 |
| Klee, WA | 3 |
| Traynor, JR | 1 |
| Nahorski, SR | 1 |
| Smart, D | 4 |
| Smith, G | 2 |
| Lambert, DG | 7 |
| Patt, RB | 1 |
| Lustik, S | 1 |
| Litman, RS | 1 |
| Atcheson, R | 3 |
| Rowbotham, DJ | 3 |
| Hirst, RA | 1 |
| Hilton, AB | 1 |
| Lockhart, EM | 1 |
| Penning, DH | 1 |
| Lautraite, C | 1 |
| André, N | 1 |
| Portas, M | 1 |
| Bernard, JL | 1 |
| Chen, ZW | 1 |
| Yang, K | 1 |
| Wang, Y | 1 |
| Han, JS | 1 |
| Kim, CH | 1 |
| Rothman, RB | 1 |
| Mattson, MV | 1 |
| Bykov, V | 1 |
| George, C | 1 |
| Long, JB | 1 |
| Simonds, WF | 1 |
20 other studies available for fentanyl and Neuroblastoma
| Article | Year |
|---|---|
Fentanyl Initiated Polymers Prepared by ATRP for Targeted Delivery.
Topics: Cell Line, Tumor; Drug Delivery Systems; Fentanyl; Fluorescent Dyes; Humans; Neuroblastoma; Neurons; | 2017 |
Morphine and fentanyl differently affect MOP and NOP gene expression in human neuroblastoma SH-SY5Y cells.
Topics: Cell Line, Tumor; Fentanyl; Humans; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Neuroblasto | 2013 |
Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects.
Topics: Analgesics, Opioid; Aniline Compounds; Animals; Cell Line, Transformed; Conditioning, Operant; Dopam | 2017 |
Dexmedetomidine infusion for sedation in the intensive care setting in an infant with airway compromise due to congenital mediastinal neuroblastoma.
Topics: Airway Management; Airway Obstruction; Analgesics, Opioid; Antineoplastic Agents; Carboplatin; Criti | 2012 |
Modulation of extracellular signal-regulated kinase (ERK) activity by acute and chronic opioid treatment in neuronal and glial cell lines.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Diprenorphine; Drug Administration Schedule; Enzyme Ac | 2004 |
Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for mu or delta opiate receptors.
Topics: Animals; Benzimidazoles; Cell Line; Cell Membrane; Chemical Phenomena; Chemistry; Drug Evaluation, P | 1984 |
Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.
Topics: Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; GTP-Binding Proteins; Gua | 1995 |
Mu-opioids activate phospholipase C in SH-SY5Y human neuroblastoma cells via calcium-channel opening.
Topics: Calcium; Calcium Channels; Carbachol; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activatio | 1995 |
The use of transdermal fentanyl in a six-year-old patient with neuroblastoma and diffuse abdominal pain.
Topics: Abdominal Pain; Administration, Cutaneous; Child; Fentanyl; Humans; Male; Neuroblastoma | 1993 |
Fentanyl inhibits the release of [3H]noradrenaline from SH-SY5Y human neuroblastoma cells.
Topics: Atropine; Carbachol; Cell Differentiation; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePh | 1994 |
mu-Opioid receptor stimulation of inositol (1,4,5)trisphosphate formation via a pertussis toxin-sensitive G protein.
Topics: Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; GTP-Binding Proteins; Humans; I | 1994 |
Effects of morphine and its metabolites on opiate receptor binding, cAMP formation and [3H]noradrenaline release from SH-SY5Y cells.
Topics: Cell Line; Cyclic AMP; Diprenorphine; Dose-Response Relationship, Drug; Fentanyl; Glucuronates; Huma | 1993 |
Fentanyl inhibits the uptake of [3H]noradrenaline in cultured neuronal cells.
Topics: Adrenal Gland Neoplasms; Animals; Dose-Response Relationship, Drug; Fentanyl; Humans; Imipramine; Mo | 1993 |
Desensitization of the mu-opioid activation of phospholipase C in SH-SY5Y cells: the role of protein kinases C and A and Ca(2+)-activated K+ currents.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1995 |
Tyr-D-Arg2-Phe-sarcosine4 activates phospholipase C-coupled mu2-opioid receptors in SH-SY5Y cells.
Topics: Analgesics; Analgesics, Opioid; Cyclic AMP; Fentanyl; Humans; Inositol 1,4,5-Trisphosphate; Neurobla | 1996 |
Epidural analgesia in parturients with previous spinal irradiation.
Topics: Adolescent; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Loc | 1998 |
[Value of transdermal fentanyl administration in child in palliative care].
Topics: Administration, Cutaneous; Analgesics, Opioid; Brain Neoplasms; Child; Fentanyl; Humans; Male; Neopl | 1999 |
The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen2, D-Pen5] enkephalin on differentiated SH-SY5Y cells in humans.
Topics: Acids; Analgesics; Analgesics, Opioid; Animals; Cell Differentiation; CHO Cells; Cricetinae; Drug Sy | 2001 |
Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro.
Topics: Acylation; Adenylyl Cyclase Inhibitors; Analgesia; Animals; Brain; Cell Membrane; Chemical Phenomena | 1989 |
Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells.
Topics: Affinity Labels; Animals; Cell Line; Fentanyl; Glioma; Glycoproteins; Macromolecular Substances; Mem | 1985 |