fentanyl has been researched along with Mydriasis in 2 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Mydriasis: Dilation of pupils to greater than 6 mm combined with failure of the pupils to constrict when stimulated with light. This condition may occur due to injury of the pupillary fibers in the oculomotor nerve, in acute angle-closure glaucoma, and in ADIE SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In humans, fentanyl-induced miosis was completely blocked by 50mg naltrexone, and LY2456302 dose-dependently blocked miosis at 25 and 60 mg (minimal-to-no blockade at 4-10mg)." | 5.19 | Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human. ( Bell, RL; Gonzales, CR; Hart, JC; Lowe, SL; McKinzie, DL; McKinzie, JH; Mitch, CH; Need, AB; Rorick-Kehn, LM; Statnick, MA; Stoltz, RR; Suico, JG; Tauscher-Wisniewski, S; Weller, MA; Witcher, JW; Wong, CJ, 2014) |
| "Clonidine was a more potent inhibitor of fluctuations but significantly enhanced the light reflex." | 1.28 | Separate neural mechanisms mediate sufentanil-induced pupillary responses in the cat. ( Sharpe, LG, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rorick-Kehn, LM | 1 |
| Witcher, JW | 1 |
| Lowe, SL | 1 |
| Gonzales, CR | 1 |
| Weller, MA | 1 |
| Bell, RL | 1 |
| Hart, JC | 1 |
| Need, AB | 1 |
| McKinzie, JH | 1 |
| Statnick, MA | 1 |
| Suico, JG | 1 |
| McKinzie, DL | 1 |
| Tauscher-Wisniewski, S | 1 |
| Mitch, CH | 1 |
| Stoltz, RR | 1 |
| Wong, CJ | 1 |
| Sharpe, LG | 1 |
1 trial available for fentanyl and Mydriasis
| Article | Year |
|---|---|
Determining pharmacological selectivity of the kappa opioid receptor antagonist LY2456302 using pupillometry as a translational biomarker in rat and human.
Topics: Adolescent; Adult; Animals; Benzamides; Cross-Over Studies; Dose-Response Relationship, Drug; Double | 2014 |
1 other study available for fentanyl and Mydriasis
| Article | Year |
|---|---|
Separate neural mechanisms mediate sufentanil-induced pupillary responses in the cat.
Topics: Analgesics, Opioid; Animals; Cats; Clonidine; Drug Interactions; Fentanyl; Male; Morphine; Mydriasis | 1991 |