Page last updated: 2024-10-27

fentanyl and Muscle Rigidity

fentanyl has been researched along with Muscle Rigidity in 88 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Muscle Rigidity: Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)

Research Excerpts

ExcerptRelevanceReference
"Two cases of fentanyl-induced muscle rigidity are presented."8.79Muscle rigidity due to fentanyl infusion in the pediatric patient. ( Evans, OB; Glick, C; Parks, BR, 1996)
"We report here the case of an infant who developed life-threatening rigid-chest syndrome after receiving an accidental overdose of methadone."7.76Methadone-induced rigid-chest syndrome after substantial overdose. ( Hack, RA; Lynch, RE, 2010)
"We searched PubMed and EMBASE (through August 2009) for previous reports of morphine-related muscle rigidity and/or laryngeal spasm, using the search terms (muscle rigidity OR chest rigidity OR laryngeal spasm) AND (morphine OR fentanyl OR opioid)."7.75Morphine-induced muscle rigidity in a term neonate. ( Ceelie, I; de Wildt, SN; van der Lee, R, 2009)
"This study was undertaken to search for an alternative experimental model in the evaluation of fentanyl-induced muscle rigidity."7.67Fentanyl-induced muscle rigidity in unanesthetized and ketamine- or thiopental-anesthetized rats. ( Chan, SH; Lee, TY; Lui, PW, 1989)
"Systemic pretreatment with ketanserin, a relatively specific type-2 serotonin receptor antagonist, significantly attenuated the muscle rigidity produced in rats by the potent short-acting opiate agonist alfentanil."7.67Ketanserin pretreatment reverses alfentanil-induced muscle rigidity. ( Cline, EJ; Koob, GF; Smith, NT; Weinger, MB, 1987)
"The degree of opiate-induced muscular rigidity, simultaneous changes in arterial paCO2, cardiac indices (CI) prior to opioid and relaxant administration, onset and recovery from neuromuscular blockade (by electromyographic train-of-four registration), and motor response to laryngoscopy and intubation were recorded."6.66[Fentanyl versus sufentanil basic anesthesia. Hypnotic effect, muscle rigidity and efficacy of competitive muscle relaxants]. ( Brandt, L; Dick, W; Eberle, B; el-Gindi, M; Ellmauer, S; Hennes, HJ, 1989)
"A large percentage of opioid overdose fatalities involve fentanyl or one of its legal or illegal analogs (F/FAs)."5.62Wooden Chest syndrome: The atypical pharmacology of fentanyl overdose. ( Ann LeQuang, J; Pergolizzi, JV; Raffa, RB; Vortsman, E; Webster, LR, 2021)
"Intense generalized muscle rigidity is an undesirable side effect of potent opiate agonists."5.28Dexmedetomidine, acting through central alpha-2 adrenoceptors, prevents opiate-induced muscle rigidity in the rat. ( Maze, M; Segal, IS; Weinger, MB, 1989)
"Two cases of fentanyl-induced muscle rigidity are presented."4.79Muscle rigidity due to fentanyl infusion in the pediatric patient. ( Evans, OB; Glick, C; Parks, BR, 1996)
"Since its introduction into clinical practice, it has been known that fentanyl and other synthetic opioids may cause skeletal muscle rigidity."3.78Chest wall rigidity in two infants after low-dose fentanyl administration. ( Dewhirst, E; Naguib, A; Tobias, JD, 2012)
"We report here the case of an infant who developed life-threatening rigid-chest syndrome after receiving an accidental overdose of methadone."3.76Methadone-induced rigid-chest syndrome after substantial overdose. ( Hack, RA; Lynch, RE, 2010)
"We searched PubMed and EMBASE (through August 2009) for previous reports of morphine-related muscle rigidity and/or laryngeal spasm, using the search terms (muscle rigidity OR chest rigidity OR laryngeal spasm) AND (morphine OR fentanyl OR opioid)."3.75Morphine-induced muscle rigidity in a term neonate. ( Ceelie, I; de Wildt, SN; van der Lee, R, 2009)
"Systemic pretreatment with ketanserin, a relatively specific type-2 serotonin receptor antagonist, significantly attenuated the muscle rigidity produced in rats by the potent short-acting opiate agonist alfentanil."3.67Ketanserin pretreatment reverses alfentanil-induced muscle rigidity. ( Cline, EJ; Koob, GF; Smith, NT; Weinger, MB, 1987)
"This study was undertaken to search for an alternative experimental model in the evaluation of fentanyl-induced muscle rigidity."3.67Fentanyl-induced muscle rigidity in unanesthetized and ketamine- or thiopental-anesthetized rats. ( Chan, SH; Lee, TY; Lui, PW, 1989)
"During fentanyl-induced muscular rigidity BIS recordings reflect EMG variations."2.70Biasing effect of the electromyogram on BIS: a controlled study during high-dose fentanyl induction. ( Gillbe, C; Mofeez, A; Renna, M; Wigmore, T, 2002)
"The degree of opiate-induced muscular rigidity, simultaneous changes in arterial paCO2, cardiac indices (CI) prior to opioid and relaxant administration, onset and recovery from neuromuscular blockade (by electromyographic train-of-four registration), and motor response to laryngoscopy and intubation were recorded."2.66[Fentanyl versus sufentanil basic anesthesia. Hypnotic effect, muscle rigidity and efficacy of competitive muscle relaxants]. ( Brandt, L; Dick, W; Eberle, B; el-Gindi, M; Ellmauer, S; Hennes, HJ, 1989)
"A large percentage of opioid overdose fatalities involve fentanyl or one of its legal or illegal analogs (F/FAs)."1.62Wooden Chest syndrome: The atypical pharmacology of fentanyl overdose. ( Ann LeQuang, J; Pergolizzi, JV; Raffa, RB; Vortsman, E; Webster, LR, 2021)
"Muscle rigidity was the most common atypical presentation, observed in 240 (15."1.48Rigidity, dyskinesia and other atypical overdose presentations observed at a supervised injection site, Vancouver, Canada. ( Gauthier, T; Kinshella, MW; Lysyshyn, M, 2018)
"This implied muscular rigidity was appreciably attenuated by intracerebroventricular administration of NPY (4 nmol/2."1.31Inhibition by neuropeptide Y of fentanyl-induced muscular rigidity at the locus coeruleus in rats. ( Lai, S; Lui, P, 2000)
"The efficacy of fentanyl to elicit muscular rigidity in this manner was significantly reduced by previous intrathecal administration of either 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801), D-(-)-2-amino-5-phosphonovaleric acid (AP5), or (+/-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP)."1.30Involvement of cerulospinal glutamatergic neurotransmission in fentanyl-induced muscular rigidity in the rat. ( Chan, SH; Fu, MJ; Lee, TY; Lui, PW; Tsen, LY, 1997)
"This implied muscular rigidity was not blocked by i."1.30Involvement of spinal adenosine A1 and A2 receptors in fentanyl-induced muscular rigidity in the rat. ( Lui, PW, 1997)
"This implied muscular rigidity was appreciably antagonized by prior intrathecal (10 microliters) administration of prazosin (5 or 10 nmol), but not equimolar dose of yohimbine."1.29Inhibition by intrathecal prazosin but not yohimbine of fentanyl-induced muscular rigidity in the rat. ( Chan, SH; Fu, MJ; Lee, TY; Lui, PW; Tsen, LY; Yeh, CP, 1995)
"Fentanyl was infused at a rate of 150 micrograms/min until a total of 15 micrograms/kg had been administered."1.29Fentanyl-induced rigidity and unconsciousness in human volunteers. Incidence, duration, and plasma concentrations. ( Ashburn, MA; Bailey, PL; LeMaire, L; Stanley, TH; Streisand, JB; Tarver, SD; Varvel, J, 1993)
"Previously, reversal of fentanyl-induced muscular rigidity was measured by subjective rating criteria not suitable for quantitative potency comparisons."1.29Automated method for the measurement of fentanyl-induced muscular rigidity. ( Del Vecchio, RA, 1993)
"This implied muscular rigidity was appreciably and dose-dependently antagonized by prior intracerebroventricular (i."1.29Antagonization of fentanyl-induced muscular rigidity by neurotensin at the locus coeruleus of the rat. ( Chan, SH; Lee, TY; Lui, PW; Tsou, MY; Wang, SW, 1994)
"This correlate of opiate-induced muscular rigidity was appreciably antagonized by a pretreatment with the specific alpha 1-adrenoceptor blocker, prazosin (250 micrograms/kg, i."1.28Involvement of coerulospinal noradrenergic pathway in fentanyl-induced muscular rigidity in rats. ( Chan, SH; Lee, TY; Lui, PW, 1990)
"This intense rigidity often resembled seizures, in that the phenomenon entailed severe stiffness of both limbs and trunk, with an explosive onset of myoclonic limb movements, and associated vertical nystagmus."1.28Seizures during opioid anesthetic induction--are they opioid-induced rigidity? ( Benthuysen, JL; Bickford, RG; Blasco, T; Dec-Silver, H; Duke, PC; Head, N; Sanford, TJ; Smith, NT, 1989)
"Whereas muscular rigidity is a well-known phenomenon that is related to anesthesia induced by large doses of narcotic drugs, the precise underlying mechanism(s) remain to be fully elucidated."1.28Differential effects of prazosin and yohimbine on fentanyl-induced muscular rigidity in rats. ( Chan, SH; Lee, TY; Lui, PW; Pan, JT; Tsou, MY, 1989)
"Whereas muscular rigidity is a well-known side effect that is associated with high-dose fentanyl anesthesia, a paucity of information exists with regard to its underlying mechanism(s)."1.28Involvement of locus coeruleus and noradrenergic neurotransmission in fentanyl-induced muscular rigidity in the rat. ( Chan, SH; Lee, TY; Lui, PW, 1989)
"Intense generalized muscle rigidity is an undesirable side effect of potent opiate agonists."1.28Dexmedetomidine, acting through central alpha-2 adrenoceptors, prevents opiate-induced muscle rigidity in the rat. ( Maze, M; Segal, IS; Weinger, MB, 1989)
"In a separate test, muscular rigidity is induced by the opioid, fentanyl, and subsequently, test compounds are assessed for their ability to reverse muscular rigidity."1.28An in vivo alpha-2 assay reversal of opioid-induced muscular rigidity and neuroleptic-induced ptosis. ( Benvenga, MJ; Capacchione, JF; Del Vecchio, RA; Jerussi, TP, 1992)
"Thiopental (4 mg/kg) was administered to a ten-patient control group."1.27Physiology of alfentanil-induced rigidity. ( Benthuysen, JL; Dec-Silver, H; Head, N; Sanford, TJ; Smith, NT, 1986)
"The findings are muscular rigidity, fall in chest wall compliance, hypoventilation, respiratory acidosis, and hypotension."1.27Delayed muscular rigidity and respiratory depression following fentanyl anesthesia. ( Caspi, J; Hechtman, HB; Khazam, A; Klausner, JM; Lelcuk, S; Marin, G; Rozin, RR, 1988)
"Alfentanil in combination with etomidate and N2O/O2 was given to 50 patients as single dosage (0."1.27[Alfentanil in routine clinical use. A study of 50 patients]. ( Löffler, B, 1985)

Research

Studies (88)

TimeframeStudies, this research(%)All Research%
pre-199038 (43.18)18.7374
1990's25 (28.41)18.2507
2000's8 (9.09)29.6817
2010's14 (15.91)24.3611
2020's3 (3.41)2.80

Authors

AuthorsStudies
Sasaki, K3
Rabozzi, R3
Kasai, S3
Ikeda, K3
Ishikawa, T3
Torralva, R1
Janowsky, A1
Pergolizzi, JV2
Dahan, A1
Ann LeQuang, J2
Raffa, RB2
Webster, LR1
Vortsman, E1
Roan, JP1
Bajaj, N1
Davis, FA1
Kandinata, N1
Buxton, JA1
Gauthier, T2
Kinshella, MW2
Godwin, J1
Lysyshyn, M1
Gill, H1
Kelly, E1
Henderson, G1
Çoruh, B2
Tonelli, MR2
Park, DR2
Medford, ARL1
Liu, X1
Zou, Y1
Zhao, J1
Huang, Y1
Soares, JH1
Brosnan, RJ1
Smith, A1
Mayhew, PD1
Dimitriou, V1
Zogogiannis, I1
Liotiri, D1
Wambi, F1
Tawfeeq, N1
Koumi, A1
Geldhof, G1
Elakkumanan, LB1
Punj, J1
Talwar, P1
Rajaraman, P1
Pandey, R1
Darlong, V1
Hung, KC1
van der Lee, R1
Ceelie, I1
de Wildt, SN1
Eventov-Friedman, S1
Rozin, I1
Shinwell, ES1
Lynch, RE1
Hack, RA1
Dewhirst, E1
Naguib, A1
Tobias, JD1
Roy, S1
Fortier, LP1
Renna, M1
Wigmore, T1
Mofeez, A1
Gillbe, C1
Palacio, FJ1
Ortiz-Gómez, JR1
Fornet, I1
López, MA1
Morillas, P1
Bovill, JG2
Sebel, PS2
Stanley, TH4
Wangler, MA1
Gupta, B1
Scamman, FL1
Christian, CM1
Waller, JL1
Moldenhauer, CC1
Jaffe, TB1
Ramsey, FM1
Comstock, MK1
Carter, JG1
Moyers, JR1
Stevens, WC1
Hill, AB1
Nahrwold, ML1
de Rosayro, AM1
Knight, PR1
Jones, RM1
Bolles, RE1
Bucx, MJ1
Van Geel, RT1
Meursing, AE1
Stijnen, T1
Scheck, PA1
Fu, MJ5
Lin, TC1
Lui, PW14
Lee, TY13
Chan, SH12
Wang, SW1
Tsou, MY2
Jackson, FW1
Kuo, TB1
Chang, GJ1
Del Vecchio, RA2
Streisand, JB1
Bailey, PL3
LeMaire, L1
Ashburn, MA1
Tarver, SD1
Varvel, J1
MacGregor, DA1
Bauman, LA1
Tsen, LY2
Yeh, CP1
Glick, C1
Evans, OB1
Parks, BR1
Lemmen, RJ1
Semmekrot, BA1
Viscomi, CM1
Bolisetty, S1
Kitchanan, S1
Whitehall, J1
Lai, S1
Lui, P1
Müller, P1
Vogtmann, C1
Benvenga, MJ2
Capacchione, JF2
Jerussi, TP2
Lu, PK1
Hsieh, JC1
Buolamwini, JK1
Knaus, EE1
Mets, B1
James, MF1
Wedell, D1
Hersh, EV1
Doolittle, GM1
Greiner, AS1
Strong, WE1
Matson, M1
Smith, NT5
Benthuysen, JL4
Bickford, RG1
Sanford, TJ2
Blasco, T1
Duke, PC1
Head, N2
Dec-Silver, H2
Pan, JT1
Weinger, MB3
Segal, IS1
Maze, M1
Eberle, B1
Brandt, L1
Hennes, HJ1
el-Gindi, M1
Ellmauer, S1
Dick, W2
Janik, R1
Neidhart, P1
Burgener, MC1
Schwieger, I1
Suter, PM1
Chang, J1
Fish, KJ1
Wilbrink, J1
Zwanikken, P1
Pace, NL1
Blasco, TA2
Lee, D1
Amalric, M1
Swerdlow, NR1
Koob, GF3
Cline, EJ2
Kien, ND1
Quam, DD1
Goldberg, M1
Ishak, S1
Garcia, C1
McKenna, J1
Mirenda, J1
Tabatabai, M1
Wong, K1
Caspi, J2
Klausner, JM2
Safadi, T1
Amar, R1
Rozin, RR2
Merin, G1
Lelcuk, S1
Khazam, A1
Marin, G1
Hechtman, HB1
Tommasino, C1
Scafuro, M1
Di Gregorio, AM1
Miele, E1
Cafaggi, G1
Silbert, BS1
Vacanti, CA1
Bonnet, F1
Kergrohen, F1
Lafosse, JE1
Loriferne, JF1
Salvat, A1
Debras, C1
Löffler, B1
Gal, TJ1
DiFazio, CA1
Morgan, M1
Lumley, J1
Gillies, ID1
Ngai, SH1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Opioid Free Versus Opioid Balanced Anesthesia in Middle Ear Surgery.[NCT03809949]Phase 460 participants (Actual)Interventional2019-01-16Completed
Efficacy of Intermittent Superficial Parasternal Intercostal Plane Block on Postoperative Pain Control in Patients Undergoing Cardiac Surgery With Median Sternotomy - EPOCH Randomized Clinical Trial[NCT06028126]310 participants (Anticipated)Interventional2023-09-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

8 reviews available for fentanyl and Muscle Rigidity

ArticleYear
Noradrenergic Mechanisms in Fentanyl-Mediated Rapid Death Explain Failure of Naloxone in the Opioid Crisis.
    The Journal of pharmacology and experimental therapeutics, 2019, Volume: 371, Issue:2

    Topics: Adrenergic Neurons; Analgesics, Opioid; Drug Overdose; Fentanyl; Humans; Muscle Rigidity; Naloxone;

2019
Overdoses due to fentanyl and its analogues (F/FAs) push naloxone to the limit.
    Journal of clinical pharmacy and therapeutics, 2021, Volume: 46, Issue:6

    Topics: Diaphragm; Dose-Response Relationship, Drug; Fentanyl; Heroin; Humans; Laryngismus; Muscle Rigidity;

2021
Impossible mask ventilation after an unusually low dose fentanyl-induced muscle rigidity in a patient with essential tremor: a case report and review of the literature.
    Middle East journal of anaesthesiology, 2014, Volume: 22, Issue:6

    Topics: Aged; Analgesics, Opioid; Essential Tremor; Fentanyl; Humans; Male; Masks; Muscle Rigidity; Respirat

2014
Opioid analgesics in anesthesia: with special reference to their use in cardiovascular anesthesia.
    Anesthesiology, 1984, Volume: 61, Issue:6

    Topics: Alfentanil; Alphaprodine; Analgesics, Opioid; Anesthesia, General; Animals; Awareness; Brain; Cardia

1984
Opioid analgesics in anesthesia: with special reference to their use in cardiovascular anesthesia.
    Anesthesiology, 1984, Volume: 61, Issue:6

    Topics: Alfentanil; Alphaprodine; Analgesics, Opioid; Anesthesia, General; Animals; Awareness; Brain; Cardia

1984
Opioid analgesics in anesthesia: with special reference to their use in cardiovascular anesthesia.
    Anesthesiology, 1984, Volume: 61, Issue:6

    Topics: Alfentanil; Alphaprodine; Analgesics, Opioid; Anesthesia, General; Animals; Awareness; Brain; Cardia

1984
Opioid analgesics in anesthesia: with special reference to their use in cardiovascular anesthesia.
    Anesthesiology, 1984, Volume: 61, Issue:6

    Topics: Alfentanil; Alphaprodine; Analgesics, Opioid; Anesthesia, General; Animals; Awareness; Brain; Cardia

1984
Muscle rigidity due to fentanyl infusion in the pediatric patient.
    Southern medical journal, 1996, Volume: 89, Issue:11

    Topics: Age Factors; Anesthetics, Intravenous; Child; Drug Monitoring; Fentanyl; Humans; Infant; Male; Muscl

1996
A review of the opioid analgesics fentanyl, alfentanil, and sufentanil.
    Compendium (Newtown, Pa.), 1991, Volume: 12, Issue:3

    Topics: Alfentanil; Analgesics, Opioid; Anesthesia, Dental; Anesthesia, Intravenous; Fentanyl; Humans; Muscl

1991
[The possible mechanism of fentanyl-induced muscle rigidity].
    Ma zui xue za zhi = Anaesthesiologica Sinica, 1991, Volume: 29, Issue:1

    Topics: Alfentanil; Animals; Fentanyl; Humans; Locus Coeruleus; Muscle Rigidity; Narcotics

1991
Parkinsonism, levodopa, and anesthesia.
    Anesthesiology, 1972, Volume: 37, Issue:3

    Topics: Amantadine; Anesthesia; Animals; Apomorphine; Benperidol; Blood-Brain Barrier; Brain; Cardiovascular

1972

Trials

6 trials available for fentanyl and Muscle Rigidity

ArticleYear
Biasing effect of the electromyogram on BIS: a controlled study during high-dose fentanyl induction.
    Journal of clinical monitoring and computing, 2002, Volume: 17, Issue:6

    Topics: Aged; Anesthetics, Intravenous; Coronary Artery Bypass; Dose-Response Relationship, Drug; Electromyo

2002
Forces applied during laryngoscopy in children. Are volatile anaesthetics essential for suxamethonium induced muscle rigidity?
    Acta anaesthesiologica Scandinavica, 1994, Volume: 38, Issue:5

    Topics: Adolescent; Anesthetics, Inhalation; Biomechanical Phenomena; Child; Child, Preschool; Cricoid Carti

1994
[Fentanyl versus sufentanil basic anesthesia. Hypnotic effect, muscle rigidity and efficacy of competitive muscle relaxants].
    Der Anaesthesist, 1989, Volume: 38, Issue:7

    Topics: Anesthetics; Clinical Trials as Topic; Coronary Artery Bypass; Drug Interactions; Female; Fentanyl;

1989
[Sufentanil: the effect on cardiocirculatory parameters and intubation conditions on administration of pancuronium or vecuronium].
    Der Anaesthesist, 1989, Volume: 38, Issue:12

    Topics: Adult; Anesthetics; Drug Combinations; Fentanyl; Hemodynamics; Humans; Intubation, Intratracheal; Mi

1989
Chest wall rigidity during fentanyl- and midazolam-fentanyl induction: ventilatory and haemodynamic effects.
    Acta anaesthesiologica Scandinavica, 1989, Volume: 33, Issue:1

    Topics: Clinical Trials as Topic; Double-Blind Method; Female; Fentanyl; Hemodynamics; Humans; Male; Midazol

1989
Prolonged antagonism of opioid action with intravenous nalmefene in man.
    Anesthesiology, 1986, Volume: 64, Issue:2

    Topics: Adult; Drug Interactions; Fentanyl; Humans; Male; Muscle Rigidity; Naltrexone; Pain; Respiration; Ti

1986

Other Studies

74 other studies available for fentanyl and Muscle Rigidity

ArticleYear
Fentanyl-induced muscle rigidity in a dog during weaning from mechanical ventilation after emergency abdominal surgery: A case report.
    Veterinary medicine and science, 2023, Volume: 9, Issue:1

    Topics: Abdominal Muscles; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Female; Fentanyl; Muscle Rigidit

2023
Fentanyl-induced muscle rigidity in a dog during weaning from mechanical ventilation after emergency abdominal surgery: A case report.
    Veterinary medicine and science, 2023, Volume: 9, Issue:1

    Topics: Abdominal Muscles; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Female; Fentanyl; Muscle Rigidit

2023
Fentanyl-induced muscle rigidity in a dog during weaning from mechanical ventilation after emergency abdominal surgery: A case report.
    Veterinary medicine and science, 2023, Volume: 9, Issue:1

    Topics: Abdominal Muscles; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Female; Fentanyl; Muscle Rigidit

2023
Fentanyl-induced muscle rigidity in a dog during weaning from mechanical ventilation after emergency abdominal surgery: A case report.
    Veterinary medicine and science, 2023, Volume: 9, Issue:1

    Topics: Abdominal Muscles; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Female; Fentanyl; Muscle Rigidit

2023
Fentanyl-induced muscle rigidity in a dog during weaning from mechanical ventilation after emergency abdominal surgery: A case report.
    Veterinary medicine and science, 2023, Volume: 9, Issue:1

    Topics: Abdominal Muscles; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Female; Fentanyl; Muscle Rigidit

2023
Fentanyl-induced muscle rigidity in a dog during weaning from mechanical ventilation after emergency abdominal surgery: A case report.
    Veterinary medicine and science, 2023, Volume: 9, Issue:1

    Topics: Abdominal Muscles; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Female; Fentanyl; Muscle Rigidit

2023
Fentanyl-induced muscle rigidity in a dog during weaning from mechanical ventilation after emergency abdominal surgery: A case report.
    Veterinary medicine and science, 2023, Volume: 9, Issue:1

    Topics: Abdominal Muscles; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Female; Fentanyl; Muscle Rigidit

2023
Fentanyl-induced muscle rigidity in a dog during weaning from mechanical ventilation after emergency abdominal surgery: A case report.
    Veterinary medicine and science, 2023, Volume: 9, Issue:1

    Topics: Abdominal Muscles; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Female; Fentanyl; Muscle Rigidit

2023
Fentanyl-induced muscle rigidity in a dog during weaning from mechanical ventilation after emergency abdominal surgery: A case report.
    Veterinary medicine and science, 2023, Volume: 9, Issue:1

    Topics: Abdominal Muscles; Analgesics, Opioid; Animals; Dog Diseases; Dogs; Female; Fentanyl; Muscle Rigidit

2023
Wooden Chest syndrome: The atypical pharmacology of fentanyl overdose.
    Journal of clinical pharmacy and therapeutics, 2021, Volume: 46, Issue:6

    Topics: Diaphragm; Fentanyl; Heroin; Humans; Laryngismus; Muscle Rigidity; Opiate Overdose; Syndrome; Thorac

2021
Opioids and Chest Wall Rigidity During Mechanical Ventilation.
    Annals of internal medicine, 2018, 05-01, Volume: 168, Issue:9

    Topics: Analgesics, Opioid; Female; Fentanyl; Humans; Middle Aged; Muscle Rigidity; Naloxone; Narcotic Antag

2018
A 52-year-old man with fentanyl-induced muscle rigidity.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2018, 04-30, Volume: 190, Issue:17

    Topics: Analgesics, Opioid; Fentanyl; Humans; Male; Middle Aged; Muscle Rigidity; Needle-Exchange Programs;

2018
Rigidity, dyskinesia and other atypical overdose presentations observed at a supervised injection site, Vancouver, Canada.
    Harm reduction journal, 2018, 12-22, Volume: 15, Issue:1

    Topics: Analgesics, Opioid; Arrhythmias, Cardiac; British Columbia; Drug Overdose; Dyskinesia, Drug-Induced;

2018
How the complex pharmacology of the fentanyls contributes to their lethality.
    Addiction (Abingdon, England), 2019, Volume: 114, Issue:9

    Topics: Drug Overdose; Fentanyl; Humans; Muscle Rigidity; Naloxone; Narcotic Antagonists; Narcotics; Recepto

2019
Fentanyl-induced chest wall rigidity.
    Chest, 2013, Volume: 143, Issue:4

    Topics: Aged; Analgesics, Opioid; Bronchoscopy; Fentanyl; Humans; Male; Muscle Rigidity; Naloxone; Narcotic

2013
Use of fentanyl and safety of endobronchial ultrasound.
    Chest, 2013, Volume: 144, Issue:3

    Topics: Analgesics, Opioid; Bronchoscopy; Fentanyl; Humans; Male; Muscle Rigidity; Thoracic Wall

2013
Response.
    Chest, 2013, Volume: 144, Issue:3

    Topics: Analgesics, Opioid; Bronchoscopy; Fentanyl; Humans; Male; Muscle Rigidity; Thoracic Wall

2013
Emergency scenario of fentanyl induced faciocervical rigidity and complete upper airway obstruction during anesthesia induction.
    Chinese medical journal, 2014, Volume: 127, Issue:3

    Topics: Aged; Airway Obstruction; Analgesics, Opioid; Anesthesia, General; Fentanyl; Humans; Male; Muscle Ri

2014
Rabbit model of chest wall rigidity induced by fentanyl and the effects of apomorphine.
    Respiratory physiology & neurobiology, 2014, Oct-01, Volume: 202

    Topics: Analgesics, Opioid; Animals; Apomorphine; Disease Models, Animal; Dopamine Agonists; Fentanyl; Lung

2014
An atypical presentation of fentanyl rigidity following administration of low dose fentanyl in a child during intraoperative period.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:11

    Topics: Anesthetics, Inhalation; Child, Preschool; Cryptorchidism; Fentanyl; Humans; Intraoperative Complica

2008
The possible mechanism of clonidine to suppress fentanyl-induced coughing.
    Acta anaesthesiologica Scandinavica, 2009, Volume: 53, Issue:9

    Topics: Adrenergic alpha-Agonists; Anesthetics, Intravenous; Clonidine; Cough; Fentanyl; Humans; Muscle Rigi

2009
Morphine-induced muscle rigidity in a term neonate.
    The Annals of pharmacotherapy, 2009, Volume: 43, Issue:10

    Topics: Analgesics, Opioid; Fentanyl; Humans; Infant, Newborn; Male; Morphine; Muscle Rigidity; Naloxone; Na

2009
Case of chest-wall rigidity in a preterm infant caused by prenatal fentanyl administration.
    Journal of perinatology : official journal of the California Perinatal Association, 2010, Volume: 30, Issue:2

    Topics: Cesarean Section; Female; Fentanyl; Humans; Infant, Newborn; Infant, Premature, Diseases; Muscle Rig

2010
Methadone-induced rigid-chest syndrome after substantial overdose.
    Pediatrics, 2010, Volume: 126, Issue:1

    Topics: Drug Administration Schedule; Drug Overdose; Fentanyl; Follow-Up Studies; Humans; Infant, Newborn; I

2010
Chest wall rigidity in two infants after low-dose fentanyl administration.
    Pediatric emergency care, 2012, Volume: 28, Issue:5

    Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Fentanyl; Follow-Up Studies; Humans; H

2012
Fentanyl-induced rigidity during emergence from general anesthesia potentiated by venlafexine.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2003, Volume: 50, Issue:1

    Topics: Adult; Analgesics, Opioid; Anesthesia Recovery Period; Anesthesia, General; Antidepressive Agents, S

2003
[Remifentanil bolus for cesarean section in high-risk patients: study of 12 cases].
    Revista espanola de anestesiologia y reanimacion, 2008, Volume: 55, Issue:2

    Topics: Adult; Anesthetics, Intravenous; Atracurium; Cesarean Section; Female; Fentanyl; Fetus; Hemodynamics

2008
Preferred treatment of fentanyl-induced postoperative rigidity.
    Anesthesiology, 1983, Volume: 59, Issue:6

    Topics: Anesthesia; Fentanyl; Humans; Muscle Rigidity

1983
Fentanyl-O2-N2O rigidity and pulmonary compliance.
    Anesthesia and analgesia, 1983, Volume: 62, Issue:3

    Topics: Adult; Anesthesia, General; Fentanyl; Humans; Infusions, Parenteral; Intraoperative Complications; L

1983
Postoperative rigidity following fentanyl anesthesia.
    Anesthesiology, 1983, Volume: 58, Issue:3

    Topics: Anesthesia; Fentanyl; Humans; Male; Middle Aged; Muscle Rigidity; Postoperative Complications

1983
Attenuation of fentanyl-induced truncal rigidity.
    Anesthesiology, 1983, Volume: 58, Issue:6

    Topics: Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Fentanyl; Humans; Middle Aged; Muscle Contra

1983
Fentanyl and convulsions.
    Anesthesia and analgesia, 1983, Volume: 62, Issue:9

    Topics: Electroencephalography; Fentanyl; Humans; Muscle Rigidity; Seizures

1983
Rigidity and hypercarbia associated with high dose fentanyl induction of anesthesia.
    Anesthesia and analgesia, 1981, Volume: 60, Issue:5

    Topics: Anesthesia, Intravenous; Fentanyl; Humans; Hypercapnia; Muscle Rigidity

1981
Prevention of rigidity during fentanyl--oxygen induction of anesthesia.
    Anesthesiology, 1981, Volume: 55, Issue:4

    Topics: Anesthesia, General; Female; Fentanyl; Hemodynamics; Humans; Male; Muscle Rigidity; Oxygen; Pancuron

1981
Involvement of G(o) alpha subtype of guanine nucleotide-binding regulatory protein at the locus coeruleus in fentanyl-induced muscular rigidity in the rat.
    Neuroscience letters, 1994, Jan-03, Volume: 165, Issue:1-2

    Topics: Animals; Electromyography; Fentanyl; Fluorescent Antibody Technique; GTP-Binding Proteins; Immunohis

1994
Antagonization of fentanyl-induced muscular rigidity by neurotensin at the locus coeruleus of the rat.
    Regulatory peptides, 1994, Apr-14, Volume: 51, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Electromyography; Fentanyl; Injections, Intravenous; Inje

1994
Fentanyl and the wooden chest.
    Gastroenterology, 1994, Volume: 106, Issue:3

    Topics: Cholangiopancreatography, Endoscopic Retrograde; Dose-Response Relationship, Drug; Fentanyl; Humans;

1994
Power spectral analysis of electromyographic and systemic arterial pressure signals during fentanyl-induced muscular rigidity in the rat.
    British journal of anaesthesia, 1994, Volume: 72, Issue:3

    Topics: Anesthesia, Intravenous; Animals; Blood Pressure; Disease Models, Animal; Electromyography; Fentanyl

1994
Antagonization of fentanyl-induced muscular rigidity by denervation of the coerulospinal noradrenergic pathway in the rat.
    Neuroscience letters, 1993, Jul-23, Volume: 157, Issue:2

    Topics: Animals; Benzylamines; Biomarkers; Dopamine beta-Hydroxylase; Electromyography; Fentanyl; Locus Coer

1993
Automated method for the measurement of fentanyl-induced muscular rigidity.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:2

    Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; Dioxanes; Dose-Response Relationship, D

1993
Fentanyl-induced rigidity and unconsciousness in human volunteers. Incidence, duration, and plasma concentrations.
    Anesthesiology, 1993, Volume: 78, Issue:4

    Topics: Adult; Fentanyl; Heart Rate; Humans; Male; Muscle Rigidity; Unconsciousness

1993
Involvement of potassium and calcium channels at the locus coeruleus in fentanyl-induced muscular rigidity in the rat.
    Neuroscience letters, 1995, Oct-27, Volume: 199, Issue:3

    Topics: Animals; Calcium Channels; Diazoxide; Electromyography; Fentanyl; Locus Coeruleus; Male; Methanol; M

1995
Chest wall rigidity during infusion of fentanyl in a two-month-old infant after heart surgery.
    Journal of clinical anesthesia, 1996, Volume: 8, Issue:3

    Topics: Analgesics, Opioid; Anesthetics, Intravenous; Cardiac Surgical Procedures; Fentanyl; Humans; Infant;

1996
Inhibition by intrathecal prazosin but not yohimbine of fentanyl-induced muscular rigidity in the rat.
    Neuroscience letters, 1995, Dec-08, Volume: 201, Issue:2

    Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Electromyography; Fentanyl; Injections, I

1995
Muscle rigidity causing life-threatening hypercapnia following fentanyl administration in a premature infant.
    European journal of pediatrics, 1996, Volume: 155, Issue:12

    Topics: Analgesics, Opioid; Anesthetics, Intravenous; Fentanyl; Humans; Hypercapnia; Infant, Newborn; Infant

1996
Involvement of spinal adenosine A1 and A2 receptors in fentanyl-induced muscular rigidity in the rat.
    Neuroscience letters, 1997, Mar-21, Volume: 224, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Fentanyl; Male; Muscle Rigidity; Rats; Rats, Sprague-Dawl

1997
Opioid-induced rigidity after intravenous fentanyl.
    Obstetrics and gynecology, 1997, Volume: 89, Issue:5 Pt 2

    Topics: Adult; Anesthetics, Intravenous; Antipsychotic Agents; Drug Synergism; Female; Fentanyl; Genitalia,

1997
Involvement of cerulospinal glutamatergic neurotransmission in fentanyl-induced muscular rigidity in the rat.
    Anesthesiology, 1997, Volume: 87, Issue:6

    Topics: Analgesics, Opioid; Animals; Electromyography; Fentanyl; Locus Coeruleus; Male; Muscle Rigidity; Rat

1997
Generalized muscle rigidity in a neonate following intrathecal fentanyl during caesarean delivery.
    Intensive care medicine, 1999, Volume: 25, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Analgesics, Opioid; Anesthesia, Spinal; Cesarean Section; Female; Fent

1999
Inhibition by neuropeptide Y of fentanyl-induced muscular rigidity at the locus coeruleus in rats.
    Neuroscience letters, 2000, Feb-25, Volume: 280, Issue:3

    Topics: Animals; Cerebral Ventricles; Electromyography; Fentanyl; Injections, Intraventricular; Locus Coerul

2000
Three cases with different presentation of fentanyl-induced muscle rigidity--a rare problem in intensive care of neonates.
    American journal of perinatology, 2000, Volume: 17, Issue:1

    Topics: Analgesics, Opioid; Fentanyl; Humans; Infant, Newborn; Male; Muscle Rigidity; Narcotics

2000
An in vivo alpha-2 assay reversal of opioid-induced muscular rigidity and neuroleptic-induced ptosis.
    Journal of pharmacological and toxicological methods, 1992, Volume: 27, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blepharoptosis; Drug Evaluation, P

1992
Post-operative muscle rigidity in an infant.
    European journal of anaesthesiology, 1992, Volume: 9, Issue:5

    Topics: Anesthesia, Intravenous; Apnea; Drug Interactions; Fentanyl; Humans; Hydrocephalus; Infant; Male; Mu

1992
Synthesis and antinociceptive activity of 1-[2-(pyridyl)ethyl] and 1-[2-(dihydropyridyl)ethyl] analogues of fentanyl.
    Drug design and discovery, 1992, Volume: 8, Issue:4

    Topics: Analgesics; Animals; Fentanyl; Muscle Rigidity; Rats; Structure-Activity Relationship

1992
Another complication of opiate-induced chest wall rigidity.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1992, Apr-04, Volume: 81, Issue:7

    Topics: Adult; Anesthesia, Intravenous; Central Venous Pressure; Droperidol; Fentanyl; Humans; Male; Muscle

1992
Involvement of coerulospinal noradrenergic pathway in fentanyl-induced muscular rigidity in rats.
    Neuroscience letters, 1990, Jan-01, Volume: 108, Issue:1-2

    Topics: Adrenergic Fibers; Animals; Dose-Response Relationship, Drug; Fentanyl; Locus Coeruleus; Male; Micro

1990
Anesthetic complications in an infant with hyperexplexia.
    Anesthesiology, 1990, Volume: 73, Issue:1

    Topics: Anesthesia; Apnea; Fentanyl; Hernia, Inguinal; Humans; Infant; Intraoperative Complications; Male; M

1990
Probable seizure after alfentanil.
    Anesthesia and analgesia, 1989, Volume: 68, Issue:5

    Topics: Alfentanil; Fentanyl; Humans; Male; Middle Aged; Muscle Rigidity; Seizures

1989
Fentanyl-induced muscle rigidity in unanesthetized and ketamine- or thiopental-anesthetized rats.
    Anesthesiology, 1989, Volume: 70, Issue:6

    Topics: Anesthesia; Animals; Blood Pressure; Carbon Dioxide; Fentanyl; Heart Rate; Injections, Intravenous;

1989
Seizures during opioid anesthetic induction--are they opioid-induced rigidity?
    Anesthesiology, 1989, Volume: 71, Issue:6

    Topics: Alfentanil; Anesthetics; Electroencephalography; Electromyography; Fentanyl; Humans; Muscle Rigidity

1989
Differential effects of prazosin and yohimbine on fentanyl-induced muscular rigidity in rats.
    Neuropharmacology, 1989, Volume: 28, Issue:11

    Topics: Animals; Blood Pressure; Electromyography; Fentanyl; Heart Rate; Male; Muscle Rigidity; Muscles; Pra

1989
Involvement of locus coeruleus and noradrenergic neurotransmission in fentanyl-induced muscular rigidity in the rat.
    Neuroscience letters, 1989, Jan-02, Volume: 96, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic Fibers; Anesthetics; Animals; Dose-Response Relationship, D

1989
Dexmedetomidine, acting through central alpha-2 adrenoceptors, prevents opiate-induced muscle rigidity in the rat.
    Anesthesiology, 1989, Volume: 71, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alfentanil; Analgesics, Opioid; Animals; Di

1989
Reversal of opioid-induced muscular rigidity in rats: evidence for alpha-2 adrenergic involvement.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 28, Issue:2

    Topics: Adrenergic alpha-Agonists; Anesthetics; Animals; Dopamine Antagonists; Fentanyl; Histamine; Histamin

1987
Acute respiratory arrest and rigidity after anesthesia with sufentanil: a case report.
    Anesthesiology, 1985, Volume: 63, Issue:6

    Topics: Acute Disease; Adult; Anesthesia, General; Anesthetics; Apnea; Coma; Fentanyl; Humans; Male; Muscle

1985
Anesthetic induction with fentanyl.
    Anesthesia and analgesia, 1985, Volume: 64, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Anesthesia, General; Awareness; Consciousness; Fentanyl; Hemod

1985
Physiology of alfentanil-induced rigidity.
    Anesthesiology, 1986, Volume: 64, Issue:4

    Topics: Alfentanil; Electroencephalography; Electromyography; Fentanyl; Hemodynamics; Humans; Muscle Rigidit

1986
The role of the nucleus raphe pontis and the caudate nucleus in alfentanil rigidity in the rat.
    Brain research, 1986, Oct-29, Volume: 386, Issue:1-2

    Topics: Alfentanil; Animals; Catatonia; Caudate Nucleus; Electromyography; Fentanyl; Male; Muscle Rigidity;

1986
Ketanserin pretreatment reverses alfentanil-induced muscle rigidity.
    Anesthesiology, 1987, Volume: 67, Issue:3

    Topics: Adjuvants, Anesthesia; Alfentanil; Animals; Fentanyl; Ketanserin; Male; Muscle Rigidity; Preanesthet

1987
Intracranial pressure increases during alfentanil-induced rigidity.
    Anesthesiology, 1988, Volume: 68, Issue:3

    Topics: Alfentanil; Animals; Fentanyl; Intracranial Pressure; Male; Muscle Rigidity; Rats; Stimulation, Chem

1988
Localization of brainstem sites which mediate alfentanil-induced muscle rigidity in the rat.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 29, Issue:3

    Topics: Alfentanil; Animals; Brain Stem; Fentanyl; Muscle Rigidity; Naloxone; Quaternary Ammonium Compounds;

1988
Postoperative rigidity following sufentanil administration.
    Anesthesiology, 1985, Volume: 63, Issue:2

    Topics: Adult; Anesthesia, General; Fentanyl; Humans; Male; Muscle Rigidity; Nitrous Oxide; Pancuronium; Pos

1985
Delayed and prolonged rigidity greater than 24 h following high-dose fentanyl anesthesia.
    Anesthesiology, 1988, Volume: 69, Issue:4

    Topics: Aged; Anesthesia; Fentanyl; Humans; Male; Muscle Rigidity; Naloxone; Time Factors

1988
Delayed respiratory depression following fentanyl anesthesia for cardiac surgery.
    Critical care medicine, 1988, Volume: 16, Issue:3

    Topics: Aged; Anesthesia, Intravenous; Coronary Artery Bypass; Female; Fentanyl; Humans; Male; Middle Aged;

1988
Delayed muscular rigidity and respiratory depression following fentanyl anesthesia.
    Archives of surgery (Chicago, Ill. : 1960), 1988, Volume: 123, Issue:1

    Topics: Aged; Anesthesia, Intravenous; Colectomy; Fentanyl; Humans; Male; Middle Aged; Muscle Rigidity; Post

1988
[Rigidity caused by fentanyl during recovery from anesthesia. Description of a clinical case].
    Minerva anestesiologica, 1987, Volume: 53, Issue:5

    Topics: Adult; Anesthesia Recovery Period; Anesthesia, General; Fentanyl; Humans; Intervertebral Disc Displa

1987
Amantidine in prevention of fentanyl-induced muscle rigidity.
    Anesthesia and analgesia, 1987, Volume: 66, Issue:12

    Topics: Amantadine; Female; Fentanyl; Humans; Middle Aged; Muscle Rigidity

1987
Post-operative rigidity after fentanyl administration.
    European journal of anaesthesiology, 1986, Volume: 3, Issue:5

    Topics: Aged; Anesthesia; Female; Fentanyl; Humans; Muscle Rigidity; Naloxone; Nitrous Oxide; Postoperative

1986
Concerning the possible nature of reported fentanyl seizures.
    Anesthesiology, 1985, Volume: 62, Issue:2

    Topics: Animals; Catalepsy; Epilepsy, Tonic-Clonic; Fentanyl; Humans; Muscle Rigidity; Rats

1985
[Alfentanil in routine clinical use. A study of 50 patients].
    Der Anaesthesist, 1985, Volume: 34, Issue:1

    Topics: Adolescent; Adult; Aged; Alfentanil; Anesthesia, General; Atropine; Blood Pressure; Child; Etomidate

1985
Neuroleptanaesthesia for major surgery. Experience with 500 cases.
    British journal of anaesthesia, 1974, Volume: 46, Issue:4

    Topics: Adolescent; Adult; Age Factors; Aged; Atropine; Blood Pressure; Child; Droperidol; Female; Fentanyl;

1974
Dangers of innovar.
    The Medical letter on drugs and therapeutics, 1974, May-10, Volume: 16, Issue:10

    Topics: Droperidol; Drug Combinations; Fentanyl; Humans; Hypotension; Muscle Rigidity; Postoperative Complic

1974