Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Meningioma: A relatively common neoplasm of the CENTRAL NERVOUS SYSTEM that arises from arachnoidal cells. The majority are well differentiated vascular tumors which grow slowly and have a low potential to be invasive, although malignant subtypes occur. Meningiomas have a predilection to arise from the parasagittal region, cerebral convexity, sphenoidal ridge, olfactory groove, and SPINAL CANAL. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2056-7)
| Trial | Phase | Enrollment | Study Type | Start Date | Status |
|---|
| Anaesthesia for Supratentorial Tumor Resection : a Double-blind Comparison of Target Plasma Concentration of Propofol-remifentanil and Sevoflurane-sufentanil[NCT00389883] | Phase 3 | 69 participants (Actual) | Interventional | 2006-11-30 | Completed |
| Anesthesiological Strategies in Elective Craniotomy: Randomized, Equivalence, Open Trial[NCT00741351] | Phase 3 | 411 participants (Actual) | Interventional | 2007-12-31 | Completed |
| The Effect of Furosemide Versus Placebo on Brain Relaxation and Incidence of Significant Intravascular Volume Depletion in Human Subjects Receiving Mannitol[NCT01054404] | | 23 participants (Actual) | Interventional | 2010-02-28 | Terminated (stopped due to Concern for volume depletion and electrolyte abnormalities in furosemide arm.) |
| Clinical Effectiveness of Hypertonic Sodium Lactate Infusion for Intraoperative Brain Relaxation in Patients Undergoing Scheduled Craniotomy for Supratentorial Brain Tumor Resection: Study Protocol of a Single Center Double-blind Randomized Controlled Pha[NCT04488874] | Phase 3 | 50 participants (Actual) | Interventional | 2020-09-29 | Completed |
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"Rating of brain relaxation will be on a 4-point scale:~0 = brain very relaxed under dura, acceptable~= brain adequately relaxed under dura, acceptable~= brain slightly tense under dura, acceptable~= brain very tense under bulging dura, unacceptable" (NCT01054404)
Timeframe: just prior to dural opening for each subject
| Article | Year |
|---|
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
A prospective, comparative trial of three anesthetics for elective supratentorial craniotomy. Propofol/fentanyl, isoflurane/nitrous oxide, and fentanyl/nitrous oxide.Anesthesiology, 1993, Volume: 78, Issue:6
Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Craniotomy; Female; Fentanyl; Glioma; | 1993 |
Effect of anaesthesia on intracranial pressure in patients with space-occupying lesions.Lancet (London, England), 1969, Jan-11, Volume: 1, Issue:7585
Topics: Adolescent; Adult; Aged; Anesthesia, Endotracheal; Benperidol; Blood Pressure; Blood Volume; Brain A | 1969 |
| Article | Year |
|---|
Intraoperative aberrant bispectral index values due to facial nerve monitoring.Journal of clinical anesthesia, 2017, Volume: 37Topics: Anesthesia, General; Anesthetics, Intravenous; Artifacts; Consciousness Monitors; Craniotomy; Electr | 2017 |
[Total intravenous anesthesia with propofol and fentanyl in surgery of the posterior cranial fossa].Minerva anestesiologica, 1993, Volume: 59, Issue:11
Topics: Adult; Aged; Anesthesia, Intravenous; Cerebrovascular Circulation; Cranial Fossa, Posterior; Embolis | 1993 |
[Normalization of acupuncture anesthesia used in operation of neoplasm in functional area or deep site of brain].Zhen ci yan jiu = Acupuncture research, 1996, Volume: 21, Issue:2
Topics: Acupuncture Analgesia; Acupuncture Points; Adjuvants, Anesthesia; Adolescent; Adult; Aged; Brain Neo | 1996 |
[Clinical application of combined acupuncture-drug anesthesia in cerebral functional area operation].Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1998, Volume: 18, Issue:3
Topics: Acupuncture Analgesia; Adult; Aged; Anesthetics, Combined; Anesthetics, Intravenous; Brain Neoplasms | 1998 |
CBF and CMRO2 during continuous etomidate infusion supplemented with N2O and fentanyl in patients with supratentorial cerebral tumour. A dose-response study.Acta anaesthesiologica Scandinavica, 1985, Volume: 29, Issue:5
Topics: Adult; Aged; Anesthetics; Brain; Brain Neoplasms; Carbon Dioxide; Cerebrovascular Circulation; Dose- | 1985 |
Neuroleptanalgesia for carotid angiography in neurosurgical patients.Military medicine, 1973, Volume: 138, Issue:2
Topics: Adult; Benperidol; Cerebral Angiography; Craniocerebral Trauma; Fentanyl; Humans; Male; Meningioma; | 1973 |