fentanyl and Lassitude studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Research Excerpts

Excerpt	Relevance	Reference
"We conducted a pilot study to examine the effect of prophylactic fentanyl buccal tablet (FBT) on exercise-induced dyspnea."	9.24	Effect of Prophylactic Fentanyl Buccal Tablet on Episodic Exertional Dyspnea: A Pilot Double-Blind Randomized Controlled Trial. ( Balachandran, DD; Bruera, E; Frisbee-Hume, S; Hui, D; Kilgore, K; Liu, D; Park, M, 2017)
"To determine the feasibility of conducting a randomized trial of subcutaneous fentanyl in patients with cancer, and examine the effects of fentanyl on dyspnea, walk distance, vital signs, and adverse events."	9.19	Effects of prophylactic subcutaneous fentanyl on exercise-induced breakthrough dyspnea in cancer patients: a preliminary double-blind, randomized, controlled trial. ( Bruera, E; Chisholm, G; Frisbee-Hume, S; Hui, D; Morgado, M; Reddy, S; Xu, A, 2014)
"We conducted a pilot study to examine the effect of prophylactic fentanyl buccal tablet (FBT) on exercise-induced dyspnea."	5.24	Effect of Prophylactic Fentanyl Buccal Tablet on Episodic Exertional Dyspnea: A Pilot Double-Blind Randomized Controlled Trial. ( Balachandran, DD; Bruera, E; Frisbee-Hume, S; Hui, D; Kilgore, K; Liu, D; Park, M, 2017)
"To determine the feasibility of conducting a randomized trial of subcutaneous fentanyl in patients with cancer, and examine the effects of fentanyl on dyspnea, walk distance, vital signs, and adverse events."	5.19	Effects of prophylactic subcutaneous fentanyl on exercise-induced breakthrough dyspnea in cancer patients: a preliminary double-blind, randomized, controlled trial. ( Bruera, E; Chisholm, G; Frisbee-Hume, S; Hui, D; Morgado, M; Reddy, S; Xu, A, 2014)
"Modafinil 200 mg was administered to the treatment group patients 1 h before sedation/analgesia."	2.75	Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills. ( Boesjes, H; Galvin, E; Hol, J; Klein, J; Ubben, JF; Verbrugge, SJ, 2010)
"Head and neck cancers (HNC) represent 5% of all malignancies worldwide with about 180,000 cancer deaths per year."	2.66	Is pain part of a systemic syndrome in head and neck cancer? ( Argenone, A; Bossi, P; Depenni, R; Ghiani, M, 2020)
"We examined 87 hospitalized end-of-life cancer patients who were given betamethasone for relief of CRF at our hospital between January 2008 and January 2014."	1.46	Predictors of the Usefulness of Corticosteroids for Cancer-Related Fatigue in End-of-Life Patients. ( Hosokawa, T; Kanbayashi, Y, 2017)
"Supraventricular tachycardia is uncommon in pregnancy."	1.40	Management of labour and delivery in a woman with refractory supraventricular tachycardia. ( Dennis, AT; Gerstman, MD, 2014)

Research

Studies (13)

Authors

Clinical Trials (11)

Trial Overview

Trial Outcomes

Retention Rate

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (15.38)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (23.08)	29.6817
2010's	7 (53.85)	24.3611
2020's	1 (7.69)	2.80

Authors	Studies
Bossi, P	1
Ghiani, M	1
Argenone, A	1
Depenni, R	1
Hui, D	2
Kilgore, K	1
Frisbee-Hume, S	2
Park, M	1
Liu, D	1
Balachandran, DD	1
Bruera, E	2
Xu, A	1
Chisholm, G	1
Morgado, M	1
Reddy, S	1
Dennis, AT	1
Gerstman, MD	1
Hiura, M	1
Sakata, M	1
Ishii, K	1
Toyohara, J	1
Oda, K	1
Nariai, T	1
Ishiwata, K	1
Kanbayashi, Y	1
Hosokawa, T	1
Galvin, E	1
Boesjes, H	1
Hol, J	1
Ubben, JF	1
Klein, J	1
Verbrugge, SJ	1
Bekker, A	1
Haile, M	1
Kline, R	1
Didehvar, S	1
Babu, R	1
Martiniuk, F	1
Urban, M	1
Chung, F	1
Kayumov, L	1
Sinclair, DR	1
Edward, R	1
Moller, HJ	1
Shapiro, CM	1
Puura, A	1
Puolakka, P	1
Rorarius, M	1
Salmelin, R	1
Lindgren, L	1
Darwish, M	1
Kirby, M	1
Jiang, JG	1
Tracewell, W	1
Robertson, P	1
Tolksdorf, W	1
Berlin, J	1
Bethke, U	1
Nieder, G	1
Pichlmayr, I	1
Lips, U	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Morphine or Fentanyl for Refractory Dyspnea in COPD[NCT03834363]	Phase 4	60 participants (Anticipated)	Interventional	2019-11-15	Recruiting
Effects of Prophylactic Subcutaneous Fentanyl on Exercise-Induced Breakthrough Dyspnea in Cancer Patients: A Preliminary Double-Blind, Randomized Controlled Trial[NCT01515566]	Phase 1/Phase 2	26 participants (Actual)	Interventional	2012-04-30	Completed
A Randomized, Double Blind, Placebo Controlled Evaluation of Modafinil vs Placebo for the Treatment of General Anesthesia Related Delayed Emergence in Patients With the Diagnosis of Obstructive Sleep Apnea[NCT02494102]	Phase 4	105 participants (Actual)	Interventional	2016-02-29	Terminated
Impact of Dexmedetomidine Supplemented Analgesia on Long-term Survival in Elderly Patients After Cancer Surgery: a Multicenter Randomized Controlled Trial[NCT03012971]		1,500 participants (Actual)	Interventional	2017-01-06	Active, not recruiting
Impact of Perioperative Dexmedetomidine on Long-term Outcomes in Elderly Patients After Cardiac Surgery: 6-year Follow-up of a Randomized Controlled Trial[NCT03289325]		285 participants (Actual)	Interventional	2016-12-05	Completed
Impact of Dexmedetomidine on Long-term Outcome in Elderly Patients After Noncardiac Surgery: 3-year Follow-up of a Randomized Controlled Trial[NCT02809937]	Phase 4	700 participants (Actual)	Interventional	2011-05-31	Completed
Pilot Study on the Effect of Dexmedetomidine on Inflammatory Responses in Patients Undergoing Lumbar Spinal Fusion[NCT01377623]		66 participants (Actual)	Interventional	2010-09-30	Terminated
Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General anesthesia---a Randomized Control Double-Blind Clinical Trial[NCT02613806]	Phase 4	118 participants (Anticipated)	Interventional	2015-12-31	Not yet recruiting
Effect of Dexmedetomidine as Anesthetic Coadjuvant on Plasmatic Cortisol Response in Transsphenoidal Surgery for Pituitary Tumors[NCT02549768]	Phase 4	40 participants (Anticipated)	Interventional	2015-09-30	Recruiting
Impact of Dexmedetomidine Supplemented Analgesia on Incidence of Delirium in Elderly Patients After Cancer Surgery: a Multicenter Randomized Controlled Trial[NCT03012984]		1,500 participants (Actual)	Interventional	2017-01-06	Completed
Impact of Dexmedetomidine on Long-term Outcome in Elderly Patients After Noncardiac Surgery: 5-year Follow-up of a Randomized Controlled Trial[NCT03436472]		700 participants (Actual)	Interventional	2017-06-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Retention rate is defined as the percentage of subjects able to complete the study. (NCT01515566)
Timeframe: Baseline to study completion, up to 100 minutes.

Effect of Fentanyl on Walk Distance

Intervention	percentage of participants (Number)
Fentanyl	100
Placebo	100

Ambulatory patients with breakthrough dyspnea performed a baseline 6 minute walk test (6MWT), and then received either subcutaneous fentanyl or placebo 15 minutes before a second 6MWT. The change in walk distance was documented between the first and second 6MWT. (NCT01515566)
Timeframe: Baseline 6 minute walk test (6MWT) to second 6MWT, up to 100 minutes for study participation.

Effect of Fentanyl Versus Placebo for Exercise-Induced and Breakthrough Dyspnea

Intervention	feet (Mean)
	Walk Distance (Baseline Walk Test)	Walk Distance (Second Walk Test)
Fentanyl	397.7	434.9
Placebo	399	417.9

"Participants receive either Fentanyl subcutaneous (SQ) 15 minutes before walking test, or Placebo (SQ) 15 minutes before walking test. During the study, trained research staff perform study assessments and monitor participant carefully throughout the study period. Six-minute walk tests were carried out following guidelines from the American Thoracic Society. The intensity of dyspnea at 0, 1, 2, 3, 4, 5 and 6 minute of each walk test were assessed using a validated numeric rating scale (NRS) ranging from 0 (no shortness of breath) to 10 (worst possible shortness of breath) and every 5 minutes during the rest period." (NCT01515566)
Timeframe: Baseline to 100 minutes for study participation.

Length of Time From Extubation to Discharge From Postanesthesia Recovery Unit

Intervention	units on a scale (Mean)
	Dyspnea at 0 minutes (Baseline walk test)	Dyspnea at 6 minutes (Baseline walk test)	Dyspnea at 0 minutes (Second walk test)	Dyspnea at 6 minutes (Second walk test)
Fentanyl	2	6	1	4
Placebo	3	7	2	5

Length of time of above compared between groups (NCT02494102)
Timeframe: 24 hours

Postanesthesia Quality Recovery Scale Score

Intervention	minutes (Mean)
Placebo	53.5
Modafinil	61.0

Postanesthesia quality recovery scale (PQRS). Component and aggregate scoring on the scale. Measures physiology, nociceptive, emotional activities of daily living cognitive and overall patient perspective. The scale is dimensionless and the aggregate of all individually tested dimensions is scaled from 17-65. A higher value implies improved postanesthesia recovery. Mean difference was assessed in each patient and aggregated thus patients with no difference between pre- and post-operative scores were zeroed (received a zero score if the difference was zero). A negative value was associated with worse outcome. (NCT02494102)
Timeframe: baseline and 6 hours after surgery

Concentration of IL-1a

Concentration of IL-6

Concentration of IL-8

Concentration of TNF-alpha

Quality of Recovery Score (QoR-40)

Intervention	units on a scale (Mean)
Placebo	-5.67
Modafinil	-8.91

Intervention	pg/ml (Median)
Dexmedetomidine Group (PFD)	2.52
Placebo Group (PFS)	2.58

Intervention	pg/ml (Median)
Dexmedetomidine Group (PFD)	60.8
Placebo Group (PFS)	50.0

Intervention	pg/ml (Median)
Dexmedetomidine Group (PFD)	20.9
Placebo Group (PFS)	16.4

Intervention	pg/ml (Median)
Dexmedetomidine Group (PFD)	10.1
Placebo Group (PFS)	7.9

The QoR-40 is a 40 item questionnaire in which each question is answered with a score of 1-5. QoR-40 scores range from 40 (extremely poor quality of recovery) to 200 (excellent quality of recovery). (NCT01377623)
Timeframe: Post-operative Day 3

Article	Year
Effect of Prophylactic Fentanyl Buccal Tablet on Episodic Exertional Dyspnea: A Pilot Double-Blind Randomized Controlled Trial. Journal of pain and symptom management, 2017, Volume: 54, Issue:6 Topics: Administration, Buccal; Adult; Aged; Analgesics, Opioid; Comorbidity; Double-Blind Method; Dyspnea;	2017
Effects of prophylactic subcutaneous fentanyl on exercise-induced breakthrough dyspnea in cancer patients: a preliminary double-blind, randomized, controlled trial. Journal of pain and symptom management, 2014, Volume: 47, Issue:2 Topics: Adult; Aged; Analgesics, Opioid; Double-Blind Method; Dyspnea; Exercise; Exercise Test; Fatigue; Fea	2014
Modafinil reduces patient-reported tiredness after sedation/analgesia but does not improve patient psychomotor skills. Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesia; Anesthesia Recovery Period; Anesthetics, Inha	2010
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. Journal of neurosurgical anesthesiology, 2013, Volume: 25, Issue:1 Topics: Adrenergic alpha-Agonists; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Intravenous	2013
Etoricoxib pre-medication for post-operative pain after laparoscopic cholecystectomy. Acta anaesthesiologica Scandinavica, 2006, Volume: 50, Issue:6 Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Non-Narcotic; Ana	2006
Bioequivalence following buccal and sublingual placement of fentanyl buccal tablet 400 microg in healthy subjects. Clinical drug investigation, 2008, Volume: 28, Issue:1 Topics: Administration, Buccal; Administration, Sublingual; Adult; Analgesics, Opioid; Area Under Curve; Chr	2008
[Psychosomatic effects of intramuscular premedication wtih flunitrazepam, innovar and a placebo in combination with atropine (author's transl)]. Anasthesie, Intensivtherapie, Notfallmedizin, 1981, Volume: 16, Issue:1 Topics: Adult; Amnesia; Anti-Anxiety Agents; Anxiety; Atropine; Droperidol; Drug Combinations; Drug Therapy,	1981

Article	Year
Management of labour and delivery in a woman with refractory supraventricular tachycardia. International journal of obstetric anesthesia, 2014, Volume: 23, Issue:1 Topics: Adult; Amides; Amnion; Analgesia, Patient-Controlled; Analgesics, Opioid; Anesthesia, Epidural; Anes	2014
Central μ-Opioidergic System Activation Evoked by Heavy and Severe-Intensity Cycling Exercise in Humans: a Pilot Study Using Positron Emission Tomography with 11C-Carfentanil. International journal of sports medicine, 2017, Volume: 38, Issue:1 Topics: Affect; Carbon Radioisotopes; Exercise; Exercise Test; Fatigue; Fentanyl; Humans; Limbic System; Mal	2017
Predictors of the Usefulness of Corticosteroids for Cancer-Related Fatigue in End-of-Life Patients. Clinical drug investigation, 2017, Volume: 37, Issue:4 Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Betamethasone; Fatigue; Female; Fentanyl; G	2017
What is the driving performance of ambulatory surgical patients after general anesthesia? Anesthesiology, 2005, Volume: 103, Issue:5 Topics: Adjuvants, Anesthesia; Adult; Ambulatory Surgical Procedures; Anesthesia, General; Anesthetics, Intr	2005
[EEG effects of premedication with thalamonal. a clinical study on 16 patients (author's transl)]. Der Anaesthesist, 1980, Volume: 29, Issue:7 Topics: Adult; Aged; Blood Pressure; Droperidol; Electroencephalography; Fatigue; Female; Fentanyl; Humans;	1980

fentanyl and Lassitude