fentanyl has been researched along with Injury, Myocardial Reperfusion in 12 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neither halothane nor sevoflurane protected the heart against the effects of acute and severe regional myocardial ischemia." | 7.70 | Anesthetic modulation of myocardial ischemia and reperfusion injury in pigs: comparison between halothane and sevoflurane. ( Coetzee, A; Coetzee, J; Conradie, S, 1999) |
| "We investigated the involvement of central and peripheral opioid receptors (OR) in the cardioprotective effects of fentanyl (FENT) in a model of myocardial ischemia/reperfusion injury associated with pharmacologically induced sympathetic overactivity in anesthetized rabbits." | 3.73 | Pharmacologic evidence for the involvement of central and peripheral opioid receptors in the cardioprotective effects of fentanyl. ( Lessa, MA; Tibiriçá, E, 2006) |
| "Neither halothane nor sevoflurane protected the heart against the effects of acute and severe regional myocardial ischemia." | 3.70 | Anesthetic modulation of myocardial ischemia and reperfusion injury in pigs: comparison between halothane and sevoflurane. ( Coetzee, A; Coetzee, J; Conradie, S, 1999) |
| "Treatment with fentanyl 740 nmol litre-1 improved post-ischaemic mechanical function, assessed as developed pressure, +dP/dtmax and -dP/dtmin, compared with controls after 60 min of reperfusion." | 1.31 | Fentanyl protects the heart against ischaemic injury via opioid receptors, adenosine A1 receptors and KATP channel linked mechanisms in rats. ( Foëx, P; Kato, R; Ross, S, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Lassen, TR | 1 |
| Hjortbak, MV | 1 |
| Hauerslev, M | 1 |
| Tonnesen, PT | 1 |
| Kristiansen, SB | 1 |
| Jensen, RV | 1 |
| Bøtker, HE | 1 |
| Xu, YC | 1 |
| Li, RP | 1 |
| Xue, FS | 1 |
| Cui, XL | 1 |
| Wang, SY | 1 |
| Liu, GP | 1 |
| Yang, GZ | 1 |
| Sun, C | 1 |
| Liao, X | 1 |
| Zhao, ZH | 1 |
| Hao, W | 1 |
| Meng, QT | 1 |
| Du, XB | 1 |
| Lei, SQ | 1 |
| Xia, ZY | 1 |
| Xu, Q | 1 |
| Li, QG | 1 |
| Fan, GR | 1 |
| Liu, QH | 1 |
| Mi, FL | 1 |
| Liu, B | 1 |
| Gross, ER | 1 |
| Hsu, AK | 1 |
| Gross, GJ | 1 |
| Murphy, GS | 1 |
| Szokol, JW | 1 |
| Marymont, JH | 1 |
| Avram, MJ | 1 |
| Vender, JS | 1 |
| Kawamura, T | 1 |
| Kadosaki, M | 1 |
| Nara, N | 1 |
| Kaise, A | 1 |
| Suzuki, H | 1 |
| Endo, S | 1 |
| Wei, J | 1 |
| Inada, K | 1 |
| Lessa, MA | 1 |
| Tibiriçá, E | 1 |
| Piriou, V | 1 |
| Ross, S | 2 |
| Pigott, D | 1 |
| Evans, R | 1 |
| Foex, P | 2 |
| Conradie, S | 1 |
| Coetzee, A | 1 |
| Coetzee, J | 1 |
| Kato, R | 1 |
| Colson, P | 1 |
| Galy, A | 1 |
| Grolleau, D | 1 |
| Séguin, J | 1 |
| Saussine, M | 1 |
| Cuchet, D | 1 |
| Chaptal, PA | 1 |
| Roquefeuil, B | 1 |
3 trials available for fentanyl and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Opioids and cardioprotection: the impact of morphine and fentanyl on recovery of ventricular function after cardiopulmonary bypass.
Topics: Aged; Analgesics, Opioid; Anesthetics, Intravenous; Cardiopulmonary Bypass; Cardiovascular Physiolog | 2006 |
Effects of sevoflurane on cytokine balance in patients undergoing coronary artery bypass graft surgery.
Topics: Aged; Anesthetics, Inhalation; Coronary Artery Bypass; Creatine Kinase, MB Form; Double-Blind Method | 2006 |
Myocardial depressant effect of nitrous oxide after coronary artery bypass graft surgery.
Topics: Aged; Anesthesia, Intravenous; Contraindications; Coronary Artery Bypass; Depression, Chemical; Fema | 1992 |
9 other studies available for fentanyl and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Influence of strain, age, origin, and anesthesia on the cardioprotective efficacy by local and remote ischemic conditioning in an ex vivo rat model.
Topics: Analgesia; Animals; Barbiturates; Butyrophenones; Drug Combinations; Fentanyl; Hypnotics and Sedativ | 2021 |
κ-Opioid receptors are involved in enhanced cardioprotection by combined fentanyl and limb remote ischemic postconditioning.
Topics: Animals; Extremities; Fentanyl; Ischemic Postconditioning; Male; Myocardial Reperfusion Injury; Nalt | 2015 |
Long non-coding RNA MALAT1 functions as a mediator in cardioprotective effects of fentanyl in myocardial ischemia-reperfusion injury.
Topics: Animals; Cardiotonic Agents; Cell Line; Fentanyl; Gene Knockdown Techniques; Membrane Proteins; Mice | 2017 |
Protective effects of fentanyl preconditioning on cardiomyocyte apoptosis induced by ischemia-reperfusion in rats.
Topics: Animals; Apoptosis; Fentanyl; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protective Age | 2017 |
The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta.
Topics: Animals; Cardiotonic Agents; Cell Line; Enzyme Inhibitors; Fentanyl; Glycogen Synthase Kinase 3; Gly | 2006 |
Pharmacologic evidence for the involvement of central and peripheral opioid receptors in the cardioprotective effects of fentanyl.
Topics: Animals; Arrhythmias, Cardiac; Cardiotonic Agents; Dose-Response Relationship, Drug; Female; Fentany | 2006 |
Beneficial effect of concomitant administration of isoflurane and nicorandil.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Drug Therapy, Co | 1997 |
Anesthetic modulation of myocardial ischemia and reperfusion injury in pigs: comparison between halothane and sevoflurane.
Topics: Adjuvants, Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Fentanyl; Halotha | 1999 |
Fentanyl protects the heart against ischaemic injury via opioid receptors, adenosine A1 receptors and KATP channel linked mechanisms in rats.
Topics: Adenosine Triphosphate; Analgesics, Opioid; Animals; Fentanyl; Hemodynamics; Male; Myocardial Reperf | 2000 |