fentanyl has been researched along with Inflammation in 40 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fentanyl is a potent analgesic with a rapid onset and short half-life that make it a useful treatment for pain and a lethal drug of abuse." | 8.31 | Continuous fentanyl administration and spontaneous withdrawal decreases home cage wheel running in rats with and without hindpaw inflammation. ( Hilgendorf, TN; Kandasamy, R; Morgan, MM, 2023) |
| "In 99 patients receiving IV fentanyl, midazolam, or both, we evaluated drug doses, covariates likely to influence drug effects (age, body mass index, and renal and hepatic dysfunction); delirium risk factors; concomitant administration of CYP3A and P-glycoprotein substrates/inhibitors; ABCB1, ABCG2, and CYP3A5 genetic polymorphisms; and fentanyl and midazolam plasma levels." | 7.79 | Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors. ( Cossette, M; Leger, C; Michaud, V; Skrobik, Y; Turgeon, J, 2013) |
| " Here, by using a chronic inflammation model, namely subplantar injection of Complete Freund's adjuvant, we show a peripheral synergistic interaction between the histamine H(3) receptor agonist R-(alpha)-methylhistamine and fentanyl on the inhibition of thermal hyperalgesia and of peripheral substance P accumulation." | 7.76 | Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice. ( Ciruela, F; Fernández-Dueñas, V; Gandía, J; Planas, E; Poveda, R; Sánchez, S, 2010) |
| " Here we show that rats with chronic morphine treatment do not develop signs of tolerance at peripheral mu-opioid receptors (micro-receptors) in the presence of painful CFA-induced paw inflammation." | 7.74 | Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain. ( Binder, W; Brack, A; Fischer, O; Mousa, SA; Rittner, HL; Schäfer, M; Shakibaei, M; Shaqura, M; Stein, C; Urban, F; Zöllner, C, 2008) |
| "Moreover, fentany-linduced-hyperalgesia and changes in the expression of the aforementioned proteins can be attenuated by TAK-242, an inhibitor of TLR4, as well as ketamine." | 5.91 | A single dose of ketamine relieves fentanyl-induced-hyperalgesia by reducing inflammation initiated by the TLR4/NF-κB pathway in rat spinal cord neurons. ( Chang, L; Chen, J; Li, Q; Liu, P; Luo, Q; Shu, H; Wang, L; Wu, G; Xiong, Y; Zhou, X, 2023) |
| " Its dose-response curve was shifted to the right between 1." | 5.30 | The antinociceptive effect of the mu-opioid fentanyl is reduced in the presence of the alpha(2)-adrenergic antagonist idazoxan in inflammation. ( Herrero, JF; Solano, RE, 1999) |
| "The results indicated that low dosage of fentanyl supplemented with DEX almost had the same anesthesia effects and inflammation extent compared with high dose of fentanyl, which suggested that infusion DEX might decrease fentanyl consumption in pediatric cardiac surgery." | 5.24 | Clinical efficacy of dexmedetomidine in the diminution of fentanyl dosage in pediatric cardiac surgery. ( Li, Y; Sun, Y; Wang, X; Xia, Y; Ye, H; Yuan, X, 2017) |
| "TIVA with propofol and remifentanil and INHAL with sevoflurane and fentanyl induced similar inflammatory responses during colorectal cancer surgery." | 5.15 | Inflammatory response in patients undergoing colorectal cancer surgery: the effect of two different anesthetic techniques. ( Bengtson, JP; Bengtsson, A; Kvarnström, A; Sarbinowski, R; Tylman, M, 2011) |
| " We studied the analgesic efficacy and side-effect profile of a pH-sensitive fentanyl analog, (±)- N -(3-fluoro-1-phenethylpiperidine-4-yl)- N -phenyl propionamide (NFEPP), during the evolution of colitis induced in mice with dextran sulphate sodium." | 4.31 | Evolving acidic microenvironments during colitis provide selective analgesic targets for a pH-sensitive opioid. ( Alizadeh, E; Bunnett, NW; Degro, CE; Guzman-Rodriguez, M; Hurlbut, D; Jiménez-Vargas, NN; Lomax, AE; Reed, DE; Stein, C; Tsang, Q; Vanner, SJ; Yu, Y, 2023) |
| "Fentanyl is a potent analgesic with a rapid onset and short half-life that make it a useful treatment for pain and a lethal drug of abuse." | 4.31 | Continuous fentanyl administration and spontaneous withdrawal decreases home cage wheel running in rats with and without hindpaw inflammation. ( Hilgendorf, TN; Kandasamy, R; Morgan, MM, 2023) |
| "Antinociceptive effect of narcotic analgesics, fentanyl, oxycodone and methadone in inflammatory pain state was described in the von Frey filament test using the complete Freund's adjuvant (CFA)-induced mouse inflammatory pain model." | 3.80 | Differential alternation of the antinociceptive effect of narcotic analgesics on the inflammatory pain state. ( Aoki, Y; Mizoguchi, H; Sakurada, S; Sakurada, T; Watanabe, C, 2014) |
| "In 99 patients receiving IV fentanyl, midazolam, or both, we evaluated drug doses, covariates likely to influence drug effects (age, body mass index, and renal and hepatic dysfunction); delirium risk factors; concomitant administration of CYP3A and P-glycoprotein substrates/inhibitors; ABCB1, ABCG2, and CYP3A5 genetic polymorphisms; and fentanyl and midazolam plasma levels." | 3.79 | Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors. ( Cossette, M; Leger, C; Michaud, V; Skrobik, Y; Turgeon, J, 2013) |
| " Here, by using a chronic inflammation model, namely subplantar injection of Complete Freund's adjuvant, we show a peripheral synergistic interaction between the histamine H(3) receptor agonist R-(alpha)-methylhistamine and fentanyl on the inhibition of thermal hyperalgesia and of peripheral substance P accumulation." | 3.76 | Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice. ( Ciruela, F; Fernández-Dueñas, V; Gandía, J; Planas, E; Poveda, R; Sánchez, S, 2010) |
| " Here we show that rats with chronic morphine treatment do not develop signs of tolerance at peripheral mu-opioid receptors (micro-receptors) in the presence of painful CFA-induced paw inflammation." | 3.74 | Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain. ( Binder, W; Brack, A; Fischer, O; Mousa, SA; Rittner, HL; Schäfer, M; Shakibaei, M; Shaqura, M; Stein, C; Urban, F; Zöllner, C, 2008) |
| "05), 24 h dosage of analgesia were significantly less (P < 0." | 2.80 | Preoperative and postoperative analgesic techniques in the treatment of patients undergoing transabdominal hysterectomy: a preliminary randomized trial. ( Chen, JQ; Hu, YM; Miao, JZ; Wen, LY; Wu, Z; Xue, R, 2015) |
| "Moreover, fentany-linduced-hyperalgesia and changes in the expression of the aforementioned proteins can be attenuated by TAK-242, an inhibitor of TLR4, as well as ketamine." | 1.91 | A single dose of ketamine relieves fentanyl-induced-hyperalgesia by reducing inflammation initiated by the TLR4/NF-κB pathway in rat spinal cord neurons. ( Chang, L; Chen, J; Li, Q; Liu, P; Luo, Q; Shu, H; Wang, L; Wu, G; Xiong, Y; Zhou, X, 2023) |
| "Infective endocarditis is associated with significant morbidity and mortality, despite advances in diagnosis and treatment strategies." | 1.51 | No Fever, No Murmur, No Problem? A Concealed Case of Infective Endocarditis. ( Gorman, M; McCann, M; McKeown, B, 2019) |
| "Carrageenan-induced hyperalgesia is a widely used pain model in rodents." | 1.40 | Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain. ( Ko, MC; Lee, H; Rice, KC; Sukhtankar, DD, 2014) |
| "loperamide was abolished by i." | 1.38 | Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids. ( Al-Khrasani, M; Fürst, S; Khalefa, BI; Mousa, SA; Schäfer, M; Shaqura, M, 2012) |
| "In prestressed rats, fULD-induced hyperalgesia and the exaggerated inflammatory hyperalgesia were prevented NMDA receptor antagonists." | 1.37 | Endogenous opioids released during non-nociceptive environmental stress induce latent pain sensitization Via a NMDA-dependent process. ( Chateauraynaud, J; Gavello-Baudy, S; Laboureyras, E; Laulin, JP; Le Roy, C; Simonnet, G, 2011) |
| "fentanyl was naloxone reversible and potentiated exclusively in inflamed and NGF-treated paws." | 1.34 | Nerve growth factor governs the enhanced ability of opioids to suppress inflammatory pain. ( Cheppudira, BP; Fischer, O; Hellweg, R; Hofmann, J; Mousa, SA; Schäfer, M; Shaqura, M, 2007) |
| "hyperalgesia was unaltered by liposome injection (P > 0." | 1.32 | Tissue monocytes/macrophages in inflammation: hyperalgesia versus opioid-mediated peripheral antinociception. ( Brack, A; Labuz, D; Machelska, H; Reszka, R; Rittner, HL; Schäfer, M; Schiltz, A; Stein, C, 2004) |
| " Its dose-response curve was shifted to the right between 1." | 1.30 | The antinociceptive effect of the mu-opioid fentanyl is reduced in the presence of the alpha(2)-adrenergic antagonist idazoxan in inflammation. ( Herrero, JF; Solano, RE, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (10.00) | 18.7374 |
| 1990's | 4 (10.00) | 18.2507 |
| 2000's | 10 (25.00) | 29.6817 |
| 2010's | 18 (45.00) | 24.3611 |
| 2020's | 4 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berke, MS | 1 |
| Colding-Jørgensen, P | 1 |
| Pedersen, LG | 1 |
| Hestehave, S | 1 |
| Kalliokoski, O | 1 |
| Jensen, HE | 1 |
| Sørensen, DB | 1 |
| Hau, J | 1 |
| Abelson, KS | 1 |
| Degro, CE | 1 |
| Jiménez-Vargas, NN | 1 |
| Tsang, Q | 1 |
| Yu, Y | 1 |
| Guzman-Rodriguez, M | 1 |
| Alizadeh, E | 1 |
| Hurlbut, D | 1 |
| Reed, DE | 1 |
| Lomax, AE | 1 |
| Stein, C | 6 |
| Bunnett, NW | 1 |
| Vanner, SJ | 1 |
| Zhou, X | 1 |
| Li, Q | 1 |
| Luo, Q | 1 |
| Wang, L | 1 |
| Chen, J | 1 |
| Xiong, Y | 1 |
| Wu, G | 1 |
| Chang, L | 1 |
| Liu, P | 1 |
| Shu, H | 1 |
| Morgan, MM | 1 |
| Hilgendorf, TN | 1 |
| Kandasamy, R | 1 |
| Palomino, J | 1 |
| Echavarria, R | 1 |
| Franco-Acevedo, A | 1 |
| Moreno-Carranza, B | 1 |
| Melo, Z | 1 |
| Mousa, SA | 5 |
| Shaqura, M | 4 |
| Al-Madol, M | 1 |
| Tafelski, S | 1 |
| Khalefa, BI | 2 |
| Shakibaei, M | 2 |
| Schäfer, M | 6 |
| McCann, M | 1 |
| Gorman, M | 1 |
| McKeown, B | 1 |
| Binczak, M | 1 |
| Tournay, E | 1 |
| Billard, V | 1 |
| Rey, A | 1 |
| Jayr, C | 1 |
| Sukhtankar, DD | 1 |
| Lee, H | 1 |
| Rice, KC | 1 |
| Ko, MC | 1 |
| Aoki, Y | 1 |
| Mizoguchi, H | 1 |
| Watanabe, C | 1 |
| Sakurada, T | 1 |
| Sakurada, S | 1 |
| Ramos-Zepeda, GA | 1 |
| Herrero-Zorita, C | 1 |
| Herrero, JF | 3 |
| Chen, JQ | 1 |
| Wu, Z | 1 |
| Wen, LY | 1 |
| Miao, JZ | 1 |
| Hu, YM | 1 |
| Xue, R | 1 |
| Sun, Y | 1 |
| Ye, H | 1 |
| Xia, Y | 1 |
| Li, Y | 1 |
| Yuan, X | 1 |
| Wang, X | 1 |
| Fernández-Dueñas, V | 1 |
| Ciruela, F | 1 |
| Gandía, J | 1 |
| Sánchez, S | 2 |
| Planas, E | 2 |
| Poveda, R | 2 |
| Jan, WC | 1 |
| Chen, CH | 1 |
| Hsu, K | 1 |
| Tsai, PS | 1 |
| Huang, CJ | 1 |
| Tylman, M | 1 |
| Sarbinowski, R | 1 |
| Bengtson, JP | 1 |
| Kvarnström, A | 1 |
| Bengtsson, A | 1 |
| Le Roy, C | 1 |
| Laboureyras, E | 1 |
| Gavello-Baudy, S | 1 |
| Chateauraynaud, J | 1 |
| Laulin, JP | 1 |
| Simonnet, G | 1 |
| Miranda, HF | 1 |
| Noriega, V | 1 |
| Zepeda, RJ | 1 |
| Sierralta, F | 1 |
| Prieto, JC | 1 |
| Al-Khrasani, M | 2 |
| Fürst, S | 2 |
| Orosz, JE | 1 |
| Braz, MG | 1 |
| Golim, MA | 1 |
| Barreira, MA | 1 |
| Fecchio, D | 1 |
| Braz, LG | 1 |
| Braz, JR | 1 |
| Moshourab, R | 1 |
| Skrobik, Y | 1 |
| Leger, C | 1 |
| Cossette, M | 1 |
| Michaud, V | 1 |
| Turgeon, J | 1 |
| YELNOSKY, J | 1 |
| FIELD, WE | 1 |
| Brack, A | 2 |
| Labuz, D | 1 |
| Schiltz, A | 1 |
| Rittner, HL | 2 |
| Machelska, H | 1 |
| Reszka, R | 1 |
| Riba, P | 1 |
| Friedmann, T | 1 |
| Tímar, J | 1 |
| Obara, I | 1 |
| Makuch, W | 1 |
| Spetea, M | 1 |
| Schütz, J | 1 |
| Przewlocki, R | 1 |
| Przewlocka, B | 1 |
| Schmidhammer, H | 1 |
| Corcoran, TB | 1 |
| Engel, A | 1 |
| Sakamoto, H | 1 |
| O'Callaghan-Enright, S | 1 |
| O'Donnell, A | 1 |
| Heffron, JA | 1 |
| Shorten, G | 1 |
| Romero, A | 1 |
| Pol, O | 1 |
| Puig, MM | 1 |
| Cheppudira, BP | 1 |
| Fischer, O | 2 |
| Hofmann, J | 1 |
| Hellweg, R | 1 |
| Wan, Y | 1 |
| Xu, J | 1 |
| Ma, D | 1 |
| Zeng, Y | 1 |
| Cibelli, M | 1 |
| Maze, M | 1 |
| Rodríguez, R | 1 |
| Martínez, E | 1 |
| Santana, M | 1 |
| Rodríguez Huertas, E | 1 |
| Winterhalter, M | 1 |
| Brandl, K | 1 |
| Rahe-Meyer, N | 1 |
| Osthaus, A | 1 |
| Hecker, H | 1 |
| Hagl, C | 1 |
| Adams, HA | 1 |
| Piepenbrock, S | 1 |
| Zöllner, C | 1 |
| Binder, W | 1 |
| Urban, F | 1 |
| Antonijevic, I | 1 |
| Headley, PM | 1 |
| Brix-Christensen, V | 1 |
| Tønnesen, E | 1 |
| Sanchez, RG | 1 |
| Bilfinger, TV | 1 |
| Stefano, GB | 1 |
| Solano, RE | 1 |
| Kotani, N | 1 |
| Hashimoto, H | 1 |
| Kushikata, T | 1 |
| Yoshida, H | 1 |
| Muraoka, M | 1 |
| Takahashi, S | 1 |
| Matsuki, A | 1 |
| Newton, WM | 1 |
| Cusick, PK | 1 |
| Raffe, MR | 1 |
| Joris, JL | 1 |
| Dubner, R | 1 |
| Hargreaves, KM | 1 |
| Millan, MJ | 1 |
| Shippenberg, TS | 1 |
| Herz, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Association Between Changes in Cerebral Gray Matter Volume and Postoperative Cognitive Dysfunction in Elderly Patients Following Sevoflurane Anesthesia (POCD-MRI)[NCT02045004] | 100 participants (Actual) | Observational | 2015-07-14 | Completed | |||
| Release of Serum Neurofilament Light (NFL), Biomarker of Neuronal Injury, in Surgery Under General Anaesthesia (GA) Compared to Surgery With Hypno-analgesia (Hyp): A Prospective, Non-inferiority Study[NCT04500236] | 100 participants (Anticipated) | Interventional | 2020-09-01 | Recruiting | |||
| Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium: A Multicenter, Randomized, Double-Blind Clinical Trail[NCT02928692] | Phase 3 | 750 participants (Anticipated) | Interventional | 2016-11-30 | Recruiting | ||
| Effect of General Anesthesia on Early Postoperative Cognitive Dysfunction in Elective Versus Emergency Cesarean Section[NCT03818009] | 58 participants (Actual) | Observational | 2019-01-14 | Completed | |||
| Impact of Dexmedetomidine on the Incidence of Postoperative Delirium in Patients After Cardiac Surgery: a Randomized, Double-blinded, and Placebo-controlled Clinical Trial[NCT02267538] | Phase 4 | 285 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| Effect of Remifentanil on Postoperative Cognitive Function in Patients Undergoing Major Abdominal Surgery[NCT01627873] | Phase 4 | 622 participants (Actual) | Interventional | 2009-08-31 | Completed | ||
| A Phase I Clinical Study Evaluating the Safety, Tolerability and Pharmacokinetics of HSK21542 in Healthy Volunteers[NCT04213196] | Phase 1 | 66 participants (Actual) | Interventional | 2020-01-09 | Completed | ||
| Epithelial Healing and Visual Outcomes of Patients Using Omega-3 Supplements as an Adjunct Therapy Before and After Photorefractive Keratectomy (PRK) Surgery[NCT01059019] | 17 participants (Actual) | Interventional | 2010-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Delirium was assessed with the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) twice daily during the first five days after surgery. (NCT02267538)
Timeframe: During the first five days after surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| DEX Group | 7 |
| CTRL Group | 11 |
Results was presented as median (95% confidence interval). (NCT02267538)
Timeframe: From end of surgery until discharge from hospital or 30 days after surgery
| Intervention | days (Median) |
|---|---|
| DEX Group | 9 |
| CTRL Group | 9 |
Results was presented as median (95% confidence interval). (NCT02267538)
Timeframe: From end of surgery until discharge from Intensive Care Unit or 30 days after surgery
| Intervention | hours (Median) |
|---|---|
| DEX Group | 45.0 |
| CTRL Group | 46.0 |
"Cognitive function was assessed with the Mini Mental State Examination (MMSE) at baseline (the day before surgery) and on the sixth day after surgery, and with modified telephone interview for cognitive status (m-TICS) on the 30th day after surgery.~The introduction of MMSE scale has been explained in the baseline part in the result section.~The Telephone Interview for Cognitive Status-modified scale(m-TICS) is one of the most popular telephone interview-based screening instruments for mild cognitive impairment and dementia. It consists 11 items including wordlist memory, orientation, attention, repetition, conceptual knowledge and nonverbal praxis, which score ranges from 0 to 48, with higher scores indicating better cognitive function" (NCT02267538)
Timeframe: on the sixth day after surgery, and on the 30th day after surgery
| Intervention | units on a scale (Median) | |
|---|---|---|
| MMSE score on postoperative day 6 | m-TICS score on postoperative day 30 | |
| CTRL Group | 29 | 34 |
| DEX Group | 29 | 34 |
Non-delirium complications was defined as any conditions other than delirium that occurred during the first 30 days after surgery and required therapeutic intervention.Complications listed here were not considered adverse events in this study. (NCT02267538)
Timeframe: Occurrence of non-delirium complications will be monitored until 30 days after surgery.
| Intervention | Participants (Count of Participants) | |||||||
|---|---|---|---|---|---|---|---|---|
| Stroke | New onset arrythmia | Pulmonary complications | Upper gastrointestinal bleeding | Surgical bleeding | Wound dehiscence or infection | Acute kidney injury | IABP assistance | |
| CTRL Group | 3 | 51 | 27 | 4 | 3 | 7 | 44 | 12 |
| DEX Group | 3 | 42 | 15 | 2 | 3 | 11 | 37 | 6 |
Pain intensity was assessed daily at 8 am during the first five days after surgery with the Numeric Rating Scale (NRS, 0 = no pain, 10 = the worst possible pain). (NCT02267538)
Timeframe: During the first five days after surgery
| Intervention | units on a scale (Median) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Pain score after surgery(d1), at rest | Pain score after surgery(d2), at rest | Pain score after surgery(d3), at rest | Pain score after surgery(d4), at rest | Pain score after surgery(d5), at rest | Pain score after surgery(d1), with coughing | Pain score after surgery(d2), with coughing | Pain score after surgery(d3), with coughing | Pain score after surgery(d4), with coughing | Pain score after surgery(d5), with coughing | |
| CTRL Group | 3 | 3 | 2 | 2 | 1 | 4 | 4 | 4 | 3 | 2 |
| DEX Group | 3 | 4 | 3 | 2 | 2 | 4 | 5 | 4 | 3 | 2 |
Subjective sleep quality was assessed daily at 8 am during the first five days after surgery with the Numeric Rating Scale (NRS, 0 = best sleep, 10 = the worst possible sleep). (NCT02267538)
Timeframe: During the first five days after surgery
| Intervention | units on a scale (Median) | ||||
|---|---|---|---|---|---|
| Subjective sleep quality after surgery(d1), score | Subjective sleep quality after surgery(d2), score | Subjective sleep quality after surgery(d3), score | Subjective sleep quality after surgery(d4), score | Subjective sleep quality after surgery(d5), score | |
| CTRL Group | 2 | 3 | 2 | 2 | 2 |
| DEX Group | 2 | 3 | 2 | 2 | 2 |
1 review available for fentanyl and Inflammation
| Article | Year |
|---|---|
Opioids Preconditioning Upon Renal Function and Ischemia-Reperfusion Injury: A Narrative Review.
Topics: Acute Kidney Injury; Analgesics, Opioid; Fentanyl; Humans; Inflammation; Ischemic Preconditioning; K | 2019 |
8 trials available for fentanyl and Inflammation
| Article | Year |
|---|---|
Preoperative and postoperative analgesic techniques in the treatment of patients undergoing transabdominal hysterectomy: a preliminary randomized trial.
Topics: Adult; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Double-Blind Method; Drug Therapy, Combi | 2015 |
Clinical efficacy of dexmedetomidine in the diminution of fentanyl dosage in pediatric cardiac surgery.
Topics: Adjuvants, Anesthesia; Airway Extubation; Cardiac Surgical Procedures; Child; Child, Preschool; Dexm | 2017 |
Inflammatory response in patients undergoing colorectal cancer surgery: the effect of two different anesthetic techniques.
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave | 2011 |
The effects of propofol on lipid peroxidation and inflammatory response in elective coronary artery bypass grafting.
Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Anti-Inflammatory Agents; Coronary Artery B | 2004 |
[Stress response under continuous infusion of remifentanil compared to bolus doses of fentanyl assessed by levels of cytokines, C-reactive protein, and cortisol during and after abdominal hysterectomy].
Topics: Aged; Anesthesia, General; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; C-Reactive Protein; | 2007 |
Endocrine stress response and inflammatory activation during CABG surgery. A randomized trial comparing remifentanil infusion to intermittent fentanyl.
Topics: Adrenocorticotropic Hormone; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Coronary Arter | 2008 |
Endogenous morphine levels increase following cardiac surgery as part of the antiinflammatory response?
Topics: Adult; Analgesics, Opioid; Anesthesia, Epidural; Anesthesia, General; Coronary Artery Bypass; Fentan | 1997 |
Intraoperative prostaglandin E1 improves antimicrobial and inflammatory responses in alveolar immune cells.
Topics: Adult; Alprostadil; Anesthetics, Intravenous; Blood Bactericidal Activity; Bronchoalveolar Lavage Fl | 2001 |
31 other studies available for fentanyl and Inflammation
| Article | Year |
|---|---|
Effects of Transdermal Fentanyl Treatment on Acute Pain and Inflammation in Rats with Adjuvant-induced Monoarthritis.
Topics: Acute Pain; Adjuvants, Immunologic; Analgesics, Opioid; Animals; Female; Fentanyl; Freund's Adjuvant | 2022 |
Evolving acidic microenvironments during colitis provide selective analgesic targets for a pH-sensitive opioid.
Topics: Analgesics; Analgesics, Opioid; Animals; Colitis; Colon; Fentanyl; Humans; Hydrogen-Ion Concentratio | 2023 |
A single dose of ketamine relieves fentanyl-induced-hyperalgesia by reducing inflammation initiated by the TLR4/NF-κB pathway in rat spinal cord neurons.
Topics: Animals; Cyclooxygenase 2; Fentanyl; Hyperalgesia; Inflammation; Ketamine; Neurons; NF-kappa B; Rats | 2023 |
Continuous fentanyl administration and spontaneous withdrawal decreases home cage wheel running in rats with and without hindpaw inflammation.
Topics: Animals; Fentanyl; Freund's Adjuvant; Inflammation; Motor Activity; Pain; Rats | 2023 |
Accessibility of axonal G protein coupled mu-opioid receptors requires conceptual changes of axonal membrane targeting for pain modulation.
Topics: Analgesics, Opioid; Animals; Axons; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentanyl; Freund's Adjuvant | 2017 |
No Fever, No Murmur, No Problem? A Concealed Case of Infective Endocarditis.
Topics: Adult; Amphetamine; Analgesics, Opioid; Anti-Bacterial Agents; C-Reactive Protein; Endocarditis; Eno | 2019 |
Major abdominal surgery for cancer: does epidural analgesia have a long-term effect on recurrence-free and overall survival?
Topics: Abdominal Neoplasms; Adult; Aged; Analgesia, Epidural; Anesthesia, Conduction; Anesthesia, General; | 2013 |
Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acute Pain | 2014 |
Differential alternation of the antinociceptive effect of narcotic analgesics on the inflammatory pain state.
Topics: Animals; Fentanyl; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Methadone; Mice; Narcotics; | 2014 |
Interaction of the adenosine A1 receptor agonist N6-cyclopentyladenosine and κ-opioid receptors in rat spinal cord nociceptive reflexes.
Topics: Adenosine; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Inte | 2014 |
Histamine H3 receptor activation potentiates peripheral opioid-mediated antinociception: substance P role in peripheral inflammation in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Fe | 2010 |
L-type calcium channels and μ-opioid receptors are involved in mediating the anti-inflammatory effects of naloxone.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 2011 |
Endogenous opioids released during non-nociceptive environmental stress induce latent pain sensitization Via a NMDA-dependent process.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Carrageenan; Disease Models, Animal; Excitatory A | 2011 |
Synergism between fentanyl and tramadol in tonic inflammatory pain: the orofacial formalin test.
Topics: Analgesics; Animals; Drug Synergism; Facial Pain; Fentanyl; Formaldehyde; Inflammation; Male; Mice; | 2012 |
Relative contributions of peripheral versus supraspinal or spinal opioid receptors to the antinociception of systemic opioids.
Topics: Analgesics, Opioid; Animals; Fentanyl; Inflammation; Loperamide; Male; Morphine; Pain; Rats; Rats, W | 2012 |
Cytokine profile in patients undergoing minimally invasive surgery with balanced anesthesia.
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Balanced Anesthesia; Cytokines; Female; Fe | 2012 |
Fentanyl decreases discharges of C and A nociceptors to suprathreshold mechanical stimulation in chronic inflammation.
Topics: Action Potentials; Analgesics, Opioid; Animals; Fentanyl; Freund's Adjuvant; Hindlimb; Inflammation; | 2012 |
Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member | 2013 |
A PRELIMINARY REPORT ON THE USE OF A COMBINATION OF DROPERIDOL AND FENTANYL CITRATE IN VETERINARY MEDICINE.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Behavior, Animal; Benperidol; Birds; Ca | 1964 |
Tissue monocytes/macrophages in inflammation: hyperalgesia versus opioid-mediated peripheral antinociception.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Clodronic Acid; Fentanyl; Flow Cytometry; Foo | 2004 |
Peripheral versus central antinociceptive actions of 6-amino acid-substituted derivatives of 14-O-methyloxymorphone in acute and inflammatory pain in the rat.
Topics: Acute Disease; Analgesics; Animals; Central Nervous System; Dose-Response Relationship, Drug; Fentan | 2005 |
Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2005 |
Nerve growth factor governs the enhanced ability of opioids to suppress inflammatory pain.
Topics: Analgesics, Opioid; Animals; Apoptosis Regulatory Proteins; Calcitonin Gene-Related Peptide; Enzyme- | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Chronic morphine use does not induce peripheral tolerance in a rat model of inflammatory pain.
Topics: Animals; beta-Endorphin; Cells, Cultured; Cyclophosphamide; Drug Tolerance; Fentanyl; Guanosine 5'-O | 2008 |
Perineurial defect and peripheral opioid analgesia in inflammation.
Topics: Analgesics; Animals; Fentanyl; Foot; Freund's Adjuvant; Inflammation; Male; Mannitol; Narcotics; Ner | 1995 |
Reversal by naloxone of the spinal antinociceptive actions of a systemically-administered NSAID.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carragee | 1996 |
The antinociceptive effect of the mu-opioid fentanyl is reduced in the presence of the alpha(2)-adrenergic antagonist idazoxan in inflammation.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Carrageenan; Dose-Response Relationship, | 1999 |
Innovar-Vet-induced pathologic changes in the guinea pig.
Topics: Anesthesia; Animals; Droperidol; Female; Fentanyl; Foot; Foot Diseases; Guinea Pigs; Humans; Inflamm | 1975 |
Opioid analgesia at peripheral sites: a target for opioids released during stress and inflammation?
Topics: Analgesics, Opioid; Animals; Carrageenan; Cyclazocine; Dextrorphan; Ethylketocyclazocine; Fentanyl; | 1987 |
Peripheral effect of fentanyl upon nociception in inflamed tissue of the rat.
Topics: Animals; Dose-Response Relationship, Drug; Fentanyl; Hindlimb; Inflammation; Male; Nociceptors; Pain | 1988 |