Page last updated: 2024-10-27

fentanyl and Hypoxia

fentanyl has been researched along with Hypoxia in 96 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
"Sixty-one adult female patients (ASA PS I-II; age, 32-77 years) without an apparent history of sleep apnea and respiratory disease undergoing major breast cancer surgery on an outpatient basis and with planned overnight admission were randomized to one of two anesthesia maintenance groups: sevoflurane anesthesia (SEV, n = 31) or intravenous propofol, fentanyl, and vecuronium anesthesia (TIVA, n = 30)."9.12Nocturnal episodic hypoxemia after ambulatory breast cancer surgery: comparison of sevoflurane and propofol-fentanyl anesthesia. ( Fukuda, K; Shirakami, G; Teratani, Y, 2006)
"These findings suggest that xylazine exacerbates the life-threatening effects of opioids, proposing worsened brain hypoxia as the mechanism contributing to xylazine-positive opioid-overdose deaths."8.31Xylazine effects on opioid-induced brain hypoxia. ( Choi, S; Irwin, MR; Kiyatkin, EA, 2023)
" Rats exposed to sleep-phase chronic intermittent hypercapnic hypoxia (CIHH) for 7 days exhibited exaggerated OIRD to systemic fentanyl both while anaesthetized and artificially ventilated and while conscious and breathing spontaneously, implicating heightened CNS inhibitory efficacy of fentanyl."7.96Intermittent hypercapnic hypoxia induces respiratory hypersensitivity to fentanyl accompanied by tonic respiratory depression by endogenous opioids. ( Andrade, MA; Brackley, AD; Toney, GM, 2020)
"This study sought to prospectively assess fentanyl safety in a large out-of-hospital group, to identify variables associated with post-fentanyl hypotension (HN; systolic blood pressure [SBP] < 90) or hypoxemia (HX; SpO(2) < 90%)."7.77Fentanyl in the out-of-hospital setting: variables associated with hypotension and hypoxemia. ( Krauss, WC; Shah, S; Thomas, SH, 2011)
"As compared with controls, rats preexposed to recurrent hypoxia displayed a more profound depression with fentanyl in minute ventilation, respiratory frequency, tidal volume, and tidal volume divided by inspiratory time that represents respiratory drive."7.73Recurrent hypoxia in rats during development increases subsequent respiratory sensitivity to fentanyl. ( Brown, KA; Laferrière, A; Moss, IR, 2006)
" The incidence of hypoxemia (oxyhemoglobin saturation less than 90%) and apnea (no spontaneous respiratory effort for 15 s) and the ventilatory response to carbon dioxide were evaluated."7.68Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. ( Ashburn, MA; Bailey, PL; East, KA; Moll, JW; Pace, NL; Stanley, TH, 1990)
"Recent investigations have revealed that intravenous anesthetics, including fentanyl, do not reduce the pulmonary vasoconstrictor response to alveolar hypoxia."7.66Hypoxia-induced pulmonary vasoconstriction: effects of fentanyl following different routes of administration. ( Bjertnaes, L; Hauge, A; Kriz, M, 1980)
" fentanyl affected the number of children who develop postextubation adverse upper airway respiratory events, (upper airway obstruction, laryngospasm) and/or early postoperative hypoxemia."5.14Presurgical fentanyl vs caudal block and the incidence of adverse respiratory events in children after orchidopexy. ( Bolos, ME; Chuang, AZ; Khalil, SN; Lingadevaru, HS; Maposa, D; Matuszczak, ME, 2009)
" Frequency of apnea was significantly higher in the remifentanil group (P < 0."5.13Intravenous remifentanil and propofol for gastroscopy. ( Liu, J; Si, YY; Wang, X; Wu, JC; Xu, ZY; Xue, FS; Zuo, YX, 2008)
"Sixty-one adult female patients (ASA PS I-II; age, 32-77 years) without an apparent history of sleep apnea and respiratory disease undergoing major breast cancer surgery on an outpatient basis and with planned overnight admission were randomized to one of two anesthesia maintenance groups: sevoflurane anesthesia (SEV, n = 31) or intravenous propofol, fentanyl, and vecuronium anesthesia (TIVA, n = 30)."5.12Nocturnal episodic hypoxemia after ambulatory breast cancer surgery: comparison of sevoflurane and propofol-fentanyl anesthesia. ( Fukuda, K; Shirakami, G; Teratani, Y, 2006)
"To determine whether supplemental oxygen reduces the incidence of hypoxia by 20% in study patients receiving midazolam and fentanyl for emergency department procedural sedation and analgesia."5.12The utility of supplemental oxygen during emergency department procedural sedation and analgesia with midazolam and fentanyl: a randomized, controlled trial. ( Chudnofsky, CR; Deitch, K; Dominici, P, 2007)
"4%), including hypotension in 5, hypoxemia in 7, and apnea in 5."5.11Propofol for deep procedural sedation in the ED. ( Baire, M; Frazee, BW; Lowery, D; Park, RS, 2005)
" Despite the same duration of preoxygenation, younger children were more susceptible than elder ones to the risk of hypoxemia during apnea."5.08Study of the safe threshold of apneic period in children during anesthesia induction. ( An, G; Deng, XM; Liao, X; Luo, LK; Tong, SY; Xue, FS, 1996)
" The following 4 cardiopulmonary complications were assessed: hypoxia, hypotension, arrhythmias, and apnea."4.82Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis. ( Khandwala, F; Lopez, R; Qadeer, MA; Vargo, JJ; Zuccaro, G, 2005)
" Here, we focused on the basic physiological effects of ketamine as a recreational drug and its possible interactions with fentanyl-a highly potent opioid that induces strong respiratory depression and robust brain hypoxia."4.31Basic metabolic and vascular effects of ketamine and its interaction with fentanyl. ( Choi, S; Curay, CM; Irwin, MR; Kiyatkin, EA, 2023)
"These findings suggest that xylazine exacerbates the life-threatening effects of opioids, proposing worsened brain hypoxia as the mechanism contributing to xylazine-positive opioid-overdose deaths."4.31Xylazine effects on opioid-induced brain hypoxia. ( Choi, S; Irwin, MR; Kiyatkin, EA, 2023)
"Hypoxia-induced ventilatory depression during fentanyl induced apnea (1) opposes the spontaneous emergence of a respiratory rhythm, which would have rescued the animals otherwise, and (2) prevents the effects of high dose naloxone."3.96Severe Hypoxemia Prevents Spontaneous and Naloxone-induced Breathing Recovery after Fentanyl Overdose in Awake and Sedated Rats. ( Guck, D; Haouzi, P; McCann, M; Sonobe, T; Sternick, M; Tubbs, N, 2020)
" Rats exposed to sleep-phase chronic intermittent hypercapnic hypoxia (CIHH) for 7 days exhibited exaggerated OIRD to systemic fentanyl both while anaesthetized and artificially ventilated and while conscious and breathing spontaneously, implicating heightened CNS inhibitory efficacy of fentanyl."3.96Intermittent hypercapnic hypoxia induces respiratory hypersensitivity to fentanyl accompanied by tonic respiratory depression by endogenous opioids. ( Andrade, MA; Brackley, AD; Toney, GM, 2020)
"This study sought to prospectively assess fentanyl safety in a large out-of-hospital group, to identify variables associated with post-fentanyl hypotension (HN; systolic blood pressure [SBP] < 90) or hypoxemia (HX; SpO(2) < 90%)."3.77Fentanyl in the out-of-hospital setting: variables associated with hypotension and hypoxemia. ( Krauss, WC; Shah, S; Thomas, SH, 2011)
"The desaturation response time of SpO(2) to 95% after apnea was 82."3.76Comparison of desaturation and resaturation response times between transmission and reflectance pulse oximeters. ( Ahn, HJ; Choi, SJ; Kang, JG; Kang, JY; Kim, CS; Kim, JA; Kim, JK; Sim, WS; Yang, MK, 2010)
" Anesthesia was provided with an infusion of midazolam, fentanyl, S-ketamine and low concentrations of isoflurane in oxygen."3.74Balanced anesthesia and ventilation strategies for an alpaca (Lama pacos) with an increased anesthetic-risk. ( Jäggin-Schmucker, N; Larenza, MP; Zanolari, P, 2008)
"As compared with controls, rats preexposed to recurrent hypoxia displayed a more profound depression with fentanyl in minute ventilation, respiratory frequency, tidal volume, and tidal volume divided by inspiratory time that represents respiratory drive."3.73Recurrent hypoxia in rats during development increases subsequent respiratory sensitivity to fentanyl. ( Brown, KA; Laferrière, A; Moss, IR, 2006)
" After giving hypoxic gas mixture (10% O2 in N2) to animals to cause ventilatory inhibition, lateral ventricle applications of beta-endorphins (beta-EP) antagonist naloxone (Nlx) and agonist ohmefentanyl (OMF) respectively reduced and enhanced hypoxia-induced ventilatory inhibition."3.68[Relationship between central beta-endorphins and serotonin systems in mechanism of hypoxic ventilatory regulation]. ( Hu, ST; Xu, T, 1991)
" The incidence of hypoxemia (oxyhemoglobin saturation less than 90%) and apnea (no spontaneous respiratory effort for 15 s) and the ventilatory response to carbon dioxide were evaluated."3.68Frequent hypoxemia and apnea after sedation with midazolam and fentanyl. ( Ashburn, MA; Bailey, PL; East, KA; Moll, JW; Pace, NL; Stanley, TH, 1990)
"Continuous transcutaneous oxygen and carbon dioxide monitoring during conscious sedation using diazepam, fentanyl, and methohexital indicates that hypoxia occurs in all patients maintained on room air; 36% of the patients maintained on room air showed a decrease in transcutaneous oxygen of greater than 20 mg Hg."3.67Continuous transcutaneous O2 and CO2 monitoring during conscious sedation for oral surgery. ( Kraut, RA, 1985)
"Recent investigations have revealed that intravenous anesthetics, including fentanyl, do not reduce the pulmonary vasoconstrictor response to alveolar hypoxia."3.66Hypoxia-induced pulmonary vasoconstriction: effects of fentanyl following different routes of administration. ( Bjertnaes, L; Hauge, A; Kriz, M, 1980)
"Hypoxemia was defined as oxygen saturation of <90% for ≥15 s, and apnea as lack of respiratory activity for ≥15 s."2.76Hypoxemia during moderate sedation for gastrointestinal endoscopy: causes and associations. ( Dumot, JA; Lopez, AR; Qadeer, MA; Vargo, JJ, 2011)
"Patients with liver cirrhosis frequently undergo diagnostic or therapeutic upper GI endoscopy (UGIE), and the liver disease might impair the metabolism of drugs usually administered for sedation."2.76Sedation during upper GI endoscopy in cirrhotic outpatients: a randomized, controlled trial comparing propofol and fentanyl with midazolam and fentanyl. ( Bonilha, DQ; Brito, JR; Correia, LM; Ferrari, AP; Gomes, GF; Lenz, L; Libera, ED; Nakao, FS; Rohr, MR, 2011)
"ketamine dosages were evaluated: 0."2.72Effects of ketamine on carfentanil and xylazine immobilization of white-tailed deer (Odocoileus virginianus). ( Miller, KV; Osborn, DA; Ramsay, EC; Schumacher, J; Storms, TN, 2006)
"Propofol was administered in a bolus of 1 mg/kg, followed by additional doses of 0."2.71Propofol for procedural sedation in children in the emergency department. ( Anderson, JL; Bassett, KE; Guenther, E; Pribble, CG, 2003)
"Pain was assessed using a 10-point verbal analogue scale and <3 was considered adequate analgesia."2.71Target-controlled infusion of remifentanil or fentanyl during extra-corporeal shock-wave lithotripsy. ( Acuña, D; Cortínez, LI; Dagnino, JA; De la Fuente, R; Muñoz, HR, 2005)
" While low dosing is thought to be a factor limiting naloxone's efficacy, the timing between fentanyl exposure and initiation of naloxone treatment may be another important factor."1.91The pattern of brain oxygen response induced by intravenous fentanyl limits the time window of therapeutic efficacy of naloxone. ( Curay, CM; Irwin, MR; Kiyatkin, EA, 2023)
" There were no other serious adverse events."1.51Computer-Assisted Propofol Sedation for Esophagogastroduodenoscopy Is Effective, Efficient, and Safe. ( Beecher, R; Chiorean, M; Drennan, F; Gluck, M; Koch, J; Kozarek, RA; La Selva, D; Larsen, M; Lin, OS; McCormick, S; Ross, A; Tombs, D; Venu, N; Weigel, W, 2019)
"As with other opioids, moose showed hypoxemia and varying degrees of respiratory and metabolic acidosis."1.48Effective thiafentanil immobilization and physiological responses of free-ranging moose (Alces alces) in northern Sweden. ( Arnemo, JM; Barros, DS; Ericsson, G; Evans, AL; Stenbacka, F, 2018)
"Mild hypoxemia occurred in 24% of cases and resolved with nasal cannula."1.43Deep Sedation for Pediatric Dental Procedures: Is this a Safe and Effective Option? ( Ahmed, SS; Hicks, SR; Nitu, ME; Slaven, JE, 2016)
"Surgical closure of patent ductus arteriosus (PDA) is associated with adverse outcomes."1.42Volume guarantee ventilation during surgical closure of patent ductus arteriosus. ( Abubakar, K; Keszler, M, 2015)
"High midazolam dose was associated with lower IPI levels during the procedure."1.42The value of Integrated Pulmonary Index (IPI) monitoring during endoscopies in children. ( Adiv, OE; Garah, J; Rosen, I; Shaoul, R, 2015)
" The non-cardiopulmonary adverse events were procedure-specific and unrelated to sedation."1.40Conscious sedation for upper endoscopy in the gastric bypass patient: prevalence of cardiopulmonary adverse events and predictors of sedation requirement. ( Abu Dayyeh, BK; Jirapinyo, P; Thompson, CC, 2014)
" Adverse events were defined as occurrences that warranted intervention and were classified as hypotension, desaturation, bradycardia, hypertension, arrhythmia, aspiration, respiratory depression, vomiting, cardiac arrest, respiratory arrest, angina, hypoglycemia, and/or allergic reaction."1.37Adverse events during monitored anesthesia care for GI endoscopy: an 8-year experience. ( Agostoni, M; Beretta, L; Fanti, L; Gemma, M; Pasculli, N; Testoni, PA, 2011)
"This syndrome is relatively uncommon and accompanies dyspnea and hypoxemia on changing to a sitting or standing from recumbent position."1.32[Anesthetic management for a patient with platypnea-orthodeoxia syndrome]. ( Kawamoto, K; Terasaki, H; Yoshitake, A, 2004)
" There was no association between preprocedural fasting state and adverse events."1.32Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department. ( Agrawal, D; Gupta, R; Krauss, B; Manzi, SF, 2003)
"7%) adverse effects, of which 159 (11."1.32When is a patient safe for discharge after procedural sedation? The timing of adverse effect events in 1367 pediatric procedural sedations. ( Azer, MM; Newman, DH; Pitetti, RD; Singh, S, 2003)
"Anesthetized animals showed profound hypoxemia with mild hypercapnia, tachycardia, hypertension, and acidosis prior to naloxone administration."1.31Use of naloxone to reverse carfentanil citrate-induced hypoxemia and cardiopulmonary depression in Rocky Mountain wapiti (Cervus elaphus nelsoni). ( Gaynor, JS; Larsen, RS; Moresco, A; Sleeman, JM; Wild, MA, 2001)
"Additionally, we observed laryngospasm in two patients and speculate that it might be a variant of muscle rigidity."1.31Fentanyl-induced chest wall rigidity and laryngospasm in preterm and term infants. ( Bartmann, P; Fahnenstich, H; Kau, N; Steffan, J, 2000)
"Two forms of CP (spastic diplegia and quadriplegia) and the two modalities of analgesia were compared."1.30Epidural analgesia in children with cerebral palsy. ( Brenn, BR; Brislin, RP; Rose, JB, 1998)
"Airway obstruction was more predictive of abnormal blood gas values than was hypoventilation."1.29Respiratory effects of a balanced anesthetic technique--revisited fifteen years later. ( Campbell, RL; Saxen, MA, 1994)
"The response in the newborn rabbit to anoxia, is periods of dyspnoea, primary apnoea, and gasping."1.26The role of analgesics in respiratory depression: a rabbit model. ( Cooper, LV; Stephen, GW, 1977)
"In the awake state, arterial hypoxemia is counteracted by a mechanism which tends to normalize the ventilation/perfusion ratio of the lungs by way of a hypoxia-induced vasoconstriction in poorly ventilated areas."1.26Hypoxia-induced vasoconstriction in isolated perfused lungs exposed to injectable or inhalation anesthetics. ( Bjertnaes, LJ, 1977)

Research

Studies (96)

TimeframeStudies, this research(%)All Research%
pre-199019 (19.79)18.7374
1990's18 (18.75)18.2507
2000's27 (28.13)29.6817
2010's23 (23.96)24.3611
2020's9 (9.38)2.80

Authors

AuthorsStudies
Irwin, MR3
Curay, CM2
Choi, S2
Kiyatkin, EA3
Burgraff, NJ1
Baertsch, NA1
Ramirez, JM1
Evans, RG1
Iguchi, N1
Cochrane, AD1
Marino, B1
Hood, SG1
Bellomo, R1
McCall, PR1
May, CN1
Lankadeva, YR1
Haouzi, P1
Guck, D1
McCann, M1
Sternick, M1
Sonobe, T1
Tubbs, N1
Brackley, AD1
Andrade, MA1
Toney, GM1
Mikhaeil, JS1
Pepper, CG1
Hayward, GC1
Guo, P1
Wu, H1
Liu, L1
Zhao, Q1
Jin, Z1
Xie, K1
Zhang, W1
Fang, W1
Lian, Y1
Lin, S1
Fang, J1
Raja, AS1
Miller, ES1
Flores, EJ1
Wakeman, SE1
Eng, G1
Wiemer, HM1
Butler, MB1
Froese, PC1
Lapierre, A1
Carriere, C1
Etsell, GR1
Farina, D1
Jones, J1
Murray, J1
Campbell, SG1
Kumar, A1
Kumar, N1
Sinha, C1
Barros, DS1
Evans, AL1
Arnemo, JM1
Stenbacka, F1
Ericsson, G1
Cabadas Avión, R1
Baluja, A1
Ojea Cendón, M1
Leal Ruiloba, MS1
Vázquez López, S1
Rey Martínez, M1
Magdalena López, P1
Álvarez-Escudero, J1
Lin, OS1
La Selva, D1
Kozarek, RA1
Tombs, D1
Weigel, W1
Beecher, R1
Koch, J1
McCormick, S1
Chiorean, M1
Drennan, F1
Gluck, M1
Venu, N1
Larsen, M1
Ross, A1
Tutunaru, AC1
Sonea, A1
Drion, P1
Serteyn, D1
Sandersen, C1
Keszler, M1
Abubakar, K1
Jirapinyo, P1
Abu Dayyeh, BK1
Thompson, CC1
Tsze, DS1
Vitberg, YM1
Berezow, J1
Starc, TJ1
Dayan, PS1
Hung, A1
Marshall, J1
Barnett, S1
Falchuk, ZM1
Sawhney, M1
Leffler, DA1
Garah, J1
Adiv, OE1
Rosen, I1
Shaoul, R1
Fechtner, L1
El Ali, M1
Sattar, A1
Moore, M1
Strohl, KP1
Ahmed, SS1
Hicks, SR1
Slaven, JE1
Nitu, ME1
Xu, ZY1
Wang, X1
Si, YY1
Wu, JC1
Zuo, YX1
Xue, FS3
Liu, J1
Pavlov, OO1
Awab, A1
Alilou, M1
El Moussaoui, R1
El Hijri, A1
Azzouzi, A1
Krauss, WC1
Shah, S2
Thomas, SH1
Gil, S1
Pascual, J1
Villazala, R1
Madrazo, M1
González, F1
Bernal, G1
Choi, SJ1
Ahn, HJ1
Yang, MK1
Kim, CS1
Sim, WS1
Kim, JA1
Kang, JG1
Kim, JK1
Kang, JY1
Khalil, SN1
Matuszczak, ME1
Maposa, D1
Bolos, ME1
Lingadevaru, HS1
Chuang, AZ1
Correia, LM1
Bonilha, DQ1
Gomes, GF1
Brito, JR1
Nakao, FS1
Lenz, L1
Rohr, MR1
Ferrari, AP1
Libera, ED1
Rabbitts, JA1
Groenewald, CB1
Dietz, NM1
Morales, C1
Räsänen, J1
Qadeer, MA2
Lopez, AR1
Dumot, JA1
Vargo, JJ2
Agostoni, M1
Fanti, L1
Gemma, M1
Pasculli, N1
Beretta, L1
Testoni, PA1
Kannikeswaran, N1
Chen, X1
Sethuraman, U1
Viljoen, A1
Byth, K1
Coombs, M1
Mahoney, G1
Stewart, D1
Moresco, A1
Larsen, RS1
Sleeman, JM1
Wild, MA1
Gaynor, JS1
Agrawal, D1
Manzi, SF1
Gupta, R1
Krauss, B1
Newman, DH1
Azer, MM1
Pitetti, RD1
Singh, S1
Bassett, KE2
Anderson, JL1
Pribble, CG2
Guenther, E2
Junkins, EP1
Kadish, HA1
Nelson, DS1
Kawamoto, K1
Yoshitake, A1
Terasaki, H1
Avitsian, R1
Borkowski, R1
Tetzlaff, J1
Frazee, BW1
Park, RS1
Lowery, D1
Baire, M1
Cortínez, LI1
Muñoz, HR1
De la Fuente, R1
Acuña, D1
Dagnino, JA1
Sanborn, PA1
Michna, E1
Zurakowski, D1
Burrows, PE1
Fontaine, PJ1
Connor, L1
Mason, KP1
Khandwala, F1
Lopez, R1
Zuccaro, G1
Shirakami, G1
Teratani, Y1
Fukuda, K1
Deitch, K1
Chudnofsky, CR1
Dominici, P1
Di Liddo, L1
D'Angelo, A1
Nguyen, B1
Bailey, B1
Amre, D1
Stanciu, C1
Moss, IR1
Brown, KA1
Laferrière, A1
Roberts, KD1
Leone, TA1
Edwards, WH1
Rich, WD1
Finer, NN1
Gómez Ayechu, M1
Castañeda Pascual, M1
Zaballos Barcala, N1
Unzué Rico, P1
Storms, TN1
Schumacher, J1
Osborn, DA1
Miller, KV1
Ramsay, EC1
Larenza, MP1
Zanolari, P1
Jäggin-Schmucker, N1
McPherson, RW1
Traystman, RJ1
Fassoulaki, A1
Eger, EI1
Johnson, BH1
Ferrell, LD1
Smuckler, EA1
Harper, MH1
Eger, RR1
Cahalan, MK1
Rozen, P1
Fireman, Z1
Gilat, T1
Bjertnaes, L1
Hauge, A1
Kriz, M1
Griffin, RP1
Reynolds, F2
Halpern, S1
Glanc, P1
Myhr, T1
Ryan, M1
Fong, K1
Amankwah, K1
Ohlsson, A1
Yeo, SW1
Tay, D1
Chong, JL1
Tan, TK1
Wong, PY1
Lane, MR1
Hamilton, I1
Papageorge, MB1
Hunter, MJ1
Norris, LH1
Rosenberg, MB1
Campbell, RL2
Saxen, MA1
Huang, YG1
Luo, LK2
Deng, XM2
Liao, X2
Tong, SY2
Liu, QH1
An, G1
Porter, JS1
Bonello, E1
Brenn, BR1
Brislin, RP1
Rose, JB1
Caulkett, NA1
Cribb, PH1
Haigh, JC1
Fahnenstich, H1
Steffan, J1
Kau, N1
Bartmann, P1
Cheung, PY1
Barrington, KJ1
Kafer, ER1
Marsh, HM1
Stephen, GW1
Cooper, LV1
Kalenda, Z1
Tarnow, J1
Hess, W1
Bjertnaes, LJ1
Berger, S1
Murr, R1
Schürer, L1
Enzenbach, R1
Peter, K1
Baethmann, A1
Rose, DK1
Cohen, MM1
Soutter, DI1
Noble, WH1
Baker, A1
Sachkov, VI1
Abramov, IuB1
Voĭnov, VA1
Chichenkov, ON1
Leshchenko, VV1
Nammur, F1
Xu, T1
Hu, ST1
Bailey, PL1
Pace, NL1
Ashburn, MA1
Moll, JW1
East, KA1
Stanley, TH1
Redden, RL1
Biery, KA1
Dudziak, R1
Vettermann, J1
Keykhah, MM1
Smith, DS1
O'Neil, JJ1
Harp, JR1
Kraut, RA1
Vermeire, P1
van den Bogaert, P1
Bossaert, L1
Heyndrickx, G1
van Durme, JP1
Pannier, R1
Alexander, GD1
Goldrath, M1
Brown, EM1
Smiler, BG1
Dobkin, AB1
Byles, PH1
Neville, JF1
Ferrari, HA2
Gorten, RJ1
Talton, IH1
Canent, R1
Goodrich, JK1
Susmano, A1
Passovoy, M1
Carleton, RA1
Freiberger, KU1
Havers, L1
Koenen, FW1
Siedek, M1
Benzer, H1
Kunz, H1
Lempert, J1
Mayrhofer, O1
Muhar, F1
Thompson, LW1
Talton, I1
Stephen, CR1

Clinical Trials (16)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of Oxycodone-propofol Combination Compared With a Fentanyl-propofol Combination on Conscious Sedation Effect and Early Cognitive Function During Therapeutic Endoscopic Retrograde Cholangio-pancreatography:a Prospective,Randomized, Single- Blinded[NCT03755609]100 participants (Anticipated)Interventional2018-06-01Recruiting
Importance of Integrated Pulmonary Index in Pediatric Patients Undergoing Bronchoscopy Procedures Under Sedation[NCT05137587]60 participants (Actual)Interventional2022-09-01Completed
Comparison of Efficacy and Safety of the Postoperative Analgesia Methods for Supratentorial Craniotomy by Integrated Pulmonary Index (IPI)[NCT02929147]Phase 490 participants (Anticipated)Interventional2016-11-30Not yet recruiting
Importance of Integrated Pulmonary Index in Pediatric Patients Undergoing Endoscopy Procedures Under Sedation[NCT05137574]60 participants (Actual)Interventional2021-05-10Completed
High-Flow Nasal Oxygenation Versus Standard Oxygenation in Gastrointestinal Endoscopy With Sedation. A Prospective Multicenter Randomized Study[NCT03829293]380 participants (Actual)Interventional2019-03-26Completed
Nasal Inhalation of Sevoflurane Versus Midazolm,Ketamine and Propofol For Pediatric Undergoing Upper Gastrointestinal Endoscopy[NCT05474937]74 participants (Anticipated)Interventional2022-06-01Recruiting
Do Patients Need Pre-Procedural Fasting for Coronary Artery Procedures?[NCT02562638]240 participants (Anticipated)Interventional2015-10-31Not yet recruiting
Effect of Dexmedetomidine of Gastrointestinal Motility[NCT04798482]Phase 422 participants (Actual)Interventional2021-09-14Completed
Can Medical Clowns Prevent the Usage of Sedation During the Performance of EEG in Young Children[NCT05257096]100 participants (Anticipated)Interventional2019-05-01Recruiting
[NCT02039453]160 participants (Anticipated)Interventional2013-09-30Recruiting
A Psychomotor Recuperation Study After Deep Sedation for Colonoscopy Between Target Controlled and Manual Titration of Propofol.[NCT02314559]Phase 4164 participants (Actual)Interventional2015-02-28Completed
Effect of High Flow Nasal Cannula vs. Standard Care on Respiratory Stability in Pediatric Procedural Sedation: A Randomized Controlled Pilot Trial[NCT02930525]50 participants (Actual)Interventional2016-09-30Completed
Apneic Oxygenation to Prevent Oxygen Desaturation During Intubation in the NICU[NCT05451953]110 participants (Anticipated)Interventional2022-07-21Recruiting
A Prospective Study Comparing the Efficacy and Safety of 100 mcg and 200 mcg of Intranasal Fentanyl Pectin Spray as an Analgesic in Adult Males Undergoing Outpatient Cystoscopic Procedures[NCT01756651]Phase 120 participants (Actual)Interventional2013-02-28Completed
Postoperative Management of Obstructive Sleep Apnea With CPAP vs. an Autoadjusting CPAP Device: a Randomized Controlled Single Center Trial[NCT00588848]11 participants (Actual)Interventional2008-01-31Terminated (stopped due to Difficulty with enrollment)
Dex vs Dazzle: Dexmedetomidine vs Midazolam for Intraoperative Sedation[NCT02878837]Phase 4120 participants (Actual)Interventional2016-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Apnea-Hypopnea Index (AHI)

Events are defined as apneas and hypopneas. AHI values are typically categorized as 5-14.9 events/hr = mild; 15-29.9 events/hr = moderate; and >= 30 events/hr = severe (NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.

Interventionevents per hour (Mean)
AUTOCPAP2.1
CPAP1.2

Cardiopulmonary Complications

Predefined cardiopulmonary complications: Myocardial Infarction, Arrhythmia, new onset Heart Failure, Stroke (NCT00588848)
Timeframe: 72 hours

InterventionParticipants (Count of Participants)
Autoadjusting CPAP (VPAP Auto)0
CPAP Arm (Usual Care)0

Sleep Related Hypoxemia

(NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.

InterventionPercentage of time < 90% saturation (Mean)
AUTOCPAP10.5
CPAP7.1

Reviews

1 review available for fentanyl and Hypoxia

ArticleYear
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11

    Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy

2005
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11

    Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy

2005
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11

    Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy

2005
Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:11

    Topics: Apnea; Arrhythmias, Cardiac; Cholangiopancreatography, Endoscopic Retrograde; Colonoscopy; Endoscopy

2005

Trials

20 trials available for fentanyl and Hypoxia

ArticleYear
Efficacy of an Oxycodone-Propofol Combination versus a Fentanyl-Propofol Combination in Conscious Sedation during Therapeutic Endoscopic Retrograde Cholangiopancreatography in Elderly Patients.
    Gerontology, 2021, Volume: 67, Issue:1

    Topics: Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Bradycardia; Cholangiopancreatography, E

2021
The analgesic efficacy of oxycodone hydrochloride versus fentanyl during outpatient artificial abortion operation: A randomized trial.
    Medicine, 2017, Volume: 96, Issue:26

    Topics: Abortion, Induced; Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Anesthesia, General; F

2017
Intravenous remifentanil and propofol for gastroscopy.
    Journal of clinical anesthesia, 2008, Volume: 20, Issue:5

    Topics: Adult; Anesthesia Recovery Period; Anesthetics, Combined; Anesthetics, Intravenous; Apnea; Cognition

2008
[The tissue oxygen cascade as the marker in different schemes of general anesthesia on dynamics of the hypoxic syndrome in patients, suffering an acute hemorrhage of high operative risk].
    Klinichna khirurhiia, 2008, Issue:6

    Topics: Acute Disease; Anesthesia, General; Anesthetics, Dissociative; Anesthetics, Intravenous; Female; Fen

2008
Presurgical fentanyl vs caudal block and the incidence of adverse respiratory events in children after orchidopexy.
    Paediatric anaesthesia, 2009, Volume: 19, Issue:12

    Topics: Airway Obstruction; Anesthesia, Caudal; Anesthetics, Intravenous; Child; Child, Preschool; Fentanyl;

2009
Sedation during upper GI endoscopy in cirrhotic outpatients: a randomized, controlled trial comparing propofol and fentanyl with midazolam and fentanyl.
    Gastrointestinal endoscopy, 2011, Volume: 73, Issue:1

    Topics: Analgesics, Opioid; Anesthesia Recovery Period; Bradycardia; Conscious Sedation; Deep Sedation; Endo

2011
Hypoxemia during moderate sedation for gastrointestinal endoscopy: causes and associations.
    Digestion, 2011, Volume: 84, Issue:1

    Topics: Aged; Anesthetics, Combined; Anesthetics, Intravenous; Cohort Studies; Conscious Sedation; Diazepam;

2011
Propofol for procedural sedation in children in the emergency department.
    Annals of emergency medicine, 2003, Volume: 42, Issue:6

    Topics: Adjuvants, Anesthesia; Adolescent; Analgesics, Opioid; Anesthetics, Combined; Bradycardia; Child; Ch

2003
Propofol sedation by emergency physicians for elective pediatric outpatient procedures.
    Annals of emergency medicine, 2003, Volume: 42, Issue:6

    Topics: Adjuvants, Anesthesia; Adolescent; Adult; Ambulatory Care; Bradycardia; Child; Child, Preschool; Cli

2003
Propofol for deep procedural sedation in the ED.
    The American journal of emergency medicine, 2005, Volume: 23, Issue:2

    Topics: Adolescent; Adult; Analgesics, Opioid; Apnea; Conscious Sedation; Dose-Response Relationship, Drug;

2005
Target-controlled infusion of remifentanil or fentanyl during extra-corporeal shock-wave lithotripsy.
    European journal of anaesthesiology, 2005, Volume: 22, Issue:1

    Topics: Adolescent; Adult; Analgesics, Opioid; Conscious Sedation; Drug Delivery Systems; Female; Fentanyl;

2005
Nocturnal episodic hypoxemia after ambulatory breast cancer surgery: comparison of sevoflurane and propofol-fentanyl anesthesia.
    Journal of anesthesia, 2006, Volume: 20, Issue:2

    Topics: Adult; Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics,

2006
The utility of supplemental oxygen during emergency department procedural sedation and analgesia with midazolam and fentanyl: a randomized, controlled trial.
    Annals of emergency medicine, 2007, Volume: 49, Issue:1

    Topics: Adolescent; Adult; Aged; Analgesia; Analgesics, Opioid; Capnography; Child; Child, Preschool; Consci

2007
Etomidate versus midazolam for procedural sedation in pediatric outpatients: a randomized controlled trial.
    Annals of emergency medicine, 2006, Volume: 48, Issue:4

    Topics: Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Child; Child, Preschool; Consumer Behavior

2006
Premedication for nonemergent neonatal intubations: a randomized, controlled trial comparing atropine and fentanyl to atropine, fentanyl, and mivacurium.
    Pediatrics, 2006, Volume: 118, Issue:4

    Topics: Adjuvants, Anesthesia; Atropine; Blood Pressure; Drug Therapy, Combination; Female; Fentanyl; Heart

2006
Effects of ketamine on carfentanil and xylazine immobilization of white-tailed deer (Odocoileus virginianus).
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2006, Volume: 37, Issue:3

    Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Animals, Wild; Bl

2006
Maternal hypoxaemia during labour and delivery: the influence of analgesia and effect on neonatal outcome.
    Anaesthesia, 1995, Volume: 50, Issue:2

    Topics: Adult; Analgesia, Obstetrical; Analgesics; Anesthetics; Bupivacaine; Cardiotocography; Drug Combinat

1995
Study of the safe threshold of apneic period in children during anesthesia induction.
    Journal of clinical anesthesia, 1996, Volume: 8, Issue:7

    Topics: Age Factors; Anesthesia, Intravenous; Anesthetics, Intravenous; Apnea; Body Height; Body Weight; Bra

1996
The effect of epidural opioids on maternal oxygenation during labour and delivery.
    Anaesthesia, 1996, Volume: 51, Issue:10

    Topics: Adolescent; Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Female; Fentanyl

1996
[Analgesic effects and hemodynamic and respiratory repercussions of the fentanyl-droperidol combination in the acute stage of myocardial infarction].
    Archives des maladies du coeur et des vaisseaux, 1973, Volume: 66, Issue:4

    Topics: Adult; Aged; Benperidol; Blood Gas Analysis; Blood Pressure; Butyrophenones; Cardiac Output; Clinica

1973

Other Studies

75 other studies available for fentanyl and Hypoxia

ArticleYear
Basic metabolic and vascular effects of ketamine and its interaction with fentanyl.
    Neuropharmacology, 2023, 05-01, Volume: 228

    Topics: Analgesics, Opioid; Animals; Fentanyl; Humans; Hypoxia; Hypoxia, Brain; Ketamine; Oxygen; Rats

2023
The pattern of brain oxygen response induced by intravenous fentanyl limits the time window of therapeutic efficacy of naloxone.
    Neuropharmacology, 2023, 06-15, Volume: 231

    Topics: Analgesics, Opioid; Animals; Brain; Fentanyl; Hypoxia; Hypoxia, Brain; Naloxone; Narcotic Antagonist

2023
Xylazine effects on opioid-induced brain hypoxia.
    Psychopharmacology, 2023, Volume: 240, Issue:7

    Topics: Analgesics, Opioid; Animals; Drug Overdose; Fentanyl; Heroin; Humans; Hypothermia; Hypoxia; Hypoxia,

2023
A comparative examination of morphine and fentanyl: unravelling the differential impacts on breathing and airway stability.
    The Journal of physiology, 2023, Volume: 601, Issue:20

    Topics: Albuterol; Analgesics, Opioid; Animals; Bronchodilator Agents; Epinephrine; Fentanyl; Hypoxia; Mice;

2023
Renal hemodynamics and oxygenation during experimental cardiopulmonary bypass in sheep under total intravenous anesthesia.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2020, 02-01, Volume: 318, Issue:2

    Topics: Acute Kidney Injury; Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Biomarkers; Cardiop

2020
Severe Hypoxemia Prevents Spontaneous and Naloxone-induced Breathing Recovery after Fentanyl Overdose in Awake and Sedated Rats.
    Anesthesiology, 2020, Volume: 132, Issue:5

    Topics: Analgesics, Opioid; Animals; Fentanyl; Hypnotics and Sedatives; Hypoxia; Male; Naloxone; Narcotic An

2020
Intermittent hypercapnic hypoxia induces respiratory hypersensitivity to fentanyl accompanied by tonic respiratory depression by endogenous opioids.
    The Journal of physiology, 2020, Volume: 598, Issue:15

    Topics: Analgesics, Opioid; Animals; Fentanyl; Hypoxia; Rats; Rats, Sprague-Dawley; Respiratory Hypersensiti

2020
Mechanisms of opioid-induced respiratory depression in sleep apnoea: new insights for anaesthesiology.
    The Journal of physiology, 2020, Volume: 598, Issue:18

    Topics: Analgesics, Opioid; Anesthesiology; Fentanyl; Humans; Hypercapnia; Hypoxia; Respiratory Hypersensiti

2020
Case 37-2017. A 36-Year-Old Man with Unintentional Opioid Overdose.
    The New England journal of medicine, 2017, Nov-30, Volume: 377, Issue:22

    Topics: Adult; Analgesics, Opioid; Drug Overdose; Fentanyl; Heroin; Heroin Dependence; Humans; Hypoxia; Lung

2017
Procedural sedation by advanced care paramedics for emergency gastrointestinal endoscopy.
    CJEM, 2019, Volume: 21, Issue:2

    Topics: Allied Health Personnel; Analgesics; Arrhythmias, Cardiac; Datasets as Topic; Emergency Service, Hos

2019
Oxygen through suction port: use of a three way stopcock during fiberoptic bronchoscopy.
    Anaesthesia, critical care & pain medicine, 2019, Volume: 38, Issue:1

    Topics: Alveolitis, Extrinsic Allergic; Analgesics, Opioid; Anesthetics, Local; Bronchoscopy; Equipment Desi

2019
Effective thiafentanil immobilization and physiological responses of free-ranging moose (Alces alces) in northern Sweden.
    Veterinary anaesthesia and analgesia, 2018, Volume: 45, Issue:4

    Topics: Animals; Animals, Wild; Blood Gas Analysis; Body Temperature; Carbon Dioxide; Cross-Sectional Studie

2018
Effectiveness and safety of gastrointestinal endoscopy during a specific sedation training program for non-anesthesiologists.
    Revista espanola de enfermedades digestivas, 2019, Volume: 111, Issue:3

    Topics: Adult; Aged; Conscious Sedation; Endoscopy, Gastrointestinal; Female; Fentanyl; Gastroenterologists;

2019
Computer-Assisted Propofol Sedation for Esophagogastroduodenoscopy Is Effective, Efficient, and Safe.
    Digestive diseases and sciences, 2019, Volume: 64, Issue:12

    Topics: Adult; Aged; Anesthesia Recovery Period; Anesthetics, Intravenous; Anesthetists; Blood Gas Monitorin

2019
Anaesthetic induction with alfaxalone may produce hypoxemia in rabbits premedicated with fentanyl/droperidol.
    Veterinary anaesthesia and analgesia, 2013, Volume: 40, Issue:6

    Topics: Adjuvants, Anesthesia; Administration, Intravenous; Anesthesia; Anesthetics; Anesthetics, Combined;

2013
Volume guarantee ventilation during surgical closure of patent ductus arteriosus.
    American journal of perinatology, 2015, Volume: 32, Issue:1

    Topics: Anesthesia, General; Anesthetics, Intravenous; Cardiac Surgical Procedures; Ductus Arteriosus, Paten

2015
Conscious sedation for upper endoscopy in the gastric bypass patient: prevalence of cardiopulmonary adverse events and predictors of sedation requirement.
    Digestive diseases and sciences, 2014, Volume: 59, Issue:9

    Topics: Adult; Anesthetics, Intravenous; Arrhythmias, Cardiac; Body Mass Index; Conscious Sedation; Endoscop

2014
Treatment of tetralogy of Fallot hypoxic spell with intranasal fentanyl.
    Pediatrics, 2014, Volume: 134, Issue:1

    Topics: Analgesics, Opioid; Female; Fentanyl; Humans; Hypoxia; Infant; Tetralogy of Fallot

2014
Risk Factors and Outcomes of Reversal Agent Use in Moderate Sedation During Endoscopy and Colonoscopy.
    Journal of clinical gastroenterology, 2016, Volume: 50, Issue:3

    Topics: Age Factors; Anti-Arrhythmia Agents; Antidotes; Atropine; Body Mass Index; Bradycardia; Case-Control

2016
The value of Integrated Pulmonary Index (IPI) monitoring during endoscopies in children.
    Journal of clinical monitoring and computing, 2015, Volume: 29, Issue:6

    Topics: Adolescent; Algorithms; Anesthetics, Intravenous; Capnography; Child; Child, Preschool; Conscious Se

2015
The value of Integrated Pulmonary Index (IPI) monitoring during endoscopies in children.
    Journal of clinical monitoring and computing, 2015, Volume: 29, Issue:6

    Topics: Adolescent; Algorithms; Anesthetics, Intravenous; Capnography; Child; Child, Preschool; Conscious Se

2015
The value of Integrated Pulmonary Index (IPI) monitoring during endoscopies in children.
    Journal of clinical monitoring and computing, 2015, Volume: 29, Issue:6

    Topics: Adolescent; Algorithms; Anesthetics, Intravenous; Capnography; Child; Child, Preschool; Conscious Se

2015
The value of Integrated Pulmonary Index (IPI) monitoring during endoscopies in children.
    Journal of clinical monitoring and computing, 2015, Volume: 29, Issue:6

    Topics: Adolescent; Algorithms; Anesthetics, Intravenous; Capnography; Child; Child, Preschool; Conscious Se

2015
The value of Integrated Pulmonary Index (IPI) monitoring during endoscopies in children.
    Journal of clinical monitoring and computing, 2015, Volume: 29, Issue:6

    Topics: Adolescent; Algorithms; Anesthetics, Intravenous; Capnography; Child; Child, Preschool; Conscious Se

2015
The value of Integrated Pulmonary Index (IPI) monitoring during endoscopies in children.
    Journal of clinical monitoring and computing, 2015, Volume: 29, Issue:6

    Topics: Adolescent; Algorithms; Anesthetics, Intravenous; Capnography; Child; Child, Preschool; Conscious Se

2015
The value of Integrated Pulmonary Index (IPI) monitoring during endoscopies in children.
    Journal of clinical monitoring and computing, 2015, Volume: 29, Issue:6

    Topics: Adolescent; Algorithms; Anesthetics, Intravenous; Capnography; Child; Child, Preschool; Conscious Se

2015
The value of Integrated Pulmonary Index (IPI) monitoring during endoscopies in children.
    Journal of clinical monitoring and computing, 2015, Volume: 29, Issue:6

    Topics: Adolescent; Algorithms; Anesthetics, Intravenous; Capnography; Child; Child, Preschool; Conscious Se

2015
The value of Integrated Pulmonary Index (IPI) monitoring during endoscopies in children.
    Journal of clinical monitoring and computing, 2015, Volume: 29, Issue:6

    Topics: Adolescent; Algorithms; Anesthetics, Intravenous; Capnography; Child; Child, Preschool; Conscious Se

2015
Fentanyl effects on breath generation in C57BL/6J and A/J mouse strains.
    Respiratory physiology & neurobiology, 2015, Aug-15, Volume: 215

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Fentanyl; Hypoxia; Male; Mice; Mice,

2015
Deep Sedation for Pediatric Dental Procedures: Is this a Safe and Effective Option?
    The Journal of clinical pediatric dentistry, 2016, Volume: 40, Issue:2

    Topics: Adjuvants, Anesthesia; Anesthesia Recovery Period; Anesthesia, Dental; Anesthetics, Intravenous; Cat

2016
[Rhabdomyolysis in severe acute asthma].
    Annales francaises d'anesthesie et de reanimation, 2009, Volume: 28, Issue:2

    Topics: Acidosis; Acute Disease; Adult; Albuterol; Anti-Asthmatic Agents; Asthma; Biomarkers; Combined Modal

2009
Fentanyl in the out-of-hospital setting: variables associated with hypotension and hypoxemia.
    The Journal of emergency medicine, 2011, Volume: 40, Issue:2

    Topics: Adolescent; Adult; Aged; Air Ambulances; Analgesics, Opioid; Emergency Medical Services; Female; Fen

2011
[Continuous perfusion of ropivacaine plus fentanyl for nerve-stimulator-guided paravertebral thoracic block to manage pain for a man with multiple rib fractures].
    Revista espanola de anestesiologia y reanimacion, 2009, Volume: 56, Issue:4

    Topics: Accidents, Traffic; Adult; Amides; Analgesia, Epidural; Anesthetics, Local; Autonomic Nerve Block; C

2009
Comparison of desaturation and resaturation response times between transmission and reflectance pulse oximeters.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:2

    Topics: Adult; Androstanols; Anesthetics, Intravenous; Apnea; Breast; Equipment Design; Female; Fentanyl; Fi

2010
Perioperative opioid requirements are decreased in hypoxic children living at altitude.
    Paediatric anaesthesia, 2010, Volume: 20, Issue:12

    Topics: Altitude; Analgesics, Opioid; Child, Preschool; Cleft Lip; Cleft Palate; Fentanyl; Humans; Hypoxia;

2010
Adverse events during monitored anesthesia care for GI endoscopy: an 8-year experience.
    Gastrointestinal endoscopy, 2011, Volume: 74, Issue:2

    Topics: Adolescent; Age Factors; Aged; Analgesics, Opioid; Anesthetics, Inhalation; Body Mass Index; Bradyca

2011
Utility of endtidal carbon dioxide monitoring in detection of hypoxia during sedation for brain magnetic resonance imaging in children with developmental disabilities.
    Paediatric anaesthesia, 2011, Volume: 21, Issue:12

    Topics: Anesthetics, Intravenous; Brain; Carbon Dioxide; Child; Child, Preschool; Conscious Sedation; Develo

2011
Analysis of oxygen saturations recorded during dental intravenous sedations: a retrospective quality assurance of 3500 cases.
    Anesthesia progress, 2011,Fall, Volume: 58, Issue:3

    Topics: Adult; Anesthesia, Dental; Anesthesia, Intravenous; Anesthetics, Intravenous; Conscious Sedation; Fe

2011
Use of naloxone to reverse carfentanil citrate-induced hypoxemia and cardiopulmonary depression in Rocky Mountain wapiti (Cervus elaphus nelsoni).
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 2001, Volume: 32, Issue:1

    Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Blood Gas Analysis; Cross-Over Studies; Deer

2001
Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department.
    Annals of emergency medicine, 2003, Volume: 42, Issue:5

    Topics: Adjuvants, Anesthesia; Analgesia; Anesthetics, Combined; Child; Child, Preschool; Chloral Hydrate; C

2003
When is a patient safe for discharge after procedural sedation? The timing of adverse effect events in 1367 pediatric procedural sedations.
    Annals of emergency medicine, 2003, Volume: 42, Issue:5

    Topics: Adjuvants, Anesthesia; Anesthesia Recovery Period; Anesthetics, Combined; Anesthetics, Dissociative;

2003
[Anesthetic management for a patient with platypnea-orthodeoxia syndrome].
    Masui. The Japanese journal of anesthesiology, 2004, Volume: 53, Issue:2

    Topics: Aged; Anesthesia, General; Dyspnea; Fentanyl; Heart Septal Defects, Atrial; Humans; Hypoxia; Male; M

2004
Difficulties in anesthetizing a 106-yr-old patient for total hip replacement.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2004, Volume: 51, Issue:9

    Topics: Aged; Aged, 80 and over; Anesthesia, Spinal; Anesthetics, Intravenous; Arthroplasty, Replacement, Hi

2004
Adverse cardiovascular and respiratory events during sedation of pediatric patients for imaging examinations.
    Radiology, 2005, Volume: 237, Issue:1

    Topics: Cardiovascular System; Child, Preschool; Chloral Hydrate; Conscious Sedation; Diagnostic Imaging; Fe

2005
Recurrent hypoxia in rats during development increases subsequent respiratory sensitivity to fentanyl.
    Anesthesiology, 2006, Volume: 105, Issue:4

    Topics: Analgesics, Opioid; Animals; Fentanyl; Hypoxia; Male; Rats; Rats, Sprague-Dawley; Receptors, Opioid,

2006
[Anesthetic implications of Swyer-James syndrome].
    Revista espanola de anestesiologia y reanimacion, 2006, Volume: 53, Issue:10

    Topics: Adolescent; Anesthesia, Intravenous; Asthma; Atracurium; Atropine; Bronchiectasis; Drainage; Fentany

2006
Balanced anesthesia and ventilation strategies for an alpaca (Lama pacos) with an increased anesthetic-risk.
    Schweizer Archiv fur Tierheilkunde, 2008, Volume: 150, Issue:2

    Topics: Anesthesia; Anesthetics; Animals; Camelids, New World; Female; Fentanyl; Hypnotics and Sedatives; Hy

2008
Fentanyl and cerebral vascular responsivity in dogs.
    Anesthesiology, 1984, Volume: 60, Issue:3

    Topics: Animals; Blood Pressure; Brain; Carbon Dioxide; Cerebrovascular Circulation; Dogs; Female; Fentanyl;

1984
Nitrous oxide, too, is hepatotoxic in rats.
    Anesthesia and analgesia, 1984, Volume: 63, Issue:12

    Topics: Animals; Fentanyl; Halothane; Hypoxia; Isoflurane; Liver; Male; Nitrous Oxide; Rats; Rats, Inbred St

1984
The causes of hypoxemia in elderly patients during endoscopy.
    Gastrointestinal endoscopy, 1982, Volume: 28, Issue:4

    Topics: Aged; Blood Gas Analysis; Colonoscopy; Diazepam; Female; Fentanyl; Gastroscopy; Humans; Hypoxia; Mal

1982
Hypoxia-induced pulmonary vasoconstriction: effects of fentanyl following different routes of administration.
    Acta anaesthesiologica Scandinavica, 1980, Volume: 24, Issue:1

    Topics: Anesthesia, Inhalation; Animals; Blood Pressure; Fentanyl; Hypoxia; Injections, Intra-Arterial; Pres

1980
Uterine and umbilical blood flow velocity during epidural anaesthesia for caesarean section.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1994, Volume: 41, Issue:11

    Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Arteries; Blood Flow Velocity; Cesarean Sectio

1994
General anaesthesia vs sedation for minor gynaecological procedures--a comparative study.
    Singapore medical journal, 1993, Volume: 34, Issue:5

    Topics: Adolescent; Adult; Anesthesia, General; Conscious Sedation; Female; Fentanyl; Genitalia, Female; Hum

1993
Arterial oxygen saturation during endoscopic retrograde cholangiopancreatography.
    Endoscopy, 1993, Volume: 25, Issue:4

    Topics: Aged; Cholangiopancreatography, Endoscopic Retrograde; Diazepam; Female; Fentanyl; Humans; Hypoxia;

1993
Supplemental oxygen after outpatient oral and maxillofacial surgery.
    Anesthesia progress, 1992, Volume: 39, Issue:1-2

    Topics: Adolescent; Adult; Ambulatory Surgical Procedures; Analysis of Variance; Anesthesia Recovery Period;

1992
Respiratory effects of a balanced anesthetic technique--revisited fifteen years later.
    Anesthesia progress, 1994, Volume: 41, Issue:1

    Topics: Airway Obstruction; Anesthesia, Dental; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, I

1994
Observation of early postoperative hypoxaemia in children undergoing elective plastic surgery.
    Paediatric anaesthesia, 1996, Volume: 6, Issue:1

    Topics: Adolescent; Age Factors; Air; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Inha

1996
Epidural analgesia in children with cerebral palsy.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:12

    Topics: Analgesia, Epidural; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Cerebral Palsy; Child; Con

1998
Comparative cardiopulmonary effects of carfentanil-xylazine and medetomidine-ketamine used for immobilization of mule deer and mule deer/white-tailed deer hybrids.
    Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2000, Volume: 64, Issue:1

    Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Anesthetics, Dissociative; Animal Welfare; Animals; A

2000
Fentanyl-induced chest wall rigidity and laryngospasm in preterm and term infants.
    Critical care medicine, 2000, Volume: 28, Issue:3

    Topics: Fentanyl; Humans; Hypercapnia; Hypoxia; Infant, Newborn; Infant, Premature; Laryngismus; Naloxone; N

2000
The effects of dopamine and epinephrine on hemodynamics and oxygen metabolism in hypoxic anesthetized piglets.
    Critical care (London, England), 2001, Volume: 5, Issue:3

    Topics: Animals; Animals, Newborn; Cardiotonic Agents; Disease Models, Animal; Dopamine; Dose-Response Relat

2001
The effects of anesthetic drugs and disease on the chemical regulation of ventilation.
    International anesthesiology clinics, 1977,Summer, Volume: 15, Issue:2

    Topics: Anesthetics; Anti-Anxiety Agents; Autonomic Nervous System; Barbiturates; Benzodiazepines; Carbon Di

1977
The role of analgesics in respiratory depression: a rabbit model.
    Anaesthesia, 1977, Volume: 32, Issue:4

    Topics: Analgesics, Opioid; Animals; Animals, Newborn; Depression, Chemical; Fentanyl; Hypoxia; Meperidine;

1977
Monitoring as anesthesia draws to a close.
    Acta anaesthesiologica Belgica, 1979, Volume: 30 Suppl

    Topics: Anesthesia; Blood Pressure; Carbon Dioxide; Cheyne-Stokes Respiration; Diffusion; Fentanyl; Heart Ar

1979
[Pulmonary hypertension and pulmonary edema caused by intravenous ketamine (author's transl)].
    Der Anaesthesist, 1978, Volume: 27, Issue:10

    Topics: Anesthesia, General; Coronary Disease; Fentanyl; Humans; Hypertension, Pulmonary; Hypoxia; Injection

1978
Hypoxia-induced vasoconstriction in isolated perfused lungs exposed to injectable or inhalation anesthetics.
    Acta anaesthesiologica Scandinavica, 1977, Volume: 21, Issue:2

    Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics; Animals; Diazepam; Dose-Response Relat

1977
Brain surface pO2 and rCBF in rabbits with a focal cerebral lesion and pulmonary hypoxia under fentanyl-, isoflurane- or thiopental-anesthesia.
    Advances in experimental medicine and biology, 1992, Volume: 317

    Topics: Anesthesia, General; Animals; Brain; Brain Injuries; Cerebral Cortex; Fentanyl; Hypoxia; Isoflurane;

1992
Laparoscopic cholecystectomy: the anaesthetist's point of view.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1992, Volume: 39, Issue:8

    Topics: Age Factors; Anesthesia; Anesthesia Recovery Period; Anesthesia, Intravenous; Antiemetics; Cholecyst

1992
MAO inhibitors and coronary artery surgery: a patient death.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1992, Volume: 39, Issue:10

    Topics: Acidosis; Anesthesia, Intravenous; Angina, Unstable; Cause of Death; Coronary Artery Bypass; Fentany

1992
[Stimulation of respiration with Piladox in experimental and clinical conditions during administration of drugs for general anesthesia].
    Khirurgiia, 1991, Issue:10

    Topics: Anesthesia, General; Animals; Barbiturates; Female; Fentanyl; Humans; Hypoxia; Leg; Male; Mice; Midd

1991
[Relationship between central beta-endorphins and serotonin systems in mechanism of hypoxic ventilatory regulation].
    Sheng li xue bao : [Acta physiologica Sinica], 1991, Volume: 43, Issue:6

    Topics: Animals; beta-Endorphin; Fentanyl; Hypoxia; Injections, Intraventricular; Male; Naloxone; Rabbits; R

1991
Frequent hypoxemia and apnea after sedation with midazolam and fentanyl.
    Anesthesiology, 1990, Volume: 73, Issue:5

    Topics: Adolescent; Adult; Apnea; Carbon Dioxide; Conscious Sedation; Drug Interactions; Drug Therapy, Combi

1990
Frequent hypoxemia and apnea after sedation with midazolam and fentanyl.
    Anesthesiology, 1990, Volume: 73, Issue:5

    Topics: Adolescent; Adult; Apnea; Carbon Dioxide; Conscious Sedation; Drug Interactions; Drug Therapy, Combi

1990
Frequent hypoxemia and apnea after sedation with midazolam and fentanyl.
    Anesthesiology, 1990, Volume: 73, Issue:5

    Topics: Adolescent; Adult; Apnea; Carbon Dioxide; Conscious Sedation; Drug Interactions; Drug Therapy, Combi

1990
Frequent hypoxemia and apnea after sedation with midazolam and fentanyl.
    Anesthesiology, 1990, Volume: 73, Issue:5

    Topics: Adolescent; Adult; Apnea; Carbon Dioxide; Conscious Sedation; Drug Interactions; Drug Therapy, Combi

1990
Arterial oxygen desaturation during awake endotracheal intubation.
    Anesthesia progress, 1990, Volume: 37, Issue:4

    Topics: Adult; Anesthesia, General; Blood Gas Monitoring, Transcutaneous; Carbon Dioxide; Droperidol; Female

1990
[Comments on the contribution by W. Tolksdorf, H. Bremer and B. Tokic (Anästh. Intensivther. Notfallmed. 24 (1989) 94-99): "Postoperative, opiate-induced respiratory depression is not dependent on arousal"].
    Anasthesie, Intensivtherapie, Notfallmedizin, 1990, Volume: 25, Issue:4

    Topics: Anesthesia Recovery Period; Anesthesia, General; Arousal; Fentanyl; Humans; Hypoxia; Postoperative C

1990
The influence of fentanyl upon cerebral high-energy metabolites, lactate, and glucose during severe hypoxia in the rat.
    Anesthesiology, 1988, Volume: 69, Issue:4

    Topics: Adenosine Triphosphate; Animals; Brain; Electroencephalography; Energy Metabolism; Fentanyl; Glucose

1988
Continuous transcutaneous O2 and CO2 monitoring during conscious sedation for oral surgery.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1985, Volume: 43, Issue:7

    Topics: Adult; Anesthesia, Dental; Anesthesia, Intravenous; Carbon Dioxide; Diazepam; Fentanyl; Humans; Hypo

1985
Outpatient laparoscopic sterilization under lcoal anesthesia.
    American journal of obstetrics and gynecology, 1973, Aug-15, Volume: 116, Issue:8

    Topics: Acidosis, Respiratory; Ambulatory Care; Anesthesia, Local; Blood Gas Analysis; Diazepam; Female; Fen

1973
Neuroendocrine and metabolic effects of general anaesthesia during spontaneous breathing, controlled breathing, milk hypoxia, and mild hypercarbia.
    Canadian Anaesthetists' Society journal, 1966, Volume: 13, Issue:2

    Topics: Anesthesia; Anesthetics; Animals; Benperidol; Chloroform; Cyclopropanes; Dogs; Epinephrine; Ethers;

1966
The action of droperidol and fentanyl on cardiac output and related hemodynamic parameters.
    Southern medical journal, 1974, Volume: 67, Issue:1

    Topics: Acidosis, Respiratory; Adult; Blood; Blood Circulation; Carbon Dioxide; Cardiac Output; Droperidol;

1974
Comparison of the effects of two anesthetic agents on the production of hypoxic pulmonary hypertension in dogs.
    American heart journal, 1972, Volume: 84, Issue:2

    Topics: Anesthetics; Animals; Benperidol; Dogs; Fentanyl; Hypertension, Pulmonary; Hypoxia; Neuroleptanalges

1972
[Anesthesia in emergency surgery of patients with anuria].
    Deutsche medizinische Wochenschrift (1946), 1971, Jun-11, Volume: 96, Issue:24

    Topics: Anesthesia, General; Anuria; Atropine; Fentanyl; Halothane; Heart Arrest; Humans; Hypoxia; Infusions

1971
[On the significance of oxygen supply in drug induced central respiratory depression].
    Wiener klinische Wochenschrift, 1967, Jun-16, Volume: 79, Issue:24

    Topics: Animals; Apnea; Carbon Dioxide; Fentanyl; Hypercapnia; Hypoxia; Neuroleptanalgesia; Oxygen Consumpti

1967
Variations in arterial blood values before, during and after neuroleptanalgesia.
    Southern medical journal, 1968, Volume: 61, Issue:9

    Topics: Adult; Age Factors; Aged; Arteries; Benperidol; Carbon Dioxide; Female; Fentanyl; Humans; Hydrogen-I

1968