fentanyl has been researched along with Hyperglycemia in 10 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Hyperglycemia: Abnormally high BLOOD GLUCOSE level.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fentanyl is a potent synthetic opioid used extensively in humans for general anesthesia and analgesia." | 5.48 | Fentanyl-Induced Brain Hypoxia Triggers Brain Hyperglycemia and Biphasic Changes in Brain Temperature. ( Cameron-Burr, KT; Kiyatkin, EA; Shaham, Y; Solis, E, 2018) |
| "This study investigated whether remifentanil infusion decreased intraoperative hyperglycaemia and insulin resistance compared with intermittent fentanyl administration in patients undergoing elective cardiac surgery." | 5.34 | Remifentanil and perioperative glycaemic response in cardiac surgery: an open-label randomised trial. ( Badhwar, V; Boisen, M; Esper, S; Hayanga, H; Marquez, J; Monroe, A; Ruppert, K; Sciortino, C; Subramaniam, K, 2020) |
| " We report a case of a 19-month-old girl who presented in coma and who was later found to have a fentanyl patch adhered to her back." | 3.77 | Toxic leukoencephalopathy due to transdermal fentanyl overdose. ( Bradin, SA; Foy, L; Seeyave, DM, 2011) |
| "Fentanyl is a potent synthetic opioid used extensively in humans for general anesthesia and analgesia." | 1.48 | Fentanyl-Induced Brain Hypoxia Triggers Brain Hyperglycemia and Biphasic Changes in Brain Temperature. ( Cameron-Burr, KT; Kiyatkin, EA; Shaham, Y; Solis, E, 2018) |
| "Severe hypernatremia is an unusual fact at the immediate postoperative period but may have fatal consequences for the patient and need immediate action." | 1.46 | Effects of pneumoperitoneum on severe hypernatremia in an adult patient who underwent laparoscopic surgery of hydatid cysts. ( Álvarez, R; Anta, D; Beleña, JM; Núñez, M, 2017) |
| "Chronic hyperglycemia was induced by streptozotocin injection (200 mg/kg i." | 1.28 | Hyperglycemia does not modify the pupillary effects of mu and kappa opiate agonists in mice. ( Bansinath, M; Puig, MM; Ramabadran, K; Turndorf, H, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (30.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Subramaniam, K | 1 |
| Sciortino, C | 1 |
| Ruppert, K | 1 |
| Monroe, A | 1 |
| Esper, S | 1 |
| Boisen, M | 1 |
| Marquez, J | 1 |
| Hayanga, H | 1 |
| Badhwar, V | 1 |
| Solis, E | 1 |
| Cameron-Burr, KT | 1 |
| Shaham, Y | 1 |
| Kiyatkin, EA | 1 |
| Anta, D | 1 |
| Beleña, JM | 1 |
| Álvarez, R | 1 |
| Núñez, M | 1 |
| Anand, KJ | 2 |
| Sippell, WG | 2 |
| Aynsley-Green, A | 2 |
| Foy, L | 1 |
| Seeyave, DM | 1 |
| Bradin, SA | 1 |
| Lu, CC | 1 |
| Ho, ST | 1 |
| Wang, JJ | 1 |
| Wong, CS | 1 |
| Tsai, CS | 1 |
| Chang, SY | 1 |
| Lin, CY | 1 |
| Sieber, FE | 1 |
| Brown, PR | 1 |
| Wu, Y | 1 |
| Koehler, RC | 1 |
| Traystman, RJ | 1 |
| Ellis, DJ | 1 |
| Steward, DJ | 1 |
| Bansinath, M | 1 |
| Ramabadran, K | 1 |
| Turndorf, H | 1 |
| Puig, MM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Intraoperative Continuous Remifentanil Infusion on Glycemic Response and Variability in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass: A Prospective, Randomized, Open Label Clinical Trial[NCT02349152] | Phase 4 | 116 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| Correlation Between Blood Pressure, Heart Rate and Plasma Corticotropin, Cortisol Under Surgical Skin Incision[NCT03892538] | 134 participants (Actual) | Observational | 2018-10-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Percentage of patients with two or more intraoperative blood glucose levels greater than 180 mg/dl. Percentage in both groups will be estimated, then the difference in this statistic will form the primary outcome measure of this study.~(Primary Outcome changed on 06/15/2015-Change Approved by University of Pittsburgh IRB on 06/22/2015- First patient enrolled January 2016)" (NCT02349152)
Timeframe: Intraoperative period
| Intervention | Participants (Count of Participants) |
|---|---|
| Remifentanil Group | 17 |
| Fentanyl Group | 33 |
Time to extubation after completion of surgery in the operating room and intensive care unit (NCT02349152)
Timeframe: Immediate postoperative period until 30 days post-operatively
| Intervention | Hours (Median) |
|---|---|
| Remifentanil Group | 3 |
| Fentanyl Group | 2.5 |
Coefficient of variation in blood glucose levels. Denotes how large the fluctuations in blood glucose are. Higher numbers indicate increased variation. (NCT02349152)
Timeframe: From the start of induction till 24 hours postoperatively
| Intervention | Percent of Mean Glucose Level (Mean) |
|---|---|
| Remifentanil Group | 0.2 |
| Fentanyl Group | 0.2 |
Average dose of insulin (Units/ml) calculated for each group in the intraoperative period (NCT02349152)
Timeframe: Intraoperative period; Induction to end of surgery
| Intervention | Units/ml (Median) |
|---|---|
| Remifentanil Group | 2.9 |
| Fentanyl Group | 8.1 |
Blood glucose values that exceed 180 mg% will be counted (NCT02349152)
Timeframe: Intraoperative period, Induction to end of surgery
| Intervention | number of glucose values >180mg% (Median) |
|---|---|
| Remifentanil Group | 1.2 |
| Fentanyl Group | 2 |
Total units of regular insulin required post-operatively (NCT02349152)
Timeframe: From ICU Admission (After Surgery) Until 24 hours postoperatively
| Intervention | International Units (Median) |
|---|---|
| Remifentanil Group | 28.1 |
| Fentanyl Group | 23.5 |
Telephonic call Numeric pain scale; Scale is 0-10, with 10 being the highest pain. (NCT02349152)
Timeframe: 1, 3, 6 and 12 months after discharge from the hospital
| Intervention | score on a scale (Median) | |||
|---|---|---|---|---|
| S-LANSS 1 mo | S-LANSS 3 mo | S-LANSS 6 mo | S-LANSS 12 mo | |
| Fentanyl Group | 3 | 0 | 0 | 0 |
| Remifentanil Group | 1 | 0 | 0 | 0 |
Inflammatory mediator levels, Interleukin-1b (IL-1b), Interleukin 6 (IL-6) and Tumor Necrosis Factor Alpha (TNFa) (all measured in pg/ml) taken at: Prebypass, cardiopulmonary bypass (2 samples:30 min start of bypass (CPB-30) and end of bypass (CPB-END), postbypass, ICU 8 hours postoperative period (NCT02349152)
Timeframe: Perioperative period (Intraoperatively and 8 hours postoperatively)
| Intervention | pg/ml (Median) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IL-1b Pre-bypass | IL-1b CPB-30 | IL-1b CPB-END | IL-1b post-bypass | IL-1b 8-HR | IL-6 Pre-bypass | IL-6 CPB-30 | IL-6 CPB-END | IL-6 post-bypass | IL-6 8HR | TNFa-Pre-bypass | TNFa CPB-30 | TNFa CPB-END | TNFa post-bypass | TNFa 8HR | |
| Fentanyl Group | 1.2 | 1.1 | 1.2 | 1.3 | 1.2 | 2.6 | 10.3 | 78.3 | 90.9 | 92.3 | 10.4 | 12.6 | 14.8 | 17.2 | 11.2 |
| Remifentanil Group | 1.2 | 1.1 | 1.2 | 1.1 | 1.2 | 2.8 | 7.4 | 77.2 | 136 | 93.6 | 11.7 | 14.4 | 18.2 | 24.0 | 15.4 |
Blood glucose measured every hour (NCT02349152)
Timeframe: Intraoperative period; Induction to end of surgery
| Intervention | Mg/dL (Median) | ||
|---|---|---|---|
| Mean Introperative Blood Glucose | Peak Intraoperative Blood Glucose | Lowest Intraoperative Blood Glucose | |
| Fentanyl Group | 156 | 205 | 120 |
| Remifentanil Group | 141 | 178 | 117 |
Mean and peak blood glucose levels postoperatively (NCT02349152)
Timeframe: From ICU Admission (After Surgery) Until 24 hours postoperatively
| Intervention | mg/dl (Median) | |
|---|---|---|
| Mean Postoperative Blood Glucose | Peak Postoperative Blood Glucose | |
| Fentanyl Group | 139 | 175 |
| Remifentanil Group | 139 | 185 |
Pain scores; Every day 6 hour for 48 hours postoperative period (NCT02349152)
Timeframe: Every day 6 hour for 48 hours postoperative period
| Intervention | score on a scale (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Hours 0-6 | Hrs 7-12 | Hrs 13-18 | Hrs 19-24 | Hrs 25-30 | Hrs 31-36 | Hrs 37-42 | Hrs 43-48 | |
| Fentanyl Group | 7.18 | 6.09 | 5.18 | 5.73 | 5.65 | 5.94 | 5.18 | 5.10 |
| Remifentanil Group | 6.63 | 6.53 | 6.59 | 5.88 | 5.94 | 5.89 | 5.57 | 5.08 |
Postoperative outcomes collected from the Society of Thoracic Surgery (STS) database. 30 day Mortality (outcome 1) and 30 day Readmission (outcome 2) cerebral vascular accident(outcome 3), prolonged mechanical ventilation (outcome 4), renal failure (outcome 5), atrial fibrillation (outcome 6), cardiac arrest (outcome 7) (NCT02349152)
Timeframe: 30 day outcomes
| Intervention | participants (Number) | ||||||
|---|---|---|---|---|---|---|---|
| 30 day Mortality | 30 day Readmission | Cerebral Vascular Accident | Prolonged mechanical ventilation | renal failure | atrial fibrillation | cardiac arrest | |
| Fentanyl Group | 6 | 10 | 2 | 8 | 3 | 18 | 3 |
| Remifentanil Group | 1 | 3 | 0 | 8 | 3 | 24 | 3 |
Adreno-corticotrophic hormone (ACTH), Growth Hormone (GH) and Glucagon (measured as pg/ml) taken at: Prebypass, cardiopulmonary bypass (2 samples: 30 mins after start of bypass (CPB 30) and end of bypass (CPB END), post-bypass and ICU 8 hours postoperative period (NCT02349152)
Timeframe: Perioperative period (Intraoperatively and 8 hours postoperatively)
| Intervention | pg/ml (Median) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACTH pre-bypass | ACTH CPB-30 | ACTH CPB-END | ACTH post-bypass | ACTH 8-hr | GH-Pre-bypass | GH-CPB-30 | GH-CPB-END | GH-post-bypass | GH-8HR | Glucagon pre-bypass | Glucagon CPB-30 | Glucagon CPB-End | Glucagon post-bypass | Glucagon 8-HR | |
| Fentanyl Group | 7.4 | 57.8 | 30.7 | 49.1 | 41.3 | 872 | 3202 | 2545 | 4461 | 2696 | 192 | 338 | 481 | 408 | 459 |
| Remifentanil Group | 7.4 | 4.4 | 4.4 | 8.0 | 77.0 | 495 | 826 | 947 | 37364 | 3658 | 229 | 259 | 401 | 315 | 570 |
Serum cortisol levels (measured as µg/dl) taken at: Prebypass, cardiopulmonary bypass (2 samples: at start of bypass and end of bypass), postbypass, ICU 8 hours postoperative period (NCT02349152)
Timeframe: Perioperative period (Intraoperatively and 8 hours postoperatively)
| Intervention | µg/dl (Median) | ||||
|---|---|---|---|---|---|
| Serum Cortisol Prebypass | Serum Cortisol 30 Minute After Start of CPB | Serum Cortisol End of CPB | Serum Cortisol End of Surgery | Serum Cortisol Postoperative (8 Hours) | |
| Fentanyl Group | 12 | 24.5 | 29.0 | 28.0 | 45.0 |
| Remifentanil Group | 12 | 6.0 | 5.0 | 8.5 | 36.0 |
Von frey hair objective testing (NCT02349152)
Timeframe: 96 hours postoperatively
| Intervention | g/mm^2 (Mean) | ||
|---|---|---|---|
| Preop pain threshold | 48 Hr pain threshold | 96 hr pain threshold | |
| Fentanyl Group | 3.30 | 3.83 | 3.72 |
| Remifentanil Group | 3.24 | 3.71 | 3.60 |
4 trials available for fentanyl and Hyperglycemia
| Article | Year |
|---|---|
Remifentanil and perioperative glycaemic response in cardiac surgery: an open-label randomised trial.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Blood Glucose; Cardiac Surgical Procedures; Fema | 2020 |
Randomised trial of fentanyl anaesthesia in preterm babies undergoing surgery: effects on the stress response.
Topics: Anesthesia, General; Blood Glucose; Clinical Trials as Topic; Curare; Ductus Arteriosus, Patent; Fen | 1987 |
Minimal low-flow isoflurane-based anesthesia benefits patients undergoing coronary revascularization via preventing hyperglycemia and maintaining metabolic homeostasis.
Topics: Aged; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intrave | 2003 |
Randomised trial of fentanyl anaesthesia in preterm babies undergoing surgery: effects on the stress response.
Topics: Anesthesia, General; Blood Glucose; Clinical Trials as Topic; Curare; Ductus Arteriosus, Patent; Fen | 1987 |
6 other studies available for fentanyl and Hyperglycemia
| Article | Year |
|---|---|
Fentanyl-Induced Brain Hypoxia Triggers Brain Hyperglycemia and Biphasic Changes in Brain Temperature.
Topics: Analgesics, Opioid; Animals; Body Temperature; Brain; Fentanyl; Glucose; Hyperglycemia; Hypoxia, Bra | 2018 |
Effects of pneumoperitoneum on severe hypernatremia in an adult patient who underwent laparoscopic surgery of hydatid cysts.
Topics: Analgesics, Opioid; Antibiotic Prophylaxis; Cholecystectomy, Laparoscopic; Echinococcosis; Echinococ | 2017 |
Toxic leukoencephalopathy due to transdermal fentanyl overdose.
Topics: Accidents, Home; Administration, Cutaneous; Apnea; Child, Preschool; Coma; Decerebrate State; Delaye | 2011 |
Cerebral blood flow responsivity to CO2 in anesthetized chronically diabetic dogs.
Topics: Animals; Blood Glucose; Carbon Dioxide; Cerebrovascular Circulation; Diabetes Mellitus, Experimental | 1993 |
Fentanyl dosage is associated with reduced blood glucose in pediatric patients after hypothermic cardiopulmonary bypass.
Topics: Adolescent; Cardiopulmonary Bypass; Child; Child, Preschool; Fentanyl; Heart Arrest, Induced; Heart | 1990 |
Hyperglycemia does not modify the pupillary effects of mu and kappa opiate agonists in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; B | 1989 |