fentanyl has been researched along with Hypercapnia in 31 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Hypercapnia: A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients receiving midazolam had a more than doubled risk of respiratory depression as mirrored by hypercapnia and acidosis, but not hypoxemia." | 7.88 | Midazolam addition to analgosedation for pulmonary vein isolation may increase risk of hypercapnia and acidosis. ( Bürkle, G; Ehrlich, JR; Feurich, F; Kaess, BM, 2018) |
| "To assess effects of anesthesia and opioids, we studied 13 children with obstructive sleep apnea (OSA, age 4." | 5.10 | Effects of OSA, inhalational anesthesia, and fentanyl on the airway and ventilation of children. ( Hinder, M; McBrien, F; Stewart, P; Waters, KA; Wharton, S, 2002) |
| "Respiratory effects, nausea, somnolence, and pruritus were compared during a 48-hr period of continuous epidural morphine (n = 34) and fentanyl (n = 32) infusion in 66 patients following elective total replacement of the hip or knee joint." | 5.07 | Side effects during continuous epidural infusion of morphine and fentanyl. ( Berghausen, EJ; Dumont, SW; Heine, MF; Huang, KC; Schroeder, JA; Tsueda, K; Vogel, RL; White, MJ, 1992) |
| "Patients receiving midazolam had a more than doubled risk of respiratory depression as mirrored by hypercapnia and acidosis, but not hypoxemia." | 3.88 | Midazolam addition to analgosedation for pulmonary vein isolation may increase risk of hypercapnia and acidosis. ( Bürkle, G; Ehrlich, JR; Feurich, F; Kaess, BM, 2018) |
| "Since its introduction into clinical practice, it has been known that fentanyl and other synthetic opioids may cause skeletal muscle rigidity." | 3.78 | Chest wall rigidity in two infants after low-dose fentanyl administration. ( Dewhirst, E; Naguib, A; Tobias, JD, 2012) |
| "Targeted temperature management after cardiac arrest requires deep sedation to prevent shivering and discomfort." | 1.46 | Isoflurane Sedation on the ICU in Cardiac Arrest Patients Treated With Targeted Temperature Management: An Observational Propensity-Matched Study. ( Engels, M; Jörres, A; Krannich, A; Kruse, J; Leithner, C; Nee, J; Petzinka, V; Schröder, T; Storm, C, 2017) |
| "In patients with chronic obstructive pulmonary disease (COPD), IF also elicits sustained decreases in the exercise ventilatory response but with little or no resultant CO2 retention due to concomitant decreases in physiological VD/VT (dead space-to-ventilation ratio)." | 1.42 | Type III-IV muscle afferents are not required for steady-state exercise hyperpnea in healthy subjects and patients with COPD or heart failure. ( Poon, CS; Song, G, 2015) |
| "We observed chest wall rigidity in 8 patients after low dosage of fentanyl (3-5 microg/kg body weight)." | 1.31 | Fentanyl-induced chest wall rigidity and laryngospasm in preterm and term infants. ( Bartmann, P; Fahnenstich, H; Kau, N; Steffan, J, 2000) |
| "Fentanyl was given intravenously in fractional doses, (fig 1), during NLA, and other general anaesthesias, for operation and diagnostic examination ( exeption of cardiosurgery), in children and adolescents from two month-to nineteen years of age, (tab." | 1.26 | [Naloxone as a drug for improving anesthesia results in children]. ( Cukier, K; Cwizewicz-Adamska, J; Czekuć, E; Rondio, Z; Ryterski, S, 1979) |
| "If naloxone 0." | 1.26 | Restlessness and shivering after naloxone reversal of fentanyl-supplemented anaesthesia. ( Tammisto, T; Tigerstedt, I, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (35.48) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 4 (12.90) | 29.6817 |
| 2010's | 11 (35.48) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Mikhaeil, JS | 1 |
| Pepper, CG | 1 |
| Hayward, GC | 1 |
| Kaess, BM | 1 |
| Feurich, F | 1 |
| Bürkle, G | 1 |
| Ehrlich, JR | 1 |
| Agrafiotis, M | 1 |
| Tryfon, S | 1 |
| Siopi, D | 1 |
| Chassapidou, G | 1 |
| Galanou, A | 1 |
| Tsara, V | 1 |
| Poon, CS | 1 |
| Song, G | 1 |
| Cornelius, B | 1 |
| Sakai, T | 1 |
| Krannich, A | 1 |
| Leithner, C | 1 |
| Engels, M | 1 |
| Nee, J | 1 |
| Petzinka, V | 1 |
| Schröder, T | 1 |
| Jörres, A | 1 |
| Kruse, J | 1 |
| Storm, C | 1 |
| Amann, M | 2 |
| Blain, GM | 1 |
| Proctor, LT | 1 |
| Sebranek, JJ | 1 |
| Pegelow, DF | 1 |
| Dempsey, JA | 1 |
| Kaufman, MP | 1 |
| Parkes, MJ | 1 |
| Runnels, S | 1 |
| Morgan, DE | 1 |
| Trinity, JD | 1 |
| Fjeldstad, AS | 1 |
| Wray, DW | 1 |
| Reese, VR | 1 |
| Richardson, RS | 1 |
| Drummond, GB | 1 |
| Dhonneur, G | 1 |
| Kirov, K | 1 |
| Duvaldestin, P | 1 |
| Dewhirst, E | 1 |
| Naguib, A | 1 |
| Tobias, JD | 1 |
| Sarang, A | 1 |
| Dinsmore, J | 1 |
| Vasilakos, K | 1 |
| Wilson, RJ | 1 |
| Kimura, N | 1 |
| Remmers, JE | 1 |
| McPherson, RW | 1 |
| Traystman, RJ | 1 |
| Rafferty, TD | 1 |
| Marrero, O | 1 |
| Nardi, D | 1 |
| Schachter, EN | 1 |
| Mentelos, R | 1 |
| Hastings, A | 1 |
| Roselli, D | 1 |
| Flecknell, PA | 1 |
| John, M | 1 |
| Mitchell, M | 1 |
| Shurey, C | 1 |
| Simpkin, S | 1 |
| Comstock, MK | 1 |
| Carter, JG | 1 |
| Moyers, JR | 1 |
| Stevens, WC | 1 |
| Mora, CT | 1 |
| Torjman, M | 1 |
| White, PF | 1 |
| Lemmen, RJ | 1 |
| Semmekrot, BA | 1 |
| Fahnenstich, H | 1 |
| Steffan, J | 1 |
| Kau, N | 1 |
| Bartmann, P | 1 |
| Waters, KA | 1 |
| McBrien, F | 1 |
| Stewart, P | 1 |
| Hinder, M | 1 |
| Wharton, S | 1 |
| Ainslie, SG | 1 |
| Eisele, JH | 1 |
| Corkill, G | 1 |
| Rondio, Z | 1 |
| Czekuć, E | 1 |
| Ryterski, S | 1 |
| Cukier, K | 1 |
| Cwizewicz-Adamska, J | 1 |
| Tammisto, T | 1 |
| Tigerstedt, I | 1 |
| White, MJ | 1 |
| Berghausen, EJ | 1 |
| Dumont, SW | 1 |
| Tsueda, K | 1 |
| Schroeder, JA | 1 |
| Vogel, RL | 1 |
| Heine, MF | 1 |
| Huang, KC | 1 |
| Mills, CA | 2 |
| Flacke, JW | 2 |
| Flacke, WE | 2 |
| Bloor, BC | 2 |
| Liu, MD | 1 |
| Miller, JD | 1 |
| Davis, LJ | 1 |
| Keith, L | 1 |
| Silver, A | 1 |
| Becker, M | 1 |
| Michenfelder, JD | 1 |
| Theye, RA | 1 |
| Benzer, H | 1 |
| Kunz, H | 1 |
| Lempert, J | 1 |
| Mayrhofer, O | 1 |
| Muhar, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05327296] | Phase 3 | 235 participants (Anticipated) | Interventional | 2022-06-30 | Recruiting | ||
| A Phase 3, Multicenter, Randomized, Controlled, Open Label, Assessor-Blinded Study to Evaluate the Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensi[NCT05312385] | Phase 3 | 235 participants (Anticipated) | Interventional | 2022-04-28 | Recruiting | ||
| Comparison of Dexmedetomidine and Propofol-Remifentanil Conscious Sedation for Awake Craniotomy for Tumor Surgery: a Randomized Controlled Trial[NCT01545297] | 50 participants (Actual) | Interventional | 2012-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for fentanyl and Hypercapnia
| Article | Year |
|---|---|
Group III and IV muscle afferents contribute to ventilatory and cardiovascular response to rhythmic exercise in humans.
Topics: Adult; Analgesics, Opioid; Analysis of Variance; Bicycling; Blood Pressure; Double-Blind Method; Ele | 2010 |
Sedative and ventilatory effects of midazolam infusion: effect of flumazenil reversal.
Topics: Adult; Ambulatory Care; Anesthetics, Intravenous; Double-Blind Method; Female; Fentanyl; Flumazenil; | 1995 |
Effects of OSA, inhalational anesthesia, and fentanyl on the airway and ventilation of children.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Apnea; Carbon Dioxide; Child; Child, Preschool; Drug Sy | 2002 |
Side effects during continuous epidural infusion of morphine and fentanyl.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Carbon Dioxide; Female; Fentanyl; Hip Prosthesi | 1992 |
27 other studies available for fentanyl and Hypercapnia
| Article | Year |
|---|---|
Mechanisms of opioid-induced respiratory depression in sleep apnoea: new insights for anaesthesiology.
Topics: Analgesics, Opioid; Anesthesiology; Fentanyl; Humans; Hypercapnia; Hypoxia; Respiratory Hypersensiti | 2020 |
Midazolam addition to analgosedation for pulmonary vein isolation may increase risk of hypercapnia and acidosis.
Topics: Acidosis; Aged; Anesthetics, Intravenous; Drug Therapy, Combination; Female; Fentanyl; Follow-Up Stu | 2018 |
Successful management of drug-induced hypercapnic acidosis with naloxone and noninvasive positive pressure ventilation.
Topics: Acidosis; Aged; Analgesics, Opioid; Combined Modality Therapy; Fentanyl; Humans; Hypercapnia; Male; | 2015 |
Type III-IV muscle afferents are not required for steady-state exercise hyperpnea in healthy subjects and patients with COPD or heart failure.
Topics: Analgesics, Opioid; Electromyography; Exercise; Female; Fentanyl; Heart Failure; Heart Rate; Humans; | 2015 |
Inadvertent Endobronchial Intubation in a Patient With a Short Neck Length.
Topics: Anesthetics, Intravenous; Bronchi; Cholecystectomy, Laparoscopic; Fentanyl; Humans; Hypercapnia; Int | 2015 |
Isoflurane Sedation on the ICU in Cardiac Arrest Patients Treated With Targeted Temperature Management: An Observational Propensity-Matched Study.
Topics: Administration, Inhalation; Administration, Intravenous; Aged; Anesthetics, Inhalation; Anesthetics, | 2017 |
Isoflurane Sedation on the ICU in Cardiac Arrest Patients Treated With Targeted Temperature Management: An Observational Propensity-Matched Study.
Topics: Administration, Inhalation; Administration, Intravenous; Aged; Anesthetics, Inhalation; Anesthetics, | 2017 |
Isoflurane Sedation on the ICU in Cardiac Arrest Patients Treated With Targeted Temperature Management: An Observational Propensity-Matched Study.
Topics: Administration, Inhalation; Administration, Intravenous; Aged; Anesthetics, Inhalation; Anesthetics, | 2017 |
Isoflurane Sedation on the ICU in Cardiac Arrest Patients Treated With Targeted Temperature Management: An Observational Propensity-Matched Study.
Topics: Administration, Inhalation; Administration, Intravenous; Aged; Anesthetics, Inhalation; Anesthetics, | 2017 |
Control of breathing during dynamic exercise by thin fiber muscle afferents.
Topics: Analgesics, Opioid; Bicycling; Exercise; Feedback, Physiological; Fentanyl; Hemodynamics; Hemoglobin | 2010 |
Has intrathecal fentanyl no effects during arm exercise?
Topics: Adult; Analgesics, Opioid; Electromyography; Exercise; Feedback, Physiological; Fentanyl; Heart Rate | 2011 |
On the contribution of group III and IV muscle afferents to the circulatory response to rhythmic exercise in humans.
Topics: Adult; Blood Pressure; Carbon Dioxide; Cardiac Output; Exercise; Feedback; Fentanyl; Heart Rate; Hem | 2011 |
Effects of airway occlusion on breathing muscle electromyogram signals, during isoflurane anaesthesia, with and without the effects of fentanyl and hypercapnia.
Topics: Abdominal Muscles; Adult; Aged; Airway Obstruction; Analgesics, Opioid; Anesthetics, Inhalation; Car | 2011 |
Chest wall rigidity in two infants after low-dose fentanyl administration.
Topics: Analgesics, Opioid; Dose-Response Relationship, Drug; Female; Fentanyl; Follow-Up Studies; Humans; H | 2012 |
Anaesthesia for awake craniotomy--evolution of a technique that facilitates awake neurological testing.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Anesthesia; Anesthetics, Combined; Conscious Sedation; | 2003 |
Ancient gill and lung oscillators may generate the respiratory rhythm of frogs and rats.
Topics: Action Potentials; Analysis of Variance; Animals; Biological Clocks; Brain Stem; Dose-Response Relat | 2005 |
Fentanyl and cerebral vascular responsivity in dogs.
Topics: Animals; Blood Pressure; Brain; Carbon Dioxide; Cerebrovascular Circulation; Dogs; Female; Fentanyl; | 1984 |
Relationship between transcutaneous and arterial carbon dioxide tension in adult patients anesthetized with nitrous oxide-fentanyl and nitrous oxide-enflurane.
Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Carbon Dioxide; Enflurane; Fentanyl; Humans; Hyperc | 1981 |
Neuroleptanalgesia in the rabbit.
Topics: Acidosis; Animals; Butyrophenones; Diazepam; Drug Combinations; Etorphine; Fentanyl; Hypercapnia; Me | 1983 |
Rigidity and hypercarbia associated with high dose fentanyl induction of anesthesia.
Topics: Anesthesia, Intravenous; Fentanyl; Humans; Hypercapnia; Muscle Rigidity | 1981 |
Muscle rigidity causing life-threatening hypercapnia following fentanyl administration in a premature infant.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Fentanyl; Humans; Hypercapnia; Infant, Newborn; Infant | 1996 |
Fentanyl-induced chest wall rigidity and laryngospasm in preterm and term infants.
Topics: Fentanyl; Humans; Hypercapnia; Hypoxia; Infant, Newborn; Infant, Premature; Laryngismus; Naloxone; N | 2000 |
Fentanyl concentrations in brain and serum during respiratory acid--base changes in the dog.
Topics: Alkalosis, Respiratory; Anesthesia, General; Animals; Blood-Brain Barrier; Brain; Dogs; Fentanyl; Ha | 1979 |
[Naloxone as a drug for improving anesthesia results in children].
Topics: Adolescent; Anesthesia, Intravenous; Child; Child, Preschool; Depression, Chemical; Female; Fentanyl | 1979 |
Restlessness and shivering after naloxone reversal of fentanyl-supplemented anaesthesia.
Topics: Adult; Aged; Akathisia, Drug-Induced; Anesthesia, General; Body Temperature; Female; Fentanyl; Homeo | 1979 |
Narcotic reversal in hypercapnic dogs: comparison of naloxone and nalbuphine.
Topics: Analysis of Variance; Animals; Blood Pressure; Dogs; Epinephrine; Fentanyl; Heart Rate; Hypercapnia; | 1990 |
Cardiovascular effects of fentanyl reversal by naloxone at varying arterial carbon dioxide tensions in dogs.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cardiac Output; Dogs; Epinephrine; Fentanyl; Heart Rate; Hy | 1988 |
Anesthesia for laparoscopy.
Topics: Alphaprodine; Anesthesia; Anesthesia, Epidural; Anesthesia, General; Anesthesia, Local; Anesthetics; | 1974 |
Effects of fentanyl, droperidol, and innovar on canine cerebral metabolism and blood flow.
Topics: Animals; Benperidol; Blood Flow Velocity; Brain; Carbon Dioxide; Cerebrovascular Circulation; Dogs; | 1971 |
[On the significance of oxygen supply in drug induced central respiratory depression].
Topics: Animals; Apnea; Carbon Dioxide; Fentanyl; Hypercapnia; Hypoxia; Neuroleptanalgesia; Oxygen Consumpti | 1967 |