Page last updated: 2024-10-27

fentanyl and Heroin Dependence

fentanyl has been researched along with Heroin Dependence in 37 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Heroin Dependence: Strong dependence or addiction, both physiological and emotional, upon HEROIN.

Research Excerpts

ExcerptRelevanceReference
"The study aims to describe recent changes in Kentucky's drug overdose trends related to increased heroin and fentanyl involvement, and to discuss future directions for improved drug overdose surveillance."3.85Heroin and fentanyl overdoses in Kentucky: Epidemiology and surveillance. ( Bunn, TL; Costich, JF; Hargrove, SL; Ingram, V; Luu, H; Quesinberry, D; Ralston, W; Singleton, M; Slavova, S; Triplett, JS, 2017)
"Fentanyl has replaced heroin as a street drug for opioid dependent drug users."1.91Changing Landscape of Fentanyl/Heroin Use and Distribution. ( Bevins, N; Jensen, K; Pesce, A; Thomas, R; Tran, K, 2023)
"Pneumomediastinum is a rare complication of substance use, likely due to a Valsalva maneuver after drug inhalation."1.72Tension pneumomediastinum from opioid inhalation. ( Chicotka, S; Coffey, C; Hryniewicki, AT; Nene, RV; Odish, MF; Roderick, E; Thistlewaite, PA; Vazquez, MH, 2022)
"Sensitivity and specificity were lower for heroin (77."1.51Street fentanyl use: Experiences, preferences, and concordance between self-reports and urine toxicology. ( Carlson, RR; Daniulaityte, R; Juhascik, MP; Sizemore, IE; Strayer, KE, 2019)
"Carfentanil was detected along with other drugs in all cases with no alcohol detected in the post-mortem blood in any of the cases."1.48A Series of Deaths Involving Carfentanil in the UK and Associated Post-mortem Blood Concentrations. ( Elliott, SP; Hernandez Lopez, E, 2018)
"Heroin was the most frequently reported drug of choice (72%)."1.46Exposure to fentanyl-contaminated heroin and overdose risk among illicit opioid users in Rhode Island: A mixed methods study. ( Carroll, JJ; Green, TC; Marshall, BDL; Rich, JD, 2017)
"Fentanyl was commonly detected during this period with some clients having multiple fentanyl-positive UDS."1.46Characterizing fentanyl use in methadone-maintained clients. ( Arfken, CL; Greenwald, MK; Suchanek, J, 2017)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (13.51)29.6817
2010's24 (64.86)24.3611
2020's8 (21.62)2.80

Authors

AuthorsStudies
Nene, RV1
Hryniewicki, AT1
Roderick, E1
Chicotka, S1
Vazquez, MH1
Thistlewaite, PA1
Coffey, C1
Odish, MF1
Pesce, A1
Bevins, N1
Tran, K1
Thomas, R1
Jensen, K1
Ondocsin, J2
Holm, N1
Mars, SG2
Ciccarone, D3
Silverstein, SM1
Daniulaityte, R2
Martins, SS1
Miller, SC1
Carlson, RG1
Strickland, JC1
Victor, GA1
Jones, JD1
Sherwin, E1
Martinez, S1
Comer, SD1
Nowinski Konchak, J1
McGurk, K1
Hinami, K1
Vacchiano, M1
Aks, S1
Stevens, C1
Li, T1
Ton, E1
Zou, J1
Douglas, E1
Jones, P1
Dolan, SB1
Johnson, MW1
Dunn, KE1
Huhn, AS1
Carroll, JJ1
Marshall, BDL1
Rich, JD1
Green, TC2
Fairbairn, N1
Coffin, PO1
Walley, AY1
Unick, GJ1
Beletsky, L1
Davis, CS1
Slavova, S1
Costich, JF1
Bunn, TL1
Luu, H1
Singleton, M1
Hargrove, SL1
Triplett, JS1
Quesinberry, D1
Ralston, W1
Ingram, V1
Griswold, MK1
Chai, PR1
Krotulski, AJ1
Friscia, M1
Chapman, BP1
Varma, N1
Boyer, EW1
Logan, BK1
Babu, KM1
Dowell, D1
Noonan, RK1
Houry, D1
Raja, AS1
Miller, ES1
Flores, EJ1
Wakeman, SE1
Eng, G1
Elliott, SP1
Hernandez Lopez, E1
Ratycz, MC1
Papadimos, TJ1
Vanderbilt, AA1
Reardon, S1
Ochalek, TA1
Parker, MA1
Higgins, ST1
Sigmon, SC1
Fagiola, M1
Hahn, T1
Avella, J1
Palamar, JJ1
Salomone, A1
Bigiarini, R1
Vincenti, M1
Acosta, P1
Tofighi, B1
Schepis, TS1
McCabe, VV1
Boyd, CJ1
McCabe, SE1
Carlson, RR1
Juhascik, MP1
Strayer, KE1
Sizemore, IE1
Rouhani, S1
Park, JN1
Morales, KB1
Sherman, SG1
Rhodes, B1
Costenbader, B1
Wilson, L1
Hershow, R1
Carroll, J1
Zule, W1
Golin, C1
Brinkley-Rubinstein, L1
Stein, MD1
Kenney, SR1
Anderson, BJ1
Bailey, GL1
Fareed, A1
Buchanan-Cummings, AM1
Crampton, K1
Grant, A1
Drexler, K1
Erbas, B1
Arnold, M1
Arfken, CL1
Suchanek, J1
Greenwald, MK4
Roehrs, TA1
Perrone, J1
DeRoos, F1
Muller, AA1
Osterhoudt, KC1
Wingert, W1
Zubieta, J1
Lombardi, U1
Woods, JH1
Kilbourn, MR1
Jewett, DM1
Koeppe, RA1
Schuster, CR1
Johanson, CE1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pilot Study to Look at Feasibility of Testing and Treatment of Combination Fentanyl and Opioid Dependent Individuals With Different Buprenorphine Induction Methods[NCT04794790]Early Phase 130 participants (Anticipated)Interventional2022-05-09Recruiting
Impact of a Novel HIV Peer Navigation and Overdose Prevention Intervention on Engagement in the HIV Prevention and Treatment Cascade[NCT05977881]600 participants (Anticipated)Interventional2023-07-28Recruiting
Linking Opioid Dependent Patients From Inpatient Detoxification to Primary Care[NCT01751789]335 participants (Actual)Interventional2012-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for fentanyl and Heroin Dependence

ArticleYear
[Death from fentanyl: Causative and preventive approaches in Bavaria].
    MMW Fortschritte der Medizin, 2016, Feb-18, Volume: 158, Issue:3

    Topics: Analgesics, Opioid; Cause of Death; Chronic Pain; Drug Overdose; Drug Substitution; Fentanyl; German

2016

Trials

4 trials available for fentanyl and Heroin Dependence

ArticleYear
Naloxone-Induced Withdrawal in Individuals With and Without Fentanyl-Positive Urine Samples.
    The American journal on addictions, 2020, Volume: 29, Issue:1

    Topics: Adult; Female; Fentanyl; Heroin Dependence; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonist

2020
Mu-opioid self-administration vs passive administration in heroin abusers produces differential EEG activation.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:1

    Topics: Adult; Analgesics, Opioid; Double-Blind Method; Electroencephalography; Female; Fentanyl; Heroin Dep

2005
Opioid craving and seeking behavior in physically dependent volunteers: effects of acute withdrawal and drug reinforcement opportunity.
    Experimental and clinical psychopharmacology, 2005, Volume: 13, Issue:1

    Topics: Adult; Conditioning, Operant; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fentany

2005
Buprenorphine-induced changes in mu-opioid receptor availability in male heroin-dependent volunteers: a preliminary study.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2000, Volume: 23, Issue:3

    Topics: Adult; Analgesics, Opioid; Brain; Brain Chemistry; Buprenorphine; Double-Blind Method; Fentanyl; Her

2000

Other Studies

32 other studies available for fentanyl and Heroin Dependence

ArticleYear
Tension pneumomediastinum from opioid inhalation.
    The American journal of emergency medicine, 2022, Volume: 53

    Topics: Administration, Inhalation; Adult; Dyspnea; Fentanyl; Heroin Dependence; Humans; Male; Mediastinal E

2022
Changing Landscape of Fentanyl/Heroin Use and Distribution.
    Annals of clinical and laboratory science, 2023, Volume: 53, Issue:1

    Topics: Analgesics, Opioid; Drug Overdose; Fentanyl; Heroin; Heroin Dependence; Humans

2023
The motives and methods of methamphetamine and 'heroin' co-use in West Virginia.
    Harm reduction journal, 2023, 07-12, Volume: 20, Issue:1

    Topics: Adult; Female; Fentanyl; Health Knowledge, Attitudes, Practice; Heroin; Heroin Dependence; Humans; I

2023
"Everything is not right anymore": Buprenorphine experiences in an era of illicit fentanyl.
    The International journal on drug policy, 2019, Volume: 74

    Topics: Adult; Aged; Analgesics, Opioid; Buprenorphine; Drug Overdose; Female; Fentanyl; Heroin Dependence;

2019
Leveraging crowdsourcing methods to collect qualitative data in addiction science: Narratives of non-medical prescription opioid, heroin, and fentanyl use.
    The International journal on drug policy, 2020, Volume: 75

    Topics: Adult; Behavior, Addictive; Crowdsourcing; Data Collection; Feasibility Studies; Female; Fentanyl; H

2020
Effect of positive urine fentanyl screen on attitudes toward heroin use.
    Drug and alcohol dependence, 2020, 04-01, Volume: 209

    Topics: Adult; Analgesics, Opioid; Drug Overdose; Emergency Service, Hospital; Female; Fentanyl; Health Know

2020
Longitudinal Opioid Surveillance Project Involving Toxicologic Analysis of Postmortem Specimens from 9 Counties in Michigan Suggests the Discovery of New High-Intensity Drug Trafficking Areas.
    The American journal of forensic medicine and pathology, 2021, Sep-01, Volume: 42, Issue:3

    Topics: Adult; Analgesics, Opioid; Chromatography, Liquid; Drug Overdose; Drug Trafficking; Female; Fentanyl

2021
The discounting of death: Probability discounting of heroin use by fatal overdose likelihood and drug purity.
    Experimental and clinical psychopharmacology, 2021, Volume: 29, Issue:3

    Topics: Adult; Analgesics, Opioid; Attitude to Death; Drug Contamination; Drug Overdose; Female; Fentanyl; H

2021
Exposure to fentanyl-contaminated heroin and overdose risk among illicit opioid users in Rhode Island: A mixed methods study.
    The International journal on drug policy, 2017, Volume: 46

    Topics: Adolescent; Adult; Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Drug Contamination;

2017
Naloxone for heroin, prescription opioid, and illicitly made fentanyl overdoses: Challenges and innovations responding to a dynamic epidemic.
    The International journal on drug policy, 2017, Volume: 46

    Topics: Analgesics, Opioid; Community Health Services; Drug Overdose; Fentanyl; Heroin; Heroin Dependence; H

2017
US regional and demographic differences in prescription opioid and heroin-related overdose hospitalizations.
    The International journal on drug policy, 2017, Volume: 46

    Topics: Adult; Analgesics, Opioid; Drug Overdose; Female; Fentanyl; Heroin; Heroin Dependence; Hospitalizati

2017
Today's fentanyl crisis: Prohibition's Iron Law, revisited.
    The International journal on drug policy, 2017, Volume: 46

    Topics: Analgesics, Opioid; Fentanyl; Harm Reduction; Heroin; Heroin Dependence; Humans; Illicit Drugs; Opio

2017
Heroin uncertainties: Exploring users' perceptions of fentanyl-adulterated and -substituted 'heroin'.
    The International journal on drug policy, 2017, Volume: 46

    Topics: Adult; Drug Contamination; Drug Overdose; Drug Users; Female; Fentanyl; Harm Reduction; Heroin; Hero

2017
Heroin and fentanyl overdoses in Kentucky: Epidemiology and surveillance.
    The International journal on drug policy, 2017, Volume: 46

    Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Drug Contamination; Drug Overdose; Female; Fentanyl; He

2017
A Novel Oral Fluid Assay (LC-QTOF-MS) for the Detection of Fentanyl and Clandestine Opioids in Oral Fluid After Reported Heroin Overdose.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2017, Volume: 13, Issue:4

    Topics: Adolescent; Analgesics, Opioid; Chromatography, Liquid; Drug Contamination; Drug Overdose; Emergency

2017
Underlying Factors in Drug Overdose Deaths.
    JAMA, 2017, Dec-19, Volume: 318, Issue:23

    Topics: Analgesics, Opioid; Drug Overdose; Fentanyl; Heroin Dependence; Humans; Illicit Drugs; Mortality; Na

2017
Case 37-2017. A 36-Year-Old Man with Unintentional Opioid Overdose.
    The New England journal of medicine, 2017, Nov-30, Volume: 377, Issue:22

    Topics: Adult; Analgesics, Opioid; Drug Overdose; Fentanyl; Heroin; Heroin Dependence; Humans; Hypoxia; Lung

2017
A Series of Deaths Involving Carfentanil in the UK and Associated Post-mortem Blood Concentrations.
    Journal of analytical toxicology, 2018, May-01, Volume: 42, Issue:4

    Topics: Adult; Analgesics, Opioid; Cocaine-Related Disorders; Female; Fentanyl; Forensic Toxicology; Heroin

2018
Addressing the growing opioid and heroin abuse epidemic: a call for medical school curricula.
    Medical education online, 2018, Volume: 23, Issue:1

    Topics: Analgesics, Opioid; Awareness; Education, Medical; Fentanyl; Heroin Dependence; Humans; Opioid-Relat

2018
How digital drug users could help to halt the US opioid epidemic.
    Nature, 2018, Volume: 560, Issue:7718

    Topics: Computer Simulation; Drug Overdose; Drug Tolerance; Drug Users; Drug Utilization; Emergency Service,

2018
Fentanyl exposure among patients seeking opioid treatment.
    Journal of substance abuse treatment, 2019, Volume: 96

    Topics: Adult; Fentanyl; Heroin Dependence; Humans; Opioid-Related Disorders; Prevalence; Substance Abuse De

2019
Five Postmortem Case Reports with Qualitative Analysis of Cyclopropylfentanyl by LC-MS-MS.
    Journal of analytical toxicology, 2019, May-01, Volume: 43, Issue:4

    Topics: Adult; Autopsy; Cause of Death; Chromatography, Liquid; Drug Overdose; Fatal Outcome; Female; Fentan

2019
Testing hair for fentanyl exposure: a method to inform harm reduction behavior among individuals who use heroin.
    The American journal of drug and alcohol abuse, 2019, Volume: 45, Issue:1

    Topics: Adult; Analgesics, Opioid; Chromatography, High Pressure Liquid; Female; Fentanyl; Hair; Harm Reduct

2019
The epidemiology of prescription fentanyl misuse in the United States.
    Addictive behaviors, 2019, Volume: 96

    Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Child; Female; Fentanyl; Health Surveys; Heroin Depende

2019
Street fentanyl use: Experiences, preferences, and concordance between self-reports and urine toxicology.
    The International journal on drug policy, 2019, Volume: 71

    Topics: Adult; Chromatography, Liquid; Female; Fentanyl; Health Knowledge, Attitudes, Practice; Heroin Depen

2019
Harm reduction measures employed by people using opioids with suspected fentanyl exposure in Boston, Baltimore, and Providence.
    Harm reduction journal, 2019, 06-24, Volume: 16, Issue:1

    Topics: Adult; Aged; Analgesics, Opioid; Baltimore; Black or African American; Boston; Cross-Sectional Studi

2019
Urban, individuals of color are impacted by fentanyl-contaminated heroin.
    The International journal on drug policy, 2019, Volume: 73

    Topics: Adult; Aged; Drug Contamination; Drug Overdose; Female; Fentanyl; Heroin; Heroin Dependence; Humans;

2019
Perceptions about fentanyl-adulterated heroin and overdose risk reduction behaviors among persons seeking treatment for heroin use.
    Journal of substance abuse treatment, 2019, Volume: 104

    Topics: Adult; Analgesics, Opioid; Drug Overdose; Female; Fentanyl; Health Knowledge, Attitudes, Practice; H

2019
Reversal of overdose on fentanyl being illicitly sold as heroin with naloxone nasal spray: A case report.
    The American journal on addictions, 2015, Volume: 24, Issue:5

    Topics: Buprenorphine, Naloxone Drug Combination; Drug Overdose; Fentanyl; First Aid; Heroin; Heroin Depende

2015
Characterizing fentanyl use in methadone-maintained clients.
    Journal of substance abuse treatment, 2017, Volume: 75

    Topics: Female; Fentanyl; Heroin Dependence; Humans; Male; Methadone; Michigan; Middle Aged; Opiate Substitu

2017
The new high. EMS crews confronted with heroin-fentanyl ODs.
    JEMS : a journal of emergency medical services, 2007, Volume: 32, Issue:1

    Topics: Drug Overdose; Emergency Medical Services; Fentanyl; Heroin Dependence; Humans; United States

2007
Heroin: what's in the mix?
    Annals of emergency medicine, 2007, Volume: 50, Issue:3

    Topics: Clenbuterol; Fentanyl; Heroin; Heroin Dependence; Humans; Illicit Drugs; Quinine; Scopolamine; Xylaz

2007