fentanyl and Hemorrhage studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Research Excerpts

Excerpt	Relevance	Reference
" alfentanil in 66 unpremedicated patients undergoing suction termination of pregnancy as outpatients."	9.05	Outpatient termination of pregnancy: halothane or alfentanil-supplemented anaesthesia. ( Collins, KM; Doyle, JP; Plantevin, OM; Whitburn, RH, 1985)
"Sprague-Dawley rats (11-13 weeks) were randomly assigned to control (saline vehicle), fentanyl, or ketamine-treated groups with or without hemorrhage (n = 8 or 9 for each group)."	7.96	Fentanyl impairs but ketamine preserves the microcirculatory response to hemorrhage. ( Calderon, AS; Hinojosa-Laborde, C; Klemcke, HG; Ryan, KL; Scott, LL; Xiang, L, 2020)
" Propofol-based anesthesia is favored in order to enhance TcMEP quality."	7.88	Changes in transcranial motor evoked potentials during hemorrhage are associated with increased serum propofol concentrations. ( Feiner, J; Jasiukaitis, P; Lieberman, JA; Lyon, R; Rollins, M, 2018)
"Possible modulatory effects of mu-, delta-, and kappa-receptor agonists on the concurrent adrenal secretion of catecholamines and met-enkephalin evoked by staged hemorrhage were examined in four groups of cats (n = 5 in each group) anesthetized with halothane (1 MAC)."	7.67	Opioids preserve the adrenal medullary response evoked by severe hemorrhage: studies on adrenal catecholamine and met-enkephalin secretion in halothane anesthetized cats. ( Gaumann, DM; Lucas, DL; Tyce, GM; Yaksh, TL, 1988)
"Hemorrhage is a leading cause of battlefield and civilian trauma deaths."	7.11	Low-dose fentanyl does not alter muscle sympathetic nerve activity, blood pressure, or tolerance during progressive central hypovolemia. ( Belval, LN; Cimino, FA; Crandall, CG; Fischer, M; Hendrix, JM; Huang, M; Jarrard, CP; Laborde, CH; Watso, JC, 2022)
"Diffuse alveolar hemorrhage is a rare complication of fentanyl overdose."	5.43	Intranasal Fentanyl Intoxication Leading to Diffuse Alveolar Hemorrhage. ( Dunham, M; Ruzycki, S; Sadrzadeh, H; Tremblay, A; Yarema, M, 2016)
" alfentanil in 66 unpremedicated patients undergoing suction termination of pregnancy as outpatients."	5.05	Outpatient termination of pregnancy: halothane or alfentanil-supplemented anaesthesia. ( Collins, KM; Doyle, JP; Plantevin, OM; Whitburn, RH, 1985)
"Sprague-Dawley rats (11-13 weeks) were randomly assigned to control (saline vehicle), fentanyl, or ketamine-treated groups with or without hemorrhage (n = 8 or 9 for each group)."	3.96	Fentanyl impairs but ketamine preserves the microcirculatory response to hemorrhage. ( Calderon, AS; Hinojosa-Laborde, C; Klemcke, HG; Ryan, KL; Scott, LL; Xiang, L, 2020)
" Propofol-based anesthesia is favored in order to enhance TcMEP quality."	3.88	Changes in transcranial motor evoked potentials during hemorrhage are associated with increased serum propofol concentrations. ( Feiner, J; Jasiukaitis, P; Lieberman, JA; Lyon, R; Rollins, M, 2018)
"Possible modulatory effects of mu-, delta-, and kappa-receptor agonists on the concurrent adrenal secretion of catecholamines and met-enkephalin evoked by staged hemorrhage were examined in four groups of cats (n = 5 in each group) anesthetized with halothane (1 MAC)."	3.67	Opioids preserve the adrenal medullary response evoked by severe hemorrhage: studies on adrenal catecholamine and met-enkephalin secretion in halothane anesthetized cats. ( Gaumann, DM; Lucas, DL; Tyce, GM; Yaksh, TL, 1988)
"Hemorrhage is a leading cause of preventable battlefield and civilian trauma deaths."	3.30	Comparing the Effects of Low-Dose Ketamine, Fentanyl, and Morphine on Hemorrhagic Tolerance and Analgesia in Humans. ( Belval, LN; Cramer, MN; Crandall, CG; Foster, J; Hendrix, JM; Hinojosa-Laborde, C; Huang, M; Moralez, G; Watso, JC, 2023)
"Hemorrhage is a leading cause of battlefield and civilian trauma deaths."	3.11	Low-dose fentanyl does not alter muscle sympathetic nerve activity, blood pressure, or tolerance during progressive central hypovolemia. ( Belval, LN; Cimino, FA; Crandall, CG; Fischer, M; Hendrix, JM; Huang, M; Jarrard, CP; Laborde, CH; Watso, JC, 2022)
"A fentanyl bolus was administered to 8 of 10 dogs treated with fentanyl and to none treated with TA."	2.78	Perioperative evaluation of tumescent anaesthesia technique in bitches submitted to unilateral mastectomy. ( Credie, Lde F; da Silva, LC; de Carvalho, LR; Futema, F; Garcia, JN; Gomes, GB; Luna, SP, 2013)
"Diffuse alveolar hemorrhage is a rare complication of fentanyl overdose."	1.43	Intranasal Fentanyl Intoxication Leading to Diffuse Alveolar Hemorrhage. ( Dunham, M; Ruzycki, S; Sadrzadeh, H; Tremblay, A; Yarema, M, 2016)

Research

Studies (29)

Authors

Clinical Trials (5)

Trial Overview

Trial Outcomes

Number of Participants Experiencing Side Effects (Nausea, Dizziness)

Number of Participants Needing Intervention to Treat Blood Loss (a Composite of Use of Uterotonics, Re-aspiration, and Bimanual Massage)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (58.62)	18.7374
1990's	1 (3.45)	18.2507
2000's	4 (13.79)	29.6817
2010's	4 (13.79)	24.3611
2020's	3 (10.34)	2.80

Authors	Studies
Huang, M	2
Watso, JC	2
Belval, LN	2
Cimino, FA	1
Fischer, M	1
Jarrard, CP	1
Hendrix, JM	2
Laborde, CH	1
Crandall, CG	2
Moralez, G	1
Cramer, MN	1
Foster, J	1
Hinojosa-Laborde, C	2
Xiang, L	1
Calderon, AS	1
Klemcke, HG	1
Scott, LL	1
Ryan, KL	1
Lieberman, JA	1
Feiner, J	1
Rollins, M	1
Lyon, R	1
Jasiukaitis, P	1
Credie, Lde F	1
Luna, SP	1
Futema, F	1
da Silva, LC	1
Gomes, GB	1
Garcia, JN	1
de Carvalho, LR	1
Ruzycki, S	1
Yarema, M	1
Dunham, M	1
Sadrzadeh, H	1
Tremblay, A	1
Silva, C	1
Pinheiro, F	1
Chieira, D	1
Marques, S	1
Órfão, MR	1
O'Flaherty, JE	1
Lin, CX	1
Takizawa, D	1
Sato, E	1
Kurosaki, D	1
Hiraoka, H	1
Saito, S	1
Goto, F	1
Disma, N	1
Astuto, M	1
Giorgio, AD	1
Russo, G	1
Lehtinen, AM	1
Meites, G	1
Portecazaux, A	1
Pessey, JJ	1
Modig, J	1
Borg, T	1
Karlström, G	1
Maripuu, E	1
Sahlstedt, B	1
Woodward, G	1
Grigor'ev, MG	1
Beliakov, VA	1
Kalachev, SA	1
Dilger, JA	1
Tetzlaff, JE	1
Bell, GR	1
Kosmorsky, GS	1
Agnor, RC	1
O'Hara, JF	1
Brookes, ZL	1
Brown, NJ	1
Reilly, CS	1
Fishburne, JI	1
Esclamado, RM	1
Glenn, MG	1
McCulloch, TM	1
Cummings, CW	1
Gaumann, DM	1
Yaksh, TL	1
Tyce, GM	1
Lucas, DL	1
Saini, V	1
Carr, DB	1
Hagestad, EL	1
Lown, B	1
Verrier, RL	1
Collins, KM	1
Plantevin, OM	1
Whitburn, RH	1
Doyle, JP	1
Patel, S	1
McNeill, TW	1
DeWald, RL	1
Kuo, KN	1
Bennett, EJ	1
Salem, MR	1
Skoblin, AP	1
Grabovoĭ, AF	1
Semergeĭ, IK	1
Skovsted, P	1
Misfeldt, BB	1
Mogensen, JV	1
Brockner, J	1
Bond, RF	1
Roberts, DE	1
Manning, ES	1
Knape, H	1
Pacelli, L	1
Liverta, E	1
Achilli, M	1
Movilia, PG	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Evaluation of Treatment Effect of Cervical Collar in Moderate Obstructive Sleep Apnea[NCT03754270]		100 participants (Actual)	Interventional	2019-06-16	Completed
The Association of CPAP Compliance and Nocturnal Hypoxemia in the Perioperative Period[NCT02796846]		158 participants (Actual)	Observational	2015-06-30	Completed
Evaluation of Screening Tools for OSA in Hospitalized Medical Patients: A Validation Study[NCT01340781]		110 participants (Actual)	Observational	2012-02-29	Completed
The Effect of Acute Intravenous Morphine Administration on Sleep Disordered Breathing (SDB) in Patients With Moderate Obstructive Sleep Apnoea (OSA): A Paired Design Trial[NCT03127800]	Phase 3	6 participants (Actual)	Interventional	2016-05-20	Terminated (stopped due to Difficulties with recruitment)
Sevoflurane as an Anesthetic During Dilation and Evacuation Procedures: Does it Increase Blood Loss and Interventions for Blood Loss and Why Do Anesthesiologists Choose to Use It?[NCT01048658]	Phase 4	160 participants (Actual)	Interventional	2009-09-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	Participants (Count of Participants)
Sevoflurane	13
No Sevoflurane	11

Provider report for need to intervene due to blood loss (yes/no) (NCT01048658)
Timeframe: At time of uterine evacuation and immediately post-operatively, an average of 7.1 minutes

Number of Participants With Estimated Blood Loss Greater Than 300 mL (Yes/no)

Intervention	Participants (Count of Participants)
Sevoflurane	20
No Sevoflurane	13

Procedural blood loss greater than 300 mL. Blood loss was measured in a standardized fashion (amniotic fluid was discarded, blood was separated from tissue, and all gauze surgical drapes weighed). (NCT01048658)
Timeframe: At time of uterine evacuation, an average of 7.1 minutes

Procedure Time: T-test (Time of Speculum Placement to Time Speculum Removed)

Intervention	Participants (Count of Participants)
Sevoflurane	12
No Sevoflurane	6

Length of procedure from time of speculum placement to time of speculum removal, in minutes. (NCT01048658)
Timeframe: Time of speculum place to time of speculum removal, an average of 7.1 minutes

Patient and Provider Satisfaction With Anesthesia

Intervention	minutes (Mean)
Sevoflurane	7.0
No Sevoflurane	7.3

Scores reported on 10-cm Visual Analog Scale (VAS anchors: 0= not satisfied at all, 10= completely satisfied) . Reported as mean +/- standard deviation. Subjects and providers were blinded to anesthesia method. Subjects and providers completed post-operative questionnaire within 30 minutes of procedure completion. (NCT01048658)
Timeframe: Post-procedure, within 30 minutes

Article	Year
Low-dose fentanyl does not alter muscle sympathetic nerve activity, blood pressure, or tolerance during progressive central hypovolemia. American journal of physiology. Regulatory, integrative and comparative physiology, 2022, 01-01, Volume: 322, Issue:1 Topics: Adult; Analgesics, Opioid; Blood Pressure; Cardiovascular System; Cross-Over Studies; Double-Blind M	2022
Comparing the Effects of Low-Dose Ketamine, Fentanyl, and Morphine on Hemorrhagic Tolerance and Analgesia in Humans. Prehospital emergency care, 2023, Volume: 27, Issue:5 Topics: Adult; Analgesia; Analgesics; Analgesics, Opioid; Cross-Over Studies; Emergency Medical Services; Fe	2023
Perioperative evaluation of tumescent anaesthesia technique in bitches submitted to unilateral mastectomy. BMC veterinary research, 2013, Sep-11, Volume: 9 Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Dog Diseases; Dogs; Female; Fentanyl; Hemorrhage; I	2013
Does ketamine or magnesium affect posttonsillectomy pain in children? Paediatric anaesthesia, 2003, Volume: 13, Issue:5 Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Dissociative; Child; Child	2003
Thromboembolism after total hip replacement: role of epidural and general anesthesia. Anesthesia and analgesia, 1983, Volume: 62, Issue:2 Topics: Aged; Anesthesia, Epidural; Anesthesia, General; Bupivacaine; Epinephrine; Female; Fentanyl; Hemorrh	1983
Intraoperative blood loss in midtrimester dilatation and extraction. Obstetrics and gynecology, 1983, Volume: 62, Issue:1 Topics: Abortion, Induced; Dilatation; Epinephrine; Female; Fentanyl; Hemorrhage; Humans; Intraoperative Com	1983
Outpatient termination of pregnancy: halothane or alfentanil-supplemented anaesthesia. British journal of anaesthesia, 1985, Volume: 57, Issue:12 Topics: Abortion, Induced; Adjuvants, Anesthesia; Adolescent; Adult; Alfentanil; Ambulatory Surgical Procedu	1985

Article	Year
Fentanyl impairs but ketamine preserves the microcirculatory response to hemorrhage. The journal of trauma and acute care surgery, 2020, Volume: 89, Issue:2S Suppl 2 Topics: Administration, Topical; Analgesics; Analgesics, Opioid; Animals; Blood Pressure; Fentanyl; Heart Ra	2020
Changes in transcranial motor evoked potentials during hemorrhage are associated with increased serum propofol concentrations. Journal of clinical monitoring and computing, 2018, Volume: 32, Issue:3 Topics: Anesthesia; Anesthetics, Intravenous; Animals; Arterial Pressure; Blood Pressure; Cardiac Output; El	2018
Intranasal Fentanyl Intoxication Leading to Diffuse Alveolar Hemorrhage. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2016, Volume: 12, Issue:2 Topics: Administration, Inhalation; Alberta; Analgesics, Opioid; Combined Modality Therapy; Diagnosis, Diffe	2016
Anesthetic Management of an Acute Bleeding Ventriculo-Cutaneous Fistula. Journal of cardiothoracic and vascular anesthesia, 2016, Volume: 30, Issue:5 Topics: Aged, 80 and over; Androstanols; Anesthesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Cuta	2016
Changes in unbound concentration of propofol during hemorrhage. Clinical pharmacology and therapeutics, 2005, Volume: 78, Issue:1 Topics: Anesthesia; Blood Pressure; Blood Transfusion; Dopamine; Female; Fentanyl; Heart Rate; Hemorrhage; H	2005
Scurvy: a disease of anesthetic interest? Scurvy and anesthesia. Paediatric anaesthesia, 2008, Volume: 18, Issue:7 Topics: Airway Obstruction; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Ascorbic	2008
Opiate action on adenohypophyseal hormone secretion during anesthesia and gynecologic surgery in different phases of the menstrual cycle. Acta anaesthesiologica Scandinavica. Supplementum, 1981, Volume: 73 Topics: Adult; Anesthesia; Anesthesia, General; Anesthesia, Inhalation; Endorphins; Female; Fentanyl; Genita	1981
[Importance of flunitrazepam for the reduction of bleeding in rhinoplasty]. Cahiers d'anesthesiologie, 1984, Volume: 32, Issue:8 Suppl Topics: Adolescent; Adult; Female; Fentanyl; Flunitrazepam; Hemorrhage; Humans; Intraoperative Complications	1984
[Role of hypervolemic hemodilution and controlled hypotension in decreasing the blood loss during traumatic operations]. Sovetskaia meditsina, 1980, Issue:8 Topics: Adolescent; Adult; Blood Volume; Child; Child, Preschool; Female; Fentanyl; Hemodilution; Hemorrhage	1980
Ischaemic optic neuropathy after spinal fusion. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:1 Topics: Adult; Anesthesia, Intravenous; Anesthetics, Inhalation; Anesthetics, Intravenous; Blood Loss, Surgi	1998
Differential effects of intravenous anaesthetic agents on the response of rat mesenteric microcirculation in vivo after haemorrhage. British journal of anaesthesia, 2002, Volume: 88, Issue:2 Topics: Anesthetics, Combined; Anesthetics, Intravenous; Animals; Fentanyl; Hemodynamics; Hemorrhage; Ketami	2002
Office laparoscopic sterilization with local anesthesia. The Journal of reproductive medicine, 1977, Volume: 18, Issue:5 Topics: Adult; Anesthesia, Local; Bupivacaine; Female; Fentanyl; Hemorrhage; Humans; Laparoscopy; Middle Age	1977
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome. The Laryngoscope, 1989, Volume: 99, Issue:11 Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem	1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome. The Laryngoscope, 1989, Volume: 99, Issue:11 Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem	1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome. The Laryngoscope, 1989, Volume: 99, Issue:11 Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem	1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome. The Laryngoscope, 1989, Volume: 99, Issue:11 Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem	1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome. The Laryngoscope, 1989, Volume: 99, Issue:11 Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem	1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome. The Laryngoscope, 1989, Volume: 99, Issue:11 Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem	1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome. The Laryngoscope, 1989, Volume: 99, Issue:11 Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem	1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome. The Laryngoscope, 1989, Volume: 99, Issue:11 Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem	1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome. The Laryngoscope, 1989, Volume: 99, Issue:11 Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem	1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome. The Laryngoscope, 1989, Volume: 99, Issue:11 Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem	1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome. The Laryngoscope, 1989, Volume: 99, Issue:11 Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem	1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome. The Laryngoscope, 1989, Volume: 99, Issue:11 Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem	1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome. The Laryngoscope, 1989, Volume: 99, Issue:11 Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem	1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome. The Laryngoscope, 1989, Volume: 99, Issue:11 Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem	1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome. The Laryngoscope, 1989, Volume: 99, Issue:11 Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem	1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome. The Laryngoscope, 1989, Volume: 99, Issue:11 Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem	1989
Opioids preserve the adrenal medullary response evoked by severe hemorrhage: studies on adrenal catecholamine and met-enkephalin secretion in halothane anesthetized cats. Anesthesiology, 1988, Volume: 68, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenal Me	1988
Intraoperative therapy for massive blood loss. Middle East journal of anaesthesiology, 1986, Volume: 8, Issue:4 Topics: Adult; Anesthesia, Intravenous; Blood Coagulation Disorders; Blood Transfusion; Fentanyl; Fluid Ther	1986
Controlled hypotensive anesthesia in scoliosis surgery. The Journal of bone and joint surgery. American volume, 1974, Volume: 56, Issue:6 Topics: Adjuvants, Anesthesia; Anesthesia, Inhalation; Benperidol; Child; Fentanyl; Halothane; Hemorrhage; H	1974
[Resuscitative-anesthesiologic provisions in extensive surgical operations in the thorax and spine for scoliosis]. Vestnik khirurgii imeni I. I. Grekova, 1974, Volume: 112, Issue:2 Topics: Adolescent; Adult; Anesthesia, Endotracheal; Child; Fentanyl; Hemorrhage; Humans; Hypotension, Contr	1974
The effects of anesthesia on blood loss at caesarean section. Acta anaesthesiologica Scandinavica, 1973, Volume: 17, Issue:3 Topics: Adult; Anesthesia, General; Anesthesia, Obstetrical; Blood Transfusion; Cesarean Section; Droperidol	1973
Effects of anesthetics on myocardial contractility and total body O2 consumption during hemorrhage. Archives internationales de pharmacodynamie et de therapie, 1973, Volume: 204, Issue:2 Topics: Anesthesia, Intravenous; Anesthetics; Animals; Blood Pressure; Chloralose; Dogs; Droperidol; Female;	1973
A comparison of neuroleptanesthesia and halothane in neurosurgery. Archivum chirurgicum Neerlandicum, 1970, Volume: 22, Issue:4 Topics: Adolescent; Adult; Aged; Anesthesia, Inhalation; Blood Pressure; Child; Consciousness; Female; Fenta	1970
[Technics of general anesthesia to control bleeding in nasal surgery]. Annali di laringologia, otologia, rinologia, faringologia, 1968, Volume: 67, Issue:2 Topics: Adolescent; Adult; Aged; Anesthesia, General; Benperidol; Drainage; Fentanyl; Halothane; Hemorrhage;	1968

fentanyl and Hemorrhage