fentanyl has been researched along with Heart Failure in 17 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this pilot study, the preadministration of intranasal fentanyl prior to activity in palliative, end-stage hospitalized heart failure patients, safely reduced tachypnea, and the feeling of shortness of breath." | 7.91 | The Use of Intranasal Fentanyl for the Palliation of Incident Dyspnea in Advanced Congestive Heart Failure: A Pilot Study. ( Malik, A; Pedersen, A; Pilkey, J; Tam, JW; Wong, J, 2019) |
| "To evaluate the efficacy and safety of oral transmucosal fentanyl citrate (OTFC) in terminally ill patients experiencing dyspnea." | 7.74 | Oral transmucosal fentanyl citrate for dyspnea in terminally ill patients: an observational case series. ( Gauna, AA; Kang, SK; Swatko, ER; Triano, ML; Vanston, VJ, 2008) |
| "Secondary pulmonary hypertension is common in heart failure (HF) patients." | 6.80 | Intrathecal fentanyl blockade of afferent neural feedback from skeletal muscle during exercise in heart failure patients: Influence on circulatory power and pulmonary vascular capacitance. ( Johnson, BD; Joyner, MJ; Olson, TP; Snyder, EM; Van Iterson, EH, 2015) |
| "In this pilot study, the preadministration of intranasal fentanyl prior to activity in palliative, end-stage hospitalized heart failure patients, safely reduced tachypnea, and the feeling of shortness of breath." | 3.91 | The Use of Intranasal Fentanyl for the Palliation of Incident Dyspnea in Advanced Congestive Heart Failure: A Pilot Study. ( Malik, A; Pedersen, A; Pilkey, J; Tam, JW; Wong, J, 2019) |
| "To evaluate the efficacy and safety of oral transmucosal fentanyl citrate (OTFC) in terminally ill patients experiencing dyspnea." | 3.74 | Oral transmucosal fentanyl citrate for dyspnea in terminally ill patients: an observational case series. ( Gauna, AA; Kang, SK; Swatko, ER; Triano, ML; Vanston, VJ, 2008) |
| "Secondary pulmonary hypertension is common in heart failure (HF) patients." | 2.80 | Intrathecal fentanyl blockade of afferent neural feedback from skeletal muscle during exercise in heart failure patients: Influence on circulatory power and pulmonary vascular capacitance. ( Johnson, BD; Joyner, MJ; Olson, TP; Snyder, EM; Van Iterson, EH, 2015) |
| "In patients with chronic obstructive pulmonary disease (COPD), IF also elicits sustained decreases in the exercise ventilatory response but with little or no resultant CO2 retention due to concomitant decreases in physiological VD/VT (dead space-to-ventilation ratio)." | 1.42 | Type III-IV muscle afferents are not required for steady-state exercise hyperpnea in healthy subjects and patients with COPD or heart failure. ( Poon, CS; Song, G, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 3 (17.65) | 29.6817 |
| 2010's | 5 (29.41) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Smith, JR | 1 |
| Hart, CR | 1 |
| Ramos, PA | 1 |
| Akinsanya, JG | 1 |
| Lanza, IR | 1 |
| Joyner, MJ | 2 |
| Curry, TB | 1 |
| Olson, TP | 2 |
| Pilkey, J | 1 |
| Pedersen, A | 1 |
| Tam, JW | 1 |
| Malik, A | 1 |
| Wong, J | 1 |
| Tsukinaga, A | 1 |
| Irie, T | 1 |
| Uchimoto, K | 1 |
| Miyashita, T | 1 |
| Goto, T | 1 |
| Poon, CS | 1 |
| Song, G | 1 |
| Van Iterson, EH | 1 |
| Snyder, EM | 1 |
| Johnson, BD | 1 |
| Ives, SJ | 1 |
| Amann, M | 1 |
| Venturelli, M | 1 |
| Witman, MA | 1 |
| Groot, HJ | 1 |
| Wray, DW | 1 |
| Morgan, DE | 1 |
| Stehlik, J | 1 |
| Richardson, RS | 1 |
| Bolte, C | 1 |
| Newman, G | 1 |
| Schultz, Jel J | 1 |
| Gauna, AA | 1 |
| Kang, SK | 1 |
| Triano, ML | 1 |
| Swatko, ER | 1 |
| Vanston, VJ | 1 |
| Salehi, E | 1 |
| Müssiggang, H | 1 |
| Olivier, P | 1 |
| D'Attellis, N | 1 |
| Baron, JF | 1 |
| Myles, PS | 1 |
| Hall, JL | 1 |
| Berry, CB | 1 |
| Esmore, DS | 1 |
| Hickey, PR | 1 |
| Retzack, SM | 1 |
| Shiraishi, M | 1 |
| Murayama, K | 1 |
| Hanzawa, K | 1 |
| Warabi, K | 1 |
| Kamiyama, Y | 1 |
| Kubota, T | 1 |
| Hirota, K | 1 |
| Yoshida, H | 1 |
| Yatsu, Y | 1 |
| Maeda, A | 1 |
| Matsuki, A | 1 |
| Sterz, H | 1 |
| Freeman, AB | 1 |
| Steinbrook, RA | 1 |
| Tevelenok, IuA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Premature Fatigue in Veterans With Heart Failure: Neuronal Influences[NCT02209610] | Early Phase 1 | 32 participants (Actual) | Interventional | 2015-07-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Following dynamic single leg knee extension exercise for a given duration (4-8 min), the decline in maximal voluntary contraction force will be measured. (NCT02209610)
Timeframe: 1 minute after exercise on study day
| Intervention | percentage change (Mean) |
|---|---|
| Patients With Heart Failure: Neuromuscular Abnormalities | -30 |
| Health Control Subjects and Neuromuscular Function | -5 |
Corticospinal responsiveness will be quantified before and after exercise. (NCT02209610)
Timeframe: 1 minute after exercise on study day
| Intervention | percent change (Mean) |
|---|---|
| Patients With Heart Failure: Neuromuscular Abnormalities | -30 |
| Health Control Subjects and Neuromuscular Function | 10 |
During a 2-min maximal voluntary quadriceps contraction, central and peripheral fatigue will develop progressively and significantly more in HF vs. CTRLs. (NCT02209610)
Timeframe: During (20 second intervals) and 1 minute after exercise on study day
| Intervention | percentage change (Mean) | |
|---|---|---|
| Twitch force | Voluntary activation [VA] | |
| Health Control Subjects and Neuromuscular Function | -35 | -20 |
| Patients With Heart Failure: Neuromuscular Abnormalities | -60 | -25 |
1 review available for fentanyl and Heart Failure
| Article | Year |
|---|---|
[New aspects in the treatment of acute cardiac insufficiency].
Topics: Adrenergic beta-Antagonists; Clonidine; Diazoxide; Digitalis Glycosides; Diuretics; Droperidol; Fent | 1978 |
2 trials available for fentanyl and Heart Failure
| Article | Year |
|---|---|
Intrathecal fentanyl blockade of afferent neural feedback from skeletal muscle during exercise in heart failure patients: Influence on circulatory power and pulmonary vascular capacitance.
Topics: Aged; Analgesics, Opioid; Cross-Over Studies; Electrocardiography; Exercise; Female; Fentanyl; Heart | 2015 |
Haemodynamic comparison of propofol-fentanyl anaesthesia with midazolam-fentanyl anaesthesia in CABG patients without preoperative heart failure.
Topics: Aged; Anesthesia, Intravenous; Anesthetics, Intravenous; Coronary Artery Bypass; Female; Fentanyl; H | 2000 |
14 other studies available for fentanyl and Heart Failure
| Article | Year |
|---|---|
Metabo- and mechanoreceptor expression in human heart failure: Relationships with the locomotor muscle afferent influence on exercise responses.
Topics: Acid Sensing Ion Channels; Afferent Pathways; Aged; Case-Control Studies; Cyclooxygenase 2; Exercise | 2020 |
The Use of Intranasal Fentanyl for the Palliation of Incident Dyspnea in Advanced Congestive Heart Failure: A Pilot Study.
Topics: Administration, Intranasal; Aged; Aged, 80 and over; Analgesics, Opioid; Dyspnea; Female; Fentanyl; | 2019 |
[A Case of Combined Spinal-Epidural Anesthesia for Cesarean Section in a Patient with Right Heart Failure due to Supravalvular Pulmonary Stenosis after Jatene Operation].
Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Arteri | 2016 |
Type III-IV muscle afferents are not required for steady-state exercise hyperpnea in healthy subjects and patients with COPD or heart failure.
Topics: Analgesics, Opioid; Electromyography; Exercise; Female; Fentanyl; Heart Failure; Heart Rate; Humans; | 2015 |
The Mechanoreflex and Hemodynamic Response to Passive Leg Movement in Heart Failure.
Topics: Afferent Pathways; Aged; Cardiac Output; Fentanyl; Heart Failure; Hemodynamics; Humans; Leg; Middle | 2016 |
Kappa and delta opioid receptor signaling is augmented in the failing heart.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; C | 2009 |
Oral transmucosal fentanyl citrate for dyspnea in terminally ill patients: an observational case series.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Dyspnea; Female; Fentanyl; Heart Failure; Humans; Lung | 2008 |
[Possibilities of complications in neuroleptoanalgesia].
Topics: Aged; Female; Fentanyl; Heart Arrest; Heart Failure; Humans; Iatrogenic Disease; Male; Middle Aged; | 1966 |
[Midazolam in patients with cardiac insufficiency].
Topics: Anesthesia; Anesthetics; Drug Combinations; Fentanyl; Heart Failure; Hemodynamics; Humans; Midazolam | 1995 |
Primary pulmonary hypertension: prolonged cardiac arrest and successful resuscitation following induction of anesthesia for heart-lung transplantation.
Topics: Adult; Anesthesia, Intravenous; Cardiopulmonary Bypass; Cardiopulmonary Resuscitation; Diazepam; Fen | 1994 |
Acute right ventricular failure after pulmonary hypertensive responses to airway instrumentation: effect of fentanyl dose.
Topics: Child, Preschool; Female; Fentanyl; Heart Failure; Humans; Hypertension, Pulmonary; Intubation, Intr | 1993 |
[Epidural anesthesia for herniorrhaphy in a patient with severe dilated cardiomyopathy (DCM) under pimobendan control].
Topics: Anesthesia, Epidural; Cardiomyopathy, Dilated; Cardiotonic Agents; Dobutamine; Dopamine; Fentanyl; H | 1997 |
Recurrence of pulsus alternans after fentanyl injection in a patient with aortic stenosis and congestive heart failure.
Topics: Aged; Aortic Valve; Aortic Valve Stenosis; Arrhythmias, Cardiac; Fentanyl; Heart Failure; Heart Valv | 1985 |
[Use of drugs for neuroleptoanalgesia in the acute period of a myocardial infarct].
Topics: Acid-Base Equilibrium; Acute Disease; Aged; Benperidol; Blood Volume; Carbon Dioxide; Female; Fentan | 1971 |