fentanyl and Headache studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Headache: The symptom of PAIN in the cranial region. It may be an isolated benign occurrence or manifestation of a wide variety of HEADACHE DISORDERS.

Research Excerpts

Excerpt	Relevance	Reference
"Our aim was to evaluate pain reduction provided by intranasal fentanyl (INF) compared with placebo in addition to ibuprofen."	9.69	Additive Value of Intranasal Fentanyl on Ibuprofen for Pain Management of Children With Moderate to Severe Headaches: A Randomized Controlled Trial. ( Bailey, B; Boutin, A; Gouin, S; Gravel, J; Lebel, D, 2023)
"Using fentanyl after surgical clipping for ruptured intracranial aneurysms might decrease headache and produce few adverse effects."	7.96	Effectiveness of Low-Dose Intravenous Fentanyl for Postoperative Headache Management After Neck Clipping of Ruptured Intracranial Aneurysms. ( Ikeda, G; Ishikawa, E; Matsumaru, Y; Matsumura, A; Nakai, Y; Terakado, T; Uemura, K, 2020)
"Our aim was to evaluate pain reduction provided by intranasal fentanyl (INF) compared with placebo in addition to ibuprofen."	5.69	Additive Value of Intranasal Fentanyl on Ibuprofen for Pain Management of Children With Moderate to Severe Headaches: A Randomized Controlled Trial. ( Bailey, B; Boutin, A; Gouin, S; Gravel, J; Lebel, D, 2023)
"In two prospective, randomized studies the frequency of headache, nausea, vomiting, and analgesic requirement during the first postoperative 24 h was observed in order to study differences between the sexes and the inhalation anesthetics halothane, enflurane, isoflurane, or balanced anesthesia with enflurane/alfentanil."	5.06	[Complaints in the postoperative phase related to anesthetics]. ( Fritz, T; Guggenberger, E; Guggenberger, H; Heuser, D; Warth, H; Wittkowski, KM, 1988)
"Using fentanyl after surgical clipping for ruptured intracranial aneurysms might decrease headache and produce few adverse effects."	3.96	Effectiveness of Low-Dose Intravenous Fentanyl for Postoperative Headache Management After Neck Clipping of Ruptured Intracranial Aneurysms. ( Ikeda, G; Ishikawa, E; Matsumaru, Y; Matsumura, A; Nakai, Y; Terakado, T; Uemura, K, 2020)
"Fentanyl-induced neurotoxicity is an uncommon adverse effect of fentanyl and is seldom seen in pediatric palliative care practice."	1.42	Fentanyl-Induced Neurotoxicity in Children. ( Deodhar, J; Muckaden, MA; Ostwal, S; Salins, N, 2015)
"Bilateral sixth nerve palsy is a known though uncommon complication following dural puncture."	1.32	Bilateral sixth cranial nerve palsy after unintentional dural puncture. ( Arcand, G; Boudreault, D; Chouinard, P; Girard, F; McCormack, M; Williams, S, 2004)
"Severe hyponatremia has been described after elective surgery with subsequent permanent brain damage."	1.30	Severe hyponatremia after transsphenoidal surgery for pituitary adenomas. ( Boehnert, M; Buchfelder, M; Fahlbusch, R; Gross, P; Henig, A; Hensen, J, 1998)

Research

Studies (20)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Greatest Level of Headache Pain Experienced With the Unintentional Dural Puncture

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (10.00)	18.7374
1990's	8 (40.00)	18.2507
2000's	5 (25.00)	29.6817
2010's	3 (15.00)	24.3611
2020's	2 (10.00)	2.80

Authors	Studies
Boutin, A	1
Gouin, S	1
Bailey, B	1
Lebel, D	1
Gravel, J	1
Terakado, T	1
Nakai, Y	1
Ikeda, G	1
Uemura, K	1
Matsumaru, Y	1
Ishikawa, E	1
Matsumura, A	1
Kim, KS	1
Yeo, NK	1
Kim, SS	1
Park, WS	1
Kwak, SH	1
Cho, SH	1
Sung, GW	1
Kim, HS	1
Yi, SW	1
Cho, HJ	1
Ostwal, S	1
Salins, N	1
Deodhar, J	1
Muckaden, MA	1
Minkowski, CP	1
Epstein, D	1
Frost, JJ	1
Gorelick, DA	1
Ramachandran, K	1
Kapoor, V	1
Arcand, G	1
Girard, F	1
McCormack, M	1
Chouinard, P	1
Boudreault, D	1
Williams, S	1
Rees, SG	1
Collis, RE	2
Darwish, M	1
Kirby, M	1
Jiang, JG	1
Tracewell, W	1
Robertson, P	1
Hody, JL	1
Cohen, S	1
Amar, D	1
Pantuck, EJ	1
Singer, N	1
Divon, M	1
Baxandall, ML	1
Srikantharajah, ID	1
Edge, G	1
Kadim, MY	1
Morgan, BM	1
Kokki, H	1
Hendolin, H	1
Richardson, MG	1
Thakur, R	1
Abramowicz, JS	1
Wissler, RN	1
Dennehy, KC	1
Rosaeg, OP	1
Boehnert, M	1
Hensen, J	1
Henig, A	1
Fahlbusch, R	1
Gross, P	1
Buchfelder, M	1
Niimiya, K	1
Takeda, S	1
Fernández-Guisasola, J	1
García del Valle, S	1
Gómez-Arnau, JI	1
Davies, GG	1
Slater, RM	1
Guggenberger, H	1
Fritz, T	1
Guggenberger, E	1
Warth, H	1
Wittkowski, KM	1
Heuser, D	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Incidence of Post-Dural Puncture Headache Following Unintentional Dural Puncture: A Randomized Trial of Intrathecal Morphine Versus Saline[NCT01977898]		68 participants (Actual)	Interventional	2011-11-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Greatest reported headache pain associated with unintentional dural puncture reported on a scale of 0= no pain to 10= worst pain imaginable. (NCT01977898)
Timeframe: 5 days

Intrathecal Catheter Dwell Time

Intervention	Score on a scale (0=no pain to 10 worst) (Median)
Morphine	7
Saline	7.5

Intrathecal catheter dwell time(time from insertion to time of removal in minutes). (NCT01977898)
Timeframe: Insertion time to removal in minutes

Intrathecal Infusion Volume

Intervention	Insertion to removal time in minutes (Median)
Morphine	418
Saline	427

Intrathecal infusion volume in milliliters (NCT01977898)
Timeframe: Time of insertion of catheter to time catheter removed

Participants Who Report Post Dural Puncture Headaches

Intervention	Milliters (Median)
Morphine	12.9
Saline	16.2

Participants who report post dural puncture headaches from delivery to postpartum day 5 (NCT01977898)
Timeframe: 5 days

Repeat Epidural Blood Patch

Intervention	Participants (Count of Participants)
Morphine	21
Saline	27

Repeated epidural blood patch for headache pain after unintentional dural puncture. (NCT01977898)
Timeframe: After first epidural blood patch to 5 days after delivery

Severity of Post Dural Puncture Headache

Intervention	Participants (Count of Participants)
Morphine	1
Saline	1

Severity of post dural puncture headache on a numerical rating scale 0= no pain and 10= worst pain imaginable from the time of delivery to postpartum day 5. (NCT01977898)
Timeframe: Time of unintentional dural puncture to postpartum day 5

Treatment Method for Headache

Intervention	score on a scale (Median)
Morphine	7
Saline	7.5

Treatment method completed for unintentional dural puncture headache. (NCT01977898)
Timeframe: Unintentional dural puncture - Postpartum day 5

Article	Year
Additive Value of Intranasal Fentanyl on Ibuprofen for Pain Management of Children With Moderate to Severe Headaches: A Randomized Controlled Trial. The Journal of emergency medicine, 2023, Volume: 65, Issue:2 Topics: Adolescent; Analgesics, Opioid; Child; Double-Blind Method; Fentanyl; Headache; Humans; Ibuprofen; P	2023
Effect of Fentanyl Nasal Packing Treatment on Patients With Acute Postoperative Pain After Nasal Operation: A Randomized Double-Blind Controlled Trial. The Annals of otology, rhinology, and laryngology, 2018, Volume: 127, Issue:5 Topics: Absorbable Implants; Administration, Topical; Adult; Analgesics, Opioid; Double-Blind Method; Endosc	2018
Bioequivalence following buccal and sublingual placement of fentanyl buccal tablet 400 microg in healthy subjects. Clinical drug investigation, 2008, Volume: 28, Issue:1 Topics: Administration, Buccal; Administration, Sublingual; Adult; Analgesics, Opioid; Area Under Curve; Chr	2008
Comparison of spinal anaesthesia with epidural anaesthesia in paediatric surgery. Acta anaesthesiologica Scandinavica, 1995, Volume: 39, Issue:7 Topics: Adjuvants, Anesthesia; Adolescent; Age Factors; Anesthesia, Epidural; Anesthesia, General; Anesthesi	1995
Maternal posture influences the extent of sensory block produced by intrathecal dextrose-free bupivacaine with fentanyl for labor analgesia. Anesthesia and analgesia, 1996, Volume: 83, Issue:6 Topics: Adult; Analgesia, Obstetrical; Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Anes	1996
[Complaints in the postoperative phase related to anesthetics]. Der Anaesthesist, 1988, Volume: 37, Issue:12 Topics: Adolescent; Adult; Alfentanil; Analgesics; Anesthesia, Inhalation; Clinical Trials as Topic; Enflura	1988

Article	Year
Effectiveness of Low-Dose Intravenous Fentanyl for Postoperative Headache Management After Neck Clipping of Ruptured Intracranial Aneurysms. World neurosurgery, 2020, Volume: 134 Topics: Adult; Aged; Analgesics, Opioid; Aneurysm, Ruptured; Dose-Response Relationship, Drug; Female; Fenta	2020
Fentanyl-Induced Neurotoxicity in Children. Journal of pain & palliative care pharmacotherapy, 2015, Volume: 29, Issue:4 Topics: Akathisia, Drug-Induced; Analgesics, Opioid; Child; Female; Fentanyl; Hallucinations; Headache; Huma	2015
Differential response to IV carfentanil in chronic cocaine users and healthy controls. Addiction biology, 2012, Volume: 17, Issue:1 Topics: Adult; Analgesics, Opioid; Brain; Cocaine-Related Disorders; Dizziness; Female; Fentanyl; Half-Life;	2012
Treating ECG changes during Caesarean section: is it worth the headache? Anaesthesia, 2003, Volume: 58, Issue:3 Topics: Adult; Analgesics, Opioid; Cesarean Section; Electrocardiography; Female; Fentanyl; Headache; Humans	2003
Bilateral sixth cranial nerve palsy after unintentional dural puncture. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2004, Volume: 51, Issue:8 Topics: Abdominal Pain; Abducens Nerve Diseases; Adult; Androstanols; Anesthesia, Epidural; Anesthesia, Gene	2004
Spinal cord injury after accidental dural puncture for labour analgesia. International journal of obstetric anesthesia, 2007, Volume: 16, Issue:2 Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Anesthetics, Intravenous; Anesthetics, Local; Ba	2007
[Combined epidural and spinal anesthesia for cesarean section]. Cahiers d'anesthesiologie, 1994, Volume: 42, Issue:5 Topics: Adult; Anesthesia, Epidural; Anesthesia, Obstetrical; Anesthesia, Spinal; Bupivacaine; Cesarean Sect	1994
Decreased incidence of headache after accidental dural puncture in caesarean delivery patients receiving continuous postoperative intrathecal analgesia. Acta anaesthesiologica Scandinavica, 1994, Volume: 38, Issue:7 Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesia, Patient-Controlled; Blood Patch, Epid	1994
Combined spinal epidural analgesia with ability to walk throughout labour. Lancet (London, England), 1993, Mar-20, Volume: 341, Issue:8847 Topics: Analgesia, Epidural; Analgesia, Obstetrical; Anesthesia, Spinal; Bupivacaine; Female; Fentanyl; Head	1993
Intrathecal catheter insertion during labour reduces the risk of post-dural puncture headache. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1998, Volume: 45, Issue:1 Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Opioid; Anesthetics, Local; Bupivaca	1998
Severe hyponatremia after transsphenoidal surgery for pituitary adenomas. Kidney international. Supplement, 1998, Volume: 64 Topics: Adenoma; Adolescent; Adult; Aged; Anesthetics, Intravenous; Female; Fentanyl; Headache; Humans; Hypo	1998
[Quality of recovery from anesthesia]. Masui. The Japanese journal of anesthesiology, 1999, Volume: 48 Suppl Topics: Anesthesia; Anesthesia Recovery Period; Clinical Trials as Topic; Fentanyl; Headache; Humans; Methyl	1999
Selective spinal analgesia for extracorporeal shock wave lithotripsy. Journal of clinical anesthesia, 1989, Volume: 1, Issue:3 Topics: Analgesia, Epidural; Anesthesia, Epidural; Fentanyl; Headache; Humans; Injections, Spinal; Lidocaine	1989

fentanyl and Headache