fentanyl has been researched along with Glial Cell Tumors in 19 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have observed that treatment of human glioma cells with morphine in the nanomolar range of concentration affects the mitochondrial membrane potential." | 7.72 | Morphine but not fentanyl and methadone affects mitochondrial membrane potential by inducing nitric oxide release in glioma cells. ( Arcuri, E; Arese, M; Bacchi, A; Cardelli, P; Citro, G; Mastronicola, D; Mercadante, S; Sarti, P, 2004) |
| "A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas." | 7.67 | Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion. ( Klein, DS; Klein, PW; Mahaley, MS, 1986) |
| "Gliomas are the most common primary tumors in the central nervous system with poor prognosis." | 5.91 | Fentanyl inhibits cell invasion and migration by modulating NF-κB activation in glioma. ( Liu, DZ; Xu, SY, 2023) |
| "We have observed that treatment of human glioma cells with morphine in the nanomolar range of concentration affects the mitochondrial membrane potential." | 3.72 | Morphine but not fentanyl and methadone affects mitochondrial membrane potential by inducing nitric oxide release in glioma cells. ( Arcuri, E; Arese, M; Bacchi, A; Cardelli, P; Citro, G; Mastronicola, D; Mercadante, S; Sarti, P, 2004) |
| "Opiate receptors from NG108-15 neuroblastoma-glioma hybrid cell membranes were purified to apparent homogeneity in a form covalently labeled with the opiate affinity ligand 3-methylfentanylisothiocyanate (super-FIT)." | 3.67 | Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells. ( Burke, TR; Jacobson, AE; Klee, WA; Rice, KC; Simonds, WF, 1985) |
| "A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas." | 3.67 | Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion. ( Klein, DS; Klein, PW; Mahaley, MS, 1986) |
| "Gliomas are the most common primary tumors in the central nervous system with poor prognosis." | 1.91 | Fentanyl inhibits cell invasion and migration by modulating NF-κB activation in glioma. ( Liu, DZ; Xu, SY, 2023) |
| " We describe here an analogue of 1 with an added C-terminal β-glucosylserine residue, Ser(β-Glc)NH2, a modification that has previously been shown to improve bioavailability of opioid peptides." | 1.40 | Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance. ( Anand, JP; Jutkiewicz, EM; Mosberg, HI; Porter, V; Sobczyk-Kojiro, K; Traynor, JR; Yeomans, L, 2014) |
| "In animals without tumors, the temperature subcutaneously on the foot was 0." | 1.29 | Use of the vasodilator sodium nitroprusside during local hyperthermia: effects on tumor temperature and tumor response in a rat tumor model. ( Dahl, O; Krossnes, BK; Mella, O, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (31.58) | 18.7374 |
| 1990's | 7 (36.84) | 18.2507 |
| 2000's | 2 (10.53) | 29.6817 |
| 2010's | 3 (15.79) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Mosberg, HI | 1 |
| Yeomans, L | 1 |
| Anand, JP | 1 |
| Porter, V | 1 |
| Sobczyk-Kojiro, K | 1 |
| Traynor, JR | 1 |
| Jutkiewicz, EM | 1 |
| Liu, DZ | 1 |
| Xu, SY | 1 |
| Lin, YC | 1 |
| Liu, YT | 1 |
| Wu, ZF | 1 |
| Chan, SM | 1 |
| Wang, Y | 1 |
| Barker, K | 1 |
| Shi, S | 1 |
| Diaz, M | 1 |
| Mo, B | 1 |
| Gutstein, HB | 2 |
| Moulédous, L | 1 |
| Diaz, MF | 1 |
| Mastronicola, D | 1 |
| Arcuri, E | 1 |
| Arese, M | 1 |
| Bacchi, A | 1 |
| Mercadante, S | 1 |
| Cardelli, P | 1 |
| Citro, G | 1 |
| Sarti, P | 1 |
| Burke, TR | 2 |
| Bajwa, BS | 1 |
| Jacobson, AE | 3 |
| Rice, KC | 3 |
| Streaty, RA | 2 |
| Klee, WA | 3 |
| Uchida, M | 1 |
| Mima, M | 1 |
| Imanishi, T | 1 |
| Nitsu, T | 1 |
| Saito, K | 1 |
| Sawaragi, S | 1 |
| Todd, MM | 1 |
| Warner, DS | 1 |
| Sokoll, MD | 1 |
| Maktabi, MA | 1 |
| Hindman, BJ | 1 |
| Scamman, FL | 1 |
| Kirschner, J | 1 |
| Krossnes, BK | 1 |
| Mella, O | 1 |
| Dahl, O | 1 |
| Jiang, C | 3 |
| Pechstein, U | 1 |
| Nadstawek, J | 1 |
| Zentner, J | 1 |
| Schramm, J | 1 |
| Yan, H | 1 |
| Liang, W | 1 |
| Tobias, JD | 1 |
| Heideman, RL | 1 |
| Kim, CH | 1 |
| Rothman, RB | 1 |
| Mattson, MV | 1 |
| Bykov, V | 1 |
| George, C | 1 |
| Long, JB | 1 |
| Simonds, WF | 1 |
| Klein, DS | 1 |
| Klein, PW | 1 |
| Mahaley, MS | 1 |
| Jennett, WB | 1 |
| Barker, J | 1 |
| Fitch, W | 1 |
| McDowall, DG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Anaesthesia for Supratentorial Tumor Resection : a Double-blind Comparison of Target Plasma Concentration of Propofol-remifentanil and Sevoflurane-sufentanil[NCT00389883] | Phase 3 | 69 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| Anesthesiological Strategies in Elective Craniotomy: Randomized, Equivalence, Open Trial[NCT00741351] | Phase 3 | 411 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| The Effect of Furosemide Versus Placebo on Brain Relaxation and Incidence of Significant Intravascular Volume Depletion in Human Subjects Receiving Mannitol[NCT01054404] | 23 participants (Actual) | Interventional | 2010-02-28 | Terminated (stopped due to Concern for volume depletion and electrolyte abnormalities in furosemide arm.) | |||
| Clinical Effectiveness of Hypertonic Sodium Lactate Infusion for Intraoperative Brain Relaxation in Patients Undergoing Scheduled Craniotomy for Supratentorial Brain Tumor Resection: Study Protocol of a Single Center Double-blind Randomized Controlled Pha[NCT04488874] | Phase 3 | 50 participants (Actual) | Interventional | 2020-09-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Rating of brain relaxation will be on a 4-point scale:~0 = brain very relaxed under dura, acceptable~= brain adequately relaxed under dura, acceptable~= brain slightly tense under dura, acceptable~= brain very tense under bulging dura, unacceptable" (NCT01054404)
Timeframe: just prior to dural opening for each subject
| Intervention | units on a scale 0-3 (Mean) |
|---|---|
| Furosemide | 1.5 |
| Placebo | 1.3 |
3 trials available for fentanyl and Glial Cell Tumors
16 other studies available for fentanyl and Glial Cell Tumors
| Article | Year |
|---|---|
Development of a bioavailable μ opioid receptor (MOPr) agonist, δ opioid receptor (DOPr) antagonist peptide that evokes antinociception without development of acute tolerance.
Topics: Analgesics; Animals; Biological Availability; Drug Tolerance; Female; Glioma; Male; Mice; Mice, Inbr | 2014 |
Fentanyl inhibits cell invasion and migration by modulating NF-κB activation in glioma.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Fentanyl; Glioma; Humans; Narc | 2023 |
The successful application of high flow nasal cannula for awake craniotomy.
Topics: Adult; Airway Management; Analgesia; Analgesics, Opioid; Brain Neoplasms; Cannula; Conscious Sedatio | 2019 |
Blockade of PDGFR-β activation eliminates morphine analgesic tolerance.
Topics: Animals; Benzamides; Chronic Pain; Dose-Response Relationship, Drug; Drug Combinations; Drug Toleran | 2012 |
Modulation of extracellular signal-regulated kinase (ERK) activity by acute and chronic opioid treatment in neuronal and glial cell lines.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Diprenorphine; Drug Administration Schedule; Enzyme Ac | 2004 |
Morphine but not fentanyl and methadone affects mitochondrial membrane potential by inducing nitric oxide release in glioma cells.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Cell Line, Tumor; Electron Transport Complex IV; Fentanyl | 2004 |
Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for mu or delta opiate receptors.
Topics: Animals; Benzimidazoles; Cell Line; Cell Membrane; Chemical Phenomena; Chemistry; Drug Evaluation, P | 1984 |
[Cerebral herniation during anesthesia].
Topics: Adult; Brain; Brain Neoplasms; Cerebral Hemorrhage; Encephalocele; Female; Fentanyl; Glioma; Humans; | 1984 |
Use of the vasodilator sodium nitroprusside during local hyperthermia: effects on tumor temperature and tumor response in a rat tumor model.
Topics: Animals; Blood Pressure; Body Temperature; Butyrophenones; Fentanyl; Glioma; Hyperthermia, Induced; | 1996 |
[Normalization of acupuncture anesthesia used in operation of neoplasm in functional area or deep site of brain].
Topics: Acupuncture Analgesia; Acupuncture Points; Adjuvants, Anesthesia; Adolescent; Adult; Aged; Brain Neo | 1996 |
[Clinical application of combined acupuncture-drug anesthesia in cerebral functional area operation].
Topics: Acupuncture Analgesia; Adult; Aged; Anesthetics, Combined; Anesthetics, Intravenous; Brain Neoplasms | 1998 |
[Normalization of acupuncture anesthesia used in neurosurgery].
Topics: Acupuncture Analgesia; Adolescent; Adult; Aged; Aged, 80 and over; Brain Neoplasms; Cerebellar Neopl | 1992 |
Primary central hyperventilation in a child with a brainstem glioma: management with continuous intravenous fentanyl.
Topics: Brain Neoplasms; Brain Stem; Child; Fentanyl; Glioma; Humans; Hyperventilation; Infusions, Intraveno | 1991 |
Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro.
Topics: Acylation; Adenylyl Cyclase Inhibitors; Analgesia; Animals; Brain; Cell Membrane; Chemical Phenomena | 1989 |
Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells.
Topics: Affinity Labels; Animals; Cell Line; Fentanyl; Glioma; Glycoproteins; Macromolecular Substances; Mem | 1985 |
Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion.
Topics: Adult; Aged; Brain Neoplasms; Carmustine; Carotid Arteries; Diazepam; Droperidol; Drug Therapy, Comb | 1986 |