fentanyl has been researched along with Genetic Predisposition in 7 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fentanyl-induced emesis (FIE) is a distressing adverse effect in the postoperative setting." | 9.16 | A non-synonymous single nucleotide polymorphism in an OPRM1 splice variant is associated with fentanyl-induced emesis in women undergoing minor gynaecological surgery. ( Ithnin, F; Lee, CG; Lim, Y; Pang, GS; Sia, AT; Wang, JB; Wong, YY, 2012) |
| "OPRM1 A118G has no effect on the individual variation of postoperative nausea and vomiting, the side effects of fentanyl analgesia, in Chinese women undergoing gynecologic surgery." | 7.77 | Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting induced by fentanyl intravenous analgesia. ( Chang, YZ; Kan, QC; Wang, ZY; Yuan, JJ; Zhang, LR; Zhang, W, 2011) |
| "Fentanyl-induced emesis (FIE) is a distressing adverse effect in the postoperative setting." | 5.16 | A non-synonymous single nucleotide polymorphism in an OPRM1 splice variant is associated with fentanyl-induced emesis in women undergoing minor gynaecological surgery. ( Ithnin, F; Lee, CG; Lim, Y; Pang, GS; Sia, AT; Wang, JB; Wong, YY, 2012) |
| "OPRM1 A118G has no effect on the individual variation of postoperative nausea and vomiting, the side effects of fentanyl analgesia, in Chinese women undergoing gynecologic surgery." | 3.77 | Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting induced by fentanyl intravenous analgesia. ( Chang, YZ; Kan, QC; Wang, ZY; Yuan, JJ; Zhang, LR; Zhang, W, 2011) |
| "Inflated rates of opioid addiction among anesthesiologists may be caused by chronic exposure to low doses of aerosolized anesthetic/analgesic agents in the operating room." | 1.35 | Fentanyl and propofol exposure in the operating room: sensitization hypotheses and further data. ( Fitzgerald, K; Gold, MS; Goldberger, BA; Kolodner, D; Merlo, LJ, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, KM | 1 |
| Kim, HS | 1 |
| Lim, SH | 1 |
| Cheong, SH | 1 |
| Choi, EJ | 1 |
| Kang, H | 1 |
| Choi, HR | 1 |
| Jeon, JW | 1 |
| Yon, JH | 1 |
| Oh, M | 1 |
| Shin, JG | 1 |
| Uno, K | 1 |
| Nishizawa, D | 1 |
| Seo, S | 1 |
| Takayama, K | 1 |
| Matsumura, S | 1 |
| Sakai, N | 1 |
| Ohi, K | 1 |
| Nabeshima, T | 1 |
| Hashimoto, R | 1 |
| Ozaki, N | 1 |
| Hasegawa, J | 1 |
| Sato, N | 1 |
| Tanioka, F | 1 |
| Sugimura, H | 1 |
| Fukuda, KI | 1 |
| Higuchi, S | 1 |
| Ujike, H | 1 |
| Inada, T | 1 |
| Iwata, N | 1 |
| Sora, I | 1 |
| Iyo, M | 1 |
| Kondo, N | 1 |
| Won, MJ | 1 |
| Naruse, N | 1 |
| Uehara-Aoyama, K | 1 |
| Itokawa, M | 1 |
| Yamada, M | 1 |
| Ikeda, K | 1 |
| Miyamoto, Y | 1 |
| Nitta, A | 1 |
| Yi, Y | 1 |
| Zhao, M | 1 |
| Xu, F | 1 |
| Liu, C | 1 |
| Yin, Y | 1 |
| Yu, J | 1 |
| Merlo, LJ | 1 |
| Goldberger, BA | 1 |
| Kolodner, D | 1 |
| Fitzgerald, K | 1 |
| Gold, MS | 1 |
| Landau, R | 1 |
| Kraft, JC | 1 |
| Zhang, W | 1 |
| Yuan, JJ | 1 |
| Kan, QC | 1 |
| Zhang, LR | 1 |
| Chang, YZ | 1 |
| Wang, ZY | 1 |
| Pang, GS | 1 |
| Ithnin, F | 1 |
| Wong, YY | 1 |
| Wang, JB | 1 |
| Lim, Y | 1 |
| Sia, AT | 1 |
| Lee, CG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Pharmacogenetic Factors Contributing to Dose Requirement of Fentanyl for Postoperative Pain Control: Genetic Polymorphisms of OPRM1, ABCB1, CYP3A4 and CYP3A5[NCT00824772] | 204 participants (Actual) | Observational | 2008-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00824772)
Timeframe: 24 hr after surgery
| Intervention | mcg (Mean) |
|---|---|
| Gynecologic Patients Undergoing TAH, LAVH | 836 |
(NCT00824772)
Timeframe: 48hr after surgery
| Intervention | mcg (Mean) |
|---|---|
| Gynecologic Patients Undergoing TAH, LAVH | 1028 |
1 review available for fentanyl and Genetic Predisposition
| Article | Year |
|---|---|
Pharmacogenetics in obstetric anesthesia.
Topics: Analgesics, Opioid; Anesthesia, Obstetrical; Anesthesia, Spinal; Cesarean Section; Codeine; Female; | 2010 |
2 trials available for fentanyl and Genetic Predisposition
| Article | Year |
|---|---|
Effects of genetic polymorphisms of OPRM1, ABCB1, CYP3A4/5 on postoperative fentanyl consumption in Korean gynecologic patients.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Asian People; ATP Binding Cassette Transpo | 2013 |
A non-synonymous single nucleotide polymorphism in an OPRM1 splice variant is associated with fentanyl-induced emesis in women undergoing minor gynaecological surgery.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alternative Splicing; Anesthetics, Intravenous; Case-Con | 2012 |
4 other studies available for fentanyl and Genetic Predisposition
| Article | Year |
|---|---|
The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and Shows Associations with Dependence-Like Behavior in Genomic Association Study.
Topics: Age of Onset; Amphetamine-Related Disorders; Analgesics, Opioid; Anorexia; Cytoskeletal Proteins; Do | 2015 |
CGRP 4218T/C polymorphism correlated with postoperative analgesic effect of fentanyl.
Topics: Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Asian People; Calcitonin Gene-Relate | 2015 |
Fentanyl and propofol exposure in the operating room: sensitization hypotheses and further data.
Topics: Air Pollutants, Occupational; Anesthesiology; Anesthetics, Intravenous; Dose-Response Relationship, | 2008 |
Study of the OPRM1 A118G genetic polymorphism associated with postoperative nausea and vomiting induced by fentanyl intravenous analgesia.
Topics: Adult; Amino Acid Substitution; Analgesia, Patient-Controlled; Analgesics, Opioid; China; Elective S | 2011 |