fentanyl has been researched along with Encephalopathy, Toxic in 6 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Seven days after hydromorphone was initiated, she developed positive myoclonus, hallucinations, delirium, and involuntary, flowing movements consistent with chorea." | 7.88 | Hydromorphone-induced chorea as an atypical presentation of opioid neurotoxicity: A case report and review of the literature. ( Atayee, R; Edmonds, KP; Hirst, JM; Martin, EJ; O'Donnell, K; Vaughan, CL, 2018) |
| "Pain was well controlled." | 5.35 | Fentanyl-induced neurotoxicity and paradoxic pain. ( George, ML; Okon, TR, 2008) |
| " Seven days after hydromorphone was initiated, she developed positive myoclonus, hallucinations, delirium, and involuntary, flowing movements consistent with chorea." | 3.88 | Hydromorphone-induced chorea as an atypical presentation of opioid neurotoxicity: A case report and review of the literature. ( Atayee, R; Edmonds, KP; Hirst, JM; Martin, EJ; O'Donnell, K; Vaughan, CL, 2018) |
| "Fentanyl 20 micro g was added to both local anesthetics, and the total volume was diluted to 3 mL with 0." | 2.71 | Subarachnoid small-dose bupivacaine versus lidocaine for cervical cerclage. ( Abramovitz, S; Beilin, Y; Bernstein, HH; Bodian, C; Hossain, S; Zahn, J, 2003) |
| "Pain was well controlled." | 1.35 | Fentanyl-induced neurotoxicity and paradoxic pain. ( George, ML; Okon, TR, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martin, EJ | 1 |
| Vaughan, CL | 1 |
| Atayee, R | 1 |
| Hirst, JM | 1 |
| O'Donnell, K | 1 |
| Edmonds, KP | 1 |
| Serghini, I | 1 |
| Qamouss, Y | 1 |
| Zoubir, M | 1 |
| Lalaoui, JS | 1 |
| Boughalem, M | 1 |
| Fukushima, S | 1 |
| Takenami, T | 1 |
| Yagishita, S | 1 |
| Nara, Y | 1 |
| Hoka, S | 1 |
| Okamoto, H | 1 |
| Beilin, Y | 1 |
| Zahn, J | 1 |
| Abramovitz, S | 1 |
| Bernstein, HH | 1 |
| Hossain, S | 1 |
| Bodian, C | 1 |
| Okon, TR | 1 |
| George, ML | 1 |
| Makin, MK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Controlled Clinical Trial of Intrathecal Chloroprocaine vs. Bupivacaine for Cervical Cerclage[NCT03305575] | Phase 4 | 10 participants (Actual) | Interventional | 2017-10-13 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The time difference between local anesthetic injection and complete resolution of motor block -as measured on the Bromage scale:~I = free movement of feet, legs and hip = No block II = able to flex knees, with free movement of feet = Mild block III = unable to flex knees, but with free movement of feet = Moderate block IV = unable to move legs or feet = Complete block" (NCT03305575)
Timeframe: 6 hours
| Intervention | minutes (Mean) |
|---|---|
| Chloroprocaine | 75 |
| Bupivacaine | 99 |
The time difference between local anesthetic injection and complete resolution of sensory block. The sensory level was tested using a blunt needle tip along the patient's demratomal distribution of the spinal anesthetic. (NCT03305575)
Timeframe: 6 hours
| Intervention | minutes (Mean) |
|---|---|
| Chloroprocaine | 127 |
| Bupivacaine | 210 |
The time difference between local anesthetic injection and patient's walking for the first time postoperatively. (NCT03305575)
Timeframe: 6 hours
| Intervention | minutes (Mean) |
|---|---|
| Chloroprocaine | 110 |
| Bupivacaine | 179 |
The time difference between local anesthetic injection and the patient's voiding for the first time postoperatively. (NCT03305575)
Timeframe: 6 hours
| Intervention | minutes (Mean) |
|---|---|
| Chloroprocaine | 111 |
| Bupivacaine | 233 |
1 review available for fentanyl and Encephalopathy, Toxic
| Article | Year |
|---|---|
Strong opioids for cancer pain.
Topics: Analgesics, Opioid; Chronic Disease; Fentanyl; Humans; Morphine; Neoplasms; Neurotoxicity Syndromes; | 2001 |
1 trial available for fentanyl and Encephalopathy, Toxic
| Article | Year |
|---|---|
Subarachnoid small-dose bupivacaine versus lidocaine for cervical cerclage.
Topics: Adult; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Intravenous; Anesthetics, Local; Bupiv | 2003 |
4 other studies available for fentanyl and Encephalopathy, Toxic
| Article | Year |
|---|---|
Hydromorphone-induced chorea as an atypical presentation of opioid neurotoxicity: A case report and review of the literature.
Topics: Analgesics, Opioid; Chorea; Female; Fentanyl; Humans; Hydromorphone; Neurotoxicity Syndromes; Treatm | 2018 |
Fatal intoxication caused by the application of the multiple transdermals patchs of fentanyl.
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Chronic Pain; Female; Fentanyl; Humans; Neuroto | 2015 |
Neurotoxicity of intrathecally administered fentanyl in a rat spinal model.
Topics: Analgesics, Opioid; Animals; Catheters; Drug Tolerance; Fentanyl; Heart Rate; Hydrogen-Ion Concentra | 2011 |
Fentanyl-induced neurotoxicity and paradoxic pain.
Topics: Aged; Analgesics, Opioid; Fatal Outcome; Female; Fentanyl; Humans; Hyperalgesia; Leiomyosarcoma; Neu | 2008 |