fentanyl has been researched along with Drug Withdrawal Symptoms in 108 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of clonidine, a centrally acting alpha 2-adrenergic receptor agonist, on depth of fentanyl anesthesia and on cardiovascular response to laryngoscopy and intubation were studied." | 9.06 | Effects of clonidine on narcotic requirements and hemodynamic response during induction of fentanyl anesthesia and endotracheal intubation. ( Calvillo, O; Duke, PC; Ghignone, M; Kehler, CH; Quintin, L, 1986) |
| "To report the occurrence of bradycardia associated with the use of methadone administered to prevent withdrawal in an infant with physical tolerance following long-term opioid therapy in the pediatric intensive care unit setting." | 7.73 | Bradycardia during methadone therapy in an infant. ( Tobias, JD; Wheeler, AD, 2006) |
| "In contrast, withdrawal associated thermal hyperalgesia was found only in mice." | 5.62 | Divergent profiles of fentanyl withdrawal and associated pain in mice and rats. ( Arakawa, K; Cramer, N; Fox, ME; Jenne, C; Keller, A; Uddin, O, 2021) |
| "Drug withdrawal symptoms were monitored using the Neonatal Abstinence Score Tool (NAST), which assigns a score to each behavior indicative of withdrawal." | 5.29 | Drug withdrawal symptoms in children after continuous infusions of fentanyl. ( French, JP; Nocera, M, 1994) |
| "The effects of clonidine, a centrally acting alpha 2-adrenergic receptor agonist, on depth of fentanyl anesthesia and on cardiovascular response to laryngoscopy and intubation were studied." | 5.06 | Effects of clonidine on narcotic requirements and hemodynamic response during induction of fentanyl anesthesia and endotracheal intubation. ( Calvillo, O; Duke, PC; Ghignone, M; Kehler, CH; Quintin, L, 1986) |
| " We evaluated doses of fentanyl, midazolam and clonidine, time of extubation, length of PICU stay and occurrence of withdrawal symptoms and delirium." | 4.12 | Sedation practices during high dose rate brachytherapy for children with urogenital and perianal rhabdomyosarcoma. ( Fuchs, J; Hofbeck, M; Kumpf, M; Michel, J; Neunhoeffer, F; Paulsen, F; Sauter, L; Schmidt, A, 2022) |
| "The study showed that gabapentin can significantly prevented opioid-induced hyperalgesia (OIH) induced caused by fentanyl and morphine, suggesting a role for the addition of gabapentin in the perioperative period and during chronic pain treatment as an effective drug to prevent OIH." | 3.78 | Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats. ( Wei, W; Wei, X, 2012) |
| "To report the occurrence of bradycardia associated with the use of methadone administered to prevent withdrawal in an infant with physical tolerance following long-term opioid therapy in the pediatric intensive care unit setting." | 3.73 | Bradycardia during methadone therapy in an infant. ( Tobias, JD; Wheeler, AD, 2006) |
| "The vital signs, withdrawal symptoms and the frequency requirement of fentanyl were recorded during anesthesia, and opioid (pethidine) analgesic was received during the recovery period." | 2.90 | Impact of Ondansetron on Withdrawal Signs, Fentanyl Requirement and Pain Relief in Opioid-addicted Patients under General Anesthesia. ( Dehesh, T; Hashemian, M; Jafari, E; Jafari, M; Mahikhan, F; Rahimi, HR, 2019) |
| "Fentanyl and midazolam were adjusted to achieve a defined level of analgesia and sedation according to Hartwig score." | 2.79 | Continuous infusion of clonidine in ventilated newborns and infants: a randomized controlled trial. ( Balling, G; Behr, J; Blickheuser, R; Dohna-Schwake, C; Gebauer, C; Hahn, M; Harnischmacher, U; Hentschel, R; Hering, F; Hoehn, T; Hünseler, C; Huth, RG; Lieser, U; Möller, O; Müller, A; Müller, C; Röhlig, C; Roth, B; Schubert, S; Trieschmann, U; Wassmer, G, 2014) |
| "Following extubation, withdrawal symptoms were assessed by a modification of the Finnegan score." | 2.78 | Remifentanil-induced tolerance, withdrawal or hyperalgesia in infants: a randomized controlled trial. RAPIP trial: remifentanil-based analgesia and sedation of paediatric intensive care patients. ( Harnischmacher, U; Junghaenel, S; Link, F; Oberthuer, A; Roth, B; Stuetzer, H; Welzing, L, 2013) |
| "Patients were monitored for withdrawal symptoms using the Modified Narcotic Withdrawal Score." | 2.76 | A trial of methadone tapering schedules in pediatric intensive care unit patients exposed to prolonged sedative infusions. ( Bowens, CD; Breitzka, RL; Sheeran, PW; Thompson, DG; Thompson, JA; Thompson, MT, 2011) |
| "Naloxone has been hypothesized to limit opioid tolerance by decreasing adenylate cyclase/cyclic adenosine monophosphate activation." | 2.73 | Effect of low-dose naloxone infusion on fentanyl requirements in critically ill children. ( Darnell, CM; Roy, L; Sheeran, P; Stromberg, D; Thompson, J, 2008) |
| "Myoclonus is a common and well-described adverse effect of opioids." | 2.41 | Myoclonus secondary to withdrawal from transdermal fentanyl: case report and literature review. ( Abu-Elmagd, K; Arnold, R; Bond, G; Han, PK; Janson, D, 2002) |
| "Among inpatients with opioid use disorder, fentanyl status does not appear to be statistically significantly associated with Clinical Opioid Withdrawal Scale and Short Opiate Withdrawal Scale mean and maximum scores." | 1.91 | Fentanyl withdrawal: Understanding symptom severity and exploring the role of body mass index on withdrawal symptoms and clearance. ( Choi, CJ; Comer, S; Jones, J; Luba, R, 2023) |
| "Buprenorphine-naloxone has a very high affinity for the mu-receptor and can cause precipitated opioid withdrawal, typically more severe than withdrawal that occurs naturally, when administered while a full mu-opioid receptor agonist remains in a person's system." | 1.72 | A case of buprenorphine-precipitated withdrawal managed with high-dose buprenorphine. ( Kiyokawa, M; Murata, KA; Quattlebaum, THN, 2022) |
| "In contrast, withdrawal associated thermal hyperalgesia was found only in mice." | 1.62 | Divergent profiles of fentanyl withdrawal and associated pain in mice and rats. ( Arakawa, K; Cramer, N; Fox, ME; Jenne, C; Keller, A; Uddin, O, 2021) |
| "Unfortunately, she continued to have withdrawal symptoms despite being optimised to a dose of 32 mg." | 1.56 | High-dose buprenorphine for treatment of high potency opioid use disorder. ( Danilewitz, M; McLean, M, 2020) |
| "Clonidine treatment significantly increased fentanyl-vs." | 1.51 | Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats. ( Banks, ML; Blake, S; Bremer, PT; Faunce, KE; Hwang, CS; Janda, KD; Natori, Y; Townsend, EA; Zhou, B, 2019) |
| "Midazolam was used in 95 patients (56%), with an average dose of 35 (±14) μg/kg/h." | 1.51 | Postsurgery analgesic and sedative drug use in a French neonatal intensive care unit: A single-center retrospective cohort study. ( Benahmed-Canat, A; Canat, G; Claris, O; Kassai, B; Nguyen, KA; Paret, N; Plaisant, F; Rabilloud, M; Riche, B, 2019) |
| "Treatment with carisoprodol and phenobarbital provided additional benefit and can be considered in cases of severe carisoprodol withdrawal." | 1.46 | Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose. ( Benowitz, NL; Horng, H; Smollin, CG; Vo, KT, 2017) |
| "Hyperalgesia is a cardinal symptom of opioid withdrawal." | 1.39 | Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner. ( Endres-Becker, J; Fischer, O; Schäfer, M; Spahn, V; Stein, C; Zöllner, C, 2013) |
| "Fentanyl and saline were chronically administered via osmotic minipumps." | 1.35 | Effects of fentanyl dose and exposure duration on the affective and somatic signs of fentanyl withdrawal in rats. ( Bruijnzeel, AW; Derendorf, H; Gold, MS; Liu, J; Pan, H, 2008) |
| "Fentanyl and saline were chronically administered via osmotic minipumps." | 1.34 | The effects of buprenorphine on fentanyl withdrawal in rats. ( Booth, MM; Bruijnzeel, AW; Dennis, DM; Gold, MS; Isaac, S; Marcinkiewcz, C, 2007) |
| "Fentanyl and saline were chronically administered via minipumps." | 1.33 | Severe deficit in brain reward function associated with fentanyl withdrawal in rats. ( Bajpai, LK; Bruijnzeel, AW; Dennis, DM; Gold, M; Lewis, B; Morey, TE, 2006) |
| "Ketamine could suppress not only the place preference but also the phosphorylation of CREB produced by morphine, F9202 and F9204." | 1.32 | Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm. ( Che, LW; Chen, J; Chi, ZQ; Gao, C; Xu, XJ, 2003) |
| " With time the dosing often increases because of tolerance." | 1.32 | Methadone dosage for prevention of opioid withdrawal in children. ( Cimino, M; Fletcher, JE; Heard, AM; Heard, CM; Kielma, D; Siddappa, R, 2003) |
| "buprenorphine was nearly as efficacious as the s." | 1.31 | Buprenorphine substitution ameliorates spontaneous withdrawal in fentanyl-dependent rat pups. ( Lohmann, AB; Smith, FL, 2001) |
| "Peak fentanyl infusion rate was 5." | 1.31 | Enteral methadone to expedite fentanyl discontinuation and prevent opioid abstinence syndrome in the PICU. ( Cash, J; Lugo, RA; MacLaren, R; Pribble, CG; Vernon, DD, 2001) |
| "Naloxone was sufficient to reverse respiratory impairment after fentanyl, alfentanil and M-140." | 1.30 | Studies on the abstinence-like overshoot following reversal of the potent 19-isoamyl derivative of etorphine with naloxone. A comparison with the opioids fentanyl and alfentanil. ( Freye, E; Neruda, B; Smith, OW, 1997) |
| "Corticosterone levels were positively correlated with fentanyl SA." | 1.30 | Sex differences in effects of predictable and unpredictable footshock on fentanyl self-administration in rats. ( Grunberg, NE; Klein, LC; Popke, EJ, 1997) |
| "The fentanyl infusion was decreased by 1 microg/kg/hr every 12-24 hrs and the midazolam infusion was decreased by 0." | 1.30 | Subcutaneous administration of fentanyl and midazolam to prevent withdrawal after prolonged sedation in children. ( Tobias, JD, 1999) |
| " The switch to oral agents must take into consideration the differences in potency, half-life, and oral bioavailability between the agents." | 1.29 | Outpatient therapy of iatrogenic drug dependency following prolonged sedation in the pediatric intensive care unit. ( Deshpande, JK; Gregory, DF; Tobias, JD, 1994) |
| "Drug withdrawal symptoms were monitored using the Neonatal Abstinence Score Tool (NAST), which assigns a score to each behavior indicative of withdrawal." | 1.29 | Drug withdrawal symptoms in children after continuous infusions of fentanyl. ( French, JP; Nocera, M, 1994) |
| "morphine was studied in anesthetized rats that had been rendered tolerant to s." | 1.28 | Tolerance to the respiratory actions of opiates: withdrawal tolerance and asymmetrical cross-tolerance. ( Ayesta, FJ; Flórez, J, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (8.33) | 18.7374 |
| 1990's | 25 (23.15) | 18.2507 |
| 2000's | 35 (32.41) | 29.6817 |
| 2010's | 24 (22.22) | 24.3611 |
| 2020's | 15 (13.89) | 2.80 |
| Authors | Studies |
|---|---|
| Warstadt, NM | 1 |
| Schmitz, ZP | 1 |
| Soghoian, SE | 1 |
| Townsend, EA | 2 |
| Blough, BE | 1 |
| Epstein, DH | 1 |
| Negus, SS | 1 |
| Shaham, Y | 2 |
| Banks, ML | 2 |
| Luba, R | 3 |
| Jones, J | 3 |
| Choi, CJ | 3 |
| Comer, S | 3 |
| Wei, J | 1 |
| Lai, M | 1 |
| Li, F | 1 |
| Chen, Y | 1 |
| Li, X | 1 |
| Qiu, Y | 1 |
| Shen, H | 1 |
| Xu, P | 1 |
| Di, B | 1 |
| Frank, D | 1 |
| Elliott, L | 1 |
| Cleland, CM | 1 |
| Walters, SM | 1 |
| Joudrey, PJ | 1 |
| Russell, DM | 1 |
| Meyerson, BE | 1 |
| Bennett, AS | 1 |
| Goulooze, SC | 1 |
| Ista, E | 2 |
| van Dijk, M | 1 |
| Hankemeier, T | 1 |
| Tibboel, D | 2 |
| Knibbe, CAJ | 1 |
| Krekels, EHJ | 1 |
| Danilewitz, M | 1 |
| McLean, M | 1 |
| Jones, JD | 1 |
| Sherwin, E | 1 |
| Martinez, S | 1 |
| Comer, SD | 1 |
| McAdam, M | 1 |
| Brar, R | 1 |
| Young, S | 1 |
| Hyun, DG | 1 |
| Huh, JW | 1 |
| Hong, SB | 1 |
| Koh, Y | 1 |
| Lim, CM | 1 |
| Neimark, G | 1 |
| Tjoa, C | 1 |
| Antoine, D | 1 |
| Huhn, AS | 1 |
| Strain, EC | 1 |
| Turner, G | 1 |
| Jardot, J | 1 |
| Hammond, AS | 1 |
| Dunn, KE | 1 |
| Michel, J | 1 |
| Sauter, L | 1 |
| Neunhoeffer, F | 1 |
| Hofbeck, M | 1 |
| Kumpf, M | 1 |
| Paulsen, F | 1 |
| Schmidt, A | 1 |
| Fuchs, J | 1 |
| Uddin, O | 1 |
| Jenne, C | 1 |
| Fox, ME | 1 |
| Arakawa, K | 1 |
| Keller, A | 1 |
| Cramer, N | 1 |
| Quattlebaum, THN | 1 |
| Kiyokawa, M | 1 |
| Murata, KA | 1 |
| Silverstein, SM | 1 |
| Daniulaityte, R | 1 |
| Getz, K | 1 |
| Zule, W | 1 |
| Jimenez, SM | 1 |
| Healy, AF | 1 |
| Coelho, MA | 1 |
| Brown, CN | 1 |
| Kippin, TE | 1 |
| Szumlinski, KK | 1 |
| Högl, B | 1 |
| Lohner, H | 1 |
| Mikus, G | 1 |
| Huff, H | 1 |
| Azar, P | 1 |
| Nikoo, M | 1 |
| Miles, I | 1 |
| Mahikhan, F | 1 |
| Hashemian, M | 1 |
| Dehesh, T | 1 |
| Jafari, E | 1 |
| Jafari, M | 1 |
| Rahimi, HR | 1 |
| Benahmed-Canat, A | 1 |
| Plaisant, F | 1 |
| Riche, B | 1 |
| Rabilloud, M | 1 |
| Canat, G | 1 |
| Paret, N | 1 |
| Claris, O | 1 |
| Kassai, B | 1 |
| Nguyen, KA | 1 |
| Blake, S | 1 |
| Faunce, KE | 1 |
| Hwang, CS | 1 |
| Natori, Y | 1 |
| Zhou, B | 1 |
| Bremer, PT | 1 |
| Janda, KD | 1 |
| Welzing, L | 1 |
| Link, F | 1 |
| Junghaenel, S | 1 |
| Oberthuer, A | 1 |
| Harnischmacher, U | 2 |
| Stuetzer, H | 1 |
| Roth, B | 2 |
| Hünseler, C | 1 |
| Balling, G | 1 |
| Röhlig, C | 1 |
| Blickheuser, R | 1 |
| Trieschmann, U | 1 |
| Lieser, U | 1 |
| Dohna-Schwake, C | 1 |
| Gebauer, C | 1 |
| Möller, O | 1 |
| Hering, F | 1 |
| Hoehn, T | 1 |
| Schubert, S | 1 |
| Hentschel, R | 1 |
| Huth, RG | 1 |
| Müller, A | 1 |
| Müller, C | 1 |
| Wassmer, G | 1 |
| Hahn, M | 1 |
| Behr, J | 1 |
| Vo, KT | 1 |
| Horng, H | 1 |
| Smollin, CG | 1 |
| Benowitz, NL | 1 |
| Liu, J | 1 |
| Pan, H | 1 |
| Gold, MS | 2 |
| Derendorf, H | 1 |
| Bruijnzeel, AW | 3 |
| Goicoechea, C | 1 |
| Sánchez, E | 1 |
| Cano, C | 1 |
| Jagerovic, N | 1 |
| Martín, MI | 1 |
| Sirohi, S | 1 |
| Dighe, SV | 1 |
| Madia, PA | 1 |
| Yoburn, BC | 1 |
| Grewal, PK | 1 |
| Firnhaber-Burgos, JB | 1 |
| Park, YM | 1 |
| Cho, JH | 1 |
| Lim, YS | 1 |
| Lee, HJ | 1 |
| Kang, SG | 1 |
| Kim, L | 1 |
| Seppala, MD | 1 |
| Berge, KH | 1 |
| Bowens, CD | 1 |
| Thompson, JA | 1 |
| Thompson, MT | 1 |
| Breitzka, RL | 1 |
| Thompson, DG | 1 |
| Sheeran, PW | 1 |
| Elhabazi, K | 1 |
| Trigo, JM | 1 |
| Mollereau, C | 1 |
| Moulédous, L | 1 |
| Zajac, JM | 1 |
| Bihel, F | 1 |
| Schmitt, M | 1 |
| Bourguignon, JJ | 1 |
| Meziane, H | 1 |
| Petit-demoulière, B | 1 |
| Bockel, F | 1 |
| Maldonado, R | 1 |
| Simonin, F | 1 |
| Shabanov, PD | 1 |
| Lebedev, AA | 1 |
| Maathuis, MH | 1 |
| Dijkstra, DD | 1 |
| Wildschut, E | 1 |
| da Silva, PS | 1 |
| Passos, RM | 1 |
| Waisberg, DR | 1 |
| Wei, X | 1 |
| Wei, W | 1 |
| Fanning, JJ | 1 |
| Stucke, AG | 1 |
| Christensen, MA | 1 |
| Cassidy, LD | 1 |
| Berens, RJ | 1 |
| Stein, M | 1 |
| Schomacher, J | 1 |
| Scharbrodt, W | 1 |
| Preuss, M | 1 |
| Oertel, MF | 1 |
| Fernández-Carrión, F | 1 |
| Gaboli, M | 1 |
| González-Celador, R | 1 |
| Gómez de Quero-Masía, P | 1 |
| Fernández-de Miguel, S | 1 |
| Murga-Herrera, V | 1 |
| Serrano-Ayestarán, O | 1 |
| Sánchez-Granados, JM | 1 |
| Payo-Pérez, R | 1 |
| Al-Qadheeb, NS | 1 |
| Roberts, RJ | 1 |
| Griffin, R | 1 |
| Garpestad, E | 1 |
| Ruthazer, R | 1 |
| Devlin, JW | 1 |
| Spahn, V | 1 |
| Fischer, O | 1 |
| Endres-Becker, J | 1 |
| Schäfer, M | 1 |
| Stein, C | 1 |
| Zöllner, C | 1 |
| Holtzman, SG | 1 |
| Gao, C | 1 |
| Che, LW | 1 |
| Chen, J | 1 |
| Xu, XJ | 1 |
| Chi, ZQ | 2 |
| Multz, AS | 1 |
| Dominguez, KD | 1 |
| Lomako, DM | 1 |
| Katz, RW | 1 |
| Kelly, HW | 2 |
| Puura, A | 1 |
| Taylor, BK | 1 |
| Basbaum, AI | 1 |
| Siddappa, R | 1 |
| Fletcher, JE | 1 |
| Heard, AM | 1 |
| Kielma, D | 1 |
| Cimino, M | 1 |
| Heard, CM | 1 |
| Terman, GW | 1 |
| Jin, W | 1 |
| Cheong, YP | 1 |
| Lowe, J | 1 |
| Caron, MG | 1 |
| Lefkowitz, RJ | 1 |
| Chavkin, C | 1 |
| Bencherif, B | 1 |
| Wand, GS | 2 |
| McCaul, ME | 2 |
| Kim, YK | 2 |
| Ilgin, N | 1 |
| Dannals, RF | 3 |
| Frost, JJ | 3 |
| Ripamonti, C | 1 |
| Campa, T | 1 |
| De Conno, F | 1 |
| Finsterer, J | 1 |
| Keller, H | 1 |
| Arias, I | 1 |
| Zuntner, G | 1 |
| Taha, J | 1 |
| Favre, J | 1 |
| Janszen, M | 1 |
| Galarza, M | 1 |
| Taha, A | 1 |
| Takara, I | 1 |
| Tomiyama, H | 1 |
| Tokumine, J | 1 |
| Sugahara, K | 1 |
| Greenwald, MK | 1 |
| Ahmad, N | 1 |
| Choy, CY | 1 |
| Aris, EA | 1 |
| Balan, S | 1 |
| Ishihara, C | 1 |
| Konishi, H | 1 |
| Chiba, M | 1 |
| Minouchi, T | 1 |
| Endo, Y | 1 |
| Yamaji, A | 1 |
| Lewis, B | 1 |
| Bajpai, LK | 1 |
| Morey, TE | 1 |
| Dennis, DM | 2 |
| Gold, M | 1 |
| Wheeler, AD | 1 |
| Tobias, JD | 3 |
| Ito, H | 1 |
| Sobue, K | 1 |
| Hirate, H | 1 |
| Sugiura, T | 1 |
| So, M | 1 |
| Azami, T | 1 |
| Sasano, H | 1 |
| Katsuya, H | 1 |
| Cohen, PJ | 1 |
| Marcinkiewcz, C | 1 |
| Isaac, S | 1 |
| Booth, MM | 1 |
| Weerts, EM | 1 |
| Lee, JS | 1 |
| Pohl-Schickinger, A | 1 |
| Lemmer, J | 1 |
| Hübler, M | 1 |
| Alexi-Meskishvili, V | 1 |
| Redlin, M | 1 |
| Berger, F | 1 |
| Stiller, B | 1 |
| Darnell, CM | 1 |
| Thompson, J | 1 |
| Stromberg, D | 1 |
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| Sheeran, P | 1 |
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| Wauquier, A | 1 |
| Boulard, G | 1 |
| Maurette, P | 1 |
| Pouguet, P | 1 |
| Dautheriben, M | 1 |
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| Klein, LC | 2 |
| Popke, EJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 1B Study of Sublingual Dexmedetomidine, an Alpha 2 Adrenergic Agonist, for Treating Opioid Withdrawal[NCT05712707] | Phase 1/Phase 2 | 160 participants (Anticipated) | Interventional | 2023-02-28 | Recruiting | ||
| Behavioral Pharmacological Examination of a Novel Buprenorphine Induction Method Among Individuals Who Use Fentanyl[NCT06089707] | Phase 3 | 25 participants (Anticipated) | Interventional | 2024-01-15 | Not yet recruiting | ||
| Adjunct Methadone to Decrease the Duration of Mechanical Ventilation in the Medical Intensive Care Unit[NCT02025855] | Phase 4 | 46 participants (Anticipated) | Interventional | 2014-01-31 | Enrolling by invitation | ||
| Efficacy of Clonidine in Reducing Iatrogenic-induced Opioid Dependence in Infants:[NCT01360450] | Phase 2/Phase 3 | 12 participants (Actual) | Interventional | 2011-07-31 | Terminated (stopped due to The study was treminated because of low accural) | ||
| The Impact of Concomitant Ultra Low Dose Infusion Naloxone and Therapeutic Infusion Opioid on Opioid Requirements in Pediatric ICU Patients[NCT00286052] | Phase 3 | 128 participants | Interventional | 2002-12-31 | Completed | ||
| Early Lactate-Directed Therapy on the ICU: A Randomized Controlled Trial[NCT00270673] | Phase 3 | 350 participants (Anticipated) | Interventional | 2006-02-28 | Completed | ||
| Effect of Clonidine vs. Dexmedetomidine in Addition to Standard Treatment in Agitated Delirium in Intensive Care Patients: Pilot Study.[NCT04758936] | Phase 4 | 50 participants (Anticipated) | Interventional | 2021-02-01 | Recruiting | ||
| Effects of Clonidine and Midazolam Premedication on Bispectral Index and Recovery After Elective Surgery[NCT00638729] | 60 participants (Actual) | Interventional | 2005-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Time to complete detoxification is defined as 48 hrs off all opioids/benzodiazepines and study drug with acceptable withdrawal scores of <9 (on average we expect the infant to be enrolled in the study for 2-4 weeks). The scale used to assess withdrawal was the Modified Finnegan Neonatal Withdrawal Scale, which ranges from 0-41, 0 represents no withdrawal and 41 represent maximum withdrawal. (NCT01360450)
Timeframe: up to 4 weeks
| Intervention | days (Mean) | |
|---|---|---|
| total days on narcotics | duration on study drug in days | |
| Control | 37.2 | 14.2 |
| Treatment | 89.5 | 21 |
2 reviews available for fentanyl and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Subcutaneous fentanyl and midazolam: an alternative method of weaning after intravenous sedation in pediatric patients.
Topics: Analgesics, Opioid; Child; Fentanyl; Humans; Hypnotics and Sedatives; Injections, Intravenous; Injec | 1999 |
Myoclonus secondary to withdrawal from transdermal fentanyl: case report and literature review.
Topics: Administration, Cutaneous; Adult; Female; Fentanyl; Humans; Myoclonus; Substance Withdrawal Syndrome | 2002 |
11 trials available for fentanyl and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Naloxone-Induced Withdrawal in Individuals With and Without Fentanyl-Positive Urine Samples.
Topics: Adult; Female; Fentanyl; Heroin Dependence; Humans; Male; Middle Aged; Naloxone; Narcotic Antagonist | 2020 |
Impact of Ondansetron on Withdrawal Signs, Fentanyl Requirement and Pain Relief in Opioid-addicted Patients under General Anesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Blood Pressure; Double-Blind Method; Fentanyl; Humans; | 2019 |
Remifentanil-induced tolerance, withdrawal or hyperalgesia in infants: a randomized controlled trial. RAPIP trial: remifentanil-based analgesia and sedation of paediatric intensive care patients.
Topics: Analgesia; Analgesics, Opioid; Drug Tolerance; Fentanyl; Gestational Age; Humans; Hyperalgesia; Hypn | 2013 |
Continuous infusion of clonidine in ventilated newborns and infants: a randomized controlled trial.
Topics: Age Factors; Analgesics; Analgesics, Opioid; Clonidine; Double-Blind Method; Female; Fentanyl; Human | 2014 |
A trial of methadone tapering schedules in pediatric intensive care unit patients exposed to prolonged sedative infusions.
Topics: Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedul | 2011 |
Opioid withdrawal in critically ill neonates.
Topics: Analgesics, Opioid; Critical Illness; Dose-Response Relationship, Drug; Female; Fentanyl; Humans; In | 2003 |
Transdermal nicotine increases heart rate after endotracheal intubation.
Topics: Adjuvants, Anesthesia; Administration, Cutaneous; Adult; Anesthesia, General; Anesthetics, Intraveno | 2003 |
Opioid craving and seeking behavior in physically dependent volunteers: effects of acute withdrawal and drug reinforcement opportunity.
Topics: Adult; Conditioning, Operant; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fentany | 2005 |
Preventing the withdrawal response associated with rocuronium injection: a comparison of fentanyl with lidocaine.
Topics: Adolescent; Adult; Androstanols; Anesthesia, General; Anesthetics, Intravenous; Anesthetics, Local; | 2005 |
Effect of low-dose naloxone infusion on fentanyl requirements in critically ill children.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Conscious Sedation; Critical Illness; Doubl | 2008 |
Effects of clonidine on narcotic requirements and hemodynamic response during induction of fentanyl anesthesia and endotracheal intubation.
Topics: Adult; Aged; Anesthesia; Clonidine; Drug Interactions; Electroencephalography; Female; Fentanyl; Hem | 1986 |
95 other studies available for fentanyl and Drug Withdrawal Symptoms
| Article | Year |
|---|---|
Olanzapine/samidorphan precipitated opioid withdrawal in a patient taking transdermal fentanyl.
Topics: Administration, Cutaneous; Analgesics, Opioid; Fentanyl; Humans; Naltrexone; Olanzapine; Substance W | 2022 |
Effect of TRV130 and methadone on fentanyl-vs.-food choice and somatic withdrawal signs in opioid-dependent and post-opioid-dependent rats.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Fentanyl; Male; Methadone; Narcotics; Opioid-Related Dis | 2022 |
Fentanyl withdrawal: Understanding symptom severity and exploring the role of body mass index on withdrawal symptoms and clearance.
Topics: Analgesics, Opioid; Animals; Body Mass Index; Cattle; Female; Fentanyl; Morphine; Narcotic Antagonis | 2023 |
Fentanyl withdrawal: Understanding symptom severity and exploring the role of body mass index on withdrawal symptoms and clearance.
Topics: Analgesics, Opioid; Animals; Body Mass Index; Cattle; Female; Fentanyl; Morphine; Narcotic Antagonis | 2023 |
Fentanyl withdrawal: Understanding symptom severity and exploring the role of body mass index on withdrawal symptoms and clearance.
Topics: Analgesics, Opioid; Animals; Body Mass Index; Cattle; Female; Fentanyl; Morphine; Narcotic Antagonis | 2023 |
Fentanyl withdrawal: Understanding symptom severity and exploring the role of body mass index on withdrawal symptoms and clearance.
Topics: Analgesics, Opioid; Animals; Body Mass Index; Cattle; Female; Fentanyl; Morphine; Narcotic Antagonis | 2023 |
Assessment of abuse potential of carfentanil.
Topics: Analgesics, Opioid; Animals; Fentanyl; Heroin; Mice; Naloxone; Rats; Substance Withdrawal Syndrome | 2023 |
"As safe as possible": a qualitative study of opioid withdrawal and risk behavior among people who use illegal opioids.
Topics: Analgesics, Opioid; Drug Overdose; Fentanyl; Humans; Risk-Taking; Substance Withdrawal Syndrome; Sub | 2023 |
Supervised Multidimensional Item Response Theory Modeling of Pediatric Iatrogenic Withdrawal Symptoms.
Topics: Child; Child, Preschool; Drug Therapy, Combination; Female; Fentanyl; Humans; Iatrogenic Disease; In | 2019 |
High-dose buprenorphine for treatment of high potency opioid use disorder.
Topics: Adult; Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Dose-Response Relationship, Dru | 2020 |
Initiation of injectable opioid agonist treatment in hospital: A case report.
Topics: Analgesics, Opioid; Fentanyl; Humans; Hydromorphone; Male; Middle Aged; Opiate Substitution Treatmen | 2020 |
Iatrogenic Opioid Withdrawal Syndrome in Critically Ill Patients: a Retrospective Cohort Study.
Topics: Aged; Analgesics, Opioid; Critical Illness; Female; Fentanyl; Humans; Incidence; Male; Middle Aged; | 2020 |
Treating Fentanyl Withdrawal.
Topics: Analgesics, Opioid; Buprenorphine; Fentanyl; Humans; Narcotic Antagonists; Substance Withdrawal Synd | 2020 |
Method for Successfully Inducting Individuals Who Use Illicit Fentanyl Onto Buprenorphine/Naloxone.
Topics: Adult; Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Female; Fentanyl; Humans; Male; | 2021 |
Method for Successfully Inducting Individuals Who Use Illicit Fentanyl Onto Buprenorphine/Naloxone.
Topics: Adult; Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Female; Fentanyl; Humans; Male; | 2021 |
Method for Successfully Inducting Individuals Who Use Illicit Fentanyl Onto Buprenorphine/Naloxone.
Topics: Adult; Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Female; Fentanyl; Humans; Male; | 2021 |
Method for Successfully Inducting Individuals Who Use Illicit Fentanyl Onto Buprenorphine/Naloxone.
Topics: Adult; Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Female; Fentanyl; Humans; Male; | 2021 |
Sedation practices during high dose rate brachytherapy for children with urogenital and perianal rhabdomyosarcoma.
Topics: Brachytherapy; Child; Child, Preschool; Delirium; Fentanyl; Humans; Hypnotics and Sedatives; Infant; | 2022 |
Divergent profiles of fentanyl withdrawal and associated pain in mice and rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Female; Fentanyl; Humans; Hyperalgesia; Locomotion; M | 2021 |
A case of buprenorphine-precipitated withdrawal managed with high-dose buprenorphine.
Topics: Analgesics, Opioid; Buprenorphine; Buprenorphine, Naloxone Drug Combination; Fentanyl; Humans; Nalox | 2022 |
Topics: Analgesics, Opioid; Fentanyl; Humans; Methamphetamine; Opioid-Related Disorders; Substance Withdrawa | 2021 |
Variability in prescription opioid intake and reinforcement amongst 129 substrains.
Topics: Analgesics, Opioid; Animals; Fentanyl; Genetic Variation; Heroin; Male; Mice; Opioid-Related Disorde | 2017 |
Acute and painful exacerbation of RLS and PLM induced by opioid interaction - withdrawal syndrome.
Topics: Aged, 80 and over; Analgesics, Opioid; Drug Combinations; Fentanyl; Humans; Male; Naloxone; Nocturna | 2017 |
Methadone to buprenorphine/naloxone induction without withdrawal utilizing transdermal fentanyl bridge in an inpatient setting-Azar method.
Topics: Administration, Cutaneous; Analgesics, Opioid; Buprenorphine, Naloxone Drug Combination; Delayed-Act | 2018 |
Postsurgery analgesic and sedative drug use in a French neonatal intensive care unit: A single-center retrospective cohort study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Cohort Studies; Drug Utilization; Femal | 2019 |
Conjugate vaccine produces long-lasting attenuation of fentanyl vs. food choice and blocks expression of opioid withdrawal-induced increases in fentanyl choice in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics, Opioid; Animals; Behavior, Animal; Choice Behavior | 2019 |
Severe Carisoprodol Withdrawal After a 14-Year Addiction and Acute Overdose.
Topics: Adult; Carisoprodol; Dexmedetomidine; Drug Overdose; Fentanyl; Haloperidol; Humans; Hypnotics and Se | 2017 |
Effects of fentanyl dose and exposure duration on the affective and somatic signs of fentanyl withdrawal in rats.
Topics: Affective Symptoms; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Fentanyl; Male; Nal | 2008 |
Analgesic activity and pharmacological characterization of N-[1-phenylpyrazol-3-yl]-N-[1-(2-phenethyl)-4-piperidyl] propenamide, a new opioid agonist acting peripherally.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationshi | 2008 |
The relative potency of inverse opioid agonists and a neutral opioid antagonist in precipitated withdrawal and antagonism of analgesia and toxicity.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Inverse Agonism; Fentanyl; Male; | 2009 |
The epidural works, but the patient hurts! Acute pain management of the chronic pain patient.
Topics: Acute Disease; Analgesia, Epidural; Analgesics, Opioid; Chronic Disease; Continuity of Patient Care; | 2009 |
The withdrawal from TDF therapy could induce transient RLS.
Topics: Fentanyl; Humans; Male; Middle Aged; Restless Legs Syndrome; Substance Withdrawal Syndrome | 2010 |
The addicted physician. A rational response to an irrational disease.
Topics: Adult; Buprenorphine; Combined Modality Therapy; Denial, Psychological; Fentanyl; Humans; Male; Mand | 2010 |
Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments.
Topics: Adamantane; Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Classical; Dipeptides; Drug | 2012 |
[Behavioral correlations of gradual forced administration of psychoactive drugs].
Topics: Amphetamine; Animals; Anxiety; Behavior, Animal; Dexamethasone; Dose-Response Relationship, Drug; Dr | 2011 |
Disaster after the plaster. Fentanyl withdrawal symptoms in a curable hospice patient.
Topics: Aged, 80 and over; Analgesics, Opioid; Colonic Neoplasms; Drug Administration Schedule; Female; Fent | 2011 |
Creating or preventing opioid addiction, finding the right dose.
Topics: Female; Fentanyl; Humans; Hypnotics and Sedatives; Intensive Care Units, Pediatric; Male; Methadone; | 2011 |
Withdrawal treatment with clonidine after prolonged use of chloral hydrate in a pediatric intensive care patient.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Chloral Hydrate; Clonidine; Fentanyl; Humans; Hypnoti | 2011 |
Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats.
Topics: Amines; Analgesics, Opioid; Animals; Chronic Pain; Cyclohexanecarboxylic Acids; Drug Tolerance; Fent | 2012 |
Perioperative opiate requirements in children with previous opiate infusion.
Topics: Analgesics, Opioid; Child; Child, Preschool; Critical Illness; Drug Tolerance; Female; Fentanyl; Hos | 2012 |
Cerebrospinal fluid lactate concentration after withdrawal of metabolic suppressive therapy in subarachnoid hemorrhage.
Topics: Adult; Aged; Female; Fentanyl; Glasgow Outcome Scale; Humans; Hypnotics and Sedatives; Intensive Car | 2012 |
Withdrawal syndrome in the pediatric intensive care unit. Incidence and risk factors.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Cohort Studies; Female; Fentanyl; Humans; H | 2013 |
Impact of enteral methadone on the ability to wean off continuously infused opioids in critically ill, mechanically ventilated adults: a case-control study.
Topics: Adult; Aged; Analgesics, Opioid; Case-Control Studies; Critical Illness; Enteral Nutrition; Female; | 2012 |
Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner.
Topics: Analgesics, Opioid; Animals; Calcium; Capsaicin; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent P | 2013 |
Discrimination of a single dose of morphine followed by naltrexone: substitution of other agonists for morphine and other antagonists for naltrexone in a rat model of acute dependence.
Topics: Acute Disease; Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Male; Methadone; Morph | 2003 |
Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm.
Topics: Analgesics; Animals; Behavior, Animal; Conditioning, Psychological; Cyclic AMP Response Element-Bind | 2003 |
Prolonged dexmedetomidine infusion as an adjunct in treating sedation-induced withdrawal.
Topics: Acinetobacter Infections; Adult; Analgesics, Opioid; Dexmedetomidine; Fentanyl; Humans; Hypnotics an | 2003 |
Systemic morphine-induced release of serotonin in the rostroventral medulla is not mimicked by morphine microinjection into the periaqueductal gray.
Topics: Analgesics, Opioid; Animals; Drug Administration Routes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Fentan | 2003 |
Methadone dosage for prevention of opioid withdrawal in children.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Dose-Response Relationship, Drug; Female; F | 2003 |
G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Implants; Drug Tolerance; Electr | 2004 |
Mu-opioid receptor binding measured by [11C]carfentanil positron emission tomography is related to craving and mood in alcohol dependence.
Topics: Adult; Affect; Alcoholism; Analgesics, Opioid; Brain; Carbon Radioisotopes; Case-Control Studies; Fe | 2004 |
Withdrawal symptoms during chronic transdermal fentanyl administration managed with oral methadone.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Analgesics, Opioid; Female; Fentanyl; Humans | 2004 |
Severe withdrawal from short-term transdermal fentanyl after naloxone for uremic pruritus.
Topics: Administration, Cutaneous; Analgesics, Opioid; Drug Interactions; Drug Therapy, Combination; Fentany | 2004 |
Correlation between withdrawal symptoms and medication pump residual volume in patients with implantable SynchroMed pumps.
Topics: Adult; Aged; Aged, 80 and over; Analgesia, Epidural; Analgesics, Opioid; Baclofen; Bupivacaine; Clon | 2004 |
[Withdrawal syndrome in a critically ill child after sedation with midazolam and fentanyl].
Topics: Child; Critical Illness; Esophageal Stenosis; Esophagoplasty; Female; Fentanyl; Humans; Hypnotics an | 2004 |
Withdrawal symptom after discontinuation of transdermal fentanyl at a daily dose of 0.6 mg.
Topics: Administration, Cutaneous; Adult; Aged; Analgesics, Opioid; Female; Fentanyl; Humans; Male; Middle A | 2005 |
Severe deficit in brain reward function associated with fentanyl withdrawal in rats.
Topics: Affect; Animals; Brain; Dose-Response Relationship, Drug; Fentanyl; Male; Medial Forebrain Bundle; N | 2006 |
Bradycardia during methadone therapy in an infant.
Topics: Analgesics, Opioid; Anesthetics, Intravenous; Bradycardia; Fentanyl; Humans; Infant; Male; Methadone | 2006 |
Use of ketamine to facilitate opioid withdrawal in a child.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Child, Preschool; Female; Fentanyl; Humans; Ketamine; | 2006 |
Fentanyl abuse and dependence: further evidence for second hand exposure hypothesis. Comments by Peter J. Cohen.
Topics: Analgesics, Opioid; Anesthesiology; Fentanyl; Humans; Occupational Diseases; Physicians; Psychologic | 2006 |
The effects of buprenorphine on fentanyl withdrawal in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Buprenorphine; Disease Models, Animal; Dose-Response | 2007 |
Differences in delta- and mu-opioid receptor blockade measured by positron emission tomography in naltrexone-treated recently abstinent alcohol-dependent subjects.
Topics: Adult; Alcoholism; Analgesics, Opioid; Data Interpretation, Statistical; Female; Fentanyl; Humans; M | 2008 |
Intravenous clonidine infusion in infants after cardiovascular surgery.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Blood Pressure; Body Temperature; Clonidine; Female; Fent | 2008 |
Opiate receptor involvement in the quasi-morphine withdrawal syndrome induced by acute injection of R 18 503.
Topics: Animals; Fentanyl; Humans; Imidazoles; Male; Morphine; Narcotic Antagonists; Rats; Rats, Inbred Stra | 1982 |
[Withdrawal syndrome after stopping fentanyl sedation in neurological intensive care].
Topics: Coma; Critical Care; Fentanyl; Humans; Neurologic Examination; Pupil; Substance Withdrawal Syndrome | 1983 |
Pre-operative alcohol infusion. The need for analgesic supplementation in chronic alcoholics.
Topics: Alcoholism; Anesthesia, Inhalation; Drug Tolerance; Ethanol; Female; Fentanyl; Hemodynamics; Humans; | 1984 |
Use of T-test with nonparametric data: fentanyl withdrawal syndrome.
Topics: Female; Fentanyl; Humans; Infant; Male; Statistics as Topic; Substance Withdrawal Syndrome | 1995 |
Withdrawal symptoms during therapy with transdermal fentanyl (fentanyl TTS)?
Topics: Administration, Cutaneous; Adult; Colonic Neoplasms; Female; Fentanyl; Humans; Middle Aged; Morphine | 1994 |
Withdrawal with transdermal fentanyl.
Topics: Administration, Cutaneous; Fentanyl; Humans; Male; Middle Aged; Morphine; Substance Withdrawal Syndr | 1995 |
Immobilization stress-induced oral opioid self-administration and withdrawal in rats: role of conditioning factors and the effect of stress on "relapse" to opioid drugs.
Topics: Animals; Conditioning, Psychological; Corticosterone; Fentanyl; Immobilization; Male; Morphine; Morp | 1993 |
Outpatient therapy of iatrogenic drug dependency following prolonged sedation in the pediatric intensive care unit.
Topics: Child; Female; Fentanyl; Humans; Iatrogenic Disease; Infant; Lorazepam; Male; Methadone; Midazolam; | 1994 |
Energy expenditure and withdrawal of sedation in severe head-injured patients.
Topics: Acute Disease; Adult; Blood Pressure; Craniocerebral Trauma; Energy Metabolism; Fentanyl; Glasgow Co | 1994 |
Drug withdrawal symptoms in children after continuous infusions of fentanyl.
Topics: Critical Illness; Fentanyl; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Intensive Care | 1994 |
Fentanyl infusion and weaning in the pediatric intensive care unit: toward science-based practice.
Topics: Child; Drug Tolerance; Drug Utilization; Fentanyl; Humans; Infusions, Intravenous; Intensive Care Un | 1994 |
Prospective study on the occurrence of withdrawal in critically ill children who receive fentanyl by continuous infusion.
Topics: Chi-Square Distribution; Critical Illness; Dose-Response Relationship, Drug; Female; Fentanyl; Human | 1994 |
Increased mu opioid receptor binding detected by PET in cocaine-dependent men is associated with cocaine craving.
Topics: Adult; Analgesics, Opioid; Brain; Cocaine; Female; Fentanyl; Humans; Male; Opioid-Related Disorders; | 1996 |
Transdermal fentanyl and the opioid withdrawal syndrome.
Topics: Administration, Cutaneous; Aged; Analgesics, Opioid; Diarrhea; Fentanyl; Humans; Male; Morphine; Pal | 1996 |
Transdermal fentanyl and the opioid withdrawal syndrome.
Topics: Abdominal Pain; Administration, Cutaneous; Adult; Analgesics, Opioid; Diarrhea; Female; Fentanyl; Hu | 1996 |
Studies on the abstinence-like overshoot following reversal of the potent 19-isoamyl derivative of etorphine with naloxone. A comparison with the opioids fentanyl and alfentanil.
Topics: Alfentanil; Analgesics, Opioid; Animals; Blood Gas Analysis; Blood Pressure; Dogs; Dose-Response Rel | 1997 |
Potent reinforcing effects of dihydroetorphine in rats.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Etorphine; Fentanyl; Heroin; Male; Mo | 1997 |
Sex differences in effects of predictable and unpredictable footshock on fentanyl self-administration in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Conditioning, Operant; Corticosterone; Electroshock; | 1997 |
Opioid withdrawal in neonates after continuous infusions of morphine or fentanyl during extracorporeal membrane oxygenation.
Topics: Analgesics, Opioid; Extracorporeal Membrane Oxygenation; Fentanyl; Humans; Infant, Newborn; Infusion | 1998 |
Re: Fentanyl, morphine, and constipation.
Topics: Analgesics, Opioid; Constipation; Diarrhea; Fentanyl; Humans; Morphine; Substance Withdrawal Syndrom | 1998 |
Subcutaneous administration of fentanyl and midazolam to prevent withdrawal after prolonged sedation in children.
Topics: Analgesics, Opioid; Body Weight; Child; Child, Preschool; Conscious Sedation; Fentanyl; Humans; Hypn | 1999 |
Comparison of physical dependence of ohmefentanyl stereoisomers in mice.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fentanyl; Male; Mice; | 2000 |
Buprenorphine substitution ameliorates spontaneous withdrawal in fentanyl-dependent rat pups.
Topics: Administration, Oral; Animals; Buprenorphine; Female; Fentanyl; Injections, Subcutaneous; Narcotic A | 2001 |
Ultrarapid opioid detoxification: effects on cardiopulmonary physiology, stress hormones and clinical outcomes.
Topics: Adrenocorticotropic Hormone; Adult; Analgesics, Opioid; Analysis of Variance; Anesthesia, General; B | 2001 |
Anxiogenic-like effects of opiate withdrawal seen in the fear-potentiated startle test, an interdisciplinary probe for drug-related motivational states.
Topics: Acoustic Stimulation; Analgesics, Opioid; Animals; Anxiety; Behavior, Animal; Body Weight; Fear; Fen | 2001 |
Effects of adolescent nicotine exposure on opioid consumption and neuroendocrine responses in adult male and female rats.
Topics: Adrenocorticotropic Hormone; Aging; Analgesics, Opioid; Animals; Body Weight; Corticosterone; Drinki | 2001 |
Enteral methadone to expedite fentanyl discontinuation and prevent opioid abstinence syndrome in the PICU.
Topics: Adolescent; Analgesics, Opioid; Child; Fentanyl; Humans; Intensive Care Units, Pediatric; Methadone; | 2001 |
Discriminative stimulus properties of fentanyl and morphine: tolerance and dependence.
Topics: Analgesics, Opioid; Animals; Discrimination, Psychological; Drug Tolerance; Fentanyl; Generalization | 1976 |
[Fentanyl abuse].
Topics: Adult; Female; Fentanyl; Humans; Male; Nurses; Physicians; Substance Withdrawal Syndrome; Substance- | 1978 |
Epidural sufentanil for acute pain control in a patient with extreme opioid dependency.
Topics: Adult; Analgesia, Epidural; Analgesics; Female; Fentanyl; Humans; Methadone; Pain, Postoperative; Po | 1992 |
Fentanyl, fads, and folly: who will adopt the therapeutic orphans?
Topics: Drug Tolerance; Fentanyl; Humans; Infant; Infant, Newborn; Midazolam; Substance Withdrawal Syndrome | 1991 |
Movement disorder after withdrawal of fentanyl infusion.
Topics: Child, Preschool; Dyskinesia, Drug-Induced; Female; Fentanyl; Humans; Infant; Infusions, Intravenous | 1991 |
Parker and Radow test of drug withdrawal aversion: opposite effect in rats chronically infused with sufentanil or amphetamine.
Topics: Analgesics, Opioid; Animals; Body Weight; Choice Behavior; Dextroamphetamine; Fentanyl; Infusion Pum | 1990 |
Tolerance to the respiratory actions of opiates: withdrawal tolerance and asymmetrical cross-tolerance.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine- | 1990 |
Clonidine as a sedative adjunct in intensive care.
Topics: Clonidine; Critical Care; Drug Synergism; Drug Therapy, Combination; Fentanyl; Gastrectomy; Humans; | 1990 |
Magnitude of opioid dependence after continuous intrathecal infusion of mu- and delta-selective opioids in the rat.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; En | 1989 |
Opioid dependence in the guinea-pig myenteric plexus is controlled by non-tolerant and tolerant opioid receptors.
Topics: Animals; Drug Tolerance; Fentanyl; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Muscle Con | 1985 |
Aftereffects of morphine and fentanyl analgesia: a retrospective study.
Topics: Analgesia; Critical Care; Fentanyl; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Morphin | 1988 |