fentanyl has been researched along with Disease Models, Animal in 77 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study, we demonstrated that repeated treatment with fentanyl, but not morphine or oxycodone, causes a rapid desensitization to its ability to block the hyperalgesia associated with the attenuation of mu-opioid receptor resensitization in mice in a chronic pain-like state." | 8.84 | [Difference in tolerance to anti-hyperalgesic effect and its molecular mechanisms between chronic treatment with morphine, fentanyl and oxycodone in a chronic pain-like state]. ( Hashimoto, S; Kuzumaki, N; Nakamura, A; Narita, M; Ozeki, A; Satoshi, I; Suzuki, T; Uezono, Y, 2008) |
| "Fentanyl is an opioid commonly prescribed for cancer pain." | 7.88 | Analgesic effects of systemic fentanyl on cancer pain are mediated by not only central but also peripheral opioid receptors in mice. ( Andoh, T; Kuraishi, Y; Saiki, I; Shinohara, A, 2018) |
| "Morphine, oxycodone, and fentanyl are clinically prescribed drugs for the management of severe pain." | 7.75 | Morphine, oxycodone, and fentanyl exhibit different analgesic profiles in mouse pain models. ( Hasegawa, M; Ito, H; Kanemasa, T; Kato, A; Kihara, T; Koike, K; Masuno, K; Matsumoto, M; Matsushima, S; Minami, K; Miyoshi, T; Nakamura, A; Narita, M; Orita, S; Shimada, S; Suzuki, T; Tomii, T; Torii, M, 2009) |
| "The present study was conducted to evaluate the pain development and bone destruction during bone cancer growth in a murine model of bone cancer pain and to evaluate the analgesic efficacy of fentanyl, sufentanil, and morphine in this model." | 7.73 | Evaluation of pain-related behavior, bone destruction and effectiveness of fentanyl, sufentanil, and morphine in a murine model of cancer pain. ( El Mouedden, M; Meert, TF, 2005) |
| "Although TIVA is less prone than isoflurane anaesthesia to primary cardiovascular depression leading to asphyxia, TIVA is associated with reduced effectiveness of CPR in which resuscitation because of asphyxic haemodynamic depression occurs." | 7.72 | Comparison of isoflurane and propofol-fentanyl anaesthesia in a swine model of asphyxia. ( Kazama, T; Kurita, T; Morita, K; Sato, S, 2003) |
| "In dogs, intraoperative cardiac tamponade caused comparable changes in RBF under the different anesthetic techniques except that autoregulation was effective in maintaining RBF within the central nervous system only under isoflurane anesthesia." | 7.72 | Isoflurane preserves central nervous system blood flow during intraoperative cardiac tamponade in dogs. ( Crystal, GJ; Metwally, AA; Salem, MR, 2004) |
| "Eight rabbits tracheotomized and vascularly cannulated under 3% isoflurane anesthesia were placed on a sling that allowed for free movement of the head and extremities." | 7.72 | A rabbit model for evaluation of surgical anesthesia and analgesia: characterization and validation with isoflurane anesthesia and fentanyl analgesia. ( Arita, H; Fukuda, K; Fukunaga, A; Hanaoka, K; Hayashida, M; Yamazaki, SY, 2004) |
| "We examined the effects of intravenous anesthetics (thiopental, fentanyl and morphine) on the ventricular activation in a canine myocardial infarction model." | 7.68 | Effects of intravenous anesthetics, thiopental, fentanyl, and morphine on ventricular delayed activation in a canine myocardial infarction model. ( Hashimoto, H; Ikeda, K; Imamura, S; Nakashima, M, 1993) |
| " Interestingly, drug dosage reduction permitted to reduce the incidence of possible adverse effects, namely exploratory activity and motor coordination, thus it was demonstrated that it improved the benefit/risk profile of such treatment." | 5.37 | Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. ( Ciruela, F; Fernández, A; Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2011) |
| "The femur bone cancer pain model was developed by implanting mouse osteolytic tumor cells (NCTC 2472) into the intramedulla of the femur in C3H/HeN mice." | 5.35 | Oxycodone-induced analgesic effects in a bone cancer pain model in mice. ( Ito, H; Kato, A; Kihara, T; Matsumoto, M; Minami, K; Narita, M; Orita, S; Suzuki, T; Tomii, T, 2008) |
| "Fifty percent N2O strongly reduced hyperalgesia induced by a first inflammation and its enhancement by fentanyl, and prevented exaggerated hyperalgesia induced by second inflammatory pain or NNES." | 5.34 | Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats. ( Bessière, B; Contarino, A; Laboureyras, E; Laulin, JP; Richebé, P; Simonnet, G, 2007) |
| " Morphine, pethidine and fentanyl, which showed a biphasic dose-response relationship with respect to seizure modulation, abolished the anticonvulsant activity of propofol to exhibit their own intrinsic activity in proconvulsant doses." | 5.29 | Interactions between opioid drugs and propofol in laboratory models of seizures. ( Ahmad, I; Pleuvry, BJ, 1995) |
| "In the present study, we demonstrated that repeated treatment with fentanyl, but not morphine or oxycodone, causes a rapid desensitization to its ability to block the hyperalgesia associated with the attenuation of mu-opioid receptor resensitization in mice in a chronic pain-like state." | 4.84 | [Difference in tolerance to anti-hyperalgesic effect and its molecular mechanisms between chronic treatment with morphine, fentanyl and oxycodone in a chronic pain-like state]. ( Hashimoto, S; Kuzumaki, N; Nakamura, A; Narita, M; Ozeki, A; Satoshi, I; Suzuki, T; Uezono, Y, 2008) |
| "Fentanyl is an opioid commonly prescribed for cancer pain." | 3.88 | Analgesic effects of systemic fentanyl on cancer pain are mediated by not only central but also peripheral opioid receptors in mice. ( Andoh, T; Kuraishi, Y; Saiki, I; Shinohara, A, 2018) |
| " Here, we attempted to characterize a synergistic interaction between fentanyl, tramadol, and paracetamol on the inhibition of nociception in a model of visceral pain in mice." | 3.78 | Synergistic interaction between fentanyl and a tramadol: paracetamol combination on the inhibition of nociception in mice. ( Ciruela, F; Fernández-Dueñas, V; Poveda, R; Sánchez, S, 2012) |
| "Morphine, oxycodone, and fentanyl are clinically prescribed drugs for the management of severe pain." | 3.75 | Morphine, oxycodone, and fentanyl exhibit different analgesic profiles in mouse pain models. ( Hasegawa, M; Ito, H; Kanemasa, T; Kato, A; Kihara, T; Koike, K; Masuno, K; Matsumoto, M; Matsushima, S; Minami, K; Miyoshi, T; Nakamura, A; Narita, M; Orita, S; Shimada, S; Suzuki, T; Tomii, T; Torii, M, 2009) |
| "The present study was conducted to evaluate the pain development and bone destruction during bone cancer growth in a murine model of bone cancer pain and to evaluate the analgesic efficacy of fentanyl, sufentanil, and morphine in this model." | 3.73 | Evaluation of pain-related behavior, bone destruction and effectiveness of fentanyl, sufentanil, and morphine in a murine model of cancer pain. ( El Mouedden, M; Meert, TF, 2005) |
| "In dogs, intraoperative cardiac tamponade caused comparable changes in RBF under the different anesthetic techniques except that autoregulation was effective in maintaining RBF within the central nervous system only under isoflurane anesthesia." | 3.72 | Isoflurane preserves central nervous system blood flow during intraoperative cardiac tamponade in dogs. ( Crystal, GJ; Metwally, AA; Salem, MR, 2004) |
| "Eight rabbits tracheotomized and vascularly cannulated under 3% isoflurane anesthesia were placed on a sling that allowed for free movement of the head and extremities." | 3.72 | A rabbit model for evaluation of surgical anesthesia and analgesia: characterization and validation with isoflurane anesthesia and fentanyl analgesia. ( Arita, H; Fukuda, K; Fukunaga, A; Hanaoka, K; Hayashida, M; Yamazaki, SY, 2004) |
| "Although TIVA is less prone than isoflurane anaesthesia to primary cardiovascular depression leading to asphyxia, TIVA is associated with reduced effectiveness of CPR in which resuscitation because of asphyxic haemodynamic depression occurs." | 3.72 | Comparison of isoflurane and propofol-fentanyl anaesthesia in a swine model of asphyxia. ( Kazama, T; Kurita, T; Morita, K; Sato, S, 2003) |
| " After the treatment of mice for 6 days with implanted morphine pellets followed by their removal, both thermal hyperalgesia and mechanical allodynia were documented." | 3.71 | A murine model of opioid-induced hyperalgesia. ( Angst, MS; Clark, JD; Li, X, 2001) |
| "In this experimental pain model, activation of peripheral mu or kappa opioid receptors can attenuate capsaicin-induced thermal hyperalgesia in rats." | 3.70 | Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats. ( Johnson, MD; Ko, MC; Tuchman, JE; Wiesenauer, K; Woods, JH, 2000) |
| "We examined the effects of intravenous anesthetics (thiopental, fentanyl and morphine) on the ventricular activation in a canine myocardial infarction model." | 3.68 | Effects of intravenous anesthetics, thiopental, fentanyl, and morphine on ventricular delayed activation in a canine myocardial infarction model. ( Hashimoto, H; Ikeda, K; Imamura, S; Nakashima, M, 1993) |
| "These results suggest that hyperalgesia induced by a tourniquet may be a useful technique for the investigation of the anti-nociceptive effects of analgesic drugs in sheep." | 2.67 | Effects of non-steroidal anti-inflammatory drugs on the hyperalgesia to noxious mechanical stimulation induced by the application of a tourniquet to a forelimb of sheep. ( Nolan, AM; Welsh, EM, 1994) |
| " Furthermore, enduring exacerbation of nociceptive hypersensitivity is also observed when the same dosing regimen for either morphine, fentanyl, or oxycodone begins 1 month after nerve injury." | 1.51 | Oxycodone, fentanyl, and morphine amplify established neuropathic pain in male rats. ( Ball, JB; Fabisiak, T; Grace, PM; Green-Fulgham, SM; Kwilasz, AJ; Maier, SF; Watkins, LR, 2019) |
| "Carrageenan-induced hyperalgesia is a widely used pain model in rodents." | 1.40 | Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain. ( Ko, MC; Lee, H; Rice, KC; Sukhtankar, DD, 2014) |
| "Rats exhibited significant mechanical allodynia following 2 weeks of chronic oxaliplatin administration." | 1.40 | The contribution of Gi/o protein to opioid antinociception in an oxaliplatin-induced neuropathy rat model. ( Hasegawa, M; Kanbara, T; Kanemasa, T; Mori, T; Nakamura, A; Ogawa, K; Sakaguchi, G; Shibasaki, M; Suzuki, T; Takasu, K, 2014) |
| "Hyperalgesia is a cardinal symptom of opioid withdrawal." | 1.39 | Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner. ( Endres-Becker, J; Fischer, O; Schäfer, M; Spahn, V; Stein, C; Zöllner, C, 2013) |
| "An asphyxial cardiac arrest rat model was used and mild hypothermia (33°C) was induced 1 hr post injury by surface cooling and continued for 10 hrs to mimic the prolonged clinical application of hypothermia accompanied by intensive care interventions." | 1.38 | Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest. ( Empey, PE; Kochanek, PM; Melick, JA; Miller, TM; Philbrick, AH; Poloyac, SM, 2012) |
| "In prestressed rats, fULD-induced hyperalgesia and the exaggerated inflammatory hyperalgesia were prevented NMDA receptor antagonists." | 1.37 | Endogenous opioids released during non-nociceptive environmental stress induce latent pain sensitization Via a NMDA-dependent process. ( Chateauraynaud, J; Gavello-Baudy, S; Laboureyras, E; Laulin, JP; Le Roy, C; Simonnet, G, 2011) |
| "Long-lasting hyperalgesia was induced in male Sprague Dawley rats with subcutaneous fentanyl (4 injections, 60 μg/kg per injection at 15-minute intervals) resulting in a total dose of 240 μg/kg." | 1.37 | The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction. ( Benhamou, D; Mazoit, JX; Sitbon, P; Van Elstraete, AC, 2011) |
| " Interestingly, drug dosage reduction permitted to reduce the incidence of possible adverse effects, namely exploratory activity and motor coordination, thus it was demonstrated that it improved the benefit/risk profile of such treatment." | 1.37 | Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain. ( Ciruela, F; Fernández, A; Fernández-Dueñas, V; Planas, E; Poveda, R; Sánchez, S, 2011) |
| "The femur bone cancer pain model was developed by implanting mouse osteolytic tumor cells (NCTC 2472) into the intramedulla of the femur in C3H/HeN mice." | 1.35 | Oxycodone-induced analgesic effects in a bone cancer pain model in mice. ( Ito, H; Kato, A; Kihara, T; Matsumoto, M; Minami, K; Narita, M; Orita, S; Suzuki, T; Tomii, T, 2008) |
| "Buprenorphine has an opioid component to its supraspinal mechanism of analgesic action." | 1.35 | Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine. ( Ding, Z; Raffa, RB, 2009) |
| "Sevoflurane effects on hyperalgesia were evaluated in Sprague-Dawley rats: opioid-naive rats, rats treated with fentanyl (4 x 60 microg kg(-1)) and rats with inflammatory pain (carrageenan) treated with fentanyl (4 x 60 microg kg(-1))." | 1.35 | Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats. ( Janvier, G; Laulin, JP; Maurette, P; Richebé, P; Rivalan, B; Rivat, C; Simonnet, G, 2009) |
| "Fentanyl is a potent mu-opioid receptor agonist that is widely used for the treatment of severe chronic pain." | 1.34 | The effects of buprenorphine on fentanyl withdrawal in rats. ( Booth, MM; Bruijnzeel, AW; Dennis, DM; Gold, MS; Isaac, S; Marcinkiewcz, C, 2007) |
| "Buprenorphine (0." | 1.34 | Buprenorphine ameliorates the effect of surgery on hypothalamus-pituitary-adrenal axis, natural killer cell activity and metastatic colonization in rats in comparison with morphine or fentanyl treatment. ( Franchi, S; Panerai, AE; Sacerdote, P, 2007) |
| "Fifty percent N2O strongly reduced hyperalgesia induced by a first inflammation and its enhancement by fentanyl, and prevented exaggerated hyperalgesia induced by second inflammatory pain or NNES." | 1.34 | Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats. ( Bessière, B; Contarino, A; Laboureyras, E; Laulin, JP; Richebé, P; Simonnet, G, 2007) |
| "By opposing postoperative pain hypersensitivity and subsequent short-term tolerance induced by perioperative opioid use, ketamine not only improves exaggerated postoperative pain management but also provides better postoperative rehabilitation." | 1.33 | Ketamine improves the management of exaggerated postoperative pain observed in perioperative fentanyl-treated rats. ( Laulin, JP; Maurette, P; Richebé, P; Rivat, C; Simonnet, G, 2005) |
| "Rats treated with isoflurane had the best cognitive recovery (p < 0." | 1.33 | Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats. ( Alexander, H; Clark, RS; Dixon, CE; Jenkins, L; Kochanek, PM; Statler, KD; Vagni, V, 2006) |
| "Ketamine has not elicited the HSR in this model of experimental burns and, therefore, its protective effects were not shown to be mediated through this mechanism." | 1.32 | Ketamine reduces mortality of severely burnt rats, when compared to midazolam plus fentanyl. ( Lázaro Da Silva, A; Neder Meyer, T, 2004) |
| "The initial hyperalgesia induced by 0." | 1.31 | Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia. ( Assié, MB; Bardin, L; Carilla-Durand, E; Colpaert, FC; Cosi, C; Koek, W; Pauwels, PJ; Tarayre, JP; Vacher, B; Wiesenfeld-Hallin, Z; Xu, XJ, 2002) |
| "Propofol is a cardiac depressant with minimal diastolic effects in the adult myocardium." | 1.30 | Left ventricular systolic and diastolic function is unaltered during propofol infusion in newborn swine. ( Graham, MR; Mutch, WA; Thiessen, DB, 1998) |
| " Morphine, pethidine and fentanyl, which showed a biphasic dose-response relationship with respect to seizure modulation, abolished the anticonvulsant activity of propofol to exhibit their own intrinsic activity in proconvulsant doses." | 1.29 | Interactions between opioid drugs and propofol in laboratory models of seizures. ( Ahmad, I; Pleuvry, BJ, 1995) |
| "Xylazine was significantly more effective in obtunding deep pain (P less than 0." | 1.26 | Objective tests of analgesic drugs in ponies. ( Lumb, WV; Pippi, NL, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (5.19) | 18.7374 |
| 1990's | 10 (12.99) | 18.2507 |
| 2000's | 32 (41.56) | 29.6817 |
| 2010's | 29 (37.66) | 24.3611 |
| 2020's | 2 (2.60) | 2.80 |
| Authors | Studies |
|---|---|
| Xiong, J | 1 |
| Jin, J | 1 |
| Gao, L | 1 |
| Hao, C | 1 |
| Liu, X | 3 |
| Liu, BF | 1 |
| Chen, Y | 1 |
| Zhang, G | 1 |
| Yuan, J | 1 |
| Yang, MC | 1 |
| Wu, MJ | 1 |
| Gou, YS | 1 |
| Thevathasan, T | 1 |
| Grabitz, SD | 1 |
| Santer, P | 1 |
| Rostin, P | 1 |
| Akeju, O | 1 |
| Boghosian, JD | 1 |
| Gill, M | 1 |
| Isaacs, L | 1 |
| Cotten, JF | 1 |
| Eikermann, M | 1 |
| Xiang, L | 1 |
| Klemcke, HG | 1 |
| Wienandt, NA | 1 |
| Ryan, KL | 1 |
| Hinojosa-Laborde, C | 1 |
| Li, QB | 1 |
| Chang, L | 2 |
| Ye, F | 2 |
| Luo, QH | 1 |
| Tao, YX | 1 |
| Shu, HH | 1 |
| Luo, Q | 1 |
| Wang, Z | 1 |
| Wang, Y | 1 |
| Xia, Z | 1 |
| Shu, H | 1 |
| Shinohara, A | 1 |
| Andoh, T | 1 |
| Saiki, I | 1 |
| Kuraishi, Y | 1 |
| Rangappa, S | 1 |
| Rangan, KK | 1 |
| Sudarshan, TS | 1 |
| Murthy, SN | 1 |
| Marquart, K | 1 |
| Herbert, J | 1 |
| Amend, N | 1 |
| Thiermann, H | 1 |
| Worek, F | 1 |
| Wille, T | 1 |
| Green-Fulgham, SM | 1 |
| Ball, JB | 1 |
| Kwilasz, AJ | 1 |
| Fabisiak, T | 1 |
| Maier, SF | 1 |
| Watkins, LR | 1 |
| Grace, PM | 1 |
| Savić Vujović, KR | 1 |
| Vučković, S | 1 |
| Srebro, D | 1 |
| Ivanović, M | 1 |
| Došen-Mićović, L | 1 |
| Vučetić, Č | 1 |
| Džoljić, E | 1 |
| Prostran, M | 1 |
| Sabir, H | 1 |
| Bishop, S | 1 |
| Cohen, N | 1 |
| Maes, E | 1 |
| Dingley, J | 1 |
| Thoresen, M | 1 |
| Podolsky, AT | 1 |
| Sandweiss, A | 1 |
| Hu, J | 1 |
| Bilsky, EJ | 1 |
| Cain, JP | 1 |
| Kumirov, VK | 1 |
| Lee, YS | 1 |
| Hruby, VJ | 1 |
| Vardanyan, RS | 1 |
| Vanderah, TW | 1 |
| Sukhtankar, DD | 1 |
| Lee, H | 1 |
| Rice, KC | 1 |
| Ko, MC | 2 |
| Soares, JH | 1 |
| Brosnan, RJ | 1 |
| Smith, A | 1 |
| Mayhew, PD | 1 |
| Ramos-Zepeda, GA | 1 |
| Herrero-Zorita, C | 1 |
| Herrero, JF | 1 |
| Kanbara, T | 1 |
| Nakamura, A | 3 |
| Takasu, K | 1 |
| Ogawa, K | 1 |
| Shibasaki, M | 1 |
| Mori, T | 1 |
| Suzuki, T | 4 |
| Hasegawa, M | 2 |
| Sakaguchi, G | 1 |
| Kanemasa, T | 2 |
| Anand, JP | 1 |
| Boyer, BT | 1 |
| Mosberg, HI | 1 |
| Jutkiewicz, EM | 1 |
| Zazzeron, L | 1 |
| Liu, C | 1 |
| Franco, W | 1 |
| Nakagawa, A | 1 |
| Farinelli, WA | 1 |
| Bloch, DB | 1 |
| Anderson, RR | 1 |
| Zapol, WM | 1 |
| Elhabazi, K | 1 |
| Humbert, JP | 1 |
| Bertin, I | 1 |
| Quillet, R | 1 |
| Utard, V | 1 |
| Schneider, S | 1 |
| Schmitt, M | 1 |
| Bourguignon, JJ | 1 |
| Laboureyras, E | 3 |
| Ben Boujema, M | 1 |
| Simonnet, G | 5 |
| Ancel, C | 1 |
| Simonneaux, V | 1 |
| Beltramo, M | 1 |
| Bucher, B | 1 |
| Sorg, T | 1 |
| Meziane, H | 1 |
| Schneider, E | 1 |
| Petit-Demoulière, B | 1 |
| Ilien, B | 1 |
| Bihel, F | 1 |
| Simonin, F | 1 |
| Goicoechea, C | 1 |
| Sánchez, E | 1 |
| Cano, C | 1 |
| Jagerovic, N | 1 |
| Martín, MI | 1 |
| Kato, A | 2 |
| Minami, K | 2 |
| Ito, H | 2 |
| Tomii, T | 2 |
| Matsumoto, M | 2 |
| Orita, S | 2 |
| Kihara, T | 2 |
| Narita, M | 4 |
| Satoshi, I | 1 |
| Ozeki, A | 1 |
| Hashimoto, S | 1 |
| Kuzumaki, N | 1 |
| Uezono, Y | 1 |
| Rivat, C | 3 |
| Vera-Portocarrero, LP | 1 |
| Ibrahim, MM | 1 |
| Mata, HP | 1 |
| Stagg, NJ | 1 |
| De Felice, M | 1 |
| Porreca, F | 1 |
| Malan, TP | 1 |
| Richebé, P | 3 |
| Rivalan, B | 1 |
| Laulin, JP | 4 |
| Janvier, G | 1 |
| Maurette, P | 2 |
| Ding, Z | 1 |
| Raffa, RB | 1 |
| Long, JJ | 1 |
| Ma, J | 1 |
| Leung, LS | 1 |
| Greer, JJ | 1 |
| Ren, J | 1 |
| Matsushima, S | 1 |
| Miyoshi, T | 1 |
| Masuno, K | 1 |
| Torii, M | 1 |
| Koike, K | 1 |
| Shimada, S | 1 |
| Chi, OZ | 1 |
| Hunter, C | 1 |
| Chokshi, SK | 1 |
| Weiss, HR | 1 |
| Fernández-Dueñas, V | 2 |
| Poveda, R | 3 |
| Fernández, A | 1 |
| Sánchez, S | 3 |
| Planas, E | 2 |
| Ciruela, F | 2 |
| Van Elstraete, AC | 1 |
| Sitbon, P | 1 |
| Benhamou, D | 1 |
| Mazoit, JX | 1 |
| Hoekman, JD | 1 |
| Ho, RJ | 1 |
| Le Roy, C | 1 |
| Gavello-Baudy, S | 1 |
| Chateauraynaud, J | 1 |
| Ewan, EE | 1 |
| Martin, TJ | 1 |
| Medeiros, LF | 1 |
| de Souza, AC | 1 |
| de Souza, A | 1 |
| Cioato, SG | 1 |
| Scarabelot, VL | 1 |
| Caumo, W | 1 |
| Fernandes, LC | 1 |
| Torres, IL | 1 |
| Empey, PE | 1 |
| Miller, TM | 1 |
| Philbrick, AH | 1 |
| Melick, JA | 1 |
| Kochanek, PM | 3 |
| Poloyac, SM | 1 |
| Nardi, GM | 1 |
| Bet, AC | 1 |
| Sordi, R | 1 |
| Fernandes, D | 1 |
| Assreuy, J | 1 |
| Spahn, V | 1 |
| Fischer, O | 1 |
| Endres-Becker, J | 1 |
| Schäfer, M | 1 |
| Stein, C | 1 |
| Zöllner, C | 1 |
| Colpaert, FC | 2 |
| Tarayre, JP | 1 |
| Koek, W | 1 |
| Pauwels, PJ | 1 |
| Bardin, L | 1 |
| Xu, XJ | 1 |
| Wiesenfeld-Hallin, Z | 1 |
| Cosi, C | 1 |
| Carilla-Durand, E | 1 |
| Assié, MB | 1 |
| Vacher, B | 1 |
| Holtzman, SG | 1 |
| Kurita, T | 1 |
| Morita, K | 1 |
| Kazama, T | 1 |
| Sato, S | 1 |
| Neder Meyer, T | 1 |
| Lázaro Da Silva, A | 1 |
| Shavit, Y | 1 |
| Ben-Eliyahu, S | 1 |
| Zeidel, A | 1 |
| Beilin, B | 1 |
| Hayashida, M | 1 |
| Fukunaga, A | 1 |
| Fukuda, K | 1 |
| Yamazaki, SY | 1 |
| Arita, H | 1 |
| Hanaoka, K | 1 |
| Crystal, GJ | 1 |
| Metwally, AA | 1 |
| Salem, MR | 1 |
| Gross, ER | 1 |
| Peart, JN | 1 |
| Hsu, AK | 1 |
| Auchampach, JA | 1 |
| Gross, GJ | 1 |
| Romero, A | 1 |
| Pol, O | 1 |
| Puig, MM | 1 |
| El Mouedden, M | 1 |
| Meert, TF | 1 |
| Statler, KD | 2 |
| Alexander, H | 2 |
| Vagni, V | 2 |
| Dixon, CE | 2 |
| Clark, RS | 2 |
| Jenkins, L | 2 |
| Holubkov, R | 1 |
| Bruijnzeel, AW | 1 |
| Marcinkiewcz, C | 1 |
| Isaac, S | 1 |
| Booth, MM | 1 |
| Dennis, DM | 1 |
| Gold, MS | 1 |
| Franchi, S | 1 |
| Panerai, AE | 1 |
| Sacerdote, P | 1 |
| Wan, Y | 1 |
| Xu, J | 1 |
| Ma, D | 1 |
| Zeng, Y | 1 |
| Cibelli, M | 1 |
| Maze, M | 1 |
| Bessière, B | 1 |
| Contarino, A | 1 |
| Meert, T | 1 |
| De Witte, P | 1 |
| Schmitt, P | 1 |
| Luks, FI | 1 |
| Peers, KH | 1 |
| Deprest, JA | 1 |
| Lerut, TE | 1 |
| Ahmad, I | 1 |
| Pleuvry, BJ | 1 |
| Welsh, EM | 1 |
| Nolan, AM | 1 |
| Lee, TY | 1 |
| Fu, MJ | 1 |
| Kuo, TB | 1 |
| Lui, PW | 1 |
| Chan, SH | 1 |
| Hashimoto, H | 1 |
| Imamura, S | 1 |
| Ikeda, K | 1 |
| Nakashima, M | 1 |
| Sieber, FE | 1 |
| Brown, PR | 1 |
| Wu, Y | 1 |
| Koehler, RC | 1 |
| Traystman, RJ | 1 |
| Graham, MR | 1 |
| Thiessen, DB | 1 |
| Mutch, WA | 1 |
| Gentle, MJ | 1 |
| Hocking, PM | 1 |
| Bernard, R | 1 |
| Dunn, LN | 1 |
| Tuchman, JE | 1 |
| Johnson, MD | 1 |
| Wiesenauer, K | 1 |
| Woods, JH | 1 |
| Piersma, FE | 1 |
| Daemen, MA | 1 |
| Bogaard, AE | 1 |
| Buurman, WA | 1 |
| Guo, GW | 1 |
| He, Y | 1 |
| Jin, WQ | 1 |
| Zou, Y | 1 |
| Zhu, YC | 1 |
| Chi, ZQ | 1 |
| Li, X | 1 |
| Angst, MS | 1 |
| Clark, JD | 1 |
| Cheung, PY | 1 |
| Barrington, KJ | 1 |
| Pinault, D | 1 |
| Vergnes, M | 1 |
| Marescaux, C | 1 |
| Laudenbach, V | 1 |
| Gressens, P | 1 |
| Pippi, NL | 1 |
| Lumb, WV | 1 |
| Jageneau, AH | 1 |
| van Gerven, W | 1 |
| Kruger, R | 1 |
| van Belle, H | 1 |
| Reneman, RS | 1 |
| Yeadon, M | 1 |
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| O'Leary, VJ | 1 |
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| Freye, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fentanyl Ultra Low Doses Effects on Human Volunteer's Nociceptive Threshold. Towards a Simple Pharmacological Test Able to Predict Pain Vulnerability, Post Operative Hyperalgesia Development Risk?[NCT00454259] | Phase 4 | 48 participants (Actual) | Interventional | 2007-03-31 | Completed | ||
| Association Between Changes in Cerebral Gray Matter Volume and Postoperative Cognitive Dysfunction in Elderly Patients Following Sevoflurane Anesthesia (POCD-MRI)[NCT02045004] | 100 participants (Actual) | Observational | 2015-07-14 | Completed | |||
| Release of Serum Neurofilament Light (NFL), Biomarker of Neuronal Injury, in Surgery Under General Anaesthesia (GA) Compared to Surgery With Hypno-analgesia (Hyp): A Prospective, Non-inferiority Study[NCT04500236] | 100 participants (Anticipated) | Interventional | 2020-09-01 | Recruiting | |||
| Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium: A Multicenter, Randomized, Double-Blind Clinical Trail[NCT02928692] | Phase 3 | 750 participants (Anticipated) | Interventional | 2016-11-30 | Recruiting | ||
| Effect of General Anesthesia on Early Postoperative Cognitive Dysfunction in Elective Versus Emergency Cesarean Section[NCT03818009] | 58 participants (Actual) | Observational | 2019-01-14 | Completed | |||
| Impact of Dexmedetomidine on the Incidence of Postoperative Delirium in Patients After Cardiac Surgery: a Randomized, Double-blinded, and Placebo-controlled Clinical Trial[NCT02267538] | Phase 4 | 285 participants (Actual) | Interventional | 2014-11-30 | Completed | ||
| Effect of Remifentanil on Postoperative Cognitive Function in Patients Undergoing Major Abdominal Surgery[NCT01627873] | Phase 4 | 622 participants (Actual) | Interventional | 2009-08-31 | Completed | ||
| Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461] | 137 participants (Actual) | Observational | 2009-07-31 | Completed | |||
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis[NCT05603702] | Phase 1 | 24 participants (Anticipated) | Interventional | 2023-03-17 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Delirium was assessed with the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) twice daily during the first five days after surgery. (NCT02267538)
Timeframe: During the first five days after surgery
| Intervention | Participants (Count of Participants) |
|---|---|
| DEX Group | 7 |
| CTRL Group | 11 |
Results was presented as median (95% confidence interval). (NCT02267538)
Timeframe: From end of surgery until discharge from hospital or 30 days after surgery
| Intervention | days (Median) |
|---|---|
| DEX Group | 9 |
| CTRL Group | 9 |
Results was presented as median (95% confidence interval). (NCT02267538)
Timeframe: From end of surgery until discharge from Intensive Care Unit or 30 days after surgery
| Intervention | hours (Median) |
|---|---|
| DEX Group | 45.0 |
| CTRL Group | 46.0 |
"Cognitive function was assessed with the Mini Mental State Examination (MMSE) at baseline (the day before surgery) and on the sixth day after surgery, and with modified telephone interview for cognitive status (m-TICS) on the 30th day after surgery.~The introduction of MMSE scale has been explained in the baseline part in the result section.~The Telephone Interview for Cognitive Status-modified scale(m-TICS) is one of the most popular telephone interview-based screening instruments for mild cognitive impairment and dementia. It consists 11 items including wordlist memory, orientation, attention, repetition, conceptual knowledge and nonverbal praxis, which score ranges from 0 to 48, with higher scores indicating better cognitive function" (NCT02267538)
Timeframe: on the sixth day after surgery, and on the 30th day after surgery
| Intervention | units on a scale (Median) | |
|---|---|---|
| MMSE score on postoperative day 6 | m-TICS score on postoperative day 30 | |
| CTRL Group | 29 | 34 |
| DEX Group | 29 | 34 |
Non-delirium complications was defined as any conditions other than delirium that occurred during the first 30 days after surgery and required therapeutic intervention.Complications listed here were not considered adverse events in this study. (NCT02267538)
Timeframe: Occurrence of non-delirium complications will be monitored until 30 days after surgery.
| Intervention | Participants (Count of Participants) | |||||||
|---|---|---|---|---|---|---|---|---|
| Stroke | New onset arrythmia | Pulmonary complications | Upper gastrointestinal bleeding | Surgical bleeding | Wound dehiscence or infection | Acute kidney injury | IABP assistance | |
| CTRL Group | 3 | 51 | 27 | 4 | 3 | 7 | 44 | 12 |
| DEX Group | 3 | 42 | 15 | 2 | 3 | 11 | 37 | 6 |
Pain intensity was assessed daily at 8 am during the first five days after surgery with the Numeric Rating Scale (NRS, 0 = no pain, 10 = the worst possible pain). (NCT02267538)
Timeframe: During the first five days after surgery
| Intervention | units on a scale (Median) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Pain score after surgery(d1), at rest | Pain score after surgery(d2), at rest | Pain score after surgery(d3), at rest | Pain score after surgery(d4), at rest | Pain score after surgery(d5), at rest | Pain score after surgery(d1), with coughing | Pain score after surgery(d2), with coughing | Pain score after surgery(d3), with coughing | Pain score after surgery(d4), with coughing | Pain score after surgery(d5), with coughing | |
| CTRL Group | 3 | 3 | 2 | 2 | 1 | 4 | 4 | 4 | 3 | 2 |
| DEX Group | 3 | 4 | 3 | 2 | 2 | 4 | 5 | 4 | 3 | 2 |
Subjective sleep quality was assessed daily at 8 am during the first five days after surgery with the Numeric Rating Scale (NRS, 0 = best sleep, 10 = the worst possible sleep). (NCT02267538)
Timeframe: During the first five days after surgery
| Intervention | units on a scale (Median) | ||||
|---|---|---|---|---|---|
| Subjective sleep quality after surgery(d1), score | Subjective sleep quality after surgery(d2), score | Subjective sleep quality after surgery(d3), score | Subjective sleep quality after surgery(d4), score | Subjective sleep quality after surgery(d5), score | |
| CTRL Group | 2 | 3 | 2 | 2 | 2 |
| DEX Group | 2 | 3 | 2 | 2 | 2 |
1 review available for fentanyl and Disease Models, Animal
| Article | Year |
|---|---|
[Difference in tolerance to anti-hyperalgesic effect and its molecular mechanisms between chronic treatment with morphine, fentanyl and oxycodone in a chronic pain-like state].
Topics: Analgesics, Opioid; Animals; beta-Endorphin; Chronic Disease; Disease Models, Animal; Drug Tolerance | 2008 |
1 trial available for fentanyl and Disease Models, Animal
| Article | Year |
|---|---|
Effects of non-steroidal anti-inflammatory drugs on the hyperalgesia to noxious mechanical stimulation induced by the application of a tourniquet to a forelimb of sheep.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Clonixin; Cross-Over Studies; Disease | 1994 |
75 other studies available for fentanyl and Disease Models, Animal
| Article | Year |
|---|---|
Piperidine propionamide as a scaffold for potent sigma-1 receptor antagonists and mu opioid receptor agonists for treating neuropathic pain.
Topics: Amides; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Guinea Pigs | 2020 |
Sedative depth on neurological outcomes in a juvenile rat model of cardiopulmonary resuscitation.
Topics: Animals; Apoptosis; Brain; Cardiopulmonary Resuscitation; Child; Disease Models, Animal; Electroence | 2019 |
Calabadion 1 selectively reverses respiratory and central nervous system effects of fentanyl in a rat model.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Heterocyclic Compounds, 4 or More Rin | 2020 |
A novel rat model of extremity trauma for prehospital pain management research.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Emergency Medical Services; Fentanyl; Fibula; F | 2018 |
Role of spinal cyclooxygenase-2 and prostaglandin E2 in fentanyl-induced hyperalgesia in rats.
Topics: Analgesics, Opioid; Animals; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Dose-Response R | 2018 |
Effects of three forms of local anesthesia on perioperative fentanyl-induced hyperalgesia.
Topics: Anesthesia, Local; Animals; Disease Models, Animal; Fentanyl; Ganglia, Spinal; Humans; Hyperalgesia; | 2018 |
Analgesic effects of systemic fentanyl on cancer pain are mediated by not only central but also peripheral opioid receptors in mice.
Topics: Action Potentials; Analgesics, Opioid; Animals; Cancer Pain; Cell Line, Tumor; Disease Models, Anima | 2018 |
Antiallodynic and Antihyperalgesic Activities of Fentanyl-Loaded Dermal Clay Dressings in Rat Model of Second-Degree Burn Injury.
Topics: Animals; Bandages; Burns; Clay; Disease Models, Animal; Fentanyl; Hyperalgesia; Male; Pain; Rats; Ra | 2018 |
Effect of cholinergic crisis on the potency of different emergency anaesthesia protocols in soman-poisoned rats.
Topics: Acetylcholinesterase; Analgesics, Opioid; Anesthesia, Intravenous; Anesthetics, Intravenous; Animals | 2019 |
Oxycodone, fentanyl, and morphine amplify established neuropathic pain in male rats.
Topics: Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Fentanyl; Male; Morphine; Neuralg | 2019 |
A comparison of the antinociceptive and temperature responses to morphine and fentanyl derivatives in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Body Temperature; Disease Models, Animal; Dose-Respon | 2013 |
Neither xenon nor fentanyl induces neuroapoptosis in the newborn pig brain.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Animals, Newborn; Apoptosis; Body Temper | 2013 |
Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain.
Topics: Acute Pain; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pain; Dise | 2013 |
Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acute Pain | 2014 |
Rabbit model of chest wall rigidity induced by fentanyl and the effects of apomorphine.
Topics: Analgesics, Opioid; Animals; Apomorphine; Disease Models, Animal; Dopamine Agonists; Fentanyl; Lung | 2014 |
Interaction of the adenosine A1 receptor agonist N6-cyclopentyladenosine and κ-opioid receptors in rat spinal cord nociceptive reflexes.
Topics: Adenosine; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Inte | 2014 |
The contribution of Gi/o protein to opioid antinociception in an oxaliplatin-induced neuropathy rat model.
Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; F | 2014 |
The behavioral effects of a mixed efficacy antinociceptive peptide, VRP26, following chronic administration in mice.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Toleranc | 2016 |
Pulmonary Phototherapy to Treat Carbon Monoxide Poisoning in Rats.
Topics: Androstanols; Animals; Blood Pressure; Body Temperature; Carbon Monoxide; Carbon Monoxide Poisoning; | 2017 |
RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents.
Topics: Administration, Oral; Analgesics, Opioid; Animals; CHO Cells; Cricetinae; Cricetulus; Disease Models | 2017 |
Analgesic activity and pharmacological characterization of N-[1-phenylpyrazol-3-yl]-N-[1-(2-phenethyl)-4-piperidyl] propenamide, a new opioid agonist acting peripherally.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationshi | 2008 |
Oxycodone-induced analgesic effects in a bone cancer pain model in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Bone Neoplasms; Disease Models, Animal; F | 2008 |
Spinal NK-1 receptor-expressing neurons and descending pathways support fentanyl-induced pain hypersensitivity in a rat model of postoperative pain.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Disease Models, Animal; Dynorphins; Fentanyl; Immun | 2009 |
Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats.
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Animals; Carrageenan; Disease Models, Animal; Dose-Resp | 2009 |
Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Aminoquinolines; Analgesics, Opioid; Anesthetics, Local | 2009 |
Behavioral depression induced by an amygdala seizure and the opioid fentanyl was mediated through the nucleus accumbens.
Topics: Amygdala; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Rel | 2009 |
Ampakine therapy to counter fentanyl-induced respiratory depression.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Drug Administration Schedule; Fentanyl; Heart Rat | 2009 |
Morphine, oxycodone, and fentanyl exhibit different analgesic profiles in mouse pain models.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Fentanyl; Male; Mice; Mice, Inbred C3 | 2009 |
Effects of fentanyl pretreatment on regional cerebral blood flow in focal cerebral ischemia in rats.
Topics: Analgesics, Opioid; Animals; Antipyrine; Blood Flow Velocity; Carbon Radioisotopes; Cerebral Cortex; | 2010 |
Fentanyl-trazodone-paracetamol triple drug combination: multimodal analgesia in a mouse model of visceral pain.
Topics: Acetaminophen; Analgesics; Animals; Disease Models, Animal; Drug Combinations; Fentanyl; Male; Mice; | 2011 |
The median effective dose of ketamine and gabapentin in opioid-induced hyperalgesia in rats: an isobolographic analysis of their interaction.
Topics: Amines; Analgesics; Analgesics, Opioid; Analysis of Variance; Animals; Cyclohexanecarboxylic Acids; | 2011 |
Enhanced analgesic responses after preferential delivery of morphine and fentanyl to the olfactory epithelium in rats.
Topics: Administration, Intranasal; Analgesics, Opioid; Analysis of Variance; Animals; Central Nervous Syste | 2011 |
Endogenous opioids released during non-nociceptive environmental stress induce latent pain sensitization Via a NMDA-dependent process.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Carrageenan; Disease Models, Animal; Excitatory A | 2011 |
Rewarding electrical brain stimulation in rats after peripheral nerve injury: decreased facilitation by commonly abused prescription opioids.
Topics: Adenosine; Amines; Analgesics; Analgesics, Opioid; Animals; Brain; Clonidine; Cyclohexanecarboxylic | 2011 |
Fentanyl administration in infant rats produces long-term behavioral responses.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Animals; Animals, Newborn; Disease Models, Animal; Fe | 2012 |
Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest.
Topics: Animals; Cytochrome P-450 CYP3A; Disease Models, Animal; Fentanyl; Heart Arrest; Hypnotics and Sedat | 2012 |
Synergistic interaction between fentanyl and a tramadol: paracetamol combination on the inhibition of nociception in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Disease Models, Animal; Drug S | 2012 |
Opioid analgesics in experimental sepsis: effects on physiological, biochemical, and haemodynamic parameters.
Topics: Analgesics, Opioid; Animals; Biochemical Phenomena; Body Temperature; Body Weight; Cardiovascular Sy | 2013 |
Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner.
Topics: Analgesics, Opioid; Animals; Calcium; Capsaicin; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent P | 2013 |
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
Topics: Acetates; Adrenergic Uptake Inhibitors; Amines; Aminopyridines; Analgesia; Analgesics; Animals; Cell | 2002 |
Discrimination of a single dose of morphine followed by naltrexone: substitution of other agonists for morphine and other antagonists for naltrexone in a rat model of acute dependence.
Topics: Acute Disease; Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Male; Methadone; Morph | 2003 |
Comparison of isoflurane and propofol-fentanyl anaesthesia in a swine model of asphyxia.
Topics: Anesthetics, Combined; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Asphyxia; Blood P | 2003 |
Ketamine reduces mortality of severely burnt rats, when compared to midazolam plus fentanyl.
Topics: Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Burns; Disease | 2004 |
Effects of fentanyl on natural killer cell activity and on resistance to tumor metastasis in rats. Dose and timing study.
Topics: Adenocarcinoma; Analgesics, Opioid; Animals; Cell Line, Tumor; Disease Models, Animal; Dose-Response | 2004 |
A rabbit model for evaluation of surgical anesthesia and analgesia: characterization and validation with isoflurane anesthesia and fentanyl analgesia.
Topics: Analgesia; Analgesics, Opioid; Anesthesia; Anesthetics, Inhalation; Animals; Disease Models, Animal; | 2004 |
Isoflurane preserves central nervous system blood flow during intraoperative cardiac tamponade in dogs.
Topics: Analgesics; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Cardiac Tamponade; Central N | 2004 |
Extending the cardioprotective window using a novel delta-opioid agonist fentanyl isothiocyanate via the PI3-kinase pathway.
Topics: Analgesics, Opioid; Animals; Blood Pressure; Disease Models, Animal; Fentanyl; Heart Rate; Hemodynam | 2005 |
Ketamine improves the management of exaggerated postoperative pain observed in perioperative fentanyl-treated rats.
Topics: Animals; Disease Models, Animal; Drug Synergism; Fentanyl; Hindlimb; Ketamine; Male; Pain, Postopera | 2005 |
Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2005 |
Evaluation of pain-related behavior, bone destruction and effectiveness of fentanyl, sufentanil, and morphine in a murine model of cancer pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Bone Neoplasms; Disease Models, Animal; Fentanyl; Mic | 2005 |
Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats.
Topics: Anesthetics; Animals; Brain; Brain Injuries; Cell Survival; Cognition Disorders; Diazepam; Disease M | 2006 |
Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injury.
Topics: Anesthetics, Intravenous; Animals; Behavior, Animal; Blood Pressure; Brain Injuries; Cell Count; Dis | 2006 |
The effects of buprenorphine on fentanyl withdrawal in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Buprenorphine; Disease Models, Animal; Dose-Response | 2007 |
Buprenorphine ameliorates the effect of surgery on hypothalamus-pituitary-adrenal axis, natural killer cell activity and metastatic colonization in rats in comparison with morphine or fentanyl treatment.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Breast Neoplasms; Buprenorphine; Corticosterone; | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models, | 2007 |
Nitrous oxide (N2O) prevents latent pain sensitization and long-term anxiety-like behavior in pain and opioid-experienced rats.
Topics: Analgesics, Opioid; Animals; Anxiety; Atmosphere Exposure Chambers; Behavior, Animal; Disease Models | 2007 |
Further evidence validating adjuvant arthritis as an experimental model of chronic pain in the rat.
Topics: Animals; Arthritis; Arthritis, Experimental; Body Weight; Chronic Disease; Disease Models, Animal; D | 1982 |
Gasless laparoscopy in infants: the rabbit model.
Topics: Abdominal Muscles; Adjuvants, Anesthesia; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; | 1995 |
Interactions between opioid drugs and propofol in laboratory models of seizures.
Topics: Analgesics, Opioid; Animals; Bicuculline; Disease Models, Animal; Dose-Response Relationship, Drug; | 1995 |
Power spectral analysis of electromyographic and systemic arterial pressure signals during fentanyl-induced muscular rigidity in the rat.
Topics: Anesthesia, Intravenous; Animals; Blood Pressure; Disease Models, Animal; Electromyography; Fentanyl | 1994 |
Effects of intravenous anesthetics, thiopental, fentanyl, and morphine on ventricular delayed activation in a canine myocardial infarction model.
Topics: Action Potentials; Animals; Blood Pressure; Disease Models, Animal; Dogs; Electrocardiography; Fenta | 1993 |
Cerebral blood flow responsivity to CO2 in anesthetized chronically diabetic dogs.
Topics: Animals; Blood Glucose; Carbon Dioxide; Cerebrovascular Circulation; Diabetes Mellitus, Experimental | 1993 |
Left ventricular systolic and diastolic function is unaltered during propofol infusion in newborn swine.
Topics: Anesthetics, Intravenous; Animals; Animals, Newborn; Blood Pressure; Cardiac Output; Diastole; Disea | 1998 |
Evaluation of intraarticular opioid analgesia for the relief of articular pain in the domestic fowl.
Topics: Analgesia; Analgesics; Animals; Arthritis, Gouty; Buprenorphine; Chickens; Disease Models, Animal; F | 1999 |
Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2000 |
Interference of pain control employing opioids in in vivo immunological experiments.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Disease Models, Animal; Dose-Response Relationship, Drug | 1999 |
Comparison of physical dependence of ohmefentanyl stereoisomers in mice.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fentanyl; Male; Mice; | 2000 |
A murine model of opioid-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Heme Oxygenase (Decyclizing); Hyperal | 2001 |
A murine model of opioid-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Heme Oxygenase (Decyclizing); Hyperal | 2001 |
A murine model of opioid-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Heme Oxygenase (Decyclizing); Hyperal | 2001 |
A murine model of opioid-induced hyperalgesia.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Heme Oxygenase (Decyclizing); Hyperal | 2001 |
The effects of dopamine and epinephrine on hemodynamics and oxygen metabolism in hypoxic anesthetized piglets.
Topics: Animals; Animals, Newborn; Cardiotonic Agents; Disease Models, Animal; Dopamine; Dose-Response Relat | 2001 |
Medium-voltage 5-9-Hz oscillations give rise to spike-and-wave discharges in a genetic model of absence epilepsy: in vivo dual extracellular recording of thalamic relay and reticular neurons.
Topics: Action Potentials; Analgesics, Opioid; Animals; Behavior, Animal; Biological Clocks; Cerebral Cortex | 2001 |
[Real day in neonatology: JALON 2001, Nancy, October 6 2001. Fentanyl-ORL 1 receptor interactions in the perinatal period: should the "principle of precaution" be applied to premature newborns?].
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Fentanyl; Humans; Infant, Newborn; Infant, Newb | 2001 |
Objective tests of analgesic drugs in ponies.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Fentanyl; Horse Diseases; Horses; Male; Meperid | 1979 |
An improved animal model for studying the effect of drugs on myocardial metabolism during ischemia.
Topics: Animals; Coronary Disease; Disease Models, Animal; Dogs; Female; Fentanyl; Glucose; Heart Rate; Lact | 1975 |
Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigs.
Topics: Adenine Nucleotides; Animals; Ascorbic Acid; Atropine; Bronchial Hyperreactivity; Bronchoconstrictio | 1992 |
Effect of high doses of Fentanyl on myocardial infarction and cardiogenic shock in the dog.
Topics: Animals; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinica | 1974 |