fentanyl has been researched along with Critical Illness in 51 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Critical Illness: A disease or state in which death is possible or imminent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Propofol infusion syndrome is a rare condition that mainly affects critically ill patients who receive high doses of this hypnotic for a long time." | 7.96 | Propofol infusion syndrome; are high doses always required? ( Boliart de San Félix, Y; Fernández Morales, M; Sánchez Royo, E; Subirà González, A; Vila Lolo, C, 2020) |
| "In 99 patients receiving IV fentanyl, midazolam, or both, we evaluated drug doses, covariates likely to influence drug effects (age, body mass index, and renal and hepatic dysfunction); delirium risk factors; concomitant administration of CYP3A and P-glycoprotein substrates/inhibitors; ABCB1, ABCG2, and CYP3A5 genetic polymorphisms; and fentanyl and midazolam plasma levels." | 7.79 | Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors. ( Cossette, M; Leger, C; Michaud, V; Skrobik, Y; Turgeon, J, 2013) |
| " There were significant correlations between fentanyl dosage and NAST score (r = ." | 5.29 | Drug withdrawal symptoms in children after continuous infusions of fentanyl. ( French, JP; Nocera, M, 1994) |
| "Propofol infusion syndrome is a rare condition that mainly affects critically ill patients who receive high doses of this hypnotic for a long time." | 3.96 | Propofol infusion syndrome; are high doses always required? ( Boliart de San Félix, Y; Fernández Morales, M; Sánchez Royo, E; Subirà González, A; Vila Lolo, C, 2020) |
| "To characterize fentanyl population pharmacokinetics in patients with critical illness and identify patient characteristics associated with altered fentanyl concentrations." | 3.83 | Population Pharmacokinetics of Fentanyl in the Critically Ill. ( Choi, L; Ely, EW; Ferrell, BA; Girard, TD; Heltsley, R; Pandharipande, PP; Stein, CM; Vasilevskis, EE, 2016) |
| "In this large, pediatric multicenter registry, fentanyl, midazolam, and ketamine were the most commonly used induction agents, and the majority of tracheal intubations involved neuromuscular blockade." | 3.81 | Current medication practice and tracheal intubation safety outcomes from a prospective multicenter observational cohort study. ( Brown, CA; Howell, JD; Hsing, DD; Montgomery, V; Nadkarni, VM; Nishisaki, A; Parker, MM; Tarquinio, KM; Turner, DA; Walls, RM, 2015) |
| "Fifteen 4-week-old piglets were given 1 of 2 anesthetic protocols: total IV anesthesia (TIVA) (midazolam 1 mg/kg/h and fentanyl 100 μg/kg/h, n = 8) or ISO (isoflurane 1." | 3.79 | The anesthetic effects on vasopressor modulation of cerebral blood flow in an immature swine model. ( Bruins, B; Friess, SH; Kilbaugh, TJ; Margulies, SS, 2013) |
| "In 99 patients receiving IV fentanyl, midazolam, or both, we evaluated drug doses, covariates likely to influence drug effects (age, body mass index, and renal and hepatic dysfunction); delirium risk factors; concomitant administration of CYP3A and P-glycoprotein substrates/inhibitors; ABCB1, ABCG2, and CYP3A5 genetic polymorphisms; and fentanyl and midazolam plasma levels." | 3.79 | Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors. ( Cossette, M; Leger, C; Michaud, V; Skrobik, Y; Turgeon, J, 2013) |
| "Remifentanil has a significant effect on reducing the occurrence of delirium (P = 0." | 2.84 | The influence of analgesic-based sedation protocols on delirium and outcomes in critically ill patients: A randomized controlled trial. ( An, Y; Liu, D; Lyu, J; Zhao, H, 2017) |
| "Midazolam doses were lower in P than in C group (0." | 2.73 | [Protocol based sedation versus conventional treatment in critically ill patients on mechanical ventilation]. ( Asenjo B, R; Aspée L, P; Castro O, J; Lanas M, A; Pino P, S; Prat R, D; Rivas V, S; Tobar A, E, 2008) |
| "Naloxone has been hypothesized to limit opioid tolerance by decreasing adenylate cyclase/cyclic adenosine monophosphate activation." | 2.73 | Effect of low-dose naloxone infusion on fentanyl requirements in critically ill children. ( Darnell, CM; Roy, L; Sheeran, P; Stromberg, D; Thompson, J, 2008) |
| "Ketamine was not associated with mortality, on-target sedation, vasopressor dependence, or hospital length of stay." | 2.66 | Ketamine sedation in mechanically ventilated patients: A systematic review and meta-analysis. ( Fuller, BM; Manasco, AT; Roberts, BW; Stephens, RJ; Yaeger, LH, 2020) |
| "The pharmacokinetic (PK) parameters of many drugs are altered as a consequence of the pathophysiological changes associated with critical illness." | 2.58 | Altered Pharmacokinetics in Prolonged Infusions of Sedatives and Analgesics Among Adult Critically Ill Patients: A Systematic Review. ( Joynt, GM; Lee, A; Ling, L; Tse, AHW, 2018) |
| "Societal fears of opioid addiction and lack of advocacy are also causal factors in the under-treatment of pediatric pain." | 2.41 | Pain management in the critically ill child. ( Nichols, DG; Yaster, M, 2001) |
| "Pain was measured as the probability of CPOT scores of ≥ 3, and subsequently adjusted based on each patient's baseline." | 1.91 | Continuous visualization and validation of pain in critically ill patients using artificial intelligence: a retrospective observational study. ( Kobayashi, N; Murakami, H; Watanabe, K; Yamauchi, M, 2023) |
| "Different weight-based fentanyl dosing rates may be required for infants and children of different ages to achieve similar plasma concentrations." | 1.62 | Analysis of fentanyl pharmacokinetics, and its sedative effects and tolerance in critically ill children. ( Heltsley, R; Henry, E; Johnson, PN; Lim, SY; Miller, JL; Woo, S, 2021) |
| "In this study we show the feasibility and utility of using electronic record data and remnant blood samples to successfully construct population pharmacokinetic models for a heterogeneous cohort of critically ill children." | 1.51 | Factors Contributing to Fentanyl Pharmacokinetic Variability Among Diagnostically Diverse Critically Ill Children. ( Au, AK; Clark, RSB; Conley, YP; Empey, PE; Hagos, FT; Horvat, CM; Kochanek, PM; Li, L; Poloyac, SM, 2019) |
| " ABCB1 genotype has been previously associated with patient opioid requirements and may influence fentanyl dosing requirements in critically ill children." | 1.46 | ABCB1 genotype is associated with fentanyl requirements in critically ill children. ( Au, AK; Clark, RSB; Conley, YP; Empey, PE; Horvat, CM; Kochanek, PM; Li, L; Poloyac, SM, 2017) |
| " The primary outcomes of the study included the time to goal sedation and fentanyl dosage characteristics (i." | 1.46 | Relationship between rate of fentanyl infusion and time to achieve sedation in nonobese and obese critically ill children. ( Golding, CL; Johnson, PN; Miller, JL; Owora, AH; Skrepnek, GH; Thomas, AN, 2017) |
| "Analgosedation with fentanyl appears to be a safe and effective strategy to facilitate mechanical ventilation." | 1.40 | Efficacy and safety of analgosedation with fentanyl compared with traditional sedation with propofol. ( Edwin, SB; McNorton, KN; Tedders, KM, 2014) |
| " Each patient's demographic and clinical characteristics, the need for ventilatory support, the use and dosage of medications, the number of nursing staff per bed, the time elapsed from admission to the intensive care unit until the effective start of enteral feeding, and the causes for nonadministration were recorded." | 1.39 | Nurse to bed ratio and nutrition support in critically ill patients. ( Azevedo, LC; Bafi, AT; Castro, I; Freitas, FG; Honda, CK; Machado, FR; Mazza, BF; Nascente, AP; Stanich, P, 2013) |
| " Maximum venous concentration and area under the concentration curve were approximately two-fold lower in the patient group for an equivalent dose, suggesting either reduced bioavailability or increased clearance: maximum venous concentration 0." | 1.38 | Pharmacokinetics of oxycodone after subcutaneous administration in a critically ill population compared with a healthy cohort. ( Chapman, MJ; Charlton, CS; Fajumi, AO; Krishnamurthy, RB; Lai, S; Ludbrook, GL; Macintyre, PE; Martinez, AM; McConnell, H; O'Connor, SN; Ong, J; Ousley, RM; Upton, RN, 2012) |
| "Clonidine was a common part of up to two-thirds of the regimens." | 1.33 | Practice of sedation and analgesia in German intensive care units: results of a national survey. ( Fischer, M; Franck, M; Martin, J; Parsch, A; Spies, C; Wernecke, KD, 2005) |
| " There were significant correlations between fentanyl dosage and NAST score (r = ." | 1.29 | Drug withdrawal symptoms in children after continuous infusions of fentanyl. ( French, JP; Nocera, M, 1994) |
| "Total body clearance of fentanyl is highly variable and it should be dosed to effect." | 1.29 | Pharmacokinetics of continuous infusions of fentanyl in critically ill children. ( Katz, R; Kelly, HW, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (7.84) | 18.2507 |
| 2000's | 10 (19.61) | 29.6817 |
| 2010's | 28 (54.90) | 24.3611 |
| 2020's | 9 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Eimer, C | 1 |
| Reifferscheid, F | 1 |
| Jung, P | 1 |
| Rudolph, M | 1 |
| Terboven, T | 1 |
| Hoffmann, F | 1 |
| Lorenzen, U | 1 |
| Köser, A | 1 |
| Seewald, S | 1 |
| Kobayashi, N | 1 |
| Watanabe, K | 1 |
| Murakami, H | 1 |
| Yamauchi, M | 1 |
| Tang, C | 1 |
| Poloyac, SM | 3 |
| Manasco, AT | 1 |
| Stephens, RJ | 1 |
| Yaeger, LH | 1 |
| Roberts, BW | 1 |
| Fuller, BM | 1 |
| Subirà González, A | 1 |
| Fernández Morales, M | 1 |
| Sánchez Royo, E | 1 |
| Boliart de San Félix, Y | 1 |
| Vila Lolo, C | 1 |
| Hyun, DG | 1 |
| Huh, JW | 1 |
| Hong, SB | 1 |
| Koh, Y | 1 |
| Lim, CM | 1 |
| Herndon, KT | 1 |
| Claussen, KS | 1 |
| Braithwaite, JJ | 1 |
| Lim, SY | 1 |
| Miller, JL | 2 |
| Henry, E | 1 |
| Heltsley, R | 2 |
| Woo, S | 1 |
| Johnson, PN | 2 |
| Martin, NJ | 1 |
| Peitz, GJ | 1 |
| Olsen, KM | 1 |
| Merritt, HML | 1 |
| Horvat, CM | 2 |
| Au, AK | 2 |
| Conley, YP | 2 |
| Kochanek, PM | 2 |
| Li, L | 2 |
| Empey, PE | 2 |
| Clark, RSB | 2 |
| Skrepnek, GH | 1 |
| Golding, CL | 1 |
| Owora, AH | 1 |
| Thomas, AN | 1 |
| Liu, D | 1 |
| Lyu, J | 1 |
| Zhao, H | 1 |
| An, Y | 1 |
| Kovacevic, MP | 1 |
| Szumita, PM | 1 |
| Dube, KM | 1 |
| DeGrado, JR | 1 |
| Tse, AHW | 1 |
| Ling, L | 1 |
| Lee, A | 1 |
| Joynt, GM | 1 |
| Hagos, FT | 1 |
| Tanios, M | 1 |
| Nguyen, HM | 1 |
| Park, H | 1 |
| Mehta, S | 1 |
| Epstein, SK | 1 |
| Youssef, F | 1 |
| Beltran, A | 1 |
| Flores, G | 1 |
| Sidhom, R | 1 |
| Sehgal, A | 1 |
| Leo, J | 1 |
| Devlin, JW | 2 |
| Bruins, B | 1 |
| Kilbaugh, TJ | 1 |
| Margulies, SS | 1 |
| Friess, SH | 1 |
| Porhomayon, J | 1 |
| Nader, ND | 1 |
| El-Solh, AA | 1 |
| Hite, M | 1 |
| Scott, J | 1 |
| Silinskie, K | 1 |
| Sharma, A | 2 |
| Singh, PM | 1 |
| Trikha, A | 2 |
| Rewari, V | 2 |
| Honda, CK | 1 |
| Freitas, FG | 1 |
| Stanich, P | 1 |
| Mazza, BF | 1 |
| Castro, I | 1 |
| Nascente, AP | 1 |
| Bafi, AT | 1 |
| Azevedo, LC | 1 |
| Machado, FR | 1 |
| Tedders, KM | 1 |
| McNorton, KN | 1 |
| Edwin, SB | 1 |
| Varndell, W | 1 |
| Elliott, D | 1 |
| Fry, M | 1 |
| Tarquinio, KM | 1 |
| Howell, JD | 1 |
| Montgomery, V | 1 |
| Turner, DA | 1 |
| Hsing, DD | 1 |
| Parker, MM | 1 |
| Brown, CA | 1 |
| Walls, RM | 1 |
| Nadkarni, VM | 1 |
| Nishisaki, A | 1 |
| Subramaniam, R | 1 |
| Misra, M | 1 |
| Joshiraj, B | 1 |
| Krishnan, G | 1 |
| Varma, P | 1 |
| Kishore, S | 1 |
| Kudchadkar, SR | 1 |
| Shaffner, DH | 1 |
| Choi, L | 1 |
| Ferrell, BA | 1 |
| Vasilevskis, EE | 1 |
| Pandharipande, PP | 1 |
| Ely, EW | 1 |
| Stein, CM | 1 |
| Girard, TD | 1 |
| Haddad, SH | 1 |
| Gonzales, CB | 1 |
| Deeb, AM | 1 |
| Tamim, HM | 1 |
| AlDawood, AS | 1 |
| Al Babtain, I | 1 |
| Naidu, BS | 1 |
| Arabi, YM | 1 |
| Droege, CA | 1 |
| Mueller, EW | 1 |
| Mora, AG | 1 |
| Ganem, VJ | 1 |
| Ervin, AT | 1 |
| Maddry, JK | 1 |
| Bebarta, VS | 1 |
| Gagnon, DJ | 1 |
| Fontaine, GV | 1 |
| Smith, KE | 1 |
| Riker, RR | 1 |
| Miller, RR | 1 |
| Lerwick, PA | 1 |
| Lucas, FL | 1 |
| Dziodzio, JT | 1 |
| Sihler, KC | 1 |
| Fraser, GL | 1 |
| Merchan, C | 1 |
| Altshuler, D | 1 |
| Papadopoulos, J | 1 |
| Tobar A, E | 1 |
| Lanas M, A | 1 |
| Pino P, S | 1 |
| Aspée L, P | 1 |
| Rivas V, S | 1 |
| Prat R, D | 1 |
| Asenjo B, R | 1 |
| Castro O, J | 1 |
| Lu, CH | 1 |
| Man, KM | 1 |
| Ou-Yang, HY | 1 |
| Chan, SM | 1 |
| Ho, ST | 1 |
| Wong, CS | 1 |
| Liaw, WJ | 1 |
| Karamchandani, K | 1 |
| Batra, RK | 1 |
| Mirski, MA | 1 |
| Lewin, JJ | 1 |
| Ledroux, S | 1 |
| Thompson, C | 1 |
| Murakami, P | 1 |
| Zink, EK | 1 |
| Griswold, M | 1 |
| Fanning, JJ | 1 |
| Stucke, AG | 1 |
| Christensen, MA | 1 |
| Cassidy, LD | 1 |
| Berens, RJ | 1 |
| Krishnamurthy, RB | 1 |
| Upton, RN | 1 |
| Fajumi, AO | 1 |
| Lai, S | 1 |
| Charlton, CS | 1 |
| Ousley, RM | 1 |
| Martinez, AM | 1 |
| McConnell, H | 1 |
| O'Connor, SN | 1 |
| Ong, J | 1 |
| Macintyre, PE | 1 |
| Chapman, MJ | 1 |
| Ludbrook, GL | 1 |
| Al-Qadheeb, NS | 1 |
| Roberts, RJ | 1 |
| Griffin, R | 1 |
| Garpestad, E | 1 |
| Ruthazer, R | 1 |
| Skrobik, Y | 1 |
| Leger, C | 1 |
| Cossette, M | 1 |
| Michaud, V | 1 |
| Turgeon, J | 1 |
| Dominguez, KD | 1 |
| Lomako, DM | 1 |
| Katz, RW | 1 |
| Kelly, HW | 3 |
| Olofsson, K | 1 |
| Alling, C | 1 |
| Lundberg, D | 1 |
| Malmros, C | 1 |
| Takara, I | 1 |
| Tomiyama, H | 1 |
| Tokumine, J | 1 |
| Sugahara, K | 1 |
| De Jonghe, B | 1 |
| Bastuji-Garin, S | 1 |
| Fangio, P | 1 |
| Lacherade, JC | 1 |
| Jabot, J | 1 |
| Appéré-De-Vecchi, C | 1 |
| Rocha, N | 1 |
| Outin, H | 1 |
| Martin, J | 1 |
| Parsch, A | 1 |
| Franck, M | 1 |
| Wernecke, KD | 1 |
| Fischer, M | 1 |
| Spies, C | 1 |
| Jin, HS | 1 |
| Yum, MS | 1 |
| Kim, SL | 1 |
| Shin, HY | 1 |
| Lee, EH | 1 |
| Ha, EJ | 1 |
| Hong, SJ | 1 |
| Park, SJ | 1 |
| Darnell, CM | 1 |
| Thompson, J | 1 |
| Stromberg, D | 1 |
| Roy, L | 1 |
| Sheeran, P | 1 |
| French, JP | 1 |
| Nocera, M | 1 |
| Katz, R | 2 |
| Hsi, A | 1 |
| Badeva, B | 1 |
| Iskrenova, I | 1 |
| Panchev, P | 1 |
| Gerov, I | 1 |
| Nemtsova, D | 1 |
| Radichkova, V | 1 |
| Petrov, P | 1 |
| Gerzilova, L | 1 |
| Aluan, K | 1 |
| Yaster, M | 1 |
| Nichols, DG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Sedation, ANalgesia and Delirium MANagement: a Study of Medical, Surgical, Trauma, and Neuro-intensive Care Patients and a COVID-19 Sub-study.[NCT05027217] | 3,421 participants (Actual) | Observational | 2022-01-01 | Completed | |||
| The Preventative Role of Exogenous Melatonin Administration in Patients With Advanced Cancer Who Are at Risk of Delirium: a Feasibility Study Prior to a Larger Randomized Controlled Trial[NCT02200172] | Phase 2 | 60 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
| Prevention of Oversedation in Intensive Care Patients Under Mechanical Ventilation : the AWARE Multicentric Randomized Trial[NCT01617265] | 1,180 participants (Actual) | Interventional | 2012-06-30 | Completed | |||
| The Impact of Concomitant Ultra Low Dose Infusion Naloxone and Therapeutic Infusion Opioid on Opioid Requirements in Pediatric ICU Patients[NCT00286052] | Phase 3 | 128 participants | Interventional | 2002-12-31 | Completed | ||
| The Pharmacokinetics of Fentanyl in Intensive Care Patients[NCT02587273] | Phase 4 | 150 participants (Anticipated) | Interventional | 2015-10-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for fentanyl and Critical Illness
| Article | Year |
|---|---|
Ketamine sedation in mechanically ventilated patients: A systematic review and meta-analysis.
Topics: Anesthesia; Critical Illness; Fentanyl; Humans; Hypnotics and Sedatives; Ketamine; Midazolam; Observ | 2020 |
Altered Pharmacokinetics in Prolonged Infusions of Sedatives and Analgesics Among Adult Critically Ill Patients: A Systematic Review.
Topics: Adult; Analgesics; Critical Illness; Dexmedetomidine; Fentanyl; Humans; Hypnotics and Sedatives; Inf | 2018 |
Pain management in the critically ill child.
Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Child; Child, Preschool; Critical Illness; Fentan | 2001 |
10 trials available for fentanyl and Critical Illness
| Article | Year |
|---|---|
The influence of analgesic-based sedation protocols on delirium and outcomes in critically ill patients: A randomized controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Critical Illness; Deep Sedation; Emergence Delirium; Fem | 2017 |
Analgesia-first sedation in critically ill adults: A U.S. pilot, randomized controlled trial.
Topics: Aged; Analgesia; Analgesics, Opioid; Anesthesia; California; Clinical Protocols; Critical Illness; D | 2019 |
Entropy correlates with Richmond Agitation Sedation Scale in mechanically ventilated critically ill patients.
Topics: Adolescent; Adult; Aged; Anesthetics, Intravenous; Conscious Sedation; Consciousness; Consciousness | 2014 |
[Protocol based sedation versus conventional treatment in critically ill patients on mechanical ventilation].
Topics: Aged; Algorithms; Analgesia; Analgesics, Opioid; APACHE; Conscious Sedation; Critical Illness; Deep | 2008 |
Cognitive improvement during continuous sedation in critically ill, awake and responsive patients: the Acute Neurological ICU Sedation Trial (ANIST).
Topics: Acrylates; Adult; Aged; Cognition; Conscious Sedation; Critical Illness; Cross-Over Studies; Dexmede | 2010 |
Opioid withdrawal in critically ill neonates.
Topics: Analgesics, Opioid; Critical Illness; Dose-Response Relationship, Drug; Female; Fentanyl; Humans; In | 2003 |
Abolished circadian rhythm of melatonin secretion in sedated and artificially ventilated intensive care patients.
Topics: Aged; Aged, 80 and over; Circadian Rhythm; Critical Care; Critical Illness; Drug Therapy, Combinatio | 2004 |
Sedation algorithm in critically ill patients without acute brain injury.
Topics: Adult; Aged; Aged, 80 and over; Algorithms; Arousal; Brain Damage, Chronic; Conscious Sedation; Crit | 2005 |
The efficacy of the COMFORT scale in assessing optimal sedation in critically ill children requiring mechanical ventilation.
Topics: Anesthetics, Intravenous; Child, Preschool; Conscious Sedation; Critical Care; Critical Illness; Fem | 2007 |
Effect of low-dose naloxone infusion on fentanyl requirements in critically ill children.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Conscious Sedation; Critical Illness; Doubl | 2008 |
38 other studies available for fentanyl and Critical Illness
| Article | Year |
|---|---|
Pre-hospital analgesia in pediatric trauma and critically ill patients: An analysis of a German air rescue service.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Child; Critical Illness; Emergency Medical Services; Fent | 2023 |
Continuous visualization and validation of pain in critically ill patients using artificial intelligence: a retrospective observational study.
Topics: Adult; Artificial Intelligence; Critical Care; Critical Illness; Fentanyl; Humans; Intensive Care Un | 2023 |
A Modeling-Based Approach to Estimate Fentanyl Pharmacokinetics in Obese Critically Ill Children.
Topics: Child; Critical Illness; Fentanyl; Humans; Infusions, Intravenous; Obesity | 2019 |
Propofol infusion syndrome; are high doses always required?
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Anesthetics, Local; Bupivacaine; Chemical | 2020 |
Iatrogenic Opioid Withdrawal Syndrome in Critically Ill Patients: a Retrospective Cohort Study.
Topics: Aged; Analgesics, Opioid; Critical Illness; Female; Fentanyl; Humans; Incidence; Male; Middle Aged; | 2020 |
A Novel Clinical Consideration to Conserve Parenteral Fentanyl During the COVID-19 Pandemic.
Topics: Administration, Cutaneous; Anesthetics, Intravenous; Coronavirus Infections; COVID-19; Critical Illn | 2020 |
Analysis of fentanyl pharmacokinetics, and its sedative effects and tolerance in critically ill children.
Topics: Child; Child, Preschool; Critical Illness; Drug Tolerance; Fentanyl; Humans; Hypnotics and Sedatives | 2021 |
Hydromorphone Compared to Fentanyl in Patients Receiving Extracorporeal Membrane Oxygenation.
Topics: Adult; Critical Illness; Extracorporeal Membrane Oxygenation; Female; Fentanyl; Humans; Hydromorphon | 2021 |
ABCB1 genotype is associated with fentanyl requirements in critically ill children.
Topics: Alleles; Analgesics, Opioid; ATP Binding Cassette Transporter, Subfamily B; Child; Child, Preschool; | 2017 |
Relationship between rate of fentanyl infusion and time to achieve sedation in nonobese and obese critically ill children.
Topics: Adolescent; Anesthetics, Intravenous; Child; Child, Preschool; Cohort Studies; Critical Illness; Fem | 2017 |
Transition From Continuous Infusion Fentanyl to Hydromorphone in Critically Ill Patients.
Topics: Adult; Analgesics, Opioid; Critical Care; Critical Illness; Female; Fentanyl; Humans; Hydromorphone; | 2020 |
Factors Contributing to Fentanyl Pharmacokinetic Variability Among Diagnostically Diverse Critically Ill Children.
Topics: Adolescent; Analgesics, Opioid; Child; Child, Preschool; Cohort Studies; Critical Illness; Female; F | 2019 |
The anesthetic effects on vasopressor modulation of cerebral blood flow in an immature swine model.
Topics: Anesthesia; Anesthesia, Intravenous; Anesthetics; Anesthetics, Inhalation; Anesthetics, Intravenous; | 2013 |
Pre- and post-intervention study to assess the impact of a sedation protocol in critically ill surgical patients.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Benzodiazepines; Cohort Studies; Critical Care; Critica | 2013 |
Nurse to bed ratio and nutrition support in critically ill patients.
Topics: Aged; Analgesics, Opioid; APACHE; Comorbidity; Critical Illness; Energy Intake; Enteral Nutrition; F | 2013 |
Efficacy and safety of analgosedation with fentanyl compared with traditional sedation with propofol.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anesthetics, Intravenous; Critical Illness; Female; Fen | 2014 |
Emergency nurses practices in assessing and administering continuous intravenous sedation for critically ill adult patients: a retrospective record review'.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, Intravenous; Conscious Sedation; Critical Il | 2015 |
Current medication practice and tracheal intubation safety outcomes from a prospective multicenter observational cohort study.
Topics: Adolescent; Child; Child, Preschool; Critical Illness; Female; Fentanyl; Hemodynamics; Humans; Hypno | 2015 |
Anesthetic management of emergent laparoscopic bilateral adrenalectomy in a patient with a life-threatening cortisol crisis.
Topics: ACTH Syndrome, Ectopic; Adrenalectomy; Adrenocorticotropic Hormone; Anesthetics; Critical Illness; C | 2015 |
Pharmacologic recipes for tracheal intubation in the PICU: what's on the menu?
Topics: Critical Illness; Female; Fentanyl; Humans; Intubation, Intratracheal; Ketamine; Male; Midazolam; Ne | 2015 |
Population Pharmacokinetics of Fentanyl in the Critically Ill.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Critical Care; Critical Illness; Female; Fentany | 2016 |
Computerized physician order entry of a sedation protocol is not associated with improved sedation practice or outcomes in critically ill patients.
Topics: Adult; Aged; Analgesics; Cohort Studies; Critical Illness; Dose-Response Relationship, Drug; Female; | 2015 |
Fentanyl Pharmacokinetics in Critically Ill Patients: A Demonstration of Mixed Effects.
Topics: Analgesics, Opioid; Critical Illness; Female; Fentanyl; Humans; Male | 2016 |
En Route Use of Analgesics in Nonintubated, Critically Ill Patients Transported by U.S. Air Force Critical Care Air Transport Teams.
Topics: Adult; Aerospace Medicine; Afghan Campaign 2001-; Air Ambulances; Analgesics; Critical Care; Critica | 2016 |
Valproate for agitation in critically ill patients: A retrospective study.
Topics: Adult; Aged; Analgesics, Opioid; Critical Illness; Delirium; Dexmedetomidine; Female; Fentanyl; GABA | 2017 |
Methylnaltrexone Versus Naloxone for Opioid-Induced Constipation in the Medical Intensive Care Unit.
Topics: Adult; Analgesics, Opioid; Constipation; Critical Illness; Electronic Health Records; Female; Fentan | 2017 |
Composite auditory evoked potential index versus bispectral index to estimate the level of sedation in paralyzed critically ill patients: a prospective observational study.
Topics: Analgesics, Opioid; Conscious Sedation; Critical Illness; Electroencephalography; Electromyography; | 2008 |
Bispectral index correlates well with Richmond agitation sedation scale in mechanically ventilated critically ill patients.
Topics: Adolescent; Adult; Blood Gas Analysis; Conscious Sedation; Consciousness Monitors; Critical Care; Cr | 2010 |
Perioperative opiate requirements in children with previous opiate infusion.
Topics: Analgesics, Opioid; Child; Child, Preschool; Critical Illness; Drug Tolerance; Female; Fentanyl; Hos | 2012 |
Pharmacokinetics of oxycodone after subcutaneous administration in a critically ill population compared with a healthy cohort.
Topics: Absorption; Adult; Aged; Analgesia, Patient-Controlled; Analgesics, Opioid; Area Under Curve; Biolog | 2012 |
Impact of enteral methadone on the ability to wean off continuously infused opioids in critically ill, mechanically ventilated adults: a case-control study.
Topics: Adult; Aged; Analgesics, Opioid; Case-Control Studies; Critical Illness; Enteral Nutrition; Female; | 2012 |
Factors predisposing to coma and delirium: fentanyl and midazolam exposure; CYP3A5, ABCB1, and ABCG2 genetic polymorphisms; and inflammatory factors.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member | 2013 |
[Withdrawal syndrome in a critically ill child after sedation with midazolam and fentanyl].
Topics: Child; Critical Illness; Esophageal Stenosis; Esophagoplasty; Female; Fentanyl; Humans; Hypnotics an | 2004 |
Practice of sedation and analgesia in German intensive care units: results of a national survey.
Topics: Analgesia; Analgesia, Epidural; Analgesics; Analgesics, Opioid; Clonidine; Critical Illness; Data In | 2005 |
Drug withdrawal symptoms in children after continuous infusions of fentanyl.
Topics: Critical Illness; Fentanyl; Humans; Infant; Infant, Newborn; Infusions, Intravenous; Intensive Care | 1994 |
Prospective study on the occurrence of withdrawal in critically ill children who receive fentanyl by continuous infusion.
Topics: Chi-Square Distribution; Critical Illness; Dose-Response Relationship, Drug; Female; Fentanyl; Human | 1994 |
Pharmacokinetics of continuous infusions of fentanyl in critically ill children.
Topics: Adolescent; Child; Child, Preschool; Critical Illness; Fentanyl; Half-Life; Humans; Infant; Infant, | 1993 |
[Prolonged propofol (Diprivan) infusion for sedation in the critically ill].
Topics: Aged; Anesthetics, Combined; Anesthetics, Intravenous; Conscious Sedation; Critical Illness; Fentany | 1996 |