Page last updated: 2024-10-27

fentanyl and Cognition Disorders

fentanyl has been researched along with Cognition Disorders in 21 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Research Excerpts

ExcerptRelevanceReference
"The neurodevelopmental impact of fentanyl given to preterm newborns for pain control is still unknown."9.24Follow-up at the corrected age of 24 months of preterm newborns receiving continuous infusion of fentanyl for pain control during mechanical ventilation. ( Ancora, G; Faldella, G; Ferrari, F; Garetti, E; Lago, P; Merazzi, D; Pierantoni, L; Pirelli, A, 2017)
"Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is pain, with opioids including transdermal fentanyl the mainstay of treatment."7.81Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl. ( Barratt, DT; Dale, O; Kaasa, S; Klepstad, P; Somogyi, AA, 2015)
" Therefore, the present study evaluates cognitive and behavioral function as well as hippocampal damage in rats subjected to cerebral ischemia under sevoflurane compared with fentanyl/nitrous oxide (N(2)O)/O(2) anesthesia."7.75Effects of sevoflurane on cognitive deficit, motor function, and histopathology after cerebral ischemia in rats. ( Blobner, M; Eberspächer, E; Eckel, B; Engelhard, K; Hoffman, WE; Müller, K; Werner, C, 2009)
"The neurodevelopmental impact of fentanyl given to preterm newborns for pain control is still unknown."5.24Follow-up at the corrected age of 24 months of preterm newborns receiving continuous infusion of fentanyl for pain control during mechanical ventilation. ( Ancora, G; Faldella, G; Ferrari, F; Garetti, E; Lago, P; Merazzi, D; Pierantoni, L; Pirelli, A, 2017)
"The study objective was to determine whether switching patients from morphine to transdermal fentanyl resulted in a reduction of morphine-associated side effects, and an improvement in cognitive function and patients' well being while maintaining adequate pain and symptom control."5.10Opioid switching from morphine to transdermal fentanyl for toxicity reduction in palliative care. ( McNamara, P, 2002)
"Common adverse symptoms of cancer and chemotherapy are a major health burden; chief among these is pain, with opioids including transdermal fentanyl the mainstay of treatment."3.81Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl. ( Barratt, DT; Dale, O; Kaasa, S; Klepstad, P; Somogyi, AA, 2015)
" Therefore, the present study evaluates cognitive and behavioral function as well as hippocampal damage in rats subjected to cerebral ischemia under sevoflurane compared with fentanyl/nitrous oxide (N(2)O)/O(2) anesthesia."3.75Effects of sevoflurane on cognitive deficit, motor function, and histopathology after cerebral ischemia in rats. ( Blobner, M; Eberspächer, E; Eckel, B; Engelhard, K; Hoffman, WE; Müller, K; Werner, C, 2009)
"The incidence of clinical confusion was not statistically different between groups (4."2.68Postoperative cognitive impairment in the elderly. Choice of patient-controlled analgesia opioid. ( Dobkowski, W; Eliasziw, M; Ganapathy, S; Herrick, IA; Kirkby, J; Komar, W; Moote, CA, 1996)
"Postoperative pain was assessed during the first postoperative 12 hours with the Wong-Baker faces pain-rating scale."1.43REMIFENTANIL VS FENTANYL DURING DAY CASE DENTAL SURGERY IN PEOPLE WITH SPECIAL NEEDS: A COMPARATIVE, PILOT STUDY OF THEIR EFFECT ON STRESS RESPONSE AND POSTOPERATIVE PAIN. ( Kalimeris, K; Kostopanagiotou, G; Matsota, P; Perrea, D; Sklika, E; Stavropoulos, N, 2016)
"The use of TDF for the treatment of cancer pain is not associated with impairment in cognitive performance."1.40[The cognitive effects of using transdermal fentanyl in cancer pain]. ( Ali, A; Bilen, A; Turgut, N; Türkmen, A; Unlü, N, 2014)
"Rats treated with isoflurane had the best cognitive recovery (p < 0."1.33Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats. ( Alexander, H; Clark, RS; Dixon, CE; Jenkins, L; Kochanek, PM; Statler, KD; Vagni, V, 2006)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19903 (14.29)18.7374
1990's1 (4.76)18.2507
2000's10 (47.62)29.6817
2010's7 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Watkins, TJ1
Bonds, RL1
Hodges, K1
Goettle, BB1
Dobson, DA1
Maye, JP1
Unlü, N1
Bilen, A1
Ali, A1
Turgut, N1
Türkmen, A1
Barratt, DT1
Klepstad, P1
Dale, O1
Kaasa, S1
Somogyi, AA1
Sklika, E1
Kalimeris, K1
Perrea, D1
Stavropoulos, N1
Kostopanagiotou, G1
Matsota, P1
Ancora, G1
Lago, P1
Garetti, E1
Pirelli, A1
Merazzi, D1
Pierantoni, L1
Ferrari, F1
Faldella, G1
Shprecher, DR1
Flanigan, KM1
Smith, AG1
Smith, SM1
Schenkenberg, T1
Steffens, J1
Eberspächer, E1
Eckel, B1
Engelhard, K1
Müller, K1
Hoffman, WE1
Blobner, M1
Werner, C1
Pereira, LC1
Oliveira, KM1
L'Abbate, GL1
Sugai, R1
Ferreira, JA1
da Motta, LA1
Bilotta, F1
Doronzio, A1
Stazi, E1
Titi, L1
Zeppa, IO1
Cianchi, A1
Rosa, G1
Paoloni, FP1
Bergese, S1
Asouhidou, I1
Ioannou, P1
Abramowicz, AE1
Spinelli, A1
Delphin, E1
Ayrian, E1
Zelman, V1
Lumb, P1
Gallagher, R1
McNamara, P1
Kadoi, Y1
Saito, S1
Kunimoto, F1
Goto, F1
Fujita, N1
Statler, KD1
Alexander, H1
Vagni, V1
Dixon, CE1
Clark, RS1
Jenkins, L1
Kochanek, PM1
Silbert, BS1
Scott, DA1
Evered, LA1
Lewis, MS1
Kalpokas, M1
Maruff, P1
Myles, PS1
Jamrozik, K1
Wan, Y1
Xu, J1
Ma, D1
Zeng, Y1
Cibelli, M1
Maze, M1
Elsass, P1
Stibolt, O1
Klauber, PV1
Christensen, SE1
Lunding, M1
Herrick, IA1
Ganapathy, S1
Komar, W1
Kirkby, J1
Moote, CA1
Dobkowski, W1
Eliasziw, M1
Biedler, A1
Juckenhöfel, S1
Feisel, C1
Wilhelm, W1
Larsen, R1
Grigore, AM1
Mathew, J1
Grocott, HP1
Reves, JG1
Blumenthal, JA1
White, WD1
Smith, PK1
Jones, RH1
Kirchner, JL1
Mark, DB1
Newman, MF1
Bidwai, AV1
Cornelius, LR1
Stanley, TH1
Graham, TP1
Atwood, GF1
Werner, B1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Post Operative Cognitive Recovery and Neuropsychological Complications After General Anesthesia. A Comparison Between Different Techniques of Anesthesia: A Multi-Center Observational Study[NCT00507195]1,200 participants (Anticipated)Observational2007-05-31Recruiting
Association Between Changes in Cerebral Gray Matter Volume and Postoperative Cognitive Dysfunction in Elderly Patients Following Sevoflurane Anesthesia (POCD-MRI)[NCT02045004]100 participants (Actual)Observational2015-07-14Completed
Release of Serum Neurofilament Light (NFL), Biomarker of Neuronal Injury, in Surgery Under General Anaesthesia (GA) Compared to Surgery With Hypno-analgesia (Hyp): A Prospective, Non-inferiority Study[NCT04500236]100 participants (Anticipated)Interventional2020-09-01Recruiting
Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium: A Multicenter, Randomized, Double-Blind Clinical Trail[NCT02928692]Phase 3750 participants (Anticipated)Interventional2016-11-30Recruiting
Effect of General Anesthesia on Early Postoperative Cognitive Dysfunction in Elective Versus Emergency Cesarean Section[NCT03818009]58 participants (Actual)Observational2019-01-14Completed
Impact of Dexmedetomidine on the Incidence of Postoperative Delirium in Patients After Cardiac Surgery: a Randomized, Double-blinded, and Placebo-controlled Clinical Trial[NCT02267538]Phase 4285 participants (Actual)Interventional2014-11-30Completed
Effect of Remifentanil on Postoperative Cognitive Function in Patients Undergoing Major Abdominal Surgery[NCT01627873]Phase 4622 participants (Actual)Interventional2009-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Incidence of Postoperative Delirium

Delirium was assessed with the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) twice daily during the first five days after surgery. (NCT02267538)
Timeframe: During the first five days after surgery

InterventionParticipants (Count of Participants)
DEX Group7
CTRL Group11

Length of Stay in Hospital After Surgery

Results was presented as median (95% confidence interval). (NCT02267538)
Timeframe: From end of surgery until discharge from hospital or 30 days after surgery

Interventiondays (Median)
DEX Group9
CTRL Group9

Length of Stay in the Intensive Care Unit

Results was presented as median (95% confidence interval). (NCT02267538)
Timeframe: From end of surgery until discharge from Intensive Care Unit or 30 days after surgery

Interventionhours (Median)
DEX Group45.0
CTRL Group46.0

Cognitive Function

"Cognitive function was assessed with the Mini Mental State Examination (MMSE) at baseline (the day before surgery) and on the sixth day after surgery, and with modified telephone interview for cognitive status (m-TICS) on the 30th day after surgery.~The introduction of MMSE scale has been explained in the baseline part in the result section.~The Telephone Interview for Cognitive Status-modified scale(m-TICS) is one of the most popular telephone interview-based screening instruments for mild cognitive impairment and dementia. It consists 11 items including wordlist memory, orientation, attention, repetition, conceptual knowledge and nonverbal praxis, which score ranges from 0 to 48, with higher scores indicating better cognitive function" (NCT02267538)
Timeframe: on the sixth day after surgery, and on the 30th day after surgery

,
Interventionunits on a scale (Median)
MMSE score on postoperative day 6m-TICS score on postoperative day 30
CTRL Group2934
DEX Group2934

Incidence of Non-delirium Complications After Surgery

Non-delirium complications was defined as any conditions other than delirium that occurred during the first 30 days after surgery and required therapeutic intervention.Complications listed here were not considered adverse events in this study. (NCT02267538)
Timeframe: Occurrence of non-delirium complications will be monitored until 30 days after surgery.

,
InterventionParticipants (Count of Participants)
StrokeNew onset arrythmiaPulmonary complicationsUpper gastrointestinal bleedingSurgical bleedingWound dehiscence or infectionAcute kidney injuryIABP assistance
CTRL Group351274374412
DEX Group342152311376

Pain Intensity

Pain intensity was assessed daily at 8 am during the first five days after surgery with the Numeric Rating Scale (NRS, 0 = no pain, 10 = the worst possible pain). (NCT02267538)
Timeframe: During the first five days after surgery

,
Interventionunits on a scale (Median)
Pain score after surgery(d1), at restPain score after surgery(d2), at restPain score after surgery(d3), at restPain score after surgery(d4), at restPain score after surgery(d5), at restPain score after surgery(d1), with coughingPain score after surgery(d2), with coughingPain score after surgery(d3), with coughingPain score after surgery(d4), with coughingPain score after surgery(d5), with coughing
CTRL Group3322144432
DEX Group3432245432

Subjective Sleep Quality

Subjective sleep quality was assessed daily at 8 am during the first five days after surgery with the Numeric Rating Scale (NRS, 0 = best sleep, 10 = the worst possible sleep). (NCT02267538)
Timeframe: During the first five days after surgery

,
Interventionunits on a scale (Median)
Subjective sleep quality after surgery(d1), scoreSubjective sleep quality after surgery(d2), scoreSubjective sleep quality after surgery(d3), scoreSubjective sleep quality after surgery(d4), scoreSubjective sleep quality after surgery(d5), score
CTRL Group23222
DEX Group23222

Reviews

1 review available for fentanyl and Cognition Disorders

ArticleYear
The management of wound-related procedural pain (volitional incident pain) in advanced illness.
    Current opinion in supportive and palliative care, 2013, Volume: 7, Issue:1

    Topics: Administration, Buccal; Administration, Intranasal; Analgesics, Opioid; Breakthrough Pain; Cognition

2013

Trials

10 trials available for fentanyl and Cognition Disorders

ArticleYear
Evaluation of postprocedure cognitive function using 3 distinct standard sedation regimens for endoscopic procedures.
    AANA journal, 2014, Volume: 82, Issue:2

    Topics: Adjuvants, Anesthesia; Cognition; Cognition Disorders; Colonoscopy; Conscious Sedation; Female; Fent

2014
Follow-up at the corrected age of 24 months of preterm newborns receiving continuous infusion of fentanyl for pain control during mechanical ventilation.
    Pain, 2017, Volume: 158, Issue:5

    Topics: Anesthetics, Intravenous; Child Behavior Disorders; Child, Preschool; Cognition Disorders; Developme

2017
Early postoperative cognitive dysfunction and postoperative delirium after anaesthesia with various hypnotics: study protocol for a randomised controlled trial--the PINOCCHIO trial.
    Trials, 2011, Jul-06, Volume: 12

    Topics: Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Cognition; Cognition Disorde

2011
Opioid switching from morphine to transdermal fentanyl for toxicity reduction in palliative care.
    Palliative medicine, 2002, Volume: 16, Issue:5

    Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cognition Disorders;

2002
Comparative effects of propofol versus fentanyl on cerebral oxygenation state during normothermic cardiopulmonary bypass and postoperative cognitive dysfunction.
    The Annals of thoracic surgery, 2003, Volume: 75, Issue:3

    Topics: Aged; Anesthesia, General; Anesthesia, Intravenous; Blood Gas Analysis; Brain; Cardiopulmonary Bypas

2003
A comparison of the effect of high- and low-dose fentanyl on the incidence of postoperative cognitive dysfunction after coronary artery bypass surgery in the elderly.
    Anesthesiology, 2006, Volume: 104, Issue:6

    Topics: Aged; Cognition Disorders; Coronary Artery Bypass; Female; Fentanyl; Humans; Length of Stay; Male; M

2006
A clinical neuropsychological study of the postoperative course after three types of anaesthesia.
    Acta anaesthesiologica Scandinavica, 1982, Volume: 26, Issue:2

    Topics: Adult; Aged; Alfaxalone Alfadolone Mixture; Anesthetics; Clinical Trials as Topic; Cognition Disorde

1982
Postoperative cognitive impairment in the elderly. Choice of patient-controlled analgesia opioid.
    Anaesthesia, 1996, Volume: 51, Issue:4

    Topics: Aged; Aged, 80 and over; Analgesia, Patient-Controlled; Analgesics, Opioid; Cognition Disorders; Con

1996
[Cognitive impairment in the early postoperative period after remifentanil-propofol and sevoflurane-fentanyl anesthesia].
    Der Anaesthesist, 2000, Volume: 49, Issue:4

    Topics: Adult; Anesthesia, Inhalation; Anesthetics, Inhalation; Anesthetics, Intravenous; Cognition Disorder

2000
Prospective randomized trial of normothermic versus hypothermic cardiopulmonary bypass on cognitive function after coronary artery bypass graft surgery.
    Anesthesiology, 2001, Volume: 95, Issue:5

    Topics: Anesthetics, Intravenous; Cognition Disorders; Coronary Artery Bypass; Educational Status; Female; F

2001

Other Studies

10 other studies available for fentanyl and Cognition Disorders

ArticleYear
[The cognitive effects of using transdermal fentanyl in cancer pain].
    Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology, 2014, Volume: 26, Issue:3

    Topics: Administration, Cutaneous; Analgesics, Opioid; Cognition Disorders; Female; Fentanyl; Humans; Male;

2014
Innate Immune Signalling Genetics of Pain, Cognitive Dysfunction and Sickness Symptoms in Cancer Pain Patients Treated with Transdermal Fentanyl.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Cognition Disorders;

2015
REMIFENTANIL VS FENTANYL DURING DAY CASE DENTAL SURGERY IN PEOPLE WITH SPECIAL NEEDS: A COMPARATIVE, PILOT STUDY OF THEIR EFFECT ON STRESS RESPONSE AND POSTOPERATIVE PAIN.
    Middle East journal of anaesthesiology, 2016, Volume: 23, Issue:5

    Topics: Adult; Ambulatory Surgical Procedures; Analgesics, Opioid; Cognition Disorders; Female; Fentanyl; He

2016
Clinical and diagnostic features of delayed hypoxic leukoencephalopathy.
    The Journal of neuropsychiatry and clinical neurosciences, 2008,Fall, Volume: 20, Issue:4

    Topics: Adult; Analgesics, Opioid; Benzodiazepines; Brain; Cocaine; Cognition Disorders; Depressive Disorder

2008
Effects of sevoflurane on cognitive deficit, motor function, and histopathology after cerebral ischemia in rats.
    Acta anaesthesiologica Scandinavica, 2009, Volume: 53, Issue:6

    Topics: Anesthesia; Anesthetics; Anesthetics, Intravenous; Animals; Blood Gas Analysis; Brain; Brain Ischemi

2009
Outcome of fully awake craniotomy for lesions near the eloquent cortex: analysis of a prospective surgical series of 79 supratentorial primary brain tumors with long follow-up.
    Acta neurochirurgica, 2009, Volume: 151, Issue:10

    Topics: Adult; Aged; Analgesics, Opioid; Brain Mapping; Brain Neoplasms; Cerebral Cortex; Cognition Disorder

2009
Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats.
    Journal of neurotrauma, 2006, Volume: 23, Issue:1

    Topics: Anesthetics; Animals; Brain; Brain Injuries; Cell Survival; Cognition Disorders; Diazepam; Disease M

2006
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus.
    Anesthesiology, 2007, Volume: 106, Issue:3

    Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Cognition Disorders; Cytokines; Disease Models,

2007
Reversal of Innovar-induced postanesthetic somnolence and disorientation with physostigmine.
    Anesthesiology, 1976, Volume: 44, Issue:3

    Topics: Adult; Anesthesia, Intravenous; Anesthetics; Cognition Disorders; Confusion; Consciousness Disorders

1976
Use of droperidol-fentanyl sedation for cardiac catheterization in children.
    American heart journal, 1974, Volume: 87, Issue:3

    Topics: Adolescent; Bradycardia; Cardiac Catheterization; Cardiac Volume; Child; Child, Preschool; Cognition

1974