fentanyl has been researched along with Cerebral Ischemia in 22 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study is to evaluate novel multifunctional enkephalin-fentanyl opioid agonists, LYS436, LYS739 and LYS416 for their neuroprotective potential using in vitro and in vivo ischemic stroke models and to compare the effect to that of biphalin." | 7.83 | Enkephalin-Fentanyl Multifunctional Opioids as Potential Neuroprotectants for Ischemic Stroke Treatment. ( Abbruscato, TJ; Hruby, VJ; Islam, MR; Karamyan, VT; Lee, YS; Yang, L, 2016) |
| " Therefore, the present study evaluates cognitive and behavioral function as well as hippocampal damage in rats subjected to cerebral ischemia under sevoflurane compared with fentanyl/nitrous oxide (N(2)O)/O(2) anesthesia." | 7.75 | Effects of sevoflurane on cognitive deficit, motor function, and histopathology after cerebral ischemia in rats. ( Blobner, M; Eberspächer, E; Eckel, B; Engelhard, K; Hoffman, WE; Müller, K; Werner, C, 2009) |
| "This study found no change in the percent alive CA1 hippocampal neurons as a function of duration of recovery from severe forebrain ischemia in isoflurane anesthetized rats." | 7.72 | Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. ( Elsersy, H; Lynch, JR; Moldovan, M; Pearlstein, RD; Sheng, H; Warner, DS, 2004) |
| "Isoflurane improves outcome from near-complete forebrain ischemia in rats compared with fentanyl-nitrous oxide (N2O)." | 7.70 | Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats. ( Kudo, M; Mackensen, GB; Nellgârd, B; Pearlstein, RD; Sheng, H; Warner, DS, 2000) |
| "This study investigates the effects of acamprosate, a glutamatergic modulator, and the lipid peroxidation inhibitor U-101033E on neurological outcome following incomplete cerebral ischemia and reperfusion in rats." | 7.70 | [The neuroprotective effect of the glutamate antagonist acamprosate following experimental cerebral ischemia. A study with the lipid peroxidase inhibitor u-101033e]. ( Engelhard, K; Kochs, E; Lu, H; Möllenberg, O; Werner, C; Zieglgänsberger, W, 2000) |
| " The current investigation was conducted to evaluate the effect of isoflurane and N2O-fentanyl anesthesia on ischemia-induced glutamate release in the rat and to compare it with that of mild hypothermia, an intervention known to reduce glutamate release significantly." | 7.69 | Isoflurane reduces ischemia-induced glutamate release in rats subjected to forebrain ischemia. ( Cole, DJ; Drummond, JC; Goskowicz, RL; Patel, PM, 1995) |
| "Fentanyl citrate has properties, including agonism of the mu-opioid receptor and proconvulsant activity, that theoretically could pose adverse effects in ischemic brain." | 5.30 | High-dose fentanyl does not adversely affect outcome from forebrain ischemia in the rat. ( Bart, RD; Dexter, F; Morimoto, Y; Pearlstein, RD; Warner, DS, 1997) |
| "The purpose of this study is to evaluate novel multifunctional enkephalin-fentanyl opioid agonists, LYS436, LYS739 and LYS416 for their neuroprotective potential using in vitro and in vivo ischemic stroke models and to compare the effect to that of biphalin." | 3.83 | Enkephalin-Fentanyl Multifunctional Opioids as Potential Neuroprotectants for Ischemic Stroke Treatment. ( Abbruscato, TJ; Hruby, VJ; Islam, MR; Karamyan, VT; Lee, YS; Yang, L, 2016) |
| " Therefore, the present study evaluates cognitive and behavioral function as well as hippocampal damage in rats subjected to cerebral ischemia under sevoflurane compared with fentanyl/nitrous oxide (N(2)O)/O(2) anesthesia." | 3.75 | Effects of sevoflurane on cognitive deficit, motor function, and histopathology after cerebral ischemia in rats. ( Blobner, M; Eberspächer, E; Eckel, B; Engelhard, K; Hoffman, WE; Müller, K; Werner, C, 2009) |
| "This study found no change in the percent alive CA1 hippocampal neurons as a function of duration of recovery from severe forebrain ischemia in isoflurane anesthetized rats." | 3.72 | Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. ( Elsersy, H; Lynch, JR; Moldovan, M; Pearlstein, RD; Sheng, H; Warner, DS, 2004) |
| "Rats exposed to forebrain ischemia have reduced injury when anesthetized with isoflurane versus fentanyl + N(2)O." | 3.70 | The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat. ( Mackensen, GB; Massey, G; Nellgård, B; Pearlstein, RD; Warner, DS, 2000) |
| "Isoflurane improves outcome from near-complete forebrain ischemia in rats compared with fentanyl-nitrous oxide (N2O)." | 3.70 | Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats. ( Kudo, M; Mackensen, GB; Nellgârd, B; Pearlstein, RD; Sheng, H; Warner, DS, 2000) |
| "This study investigates the effects of acamprosate, a glutamatergic modulator, and the lipid peroxidation inhibitor U-101033E on neurological outcome following incomplete cerebral ischemia and reperfusion in rats." | 3.70 | [The neuroprotective effect of the glutamate antagonist acamprosate following experimental cerebral ischemia. A study with the lipid peroxidase inhibitor u-101033e]. ( Engelhard, K; Kochs, E; Lu, H; Möllenberg, O; Werner, C; Zieglgänsberger, W, 2000) |
| " The current investigation was conducted to evaluate the effect of isoflurane and N2O-fentanyl anesthesia on ischemia-induced glutamate release in the rat and to compare it with that of mild hypothermia, an intervention known to reduce glutamate release significantly." | 3.69 | Isoflurane reduces ischemia-induced glutamate release in rats subjected to forebrain ischemia. ( Cole, DJ; Drummond, JC; Goskowicz, RL; Patel, PM, 1995) |
| "This study compares the effects of propofol and fentanyl/N2O on spontaneous brain electrical activity, neurologic outcome, and neuronal damage due to incomplete cerebral ischemia in rats." | 3.68 | The effects of propofol on brain electrical activity, neurologic outcome, and neuronal damage following incomplete ischemia in rats. ( Albrecht, RF; Hoffman, WE; Kochs, E; Schulte am Esch, J; Thomas, C; Werner, C, 1992) |
| "Paroxysmal autonomic instability with dystonia (PAID) is an underdiagnosed syndrome that describes a collection of symptoms following diverse cerebral insults, such as traumatic brain injury, hydrocephalus, hemorrhagic stroke, or brain anoxia." | 1.56 | Transdermal opioid patch in treatment of paroxysmal autonomic instability with dystonia with multiple cerebral insults: A case report. ( Baik, SW; Kang, DH; Kim, GW, 2020) |
| "Fentanyl at 50 μg/kg was first administered over a 10-min period and then 50 μg/kg/h was administered continuously for the fentanyl group." | 1.37 | Effect of fentanyl on ischemic depolarization and ischemic neuronal damage of hippocampal CA1 in the gerbil. ( Danura, T; Masui, K; Morita, K; Sasaki, T; Shiraishi, K; Takeda, Y; Taninishi, H, 2011) |
| "Fentanyl inhibited an increase of the proinflammatory cytokines, TNF-alpha and IL-1beta levels, during global cerebral ischemia/reperfusion in rats." | 1.31 | Effect of fentanyl on TNF-alpha and IL-1beta levels during global ischemia/reperfusion in rats. ( Oh, WS, 2002) |
| "Fentanyl citrate has properties, including agonism of the mu-opioid receptor and proconvulsant activity, that theoretically could pose adverse effects in ischemic brain." | 1.30 | High-dose fentanyl does not adversely affect outcome from forebrain ischemia in the rat. ( Bart, RD; Dexter, F; Morimoto, Y; Pearlstein, RD; Warner, DS, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (45.45) | 18.2507 |
| 2000's | 8 (36.36) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Switzer, AR | 1 |
| Beland, B | 1 |
| Sarna, JR | 1 |
| Walzak, A | 1 |
| Pfeffer, G | 1 |
| Baik, SW | 1 |
| Kang, DH | 1 |
| Kim, GW | 1 |
| Islam, MR | 1 |
| Yang, L | 1 |
| Lee, YS | 1 |
| Hruby, VJ | 1 |
| Karamyan, VT | 1 |
| Abbruscato, TJ | 1 |
| Eberspächer, E | 1 |
| Eckel, B | 1 |
| Engelhard, K | 3 |
| Müller, K | 1 |
| Hoffman, WE | 5 |
| Blobner, M | 1 |
| Werner, C | 5 |
| Shiraishi, K | 1 |
| Takeda, Y | 1 |
| Masui, K | 1 |
| Taninishi, H | 1 |
| Sasaki, T | 1 |
| Danura, T | 1 |
| Morita, K | 1 |
| Mayer, SA | 1 |
| Elsersy, H | 1 |
| Sheng, H | 2 |
| Lynch, JR | 1 |
| Moldovan, M | 1 |
| Pearlstein, RD | 5 |
| Warner, DS | 5 |
| Fernández Sánchez, LJ | 1 |
| Pérez González, R | 1 |
| Guasch Arévalo, E | 1 |
| Martín Reyes, R | 1 |
| Gilsanz Rodríguez, F | 1 |
| Patel, PM | 1 |
| Drummond, JC | 1 |
| Cole, DJ | 1 |
| Goskowicz, RL | 1 |
| Lingamneni, P | 1 |
| Minshall, R | 1 |
| Miletich, DJ | 1 |
| Albrecht, RF | 4 |
| Thomas, C | 2 |
| Morimoto, Y | 2 |
| Bart, RD | 2 |
| Dexter, F | 2 |
| Linstedt, U | 1 |
| Maier, C | 1 |
| Petry, A | 1 |
| Kofke, WA | 1 |
| Garman, RH | 1 |
| Garman, R | 1 |
| Rose, ME | 1 |
| Miura, Y | 1 |
| Mackensen, GB | 3 |
| Nellgård, B | 3 |
| Reeker, W | 1 |
| Lu, H | 2 |
| Möllenberg, O | 2 |
| Mielke, L | 1 |
| Kochs, E | 4 |
| Massey, G | 1 |
| Kudo, M | 1 |
| Zieglgänsberger, W | 1 |
| Oh, WS | 1 |
| Pelligrino, D | 1 |
| Schulte am Esch, J | 2 |
1 trial available for fentanyl and Cerebral Ischemia
| Article | Year |
|---|---|
Hypothermia for neuroprotection after cardiac arrest.
Topics: Adolescent; Adult; Aged; Brain Ischemia; Fentanyl; Heart Arrest; Humans; Hypnotics and Sedatives; Hy | 2002 |
21 other studies available for fentanyl and Cerebral Ischemia
| Article | Year |
|---|---|
Fentanyl Overdose Causing Hippocampal Ischaemia Followed by Delayed Leukoencephalopathy.
Topics: Analgesics, Opioid; Brain Ischemia; Disease Progression; Fentanyl; Hippocampus; Humans; Hypoventilat | 2020 |
Transdermal opioid patch in treatment of paroxysmal autonomic instability with dystonia with multiple cerebral insults: A case report.
Topics: Analgesics, Opioid; Autonomic Nervous System Diseases; Basal Ganglia; Brain Ischemia; Diffusion Tens | 2020 |
Enkephalin-Fentanyl Multifunctional Opioids as Potential Neuroprotectants for Ischemic Stroke Treatment.
Topics: Analgesics, Opioid; Animals; Brain Ischemia; Dose-Response Relationship, Drug; Enkephalins; Fentanyl | 2016 |
Effects of sevoflurane on cognitive deficit, motor function, and histopathology after cerebral ischemia in rats.
Topics: Anesthesia; Anesthetics; Anesthetics, Intravenous; Animals; Blood Gas Analysis; Brain; Brain Ischemi | 2009 |
Effect of fentanyl on ischemic depolarization and ischemic neuronal damage of hippocampal CA1 in the gerbil.
Topics: Analgesics, Opioid; Animals; Brain Ischemia; CA1 Region, Hippocampal; Cell Death; Fentanyl; Gerbilli | 2011 |
Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat.
Topics: Anesthesia; Animals; Brain Ischemia; Cell Death; Fentanyl; Isoflurane; Male; Nitrous Oxide; Prosence | 2004 |
[Perioperative treatment of a pregnant woman with recent cerebral infarction secondary to noncompaction cardiomyopathy].
Topics: Adrenergic beta-Antagonists; Androstanols; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, | 2006 |
Isoflurane reduces ischemia-induced glutamate release in rats subjected to forebrain ischemia.
Topics: Anesthesia; Animals; Brain Ischemia; Dialysis; Dose-Response Relationship, Drug; Electroencephalogra | 1995 |
Brain alpha 2-adrenergic receptor binding during incomplete cerebral ischemia in the rat.
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Blood Pressure; Brain; Brain Ischemia; Car | 1993 |
The effect of halothane and isoflurane on neurologic outcome following incomplete cerebral ischemia in the rat.
Topics: Anesthesia, Inhalation; Animals; Brain Ischemia; Catecholamines; Fentanyl; Halothane; Isoflurane; Ma | 1993 |
High-dose fentanyl does not adversely affect outcome from forebrain ischemia in the rat.
Topics: Anesthesia; Anesthetics, General; Anesthetics, Intravenous; Animals; Blood Pressure; Body Temperatur | 1997 |
Intraoperative monitoring with somatosensory evoked potentials in carotid artery surgery--less reliable in patients with preoperative neurologic deficiency?
Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Arteriovenous Shunt, Surgical; Atracurium; | 1998 |
Opioid neurotoxicity: fentanyl-induced exacerbation of cerebral ischemia in rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Brain Ischemia; Dose-Response Relationship, Drug; | 1999 |
Effects of isoflurane, ketamine, and fentanyl/N2O on concentrations of brain and plasma catecholamines during near-complete cerebral ischemia in the rat.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain Ischemia; Catecholamines; Fentanyl | 1999 |
Desflurane and isoflurane improve neurological outcome after incomplete cerebral ischaemia in rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain Ischemia; Chromatography, High Pre | 1999 |
The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat.
Topics: Anesthetics; Animals; Brain Ischemia; Corticosterone; Fentanyl; Interleukin-6; Isoflurane; Metyrapon | 2000 |
Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Autonomic Nerve Block; Brain Ischemia; C | 2000 |
[The neuroprotective effect of the glutamate antagonist acamprosate following experimental cerebral ischemia. A study with the lipid peroxidase inhibitor u-101033e].
Topics: Acamprosate; Alcohol Deterrents; Anesthetics, Intravenous; Animals; Brain Ischemia; Enzyme Inhibitor | 2000 |
Effect of fentanyl on TNF-alpha and IL-1beta levels during global ischemia/reperfusion in rats.
Topics: Anesthetics, Intravenous; Animals; Arteries; Brain Ischemia; Cerebrovascular Circulation; Fentanyl; | 2002 |
Ketamine decreases plasma catecholamines and improves outcome from incomplete cerebral ischemia in rats.
Topics: Animals; Blood Glucose; Blood Pressure; Brain; Brain Ischemia; Cerebrovascular Circulation; Electroe | 1992 |
The effects of propofol on brain electrical activity, neurologic outcome, and neuronal damage following incomplete ischemia in rats.
Topics: Animals; Brain; Brain Damage, Chronic; Brain Diseases; Brain Ischemia; Depression, Chemical; Electro | 1992 |