fentanyl and Burns
fentanyl has been researched along with Burns in 33 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fentanyl injection of small dose at auricular points achieves definite analgesic effect on procedural pain in dressing changes of burn wounds, superior to subcutaneous injection of fentanyl." | 9.19 | [Prevention of procedural pain in dressing changes of burn wounds by auricular injection of small-dose fentanyl]. ( Liu, B; Liu, YF; Su, XJ; Zhang, SH; Zhu, HX, 2014) |
| "This study sought to compare the analgesic efficacy and safety of patient controlled intra-nasal (PCIN) fentanyl with oral morphine for procedural wound care in burns patients." | 9.11 | A randomised crossover trial of patient controlled intranasal fentanyl and oral morphine for procedural wound care in adult patients with burns. ( Finn, J; Fong, J; Gelavis, A; Leslie, G; Mackenzie, E; Wood, F; Wright, J, 2004) |
| "Factors that influenced the choice of dose of oral transmucosal fentanyl at the time of burns dressing change were investigated in a prospective study." | 7.75 | Factors in the choice of oral transmucosal fentanyl citrate dose for adult burns dressings. ( Hanafiah, Z; Holdcroft, A; Shah, H; Smythe, J; Williams, GJ, 2009) |
| "Serotonin syndrome is a syndrome identified by a triad of altered mental status, neuromuscular overactivity, and autonomic instability caused by the overstimulation of serotonin in the central nervous system and periphery." | 5.42 | Serotonin syndrome caused by fentanyl and methadone in a burn injury. ( Gala, G; Hillman, AD; Sultan, SM; Witenko, CJ, 2015) |
| "Fentanyl is a commonly used analgesic and sedative for the burned in the operating theater as well as the burn care units." | 5.35 | Comparative population pharmacokinetics of fentanyl using non-linear mixed effect modeling: burns vs. non-burns. ( Han, TH; Kaneda, K, 2009) |
| "Fentanyl injection of small dose at auricular points achieves definite analgesic effect on procedural pain in dressing changes of burn wounds, superior to subcutaneous injection of fentanyl." | 5.19 | [Prevention of procedural pain in dressing changes of burn wounds by auricular injection of small-dose fentanyl]. ( Liu, B; Liu, YF; Su, XJ; Zhang, SH; Zhu, HX, 2014) |
| "This study sought to compare the analgesic efficacy and safety of patient controlled intra-nasal (PCIN) fentanyl with oral morphine for procedural wound care in burns patients." | 5.11 | A randomised crossover trial of patient controlled intranasal fentanyl and oral morphine for procedural wound care in adult patients with burns. ( Finn, J; Fong, J; Gelavis, A; Leslie, G; Mackenzie, E; Wood, F; Wright, J, 2004) |
| "In this randomized, double-blinded study in 60 ASA I or II adults with >20% body-surface area thermal burns, we investigated the feasibility of patient-controlled analgesia (PCA) with fentanyl for pain management during dressing changes and determined the optimal PCA-fentanyl demand dose." | 5.11 | Patient-controlled analgesia with fentanyl for burn dressing changes. ( Fatima, T; Pawar, M; Prakash, S, 2004) |
| " The examined studies showed that dressing or cream containing morphine could potentially decrease pain, use of analgesics, and side effects associated with systemic opioid medications compared with control groups." | 4.98 | Efficacy and feasibility of opioids for burn analgesia: An evidence-based qualitative review of randomized controlled trials. ( He, GZ; Xu, XM; Yang, C, 2018) |
| "Factors that influenced the choice of dose of oral transmucosal fentanyl at the time of burns dressing change were investigated in a prospective study." | 3.75 | Factors in the choice of oral transmucosal fentanyl citrate dose for adult burns dressings. ( Hanafiah, Z; Holdcroft, A; Shah, H; Smythe, J; Williams, GJ, 2009) |
| " Opioid dosing remains challenging in burn patients, particularly in children, due to the immense variability in efficacy between patients." | 1.56 | Characterizing Fentanyl Variability Using Population Pharmacokinetics in Pediatric Burn Patients. ( Grimsrud, KN; Lima, KM; Palmieri, TL; Tran, NK, 2020) |
| "Fentanyl is a common opiate primarily metabolized by CYP3A4 subtypes." | 1.51 | Identification of Cytochrome P450 Polymorphisms in Burn Patients and Impact on Fentanyl Pharmacokinetics: A Pilot Study. ( Grimsrud, KN; Ivanova, X; Palmieri, TL; Sherwin, CM; Tran, NK, 2019) |
| "The administration of ketamine during burn wound care using a critical care RN-driven protocol was associated with reduced opioid and benzodiazepine requirements and few adverse effects." | 1.48 | CE: Original Research: The Efficacy and Safety of an RN-Driven Ketamine Protocol for Adjunctive Analgesia During Burn Wound Care. ( Baumgartner, L; MacLaren, R; Townsend, N; Winkelman, K, 2018) |
| "Serotonin syndrome is a syndrome identified by a triad of altered mental status, neuromuscular overactivity, and autonomic instability caused by the overstimulation of serotonin in the central nervous system and periphery." | 1.42 | Serotonin syndrome caused by fentanyl and methadone in a burn injury. ( Gala, G; Hillman, AD; Sultan, SM; Witenko, CJ, 2015) |
| "Ketamine has not elicited the HSR in this model of experimental burns and, therefore, its protective effects were not shown to be mediated through this mechanism." | 1.32 | Ketamine reduces mortality of severely burnt rats, when compared to midazolam plus fentanyl. ( Lázaro Da Silva, A; Neder Meyer, T, 2004) |
| "Fentanyl was delivered by i." | 1.29 | [Patient-controlled analgesia: a study of fentanyl requirements in burnt patients during the acute phase]. ( Badetti, C; Bernini, V; Manelli, JC; Pascal, L, 1994) |
Research
Studies (33)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (24.24) | 18.7374 |
| 1990's | 3 (9.09) | 18.2507 |
| 2000's | 10 (30.30) | 29.6817 |
| 2010's | 9 (27.27) | 24.3611 |
| 2020's | 3 (9.09) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Grimsrud, KN | 2 |
| Lima, KM | 1 |
| Tran, NK | 2 |
| Palmieri, TL | 2 |
| Khan, A | 1 |
| Parikh, M | 1 |
| Minhajuddin, A | 1 |
| Williams, T | 1 |
| Abrams, R | 1 |
| Kandil, E | 1 |
| Ambardekar, A | 1 |
| Al-Khalil, M | 1 |
| Sack, A | 1 |
| Elson, R | 1 |
| Pleat, J | 1 |
| Yang, C | 1 |
| Xu, XM | 1 |
| He, GZ | 1 |
| Baumgartner, L | 1 |
| Townsend, N | 1 |
| Winkelman, K | 1 |
| MacLaren, R | 1 |
| Rangappa, S | 1 |
| Rangan, KK | 1 |
| Sudarshan, TS | 1 |
| Murthy, SN | 1 |
| Ivanova, X | 1 |
| Sherwin, CM | 1 |
| Wall, SL | 1 |
| Clarke, DL | 1 |
| Allorto, NL | 1 |
| Zhang, SH | 1 |
| Liu, YF | 1 |
| Liu, B | 1 |
| Zhu, HX | 1 |
| Su, XJ | 1 |
| Hillman, AD | 1 |
| Witenko, CJ | 1 |
| Sultan, SM | 1 |
| Gala, G | 2 |
| Atkinson, TJ | 1 |
| Fudin, J | 1 |
| Pham, TC | 1 |
| Hillman, A | 1 |
| Witenko, C | 1 |
| Sultan, S | 1 |
| Shah, H | 1 |
| Smythe, J | 1 |
| Hanafiah, Z | 1 |
| Williams, GJ | 1 |
| Holdcroft, A | 1 |
| Kaneda, K | 1 |
| Han, TH | 1 |
| Tsukahara, Y | 1 |
| Ozawa, M | 1 |
| Joshita, S | 1 |
| Mochizuki, K | 1 |
| Kikuchi, T | 1 |
| Nitta, K | 1 |
| Dohgomori, H | 1 |
| Okamoto, K | 1 |
| Finn, J | 1 |
| Wright, J | 1 |
| Fong, J | 1 |
| Mackenzie, E | 1 |
| Wood, F | 1 |
| Leslie, G | 1 |
| Gelavis, A | 1 |
| Neder Meyer, T | 1 |
| Lázaro Da Silva, A | 1 |
| Prakash, S | 1 |
| Fatima, T | 1 |
| Pawar, M | 1 |
| Sullivan, SR | 1 |
| Friedrich, JB | 1 |
| Engrav, LH | 1 |
| Round, KA | 1 |
| Heimbach, DM | 1 |
| Heckbert, SR | 1 |
| Carrougher, GJ | 1 |
| Lezotte, DC | 1 |
| Wiechman, SA | 1 |
| Honari, S | 1 |
| Klein, MB | 1 |
| Gibran, NS | 1 |
| Borland, ML | 1 |
| Bergesio, R | 1 |
| Pascoe, EM | 1 |
| Turner, S | 1 |
| Woodger, S | 1 |
| Robertson, LJ | 1 |
| Drummond, PD | 1 |
| Hammond, GR | 1 |
| Han, T | 1 |
| Harmatz, JS | 1 |
| Greenblatt, DJ | 1 |
| Martyn, JA | 1 |
| Tosun, Z | 1 |
| Esmaoglu, A | 1 |
| Coruh, A | 1 |
| Kehlet, H | 1 |
| Park, R | 1 |
| Marzollo, P | 1 |
| Uggeri, E | 1 |
| Rossini, E | 1 |
| Uleri, G | 1 |
| Badetti, C | 2 |
| Bernini, V | 2 |
| Pascal, L | 1 |
| Manelli, JC | 2 |
| Viggiano, M | 1 |
| Roux, F | 1 |
| Mendizabal, H | 1 |
| Ivani, G | 1 |
| Della Rocca, M | 1 |
| de Negri, P | 1 |
| Wood, M | 1 |
| Grigorov, G | 1 |
| Emanuilov, Ia | 1 |
| De Castro, J | 1 |
| Brown, AS | 1 |
| Roberts, FW | 1 |
| Thompson, WF | 1 |
Clinical Trials (4)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A pRospective, Case-controlled Evaluation of oLIceridine for Moderate or sEVEre Pain in Patients With Acute Burn Injuries. (RELIEVE)[NCT05465226] | Phase 4 | 31 participants (Actual) | Interventional | 2023-04-01 | Completed | ||
| Intravenous Sedation and Analgesia Using Propofol, Fentanyl and Ketamine (PFK) Versus General Anesthesia in Minor Urological Procedures.[NCT04285528] | 200 participants (Actual) | Interventional | 2019-04-17 | Completed | |||
| A Prospective Study Comparing the Efficacy and Safety of 100 mcg and 200 mcg of Intranasal Fentanyl Pectin Spray as an Analgesic in Adult Males Undergoing Outpatient Cystoscopic Procedures[NCT01756651] | Phase 1 | 20 participants (Actual) | Interventional | 2013-02-28 | Completed | ||
| Ketofol Versus Fentofol for Procedural Sedation of Children 3 to 17 Years Old: a Double-Blind Randomized Controlled Trial[NCT02079090] | Phase 3 | 30 participants (Actual) | Interventional | 2014-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
2 reviews available for fentanyl and Burns
| Article | Year |
|---|---|
Efficacy and feasibility of opioids for burn analgesia: An evidence-based qualitative review of randomized controlled trials.
Topics: Administration, Cutaneous; Administration, Intranasal; Administration, Mucosal; Administration, Oral | 2018 |
Plasma drug binding: implications for anesthesiologists.
Topics: Age Factors; Alfentanil; Alprenolol; Anesthesia; Anesthetics; Blood Proteins; Bupivacaine; Burns; Ca | 1986 |
Trials
7 trials available for fentanyl and Burns
| Article | Year |
|---|---|
[Prevention of procedural pain in dressing changes of burn wounds by auricular injection of small-dose fentanyl].
Topics: Acupuncture Points; Adolescent; Adult; Aged; Burns; Female; Fentanyl; Humans; Male; Middle Aged; Pai | 2014 |
A randomised crossover trial of patient controlled intranasal fentanyl and oral morphine for procedural wound care in adult patients with burns.
Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adult; Aged; Analgesia, Patient-Contro | 2004 |
Patient-controlled analgesia with fentanyl for burn dressing changes.
Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Bandages; Burns; Double-Blind Method; Elec | 2004 |
Intranasal fentanyl is an equivalent analgesic to oral morphine in paediatric burns patients for dressing changes: a randomised double blind crossover study.
Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Bandages; Burns; Child; Child, | 2005 |
Intranasal fentanyl is an equivalent analgesic to oral morphine in paediatric burns patients for dressing changes: a randomised double blind crossover study.
Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Bandages; Burns; Child; Child, | 2005 |
Intranasal fentanyl is an equivalent analgesic to oral morphine in paediatric burns patients for dressing changes: a randomised double blind crossover study.
Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Bandages; Burns; Child; Child, | 2005 |
Intranasal fentanyl is an equivalent analgesic to oral morphine in paediatric burns patients for dressing changes: a randomised double blind crossover study.
Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Bandages; Burns; Child; Child, | 2005 |
Fentanyl clearance and volume of distribution are increased in patients with major burns.
Topics: Adult; Analgesics, Opioid; Burns; Female; Fentanyl; Half-Life; Humans; Male; Metabolic Clearance Rat | 2007 |
Propofol-ketamine vs propofol-fentanyl combinations for deep sedation and analgesia in pediatric patients undergoing burn dressing changes.
Topics: Analgesia; Anesthetics, Dissociative; Anesthetics, Intravenous; Bandages; Blood Pressure; Burns; Chi | 2008 |
[Controlled analgesia in a burn patient: fentanyl sparing effect of clonidine].
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Analgesia, Patient-Controlled; Burns; Clonidine; Doubl | 1998 |
Other Studies
24 other studies available for fentanyl and Burns
| Article | Year |
|---|---|
Characterizing Fentanyl Variability Using Population Pharmacokinetics in Pediatric Burn Patients.
Topics: Adolescent; Age Factors; Analgesics, Opioid; Body Size; Burns; Child; Child, Preschool; Female; Fent | 2020 |
Opioid prescribing practices in a pediatric burn tertiary care facility: Is it time to change?
Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Adolescent; Ambulatory Care; Analg | 2020 |
A 5-year single-centre retrospective study of potential drug interactions in burns inpatients with psychiatric comorbidities.
Topics: Adult; Analgesics, Opioid; Antidepressive Agents; Arrhythmias, Cardiac; Burns; Comorbidity; Drug Int | 2020 |
CE: Original Research: The Efficacy and Safety of an RN-Driven Ketamine Protocol for Adjunctive Analgesia During Burn Wound Care.
Topics: Adult; Analgesia; Analgesics; Analgesics, Opioid; Burns; Critical Care Nursing; Female; Fentanyl; Hu | 2018 |
Antiallodynic and Antihyperalgesic Activities of Fentanyl-Loaded Dermal Clay Dressings in Rat Model of Second-Degree Burn Injury.
Topics: Animals; Bandages; Burns; Clay; Disease Models, Animal; Fentanyl; Hyperalgesia; Male; Pain; Rats; Ra | 2018 |
Identification of Cytochrome P450 Polymorphisms in Burn Patients and Impact on Fentanyl Pharmacokinetics: A Pilot Study.
Topics: Adult; Analgesics, Opioid; Burns; Cytochrome P-450 Enzyme System; Female; Fentanyl; Genotype; Humans | 2019 |
Analgesia protocols for burns dressings: Challenges with implementation.
Topics: Academic Medical Centers; Acetaminophen; Analgesics; Anesthetics, Inhalation; Bandages; Burns; Child | 2019 |
Serotonin syndrome caused by fentanyl and methadone in a burn injury.
Topics: Adult; Analgesics, Opioid; Burns; Drug Interactions; Drug Therapy, Combination; Fentanyl; Humans; Ma | 2015 |
Combined fentanyl and methadone induced serotonin syndrome is called into question.
Topics: Analgesics, Opioid; Burns; Fentanyl; Humans; Male; Methadone; Serotonin Syndrome | 2015 |
Factors in the choice of oral transmucosal fentanyl citrate dose for adult burns dressings.
Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics, Opioid; Bandages; Burns; Choice Behavior; | 2009 |
Comparative population pharmacokinetics of fentanyl using non-linear mixed effect modeling: burns vs. non-burns.
Topics: Adult; Analgesics, Opioid; Burns; Female; Fentanyl; Humans; Male; Middle Aged; Models, Biological; N | 2009 |
[Anesthesia for a patient with morbid obesity, systemic edema and airway burn].
Topics: Adult; Anesthesia, Intravenous; Burns; Edema; Fentanyl; Humans; Intubation, Intratracheal; Laryngosc | 2010 |
Ketamine reduces mortality of severely burnt rats, when compared to midazolam plus fentanyl.
Topics: Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Burns; Disease | 2004 |
"Opioid creep" is real and may be the cause of "fluid creep".
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Body Surface Area; Burns; Female; Fentanyl; Fluid Thera | 2004 |
Naloxone antagonizes the local antihyperalgesic effect of fentanyl in burnt skin of healthy humans.
Topics: Adolescent; Adult; Analgesics, Opioid; Burns; Dose-Response Relationship, Drug; Female; Fentanyl; Hu | 2007 |
Should regional anesthesia and pharmacological agents such as beta blockers and opiates be utilized in modulating pain response?
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alfentanil; Analgesia; Analgesics; Anesth | 1984 |
Anesthesia. For the burned patient.
Topics: Anesthesia; Anesthesia, Inhalation; Burns; Diazepam; Enflurane; Fentanyl; Halothane; Humans; Intubat | 1984 |
[Combination of althesin and fentanyl as an alternative anesthetic in burns].
Topics: Alfaxalone Alfadolone Mixture; Anesthesia, Intravenous; Burns; Drug Therapy, Combination; Fentanyl; | 1980 |
[Patient-controlled analgesia: a study of fentanyl requirements in burnt patients during the acute phase].
Topics: Adult; Analgesia, Patient-Controlled; Burns; Female; Fentanyl; Humans; Infusion Pumps; Male; Pain Me | 1994 |
[Anesthesia of the burned child].
Topics: Anesthesia, Intravenous; Burns; Child; Child, Preschool; Fentanyl; Humans; Propofol | 1990 |
[Combined anesthesia with flunitrazepam-fentanyl and nitrous oxide in high-risk burn patients].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, General; Burns; Female; Fentanyl; Flunitraze | 1987 |
[Experience in anesthesia and resuscitation of severely burned patients in 4 years' activity a large national center for the care of these patients].
Topics: Anesthesia; Burns; Fentanyl; Humans; Methods; Pancuronium; Shock, Traumatic | 1973 |
Neuroleptanalgesia.
Topics: Alcoholism; Analgesics; Bronchography; Burns; Dextromoramide; Fentanyl; Haloperidol; Hearing Disorde | 1969 |
Neuroleptanalgesia in the management of mass burn cases.
Topics: Burns; Debridement; Fentanyl; Humans; Neuroleptanalgesia; Phenoperidine | 1968 |