Page last updated: 2024-10-27

fentanyl and Burns

fentanyl has been researched along with Burns in 33 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.

Research Excerpts

ExcerptRelevanceReference
"Fentanyl injection of small dose at auricular points achieves definite analgesic effect on procedural pain in dressing changes of burn wounds, superior to subcutaneous injection of fentanyl."9.19[Prevention of procedural pain in dressing changes of burn wounds by auricular injection of small-dose fentanyl]. ( Liu, B; Liu, YF; Su, XJ; Zhang, SH; Zhu, HX, 2014)
"This study sought to compare the analgesic efficacy and safety of patient controlled intra-nasal (PCIN) fentanyl with oral morphine for procedural wound care in burns patients."9.11A randomised crossover trial of patient controlled intranasal fentanyl and oral morphine for procedural wound care in adult patients with burns. ( Finn, J; Fong, J; Gelavis, A; Leslie, G; Mackenzie, E; Wood, F; Wright, J, 2004)
"Factors that influenced the choice of dose of oral transmucosal fentanyl at the time of burns dressing change were investigated in a prospective study."7.75Factors in the choice of oral transmucosal fentanyl citrate dose for adult burns dressings. ( Hanafiah, Z; Holdcroft, A; Shah, H; Smythe, J; Williams, GJ, 2009)
"Serotonin syndrome is a syndrome identified by a triad of altered mental status, neuromuscular overactivity, and autonomic instability caused by the overstimulation of serotonin in the central nervous system and periphery."5.42Serotonin syndrome caused by fentanyl and methadone in a burn injury. ( Gala, G; Hillman, AD; Sultan, SM; Witenko, CJ, 2015)
"Fentanyl is a commonly used analgesic and sedative for the burned in the operating theater as well as the burn care units."5.35Comparative population pharmacokinetics of fentanyl using non-linear mixed effect modeling: burns vs. non-burns. ( Han, TH; Kaneda, K, 2009)
"Fentanyl injection of small dose at auricular points achieves definite analgesic effect on procedural pain in dressing changes of burn wounds, superior to subcutaneous injection of fentanyl."5.19[Prevention of procedural pain in dressing changes of burn wounds by auricular injection of small-dose fentanyl]. ( Liu, B; Liu, YF; Su, XJ; Zhang, SH; Zhu, HX, 2014)
"This study sought to compare the analgesic efficacy and safety of patient controlled intra-nasal (PCIN) fentanyl with oral morphine for procedural wound care in burns patients."5.11A randomised crossover trial of patient controlled intranasal fentanyl and oral morphine for procedural wound care in adult patients with burns. ( Finn, J; Fong, J; Gelavis, A; Leslie, G; Mackenzie, E; Wood, F; Wright, J, 2004)
"In this randomized, double-blinded study in 60 ASA I or II adults with >20% body-surface area thermal burns, we investigated the feasibility of patient-controlled analgesia (PCA) with fentanyl for pain management during dressing changes and determined the optimal PCA-fentanyl demand dose."5.11Patient-controlled analgesia with fentanyl for burn dressing changes. ( Fatima, T; Pawar, M; Prakash, S, 2004)
" The examined studies showed that dressing or cream containing morphine could potentially decrease pain, use of analgesics, and side effects associated with systemic opioid medications compared with control groups."4.98Efficacy and feasibility of opioids for burn analgesia: An evidence-based qualitative review of randomized controlled trials. ( He, GZ; Xu, XM; Yang, C, 2018)
"Factors that influenced the choice of dose of oral transmucosal fentanyl at the time of burns dressing change were investigated in a prospective study."3.75Factors in the choice of oral transmucosal fentanyl citrate dose for adult burns dressings. ( Hanafiah, Z; Holdcroft, A; Shah, H; Smythe, J; Williams, GJ, 2009)
" Opioid dosing remains challenging in burn patients, particularly in children, due to the immense variability in efficacy between patients."1.56Characterizing Fentanyl Variability Using Population Pharmacokinetics in Pediatric Burn Patients. ( Grimsrud, KN; Lima, KM; Palmieri, TL; Tran, NK, 2020)
"Fentanyl is a common opiate primarily metabolized by CYP3A4 subtypes."1.51Identification of Cytochrome P450 Polymorphisms in Burn Patients and Impact on Fentanyl Pharmacokinetics: A Pilot Study. ( Grimsrud, KN; Ivanova, X; Palmieri, TL; Sherwin, CM; Tran, NK, 2019)
"The administration of ketamine during burn wound care using a critical care RN-driven protocol was associated with reduced opioid and benzodiazepine requirements and few adverse effects."1.48CE: Original Research: The Efficacy and Safety of an RN-Driven Ketamine Protocol for Adjunctive Analgesia During Burn Wound Care. ( Baumgartner, L; MacLaren, R; Townsend, N; Winkelman, K, 2018)
"Serotonin syndrome is a syndrome identified by a triad of altered mental status, neuromuscular overactivity, and autonomic instability caused by the overstimulation of serotonin in the central nervous system and periphery."1.42Serotonin syndrome caused by fentanyl and methadone in a burn injury. ( Gala, G; Hillman, AD; Sultan, SM; Witenko, CJ, 2015)
"Ketamine has not elicited the HSR in this model of experimental burns and, therefore, its protective effects were not shown to be mediated through this mechanism."1.32Ketamine reduces mortality of severely burnt rats, when compared to midazolam plus fentanyl. ( Lázaro Da Silva, A; Neder Meyer, T, 2004)
"Fentanyl was delivered by i."1.29[Patient-controlled analgesia: a study of fentanyl requirements in burnt patients during the acute phase]. ( Badetti, C; Bernini, V; Manelli, JC; Pascal, L, 1994)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19908 (24.24)18.7374
1990's3 (9.09)18.2507
2000's10 (30.30)29.6817
2010's9 (27.27)24.3611
2020's3 (9.09)2.80

Authors

AuthorsStudies
Grimsrud, KN2
Lima, KM1
Tran, NK2
Palmieri, TL2
Khan, A1
Parikh, M1
Minhajuddin, A1
Williams, T1
Abrams, R1
Kandil, E1
Ambardekar, A1
Al-Khalil, M1
Sack, A1
Elson, R1
Pleat, J1
Yang, C1
Xu, XM1
He, GZ1
Baumgartner, L1
Townsend, N1
Winkelman, K1
MacLaren, R1
Rangappa, S1
Rangan, KK1
Sudarshan, TS1
Murthy, SN1
Ivanova, X1
Sherwin, CM1
Wall, SL1
Clarke, DL1
Allorto, NL1
Zhang, SH1
Liu, YF1
Liu, B1
Zhu, HX1
Su, XJ1
Hillman, AD1
Witenko, CJ1
Sultan, SM1
Gala, G2
Atkinson, TJ1
Fudin, J1
Pham, TC1
Hillman, A1
Witenko, C1
Sultan, S1
Shah, H1
Smythe, J1
Hanafiah, Z1
Williams, GJ1
Holdcroft, A1
Kaneda, K1
Han, TH1
Tsukahara, Y1
Ozawa, M1
Joshita, S1
Mochizuki, K1
Kikuchi, T1
Nitta, K1
Dohgomori, H1
Okamoto, K1
Finn, J1
Wright, J1
Fong, J1
Mackenzie, E1
Wood, F1
Leslie, G1
Gelavis, A1
Neder Meyer, T1
Lázaro Da Silva, A1
Prakash, S1
Fatima, T1
Pawar, M1
Sullivan, SR1
Friedrich, JB1
Engrav, LH1
Round, KA1
Heimbach, DM1
Heckbert, SR1
Carrougher, GJ1
Lezotte, DC1
Wiechman, SA1
Honari, S1
Klein, MB1
Gibran, NS1
Borland, ML1
Bergesio, R1
Pascoe, EM1
Turner, S1
Woodger, S1
Robertson, LJ1
Drummond, PD1
Hammond, GR1
Han, T1
Harmatz, JS1
Greenblatt, DJ1
Martyn, JA1
Tosun, Z1
Esmaoglu, A1
Coruh, A1
Kehlet, H1
Park, R1
Marzollo, P1
Uggeri, E1
Rossini, E1
Uleri, G1
Badetti, C2
Bernini, V2
Pascal, L1
Manelli, JC2
Viggiano, M1
Roux, F1
Mendizabal, H1
Ivani, G1
Della Rocca, M1
de Negri, P1
Wood, M1
Grigorov, G1
Emanuilov, Ia1
De Castro, J1
Brown, AS1
Roberts, FW1
Thompson, WF1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A pRospective, Case-controlled Evaluation of oLIceridine for Moderate or sEVEre Pain in Patients With Acute Burn Injuries. (RELIEVE)[NCT05465226]Phase 431 participants (Actual)Interventional2023-04-01Completed
Intravenous Sedation and Analgesia Using Propofol, Fentanyl and Ketamine (PFK) Versus General Anesthesia in Minor Urological Procedures.[NCT04285528]200 participants (Actual)Interventional2019-04-17Completed
A Prospective Study Comparing the Efficacy and Safety of 100 mcg and 200 mcg of Intranasal Fentanyl Pectin Spray as an Analgesic in Adult Males Undergoing Outpatient Cystoscopic Procedures[NCT01756651]Phase 120 participants (Actual)Interventional2013-02-28Completed
Ketofol Versus Fentofol for Procedural Sedation of Children 3 to 17 Years Old: a Double-Blind Randomized Controlled Trial[NCT02079090]Phase 330 participants (Actual)Interventional2014-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for fentanyl and Burns

ArticleYear
Efficacy and feasibility of opioids for burn analgesia: An evidence-based qualitative review of randomized controlled trials.
    Burns : journal of the International Society for Burn Injuries, 2018, Volume: 44, Issue:2

    Topics: Administration, Cutaneous; Administration, Intranasal; Administration, Mucosal; Administration, Oral

2018
Plasma drug binding: implications for anesthesiologists.
    Anesthesia and analgesia, 1986, Volume: 65, Issue:7

    Topics: Age Factors; Alfentanil; Alprenolol; Anesthesia; Anesthetics; Blood Proteins; Bupivacaine; Burns; Ca

1986

Trials

7 trials available for fentanyl and Burns

ArticleYear
[Prevention of procedural pain in dressing changes of burn wounds by auricular injection of small-dose fentanyl].
    Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 2014, Volume: 34, Issue:10

    Topics: Acupuncture Points; Adolescent; Adult; Aged; Burns; Female; Fentanyl; Humans; Male; Middle Aged; Pai

2014
A randomised crossover trial of patient controlled intranasal fentanyl and oral morphine for procedural wound care in adult patients with burns.
    Burns : journal of the International Society for Burn Injuries, 2004, Volume: 30, Issue:3

    Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adult; Aged; Analgesia, Patient-Contro

2004
Patient-controlled analgesia with fentanyl for burn dressing changes.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:2

    Topics: Adult; Analgesia, Patient-Controlled; Analgesics, Opioid; Bandages; Burns; Double-Blind Method; Elec

2004
Intranasal fentanyl is an equivalent analgesic to oral morphine in paediatric burns patients for dressing changes: a randomised double blind crossover study.
    Burns : journal of the International Society for Burn Injuries, 2005, Volume: 31, Issue:7

    Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Bandages; Burns; Child; Child,

2005
Intranasal fentanyl is an equivalent analgesic to oral morphine in paediatric burns patients for dressing changes: a randomised double blind crossover study.
    Burns : journal of the International Society for Burn Injuries, 2005, Volume: 31, Issue:7

    Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Bandages; Burns; Child; Child,

2005
Intranasal fentanyl is an equivalent analgesic to oral morphine in paediatric burns patients for dressing changes: a randomised double blind crossover study.
    Burns : journal of the International Society for Burn Injuries, 2005, Volume: 31, Issue:7

    Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Bandages; Burns; Child; Child,

2005
Intranasal fentanyl is an equivalent analgesic to oral morphine in paediatric burns patients for dressing changes: a randomised double blind crossover study.
    Burns : journal of the International Society for Burn Injuries, 2005, Volume: 31, Issue:7

    Topics: Administration, Intranasal; Administration, Oral; Analgesics, Opioid; Bandages; Burns; Child; Child,

2005
Fentanyl clearance and volume of distribution are increased in patients with major burns.
    Journal of clinical pharmacology, 2007, Volume: 47, Issue:6

    Topics: Adult; Analgesics, Opioid; Burns; Female; Fentanyl; Half-Life; Humans; Male; Metabolic Clearance Rat

2007
Propofol-ketamine vs propofol-fentanyl combinations for deep sedation and analgesia in pediatric patients undergoing burn dressing changes.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:1

    Topics: Analgesia; Anesthetics, Dissociative; Anesthetics, Intravenous; Bandages; Blood Pressure; Burns; Chi

2008
[Controlled analgesia in a burn patient: fentanyl sparing effect of clonidine].
    Annales francaises d'anesthesie et de reanimation, 1998, Volume: 17, Issue:1

    Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Analgesia, Patient-Controlled; Burns; Clonidine; Doubl

1998

Other Studies

24 other studies available for fentanyl and Burns

ArticleYear
Characterizing Fentanyl Variability Using Population Pharmacokinetics in Pediatric Burn Patients.
    Journal of burn care & research : official publication of the American Burn Association, 2020, 01-30, Volume: 41, Issue:1

    Topics: Adolescent; Age Factors; Analgesics, Opioid; Body Size; Burns; Child; Child, Preschool; Female; Fent

2020
Opioid prescribing practices in a pediatric burn tertiary care facility: Is it time to change?
    Burns : journal of the International Society for Burn Injuries, 2020, Volume: 46, Issue:1

    Topics: Acetaminophen; Administration, Intravenous; Administration, Oral; Adolescent; Ambulatory Care; Analg

2020
A 5-year single-centre retrospective study of potential drug interactions in burns inpatients with psychiatric comorbidities.
    Burns : journal of the International Society for Burn Injuries, 2020, Volume: 46, Issue:5

    Topics: Adult; Analgesics, Opioid; Antidepressive Agents; Arrhythmias, Cardiac; Burns; Comorbidity; Drug Int

2020
CE: Original Research: The Efficacy and Safety of an RN-Driven Ketamine Protocol for Adjunctive Analgesia During Burn Wound Care.
    The American journal of nursing, 2018, Volume: 118, Issue:7

    Topics: Adult; Analgesia; Analgesics; Analgesics, Opioid; Burns; Critical Care Nursing; Female; Fentanyl; Hu

2018
Antiallodynic and Antihyperalgesic Activities of Fentanyl-Loaded Dermal Clay Dressings in Rat Model of Second-Degree Burn Injury.
    Journal of pharmaceutical sciences, 2018, Volume: 107, Issue:10

    Topics: Animals; Bandages; Burns; Clay; Disease Models, Animal; Fentanyl; Hyperalgesia; Male; Pain; Rats; Ra

2018
Identification of Cytochrome P450 Polymorphisms in Burn Patients and Impact on Fentanyl Pharmacokinetics: A Pilot Study.
    Journal of burn care & research : official publication of the American Burn Association, 2019, 01-01, Volume: 40, Issue:1

    Topics: Adult; Analgesics, Opioid; Burns; Cytochrome P-450 Enzyme System; Female; Fentanyl; Genotype; Humans

2019
Analgesia protocols for burns dressings: Challenges with implementation.
    Burns : journal of the International Society for Burn Injuries, 2019, Volume: 45, Issue:7

    Topics: Academic Medical Centers; Acetaminophen; Analgesics; Anesthetics, Inhalation; Bandages; Burns; Child

2019
Serotonin syndrome caused by fentanyl and methadone in a burn injury.
    Pharmacotherapy, 2015, Volume: 35, Issue:1

    Topics: Adult; Analgesics, Opioid; Burns; Drug Interactions; Drug Therapy, Combination; Fentanyl; Humans; Ma

2015
Combined fentanyl and methadone induced serotonin syndrome is called into question.
    Pharmacotherapy, 2015, Volume: 35, Issue:6

    Topics: Analgesics, Opioid; Burns; Fentanyl; Humans; Male; Methadone; Serotonin Syndrome

2015
Factors in the choice of oral transmucosal fentanyl citrate dose for adult burns dressings.
    Burns : journal of the International Society for Burn Injuries, 2009, Volume: 35, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Aged; Analgesics, Opioid; Bandages; Burns; Choice Behavior;

2009
Comparative population pharmacokinetics of fentanyl using non-linear mixed effect modeling: burns vs. non-burns.
    Burns : journal of the International Society for Burn Injuries, 2009, Volume: 35, Issue:6

    Topics: Adult; Analgesics, Opioid; Burns; Female; Fentanyl; Humans; Male; Middle Aged; Models, Biological; N

2009
[Anesthesia for a patient with morbid obesity, systemic edema and airway burn].
    Masui. The Japanese journal of anesthesiology, 2010, Volume: 59, Issue:4

    Topics: Adult; Anesthesia, Intravenous; Burns; Edema; Fentanyl; Humans; Intubation, Intratracheal; Laryngosc

2010
Ketamine reduces mortality of severely burnt rats, when compared to midazolam plus fentanyl.
    Burns : journal of the International Society for Burn Injuries, 2004, Volume: 30, Issue:5

    Topics: Anesthetics, Combined; Anesthetics, Dissociative; Anesthetics, Intravenous; Animals; Burns; Disease

2004
"Opioid creep" is real and may be the cause of "fluid creep".
    Burns : journal of the International Society for Burn Injuries, 2004, Volume: 30, Issue:6

    Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Body Surface Area; Burns; Female; Fentanyl; Fluid Thera

2004
Naloxone antagonizes the local antihyperalgesic effect of fentanyl in burnt skin of healthy humans.
    The journal of pain, 2007, Volume: 8, Issue:6

    Topics: Adolescent; Adult; Analgesics, Opioid; Burns; Dose-Response Relationship, Drug; Female; Fentanyl; Hu

2007
Should regional anesthesia and pharmacological agents such as beta blockers and opiates be utilized in modulating pain response?
    The Journal of trauma, 1984, Volume: 24, Issue:9 Suppl

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alfentanil; Analgesia; Analgesics; Anesth

1984
Anesthesia. For the burned patient.
    AORN journal, 1984, Volume: 40, Issue:1

    Topics: Anesthesia; Anesthesia, Inhalation; Burns; Diazepam; Enflurane; Fentanyl; Halothane; Humans; Intubat

1984
[Combination of althesin and fentanyl as an alternative anesthetic in burns].
    L'Ateneo parmense. Acta bio-medica : organo della Societa di medicina e scienze naturali di Parma, 1980, Volume: 51, Issue:4

    Topics: Alfaxalone Alfadolone Mixture; Anesthesia, Intravenous; Burns; Drug Therapy, Combination; Fentanyl;

1980
[Patient-controlled analgesia: a study of fentanyl requirements in burnt patients during the acute phase].
    Annales francaises d'anesthesie et de reanimation, 1994, Volume: 13, Issue:6

    Topics: Adult; Analgesia, Patient-Controlled; Burns; Female; Fentanyl; Humans; Infusion Pumps; Male; Pain Me

1994
[Anesthesia of the burned child].
    Cahiers d'anesthesiologie, 1990, Volume: 38, Issue:4

    Topics: Anesthesia, Intravenous; Burns; Child; Child, Preschool; Fentanyl; Humans; Propofol

1990
[Combined anesthesia with flunitrazepam-fentanyl and nitrous oxide in high-risk burn patients].
    Khirurgiia, 1987, Volume: 40, Issue:5

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, General; Burns; Female; Fentanyl; Flunitraze

1987
[Experience in anesthesia and resuscitation of severely burned patients in 4 years' activity a large national center for the care of these patients].
    Revista espanola de anestesiologia y reanimacion, 1973, Volume: 20, Issue:2

    Topics: Anesthesia; Burns; Fentanyl; Humans; Methods; Pancuronium; Shock, Traumatic

1973
Neuroleptanalgesia.
    International anesthesiology clinics, 1969,Spring, Volume: 7, Issue:1

    Topics: Alcoholism; Analgesics; Bronchography; Burns; Dextromoramide; Fentanyl; Haloperidol; Hearing Disorde

1969
Neuroleptanalgesia in the management of mass burn cases.
    The Medical journal of Australia, 1968, Jan-27, Volume: 1, Issue:4

    Topics: Burns; Debridement; Fentanyl; Humans; Neuroleptanalgesia; Phenoperidine

1968