fentanyl has been researched along with Brain Ischemia in 22 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study is to evaluate novel multifunctional enkephalin-fentanyl opioid agonists, LYS436, LYS739 and LYS416 for their neuroprotective potential using in vitro and in vivo ischemic stroke models and to compare the effect to that of biphalin." | 7.83 | Enkephalin-Fentanyl Multifunctional Opioids as Potential Neuroprotectants for Ischemic Stroke Treatment. ( Abbruscato, TJ; Hruby, VJ; Islam, MR; Karamyan, VT; Lee, YS; Yang, L, 2016) |
| " Therefore, the present study evaluates cognitive and behavioral function as well as hippocampal damage in rats subjected to cerebral ischemia under sevoflurane compared with fentanyl/nitrous oxide (N(2)O)/O(2) anesthesia." | 7.75 | Effects of sevoflurane on cognitive deficit, motor function, and histopathology after cerebral ischemia in rats. ( Blobner, M; Eberspächer, E; Eckel, B; Engelhard, K; Hoffman, WE; Müller, K; Werner, C, 2009) |
| "This study found no change in the percent alive CA1 hippocampal neurons as a function of duration of recovery from severe forebrain ischemia in isoflurane anesthetized rats." | 7.72 | Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. ( Elsersy, H; Lynch, JR; Moldovan, M; Pearlstein, RD; Sheng, H; Warner, DS, 2004) |
| "Isoflurane improves outcome from near-complete forebrain ischemia in rats compared with fentanyl-nitrous oxide (N2O)." | 7.70 | Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats. ( Kudo, M; Mackensen, GB; Nellgârd, B; Pearlstein, RD; Sheng, H; Warner, DS, 2000) |
| "This study investigates the effects of acamprosate, a glutamatergic modulator, and the lipid peroxidation inhibitor U-101033E on neurological outcome following incomplete cerebral ischemia and reperfusion in rats." | 7.70 | [The neuroprotective effect of the glutamate antagonist acamprosate following experimental cerebral ischemia. A study with the lipid peroxidase inhibitor u-101033e]. ( Engelhard, K; Kochs, E; Lu, H; Möllenberg, O; Werner, C; Zieglgänsberger, W, 2000) |
| " The current investigation was conducted to evaluate the effect of isoflurane and N2O-fentanyl anesthesia on ischemia-induced glutamate release in the rat and to compare it with that of mild hypothermia, an intervention known to reduce glutamate release significantly." | 7.69 | Isoflurane reduces ischemia-induced glutamate release in rats subjected to forebrain ischemia. ( Cole, DJ; Drummond, JC; Goskowicz, RL; Patel, PM, 1995) |
| "Fentanyl citrate has properties, including agonism of the mu-opioid receptor and proconvulsant activity, that theoretically could pose adverse effects in ischemic brain." | 5.30 | High-dose fentanyl does not adversely affect outcome from forebrain ischemia in the rat. ( Bart, RD; Dexter, F; Morimoto, Y; Pearlstein, RD; Warner, DS, 1997) |
| "The purpose of this study is to evaluate novel multifunctional enkephalin-fentanyl opioid agonists, LYS436, LYS739 and LYS416 for their neuroprotective potential using in vitro and in vivo ischemic stroke models and to compare the effect to that of biphalin." | 3.83 | Enkephalin-Fentanyl Multifunctional Opioids as Potential Neuroprotectants for Ischemic Stroke Treatment. ( Abbruscato, TJ; Hruby, VJ; Islam, MR; Karamyan, VT; Lee, YS; Yang, L, 2016) |
| " Therefore, the present study evaluates cognitive and behavioral function as well as hippocampal damage in rats subjected to cerebral ischemia under sevoflurane compared with fentanyl/nitrous oxide (N(2)O)/O(2) anesthesia." | 3.75 | Effects of sevoflurane on cognitive deficit, motor function, and histopathology after cerebral ischemia in rats. ( Blobner, M; Eberspächer, E; Eckel, B; Engelhard, K; Hoffman, WE; Müller, K; Werner, C, 2009) |
| "This study found no change in the percent alive CA1 hippocampal neurons as a function of duration of recovery from severe forebrain ischemia in isoflurane anesthetized rats." | 3.72 | Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. ( Elsersy, H; Lynch, JR; Moldovan, M; Pearlstein, RD; Sheng, H; Warner, DS, 2004) |
| "Rats exposed to forebrain ischemia have reduced injury when anesthetized with isoflurane versus fentanyl + N(2)O." | 3.70 | The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat. ( Mackensen, GB; Massey, G; Nellgård, B; Pearlstein, RD; Warner, DS, 2000) |
| "Isoflurane improves outcome from near-complete forebrain ischemia in rats compared with fentanyl-nitrous oxide (N2O)." | 3.70 | Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats. ( Kudo, M; Mackensen, GB; Nellgârd, B; Pearlstein, RD; Sheng, H; Warner, DS, 2000) |
| "This study investigates the effects of acamprosate, a glutamatergic modulator, and the lipid peroxidation inhibitor U-101033E on neurological outcome following incomplete cerebral ischemia and reperfusion in rats." | 3.70 | [The neuroprotective effect of the glutamate antagonist acamprosate following experimental cerebral ischemia. A study with the lipid peroxidase inhibitor u-101033e]. ( Engelhard, K; Kochs, E; Lu, H; Möllenberg, O; Werner, C; Zieglgänsberger, W, 2000) |
| " The current investigation was conducted to evaluate the effect of isoflurane and N2O-fentanyl anesthesia on ischemia-induced glutamate release in the rat and to compare it with that of mild hypothermia, an intervention known to reduce glutamate release significantly." | 3.69 | Isoflurane reduces ischemia-induced glutamate release in rats subjected to forebrain ischemia. ( Cole, DJ; Drummond, JC; Goskowicz, RL; Patel, PM, 1995) |
| "This study compares the effects of propofol and fentanyl/N2O on spontaneous brain electrical activity, neurologic outcome, and neuronal damage due to incomplete cerebral ischemia in rats." | 3.68 | The effects of propofol on brain electrical activity, neurologic outcome, and neuronal damage following incomplete ischemia in rats. ( Albrecht, RF; Hoffman, WE; Kochs, E; Schulte am Esch, J; Thomas, C; Werner, C, 1992) |
| "Paroxysmal autonomic instability with dystonia (PAID) is an underdiagnosed syndrome that describes a collection of symptoms following diverse cerebral insults, such as traumatic brain injury, hydrocephalus, hemorrhagic stroke, or brain anoxia." | 1.56 | Transdermal opioid patch in treatment of paroxysmal autonomic instability with dystonia with multiple cerebral insults: A case report. ( Baik, SW; Kang, DH; Kim, GW, 2020) |
| "Fentanyl at 50 μg/kg was first administered over a 10-min period and then 50 μg/kg/h was administered continuously for the fentanyl group." | 1.37 | Effect of fentanyl on ischemic depolarization and ischemic neuronal damage of hippocampal CA1 in the gerbil. ( Danura, T; Masui, K; Morita, K; Sasaki, T; Shiraishi, K; Takeda, Y; Taninishi, H, 2011) |
| "Fentanyl inhibited an increase of the proinflammatory cytokines, TNF-alpha and IL-1beta levels, during global cerebral ischemia/reperfusion in rats." | 1.31 | Effect of fentanyl on TNF-alpha and IL-1beta levels during global ischemia/reperfusion in rats. ( Oh, WS, 2002) |
| "Fentanyl citrate has properties, including agonism of the mu-opioid receptor and proconvulsant activity, that theoretically could pose adverse effects in ischemic brain." | 1.30 | High-dose fentanyl does not adversely affect outcome from forebrain ischemia in the rat. ( Bart, RD; Dexter, F; Morimoto, Y; Pearlstein, RD; Warner, DS, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (45.45) | 18.2507 |
| 2000's | 8 (36.36) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Switzer, AR | 1 |
| Beland, B | 1 |
| Sarna, JR | 1 |
| Walzak, A | 1 |
| Pfeffer, G | 1 |
| Baik, SW | 1 |
| Kang, DH | 1 |
| Kim, GW | 1 |
| Islam, MR | 1 |
| Yang, L | 1 |
| Lee, YS | 1 |
| Hruby, VJ | 1 |
| Karamyan, VT | 1 |
| Abbruscato, TJ | 1 |
| Eberspächer, E | 1 |
| Eckel, B | 1 |
| Engelhard, K | 3 |
| Müller, K | 1 |
| Hoffman, WE | 5 |
| Blobner, M | 1 |
| Werner, C | 5 |
| Shiraishi, K | 1 |
| Takeda, Y | 1 |
| Masui, K | 1 |
| Taninishi, H | 1 |
| Sasaki, T | 1 |
| Danura, T | 1 |
| Morita, K | 1 |
| Mayer, SA | 1 |
| Elsersy, H | 1 |
| Sheng, H | 2 |
| Lynch, JR | 1 |
| Moldovan, M | 1 |
| Pearlstein, RD | 5 |
| Warner, DS | 5 |
| Fernández Sánchez, LJ | 1 |
| Pérez González, R | 1 |
| Guasch Arévalo, E | 1 |
| Martín Reyes, R | 1 |
| Gilsanz Rodríguez, F | 1 |
| Patel, PM | 1 |
| Drummond, JC | 1 |
| Cole, DJ | 1 |
| Goskowicz, RL | 1 |
| Lingamneni, P | 1 |
| Minshall, R | 1 |
| Miletich, DJ | 1 |
| Albrecht, RF | 4 |
| Thomas, C | 2 |
| Morimoto, Y | 2 |
| Bart, RD | 2 |
| Dexter, F | 2 |
| Linstedt, U | 1 |
| Maier, C | 1 |
| Petry, A | 1 |
| Kofke, WA | 1 |
| Garman, RH | 1 |
| Garman, R | 1 |
| Rose, ME | 1 |
| Miura, Y | 1 |
| Mackensen, GB | 3 |
| Nellgård, B | 3 |
| Reeker, W | 1 |
| Lu, H | 2 |
| Möllenberg, O | 2 |
| Mielke, L | 1 |
| Kochs, E | 4 |
| Massey, G | 1 |
| Kudo, M | 1 |
| Zieglgänsberger, W | 1 |
| Oh, WS | 1 |
| Pelligrino, D | 1 |
| Schulte am Esch, J | 2 |
1 trial available for fentanyl and Brain Ischemia
| Article | Year |
|---|---|
Hypothermia for neuroprotection after cardiac arrest.
Topics: Adolescent; Adult; Aged; Brain Ischemia; Fentanyl; Heart Arrest; Humans; Hypnotics and Sedatives; Hy | 2002 |
21 other studies available for fentanyl and Brain Ischemia
| Article | Year |
|---|---|
Fentanyl Overdose Causing Hippocampal Ischaemia Followed by Delayed Leukoencephalopathy.
Topics: Analgesics, Opioid; Brain Ischemia; Disease Progression; Fentanyl; Hippocampus; Humans; Hypoventilat | 2020 |
Transdermal opioid patch in treatment of paroxysmal autonomic instability with dystonia with multiple cerebral insults: A case report.
Topics: Analgesics, Opioid; Autonomic Nervous System Diseases; Basal Ganglia; Brain Ischemia; Diffusion Tens | 2020 |
Enkephalin-Fentanyl Multifunctional Opioids as Potential Neuroprotectants for Ischemic Stroke Treatment.
Topics: Analgesics, Opioid; Animals; Brain Ischemia; Dose-Response Relationship, Drug; Enkephalins; Fentanyl | 2016 |
Effects of sevoflurane on cognitive deficit, motor function, and histopathology after cerebral ischemia in rats.
Topics: Anesthesia; Anesthetics; Anesthetics, Intravenous; Animals; Blood Gas Analysis; Brain; Brain Ischemi | 2009 |
Effect of fentanyl on ischemic depolarization and ischemic neuronal damage of hippocampal CA1 in the gerbil.
Topics: Analgesics, Opioid; Animals; Brain Ischemia; CA1 Region, Hippocampal; Cell Death; Fentanyl; Gerbilli | 2011 |
Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat.
Topics: Anesthesia; Animals; Brain Ischemia; Cell Death; Fentanyl; Isoflurane; Male; Nitrous Oxide; Prosence | 2004 |
[Perioperative treatment of a pregnant woman with recent cerebral infarction secondary to noncompaction cardiomyopathy].
Topics: Adrenergic beta-Antagonists; Androstanols; Anesthesia, General; Anesthesia, Inhalation; Anesthesia, | 2006 |
Isoflurane reduces ischemia-induced glutamate release in rats subjected to forebrain ischemia.
Topics: Anesthesia; Animals; Brain Ischemia; Dialysis; Dose-Response Relationship, Drug; Electroencephalogra | 1995 |
Brain alpha 2-adrenergic receptor binding during incomplete cerebral ischemia in the rat.
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Animals; Blood Pressure; Brain; Brain Ischemia; Car | 1993 |
The effect of halothane and isoflurane on neurologic outcome following incomplete cerebral ischemia in the rat.
Topics: Anesthesia, Inhalation; Animals; Brain Ischemia; Catecholamines; Fentanyl; Halothane; Isoflurane; Ma | 1993 |
High-dose fentanyl does not adversely affect outcome from forebrain ischemia in the rat.
Topics: Anesthesia; Anesthetics, General; Anesthetics, Intravenous; Animals; Blood Pressure; Body Temperatur | 1997 |
Intraoperative monitoring with somatosensory evoked potentials in carotid artery surgery--less reliable in patients with preoperative neurologic deficiency?
Topics: Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Arteriovenous Shunt, Surgical; Atracurium; | 1998 |
Opioid neurotoxicity: fentanyl-induced exacerbation of cerebral ischemia in rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Brain Ischemia; Dose-Response Relationship, Drug; | 1999 |
Effects of isoflurane, ketamine, and fentanyl/N2O on concentrations of brain and plasma catecholamines during near-complete cerebral ischemia in the rat.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain Ischemia; Catecholamines; Fentanyl | 1999 |
Desflurane and isoflurane improve neurological outcome after incomplete cerebral ischaemia in rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain Ischemia; Chromatography, High Pre | 1999 |
The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat.
Topics: Anesthetics; Animals; Brain Ischemia; Corticosterone; Fentanyl; Interleukin-6; Isoflurane; Metyrapon | 2000 |
Periischemic cerebral blood flow (CBF) does not explain beneficial effects of isoflurane on outcome from near-complete forebrain ischemia in rats.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Autonomic Nerve Block; Brain Ischemia; C | 2000 |
[The neuroprotective effect of the glutamate antagonist acamprosate following experimental cerebral ischemia. A study with the lipid peroxidase inhibitor u-101033e].
Topics: Acamprosate; Alcohol Deterrents; Anesthetics, Intravenous; Animals; Brain Ischemia; Enzyme Inhibitor | 2000 |
Effect of fentanyl on TNF-alpha and IL-1beta levels during global ischemia/reperfusion in rats.
Topics: Anesthetics, Intravenous; Animals; Arteries; Brain Ischemia; Cerebrovascular Circulation; Fentanyl; | 2002 |
Ketamine decreases plasma catecholamines and improves outcome from incomplete cerebral ischemia in rats.
Topics: Animals; Blood Glucose; Blood Pressure; Brain; Brain Ischemia; Cerebrovascular Circulation; Electroe | 1992 |
The effects of propofol on brain electrical activity, neurologic outcome, and neuronal damage following incomplete ischemia in rats.
Topics: Animals; Brain; Brain Damage, Chronic; Brain Diseases; Brain Ischemia; Depression, Chemical; Electro | 1992 |