fentanyl has been researched along with Brain Injuries in 31 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the clinical effectiveness of bolus-dose fentanyl and midazolam to treat episodic intracranial hypertension in children with severe traumatic brain injury." | 7.83 | Fentanyl and Midazolam Are Ineffective in Reducing Episodic Intracranial Hypertension in Severe Pediatric Traumatic Brain Injury. ( Doctor, A; Kharasch, ED; Leonard, JR; Pineda, JA; Wallendorf, MJ; Welch, TP, 2016) |
| "Despite common use of narcotics in the clinical management of severe traumatic brain injury (TBI), in experimental models rats treated with fentanyl have exhibited worse functional outcome and more CA1 hippocampal death than rats treated with standard isoflurane anesthesia." | 7.72 | Hyperglycolysis is exacerbated after traumatic brain injury with fentanyl vs. isoflurane anesthesia in rats. ( Clark, RS; Janesko, KL; Jenkins, LW; Kochanek, PM; Melick, JA; Statler, KD, 2003) |
| "Remifentanil was effective, well tolerated and provided comparable haemodynamic stability to that of the hypnotic-based regimen." | 6.71 | Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308]. ( Karabinis, A; Kirkham, AJ; Komnos, A; Mandragos, K; Soukup, J; Speelberg, B; Stergiopoulos, S, 2004) |
| "To evaluate the clinical effectiveness of bolus-dose fentanyl and midazolam to treat episodic intracranial hypertension in children with severe traumatic brain injury." | 3.83 | Fentanyl and Midazolam Are Ineffective in Reducing Episodic Intracranial Hypertension in Severe Pediatric Traumatic Brain Injury. ( Doctor, A; Kharasch, ED; Leonard, JR; Pineda, JA; Wallendorf, MJ; Welch, TP, 2016) |
| "Despite common use of narcotics in the clinical management of severe traumatic brain injury (TBI), in experimental models rats treated with fentanyl have exhibited worse functional outcome and more CA1 hippocampal death than rats treated with standard isoflurane anesthesia." | 3.72 | Hyperglycolysis is exacerbated after traumatic brain injury with fentanyl vs. isoflurane anesthesia in rats. ( Clark, RS; Janesko, KL; Jenkins, LW; Kochanek, PM; Melick, JA; Statler, KD, 2003) |
| " To reach an adequate cerebral perfusion pressure (CPP), the norepinephrine dosage was adapted successively." | 2.73 | Effects of fentanyl and S(+)-ketamine on cerebral hemodynamics, gastrointestinal motility, and need of vasopressors in patients with intracranial pathologies: a pilot study. ( Bertsch, T; Horn, P; Muench, E; Quintel, M; Schmittner, MD; Vajkoczy, P; Vajkoczy, SL, 2007) |
| "Remifentanil was effective, well tolerated and provided comparable haemodynamic stability to that of the hypnotic-based regimen." | 2.71 | Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308]. ( Karabinis, A; Kirkham, AJ; Komnos, A; Mandragos, K; Soukup, J; Speelberg, B; Stergiopoulos, S, 2004) |
| "Ketamine was supposed to be contra-indicated in head injured patients although it possesses numerous advantages over other commonly used analgosedative drugs." | 2.68 | Ketamine for analgosedative therapy in intensive care treatment of head-injured patients. ( Braun, U; Gremmelt, A; Kolenda, H; Markakis, E; Rading, S, 1996) |
| "Rats treated with isoflurane had the best cognitive recovery (p < 0." | 1.33 | Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats. ( Alexander, H; Clark, RS; Dixon, CE; Jenkins, L; Kochanek, PM; Statler, KD; Vagni, V, 2006) |
| "Fentanyl-treated rats had higher mean arterial blood pressure after injury (p < 0." | 1.31 | Isoflurane improves long-term neurologic outcome versus fentanyl after traumatic brain injury in rats. ( Alexander, HL; Clark, RS; Dixon, CE; Graham, SH; Jenkins, LW; Kochanek, PM; Marion, DW; Safar, PJ; Statler, KD; Warner, DS; Wisniewski, SR, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (19.35) | 18.7374 |
| 1990's | 9 (29.03) | 18.2507 |
| 2000's | 8 (25.81) | 29.6817 |
| 2010's | 7 (22.58) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Garg, PM | 1 |
| Rebentisch, A | 1 |
| Zhang, M | 1 |
| Ware, J | 1 |
| Pippins, M | 1 |
| Taylor, C | 1 |
| Reddy, K | 1 |
| Lewis, T | 1 |
| Inder, TE | 1 |
| Hillegass, WB | 1 |
| Colton, K | 2 |
| Yang, S | 2 |
| Hu, PF | 2 |
| Chen, HH | 2 |
| Bonds, B | 2 |
| Scalea, TM | 2 |
| Stein, DM | 2 |
| Stansbury, LG | 1 |
| Melcer, T | 1 |
| Walker, J | 1 |
| Bhatnagar, V | 1 |
| Richard, E | 1 |
| Han, P | 1 |
| Sechriest, V | 1 |
| Lebedda, M | 1 |
| Quinn, K | 1 |
| Galarneau, M | 1 |
| Bucher, J | 1 |
| Koyfman, A | 1 |
| Welch, TP | 1 |
| Wallendorf, MJ | 1 |
| Kharasch, ED | 1 |
| Leonard, JR | 1 |
| Doctor, A | 1 |
| Pineda, JA | 1 |
| Mesa Suárez, P | 1 |
| Santotoribio, JD | 1 |
| Ramos Ramos, V | 1 |
| González García, MÁ | 1 |
| Pérez Ramos, S | 1 |
| Portilla Huertas, D | 1 |
| Muñoz Hoyos, A | 1 |
| Michetti, CP | 1 |
| Maguire, JF | 1 |
| Kaushik, A | 1 |
| Pullarkat, RR | 1 |
| Boro, TV | 1 |
| Rizzo, AG | 1 |
| Seoudi, H | 1 |
| Meehan, M | 1 |
| Robinson, L | 1 |
| Statler, KD | 5 |
| Alexander, HL | 2 |
| Vagni, VA | 1 |
| Nemoto, EM | 1 |
| Tofovic, SP | 1 |
| Dixon, CE | 4 |
| Jenkins, LW | 3 |
| Marion, DW | 2 |
| Kochanek, PM | 5 |
| Janesko, KL | 1 |
| Melick, JA | 1 |
| Clark, RS | 4 |
| Karabinis, A | 1 |
| Mandragos, K | 1 |
| Stergiopoulos, S | 1 |
| Komnos, A | 1 |
| Soukup, J | 1 |
| Speelberg, B | 1 |
| Kirkham, AJ | 1 |
| Alexander, H | 2 |
| Vagni, V | 2 |
| Jenkins, L | 2 |
| Holubkov, R | 1 |
| Miller, P | 1 |
| Mack, CD | 1 |
| Sammer, M | 1 |
| Rozet, I | 1 |
| Lee, LA | 1 |
| Muangman, S | 1 |
| Wang, M | 1 |
| Hollingworth, W | 1 |
| Lam, AM | 1 |
| Vavilala, MS | 1 |
| Schmittner, MD | 1 |
| Vajkoczy, SL | 1 |
| Horn, P | 1 |
| Bertsch, T | 1 |
| Quintel, M | 1 |
| Vajkoczy, P | 1 |
| Muench, E | 1 |
| Desbordes, JM | 1 |
| Maissin, F | 1 |
| White, PF | 1 |
| Schlobohm, RM | 1 |
| Pitts, LH | 1 |
| Lindauer, JM | 1 |
| Murr, R | 3 |
| Berger, S | 3 |
| Schürer, L | 3 |
| Peter, K | 3 |
| Baethmann, A | 3 |
| Enzenbach, R | 2 |
| Archer, DP | 1 |
| Samanani, N | 1 |
| Kolenda, H | 1 |
| Gremmelt, A | 1 |
| Rading, S | 1 |
| Braun, U | 1 |
| Markakis, E | 1 |
| de Nadal, M | 1 |
| Ausina, A | 1 |
| Sahuquillo, J | 1 |
| Pedraza, S | 1 |
| Garnacho, A | 1 |
| Gancedo, VA | 1 |
| Bedell, EA | 1 |
| DeWitt, DS | 1 |
| Prough, DS | 1 |
| Windsor, J | 1 |
| Varon, AJ | 1 |
| Warner, DS | 1 |
| Wisniewski, SR | 1 |
| Graham, SH | 1 |
| Safar, PJ | 1 |
| Masuo, Y | 1 |
| Wang, H | 1 |
| Pélaprat, D | 1 |
| Chi, ZQ | 1 |
| Rostène, W | 1 |
| Dabadie, P | 2 |
| Feuillerat, JP | 1 |
| Thicoipe, M | 2 |
| Maurette, P | 2 |
| Lafforgue, JL | 1 |
| Castel, JP | 1 |
| Erny, P | 1 |
| Brule, JF | 1 |
| Claverie, JP | 1 |
| Arseni, C | 1 |
| Reinhard, T | 1 |
| Chrzanowski, R | 1 |
| Kamieniecka, B | 1 |
| Mańko, E | 1 |
| Moroz, J | 1 |
| Regieli, A | 1 |
| Szaroma, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| the Research of Analgesia and Sedation Effect of Remifentanil on ICU Short Operation[NCT02635802] | Phase 4 | 1,500 participants (Anticipated) | Interventional | 2015-12-31 | Not yet recruiting | ||
| Effect of Dexmedetomidine of Gastrointestinal Motility[NCT04798482] | Phase 4 | 22 participants (Actual) | Interventional | 2021-09-14 | Completed | ||
| Prospective Study of Induction Medications Used in the Rapid Sequence Intubation of Trauma Patients and a Comparison of Effects on Outcomes[NCT04291521] | 7,000 participants (Anticipated) | Observational | 2024-01-01 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for fentanyl and Brain Injuries
| Article | Year |
|---|---|
Intubation of the Neurologically Injured Patient.
Topics: Adrenergic beta-1 Receptor Antagonists; Airway Management; Anesthetics, Dissociative; Anesthetics, I | 2015 |
4 trials available for fentanyl and Brain Injuries
| Article | Year |
|---|---|
Safety and efficacy of analgesia-based sedation with remifentanil versus standard hypnotic-based regimens in intensive care unit patients with brain injuries: a randomised, controlled trial [ISRCTN50308308].
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Analgesics, Opioid; Brain Injuries; Drug Monitoring; | 2004 |
Effects of fentanyl and S(+)-ketamine on cerebral hemodynamics, gastrointestinal motility, and need of vasopressors in patients with intracranial pathologies: a pilot study.
Topics: Adult; Aged; Analgesics, Opioid; Anesthetics, Dissociative; Brain Injuries; Cerebrovascular Circulat | 2007 |
A randomized study of drugs for preventing increases in intracranial pressure during endotracheal suctioning.
Topics: Brain Injuries; Fentanyl; Humans; Intracranial Pressure; Intubation, Intratracheal; Lidocaine; Rando | 1982 |
Ketamine for analgosedative therapy in intensive care treatment of head-injured patients.
Topics: Adolescent; Adult; Aged; Blood Pressure; Brain Injuries; Conscious Sedation; Critical Care; Dose-Res | 1996 |
26 other studies available for fentanyl and Brain Injuries
| Article | Year |
|---|---|
Clinical impact of analgesic-sedative agents and peri-operative clinical status on white matter brain injury in preterm infants following surgical NEC.
Topics: Analgesics; Brain Injuries; Fentanyl; Humans; Hypnotics and Sedatives; Hypotension; Infant; Infant, | 2023 |
Intracranial pressure response after pharmacologic treatment of intracranial hypertension.
Topics: Adult; Brain Injuries; Critical Care; Documentation; Female; Fentanyl; Humans; Hypnotics and Sedativ | 2014 |
Pharmacologic Treatment Reduces Pressure Times Time Dose and Relative Duration of Intracranial Hypertension.
Topics: Adult; Barbiturates; Brain Injuries; Dose-Response Relationship, Drug; Female; Fentanyl; Humans; Hyp | 2016 |
Glasgow Coma Scale scores, early opioids, and 4-year psychological outcomes among combat amputees.
Topics: Adult; Afghan Campaign 2001-; Amputation, Surgical; Amputation, Traumatic; Amputees; Analgesics, Opi | 2014 |
Fentanyl and Midazolam Are Ineffective in Reducing Episodic Intracranial Hypertension in Severe Pediatric Traumatic Brain Injury.
Topics: Adolescent; Brain Injuries; Cerebrovascular Circulation; Child; Child, Preschool; Drug Administratio | 2016 |
[Brain damage after general anesthesia].
Topics: Adolescent; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Biomarkers; Brai | 2016 |
Single-drug sedation with fentanyl for prehospital postintubation sedation in trauma patients.
Topics: Adult; Benzodiazepines; Brain Injuries; Conscious Sedation; Emergency Medical Services; Female; Fent | 2012 |
Moderate hypothermia may be detrimental after traumatic brain injury in fentanyl-anesthetized rats.
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Animals; Brain; Brain Injuries; Catecholamines; F | 2003 |
Hyperglycolysis is exacerbated after traumatic brain injury with fentanyl vs. isoflurane anesthesia in rats.
Topics: Anesthesia; Animals; Brain Injuries; Fentanyl; Glucose; Glycolysis; Isoflurane; Male; Rats; Rats, Sp | 2003 |
Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats.
Topics: Anesthetics; Animals; Brain; Brain Injuries; Cell Survival; Cognition Disorders; Diazepam; Disease M | 2006 |
Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injury.
Topics: Anesthetics, Intravenous; Animals; Behavior, Animal; Blood Pressure; Brain Injuries; Cell Count; Dis | 2006 |
The incidence and risk factors for hypotension during emergent decompressive craniotomy in children with traumatic brain injury.
Topics: Age Factors; Anesthesia, General; Brain Injuries; Child, Preschool; Craniotomy; Female; Fentanyl; Hu | 2006 |
[Areactive bilateral mydriasis and thiopental in neurologic intensive care].
Topics: Brain Injuries; Critical Care; Fentanyl; Humans; Pupil; Thiopental | 1984 |
Influence of isoflurane, fentanyl, thiopental, and alpha-chloralose on formation of brain edema resulting from a focal cryogenic lesion.
Topics: Anesthetics; Animals; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Chloralose; F | 1995 |
Effects of isoflurane, fentanyl, or thiopental anesthesia on regional cerebral blood flow and brain surface PO2 in the presence of a focal lesion in rabbits.
Topics: Anesthetics; Animals; Brain Injuries; Cerebrovascular Circulation; Fentanyl; Isoflurane; Oxygen; Par | 1993 |
The influence of cryogenic brain injury on nociception in the rat.
Topics: Alfentanil; Analgesia; Animals; Blood Pressure; Brain Injuries; Cryosurgery; Fentanyl; Male; Prospec | 1993 |
Effects on intracranial pressure of fentanyl in severe head injured patients.
Topics: Adolescent; Adult; Analgesics, Opioid; Blood Pressure; Brain; Brain Injuries; Female; Fentanyl; Home | 1998 |
Fentanyl infusion preserves cerebral blood flow during decreased arterial blood pressure after traumatic brain injury in cats.
Topics: Animals; Blood Gas Analysis; Brain Injuries; Cats; Cerebrovascular Circulation; Electroencephalograp | 1998 |
Fentanyl should be used with caution in patients with severe brain injury.
Topics: Analgesics, Opioid; Blood Pressure; Brain Injuries; Fentanyl; Humans; Intracranial Pressure | 1998 |
Isoflurane improves long-term neurologic outcome versus fentanyl after traumatic brain injury in rats.
Topics: Analgesics, Opioid; Animals; Brain Injuries; Fentanyl; Intracranial Pressure; Isoflurane; Male; Nerv | 2000 |
Brain surface pO2 and rCBF in rabbits with a focal cerebral lesion and pulmonary hypoxia under fentanyl-, isoflurane- or thiopental-anesthesia.
Topics: Anesthesia, General; Animals; Brain; Brain Injuries; Cerebral Cortex; Fentanyl; Hypoxia; Isoflurane; | 1992 |
Effect of brain lesions on [3H]ohmefentanyl binding site densities in the rat striatum and substantia nigra.
Topics: Animals; Brain Injuries; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl | 1992 |
[Significance of intracranial pressure in the care of patients with severe cranial injuries].
Topics: Adolescent; Adult; Aged; Barbiturates; Brain Injuries; Child; Female; Fentanyl; Humans; Intracranial | 1985 |
[Role of early care and cerebral lesions in the mortality of young patients with cranial injuries. Preliminary study concerning 92 deaths].
Topics: Adolescent; Adult; Brain Injuries; Child; Child, Preschool; Coma; Female; Fentanyl; Humans; Infant; | 1985 |
[Neuroleptoanalgesia in neurosurgical patients].
Topics: Adolescent; Adult; Aged; Biopsy; Brain; Brain Injuries; Brain Neoplasms; Cerebrovascular Disorders; | 1973 |
Neuroleptanalgesia in cerebral angiography.
Topics: Anesthetics; Benperidol; Bradycardia; Brain Injuries; Butyrophenones; Carotid Artery, Internal; Cere | 1973 |