fentanyl has been researched along with Brain Edema in 7 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In rabbits who had brain edema and intracranial hypertension induced by a combined cold lesion (over the left hemisphere) and a metabolic blocker (6-aminonicotinamide), the authors analyzed the response of multiple parameters following the administration of 6 mcg/kg/dose of fentanyl every 5 minutes for 1 hour (12 doses), combined with nitrous oxide anesthesia." | 7.67 | The effects of acute high dose fentanyl administration on experimental brain edema: analysis of intracranial pressure, systemic arterial pressure, central venous pressure and brain water content. ( James, HE; Moore, S; Tiznado, E, 1986) |
| "The study indicates that before as well as during hyperventilation, subdural ICP and AVDo2 are lower and CPP higher in propofol-anesthetized patients compared with patients anesthetized with isoflurane or sevoflurane." | 5.10 | Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesia. ( Cold, GE; Hauerberg, J; Holst, P; Landsfeldt, U; Mau, S; Olsen, KS; Petersen, CB; Petersen, KD, 2003) |
| "In rabbits who had brain edema and intracranial hypertension induced by a combined cold lesion (over the left hemisphere) and a metabolic blocker (6-aminonicotinamide), the authors analyzed the response of multiple parameters following the administration of 6 mcg/kg/dose of fentanyl every 5 minutes for 1 hour (12 doses), combined with nitrous oxide anesthesia." | 3.67 | The effects of acute high dose fentanyl administration on experimental brain edema: analysis of intracranial pressure, systemic arterial pressure, central venous pressure and brain water content. ( James, HE; Moore, S; Tiznado, E, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Jasne, AS | 1 |
| Alsherbini, KA | 1 |
| Smith, MS | 1 |
| Kuohn, LR | 1 |
| Pandhi, A | 1 |
| Vagal, A | 1 |
| Kanter, DS | 1 |
| Chen, CH | 1 |
| Mullen, AJ | 1 |
| Hofstede, D | 1 |
| Rizvi, T | 1 |
| Petersen, KD | 1 |
| Landsfeldt, U | 1 |
| Cold, GE | 1 |
| Petersen, CB | 1 |
| Mau, S | 1 |
| Hauerberg, J | 1 |
| Holst, P | 1 |
| Olsen, KS | 1 |
| Murr, R | 1 |
| Berger, S | 1 |
| Schürer, L | 1 |
| Peter, K | 1 |
| Baethmann, A | 1 |
| Hartung, J | 1 |
| Smith, AL | 1 |
| Marque, JJ | 1 |
| Tiznado, E | 1 |
| James, HE | 1 |
| Moore, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Influence of Vasopressors on Brain Oxygenation and Microcirculation in Anesthetized Patients With Cerebral Tumors[NCT02713087] | Phase 4 | 48 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for fentanyl and Brain Edema
| Article | Year |
|---|---|
Intracranial pressure and cerebral hemodynamic in patients with cerebral tumors: a randomized prospective study of patients subjected to craniotomy in propofol-fentanyl, isoflurane-fentanyl, or sevoflurane-fentanyl anesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Anesthesia, Inhalation; Anesthetics, Inhalation; Anest | 2003 |
6 other studies available for fentanyl and Brain Edema
| Article | Year |
|---|---|
Response to "Malignant cerebella edema in three-year-old girl following accidental opioid ingestion and fentanyl administration".
Topics: Analgesics, Opioid; Brain Edema; Cerebellum; Child, Preschool; Edema; Female; Fentanyl; Humans | 2020 |
Malignant cerebellar edema in three-year-old girl following accidental opioid ingestion and fentanyl administration.
Topics: Analgesics, Opioid; Brain Edema; Cerebellum; Child, Preschool; Drug Overdose; Female; Fentanyl; Huma | 2019 |
Influence of isoflurane, fentanyl, thiopental, and alpha-chloralose on formation of brain edema resulting from a focal cryogenic lesion.
Topics: Anesthetics; Animals; Brain; Brain Edema; Brain Injuries; Cerebrovascular Circulation; Chloralose; F | 1995 |
Isoflurane, fentanyl, thiopental, and brain edema.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Brain; Brain Edema; Chloralose; Fentanyl | 1996 |
Anesthetics and cerebral edema.
Topics: Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics; Animals; Brain; Brain Edema; Dogs; Dro | 1976 |
The effects of acute high dose fentanyl administration on experimental brain edema: analysis of intracranial pressure, systemic arterial pressure, central venous pressure and brain water content.
Topics: Animals; Behavior, Animal; Blood Pressure; Brain; Brain Chemistry; Brain Edema; Central Venous Press | 1986 |