fentanyl has been researched along with Asphyxia Neonatorum in 2 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Asphyxia Neonatorum: Respiratory failure in the newborn. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to assess the safety of fentanyl analgosedation during therapeutic hypothermia, by evaluating severe adverse effects and possible correlation with the neurodevelopmental outcome." | 8.12 | Fentanyl analgesia in asphyxiated newborns treated with therapeutic hypothermia. ( Bedetti, L; Berardi, A; Della Casa, E; Ferrari, F; Garetti, E; Guidotti, I; Iughetti, L; Lago, P; Lucaccioni, L; Lugli, L; Pugliese, M; Roversi, MF; Spada, C, 2022) |
| "The aim of this study was to assess the safety of fentanyl analgosedation during therapeutic hypothermia, by evaluating severe adverse effects and possible correlation with the neurodevelopmental outcome." | 4.12 | Fentanyl analgesia in asphyxiated newborns treated with therapeutic hypothermia. ( Bedetti, L; Berardi, A; Della Casa, E; Ferrari, F; Garetti, E; Guidotti, I; Iughetti, L; Lago, P; Lucaccioni, L; Lugli, L; Pugliese, M; Roversi, MF; Spada, C, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lugli, L | 1 |
| Spada, C | 1 |
| Garetti, E | 1 |
| Guidotti, I | 1 |
| Roversi, MF | 1 |
| Della Casa, E | 1 |
| Bedetti, L | 1 |
| Lucaccioni, L | 1 |
| Pugliese, M | 1 |
| Ferrari, F | 1 |
| Iughetti, L | 1 |
| Lago, P | 1 |
| Berardi, A | 1 |
| Angeles, DM | 1 |
| Wycliffe, N | 1 |
| Michelson, D | 1 |
| Holshouser, BA | 1 |
| Deming, DD | 1 |
| Pearce, WJ | 1 |
| Sowers, LC | 1 |
| Ashwal, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I-II Clinical Trial to Determine the Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia[NCT01862250] | Phase 1/Phase 2 | 13 participants (Actual) | Interventional | 2013-10-03 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Intravenous morphine (mg/kg) was given. The standard dose is 0.05 mg/kg per dose (NCT01862250)
Timeframe: Up to 2 days
| Intervention | mg/kg (Median) |
|---|---|
| Clonidine Infants With HIE | 0.02 |
Babies were assessed after administration of clonidine for the presence or absence of shivering. (NCT01862250)
Timeframe: 48hrs
| Intervention | Participants (Count of Participants) |
|---|---|
| Clonidine Infants With HIE | 0 |
"Trough clonidine blood levels were measured after 4-7 doses of clonidine were given intravenously with a dosing interval of every 8 hrs. Mean and standard deviation (SD) of the number of doses given prior to levels being drawn was 5.3 (mean) and 0.37 (SD).~Time after last dose before measurement was 9hrs (mean) and 2.7hrs (SD)." (NCT01862250)
Timeframe: 3 days
| Intervention | ng/ml (Median) |
|---|---|
| Clonidine Infants With HIE | 0.6 |
Following 2 hours of therapeutic hypothermia, the temperature of the thermo-blanket is adjusted up half degree per hour allowing passive rewarming until 36.5 degrees is reached (NCT01862250)
Timeframe: Beginning at 72 hours up to 12 hours
| Intervention | Hours (Median) |
|---|---|
| Clonidine Infants With HIE | 8.7 |
2 other studies available for fentanyl and Asphyxia Neonatorum
| Article | Year |
|---|---|
Fentanyl analgesia in asphyxiated newborns treated with therapeutic hypothermia.
Topics: Analgesia; Asphyxia Neonatorum; Fentanyl; Humans; Hypothermia; Hypothermia, Induced; Hypoxia-Ischemi | 2022 |
Use of opioids in asphyxiated term neonates: effects on neuroimaging and clinical outcome.
Topics: Analgesics, Opioid; Asphyxia Neonatorum; Female; Fentanyl; Humans; Hypoxia-Ischemia, Brain; Infant, | 2005 |