Page last updated: 2024-10-27

fentanyl and Apnea, Sleep

fentanyl has been researched along with Apnea, Sleep in 5 studies

Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.

Research Excerpts

ExcerptRelevanceReference
"The treatment of postoperative pain after uvulopalatopharyngoplasty (UPPP) and tonsillectomy presents a challenge."2.69Ketoprofen and fentanyl for pain after uvulopalatopharyngoplasty and tonsillectomy. ( Aho, M; Kokki, H; Nikanne, E; Virtaniemi, J, 1999)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's2 (40.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Mikhaeil, JS1
Pepper, CG1
Hayward, GC1
Ajala, AM1
Goodwin, JA1
Goodwin, SR1
Josephson, GD1
Ostermeier, AM1
Roizen, MF1
Hautkappe, M1
Klock, PA1
Klafta, JM1
Virtaniemi, J1
Kokki, H1
Nikanne, E1
Aho, M1
Esclamado, RM1
Glenn, MG1
McCulloch, TM1
Cummings, CW1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Postoperative Management of Obstructive Sleep Apnea With CPAP vs. an Autoadjusting CPAP Device: a Randomized Controlled Single Center Trial[NCT00588848]11 participants (Actual)Interventional2008-01-31Terminated (stopped due to Difficulty with enrollment)
The Effect of Acute Intravenous Morphine Administration on Sleep Disordered Breathing (SDB) in Patients With Moderate Obstructive Sleep Apnoea (OSA): A Paired Design Trial[NCT03127800]Phase 36 participants (Actual)Interventional2016-05-20Terminated (stopped due to Difficulties with recruitment)
Evaluation of Treatment Effect of Cervical Collar in Moderate Obstructive Sleep Apnea[NCT03754270]100 participants (Actual)Interventional2019-06-16Completed
The Association of CPAP Compliance and Nocturnal Hypoxemia in the Perioperative Period[NCT02796846]158 participants (Actual)Observational2015-06-30Completed
Evaluation of Screening Tools for OSA in Hospitalized Medical Patients: A Validation Study[NCT01340781]110 participants (Actual)Observational2012-02-29Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Apnea-Hypopnea Index (AHI)

Events are defined as apneas and hypopneas. AHI values are typically categorized as 5-14.9 events/hr = mild; 15-29.9 events/hr = moderate; and >= 30 events/hr = severe (NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.

Interventionevents per hour (Mean)
AUTOCPAP2.1
CPAP1.2

Cardiopulmonary Complications

Predefined cardiopulmonary complications: Myocardial Infarction, Arrhythmia, new onset Heart Failure, Stroke (NCT00588848)
Timeframe: 72 hours

InterventionParticipants (Count of Participants)
Autoadjusting CPAP (VPAP Auto)0
CPAP Arm (Usual Care)0

Sleep Related Hypoxemia

(NCT00588848)
Timeframe: On postoperative night number 1 from 2200 to 0600. Study participation will end within 72 hours of admission.

InterventionPercentage of time < 90% saturation (Mean)
AUTOCPAP10.5
CPAP7.1

Reviews

1 review available for fentanyl and Apnea, Sleep

ArticleYear
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:2

    Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe

1997
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:2

    Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe

1997
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:2

    Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe

1997
Three sudden postoperative respiratory arrests associated with epidural opioids in patients with sleep apnea.
    Anesthesia and analgesia, 1997, Volume: 85, Issue:2

    Topics: Adult; Aged; Analgesia, Epidural; Analgesics, Opioid; Apnea; Blood Pressure; Bupivacaine; Female; Fe

1997

Trials

1 trial available for fentanyl and Apnea, Sleep

ArticleYear
Ketoprofen and fentanyl for pain after uvulopalatopharyngoplasty and tonsillectomy.
    The Laryngoscope, 1999, Volume: 109, Issue:12

    Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Female; Fentanyl; Humans; Infusi

1999

Other Studies

3 other studies available for fentanyl and Apnea, Sleep

ArticleYear
Mechanisms of opioid-induced respiratory depression in sleep apnoea: new insights for anaesthesiology.
    The Journal of physiology, 2020, Volume: 598, Issue:18

    Topics: Analgesics, Opioid; Anesthesiology; Fentanyl; Humans; Hypercapnia; Hypoxia; Respiratory Hypersensiti

2020
Undiagnosed Graves' Disease contributing to sleep disordered breathing in a child undergoing adenotonsillectomy.
    Paediatric anaesthesia, 2008, Volume: 18, Issue:4

    Topics: Acetaminophen; Adenoidectomy; Adenoids; Analgesics, Non-Narcotic; Analgesics, Opioid; Antihypertensi

2008
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome.
    The Laryngoscope, 1989, Volume: 99, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem

1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome.
    The Laryngoscope, 1989, Volume: 99, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem

1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome.
    The Laryngoscope, 1989, Volume: 99, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem

1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome.
    The Laryngoscope, 1989, Volume: 99, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem

1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome.
    The Laryngoscope, 1989, Volume: 99, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem

1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome.
    The Laryngoscope, 1989, Volume: 99, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem

1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome.
    The Laryngoscope, 1989, Volume: 99, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem

1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome.
    The Laryngoscope, 1989, Volume: 99, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem

1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome.
    The Laryngoscope, 1989, Volume: 99, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem

1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome.
    The Laryngoscope, 1989, Volume: 99, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem

1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome.
    The Laryngoscope, 1989, Volume: 99, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem

1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome.
    The Laryngoscope, 1989, Volume: 99, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem

1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome.
    The Laryngoscope, 1989, Volume: 99, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem

1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome.
    The Laryngoscope, 1989, Volume: 99, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem

1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome.
    The Laryngoscope, 1989, Volume: 99, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem

1989
Perioperative complications and risk factors in the surgical treatment of obstructive sleep apnea syndrome.
    The Laryngoscope, 1989, Volume: 99, Issue:11

    Topics: Adjuvants, Anesthesia; Adult; Airway Obstruction; Arrhythmias, Cardiac; Chi-Square Distribution; Fem

1989