fentanyl and Aging
fentanyl has been researched along with Aging in 67 studies
Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078)
fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "We asked whether the sympathomimetic effect of nitrous oxide (N2O) predisposed patients receiving N2O to arrhythmias in response to epinephrine administration." | 9.06 | Nitrous oxide and epinephrine-induced arrhythmias. ( Donegan, JH; Fouts, KE; Lampe, GH; Litt, LL; Rampil, IJ; Rose, BM; Rupp, SM; Wauk, LZ; Whitendale, P; Wilson, CB, 1990) |
| "We asked whether the sympathomimetic effect of nitrous oxide (N2O) predisposed patients receiving N2O to arrhythmias in response to epinephrine administration." | 5.06 | Nitrous oxide and epinephrine-induced arrhythmias. ( Donegan, JH; Fouts, KE; Lampe, GH; Litt, LL; Rampil, IJ; Rose, BM; Rupp, SM; Wauk, LZ; Whitendale, P; Wilson, CB, 1990) |
| "Thus, the present preclinical study assessed the effectiveness of chronic fentanyl administration to produce antinociception in aging rats (16, 20, and 24 months)." | 3.80 | Thermal sensitivity across ages and during chronic fentanyl administration in rats. ( Carter, CS; Mitzelfelt, JD; Morgan, D, 2014) |
| "We investigated the effects of various factors (patient background, anesthesia duration, and intraoperative drug use) on the frequency and degree of postoperative nausea and vomiting (PONV) during the first 24 hours of intravenous patient-controlled analgesia (PCA) with fentanyl." | 3.72 | [Study of nausea and vomiting accompanying intravenous patient-controlled analgesia with fentanyl after cervical spine surgery]. ( Fujii, K; Kinoshita, H; Matsunaga, A; Okamura, K; Sanuki, M, 2003) |
| "The effects of age on the pharmacokinetics and pharmacodynamics of vecuronium in eight elderly patients aged 72-86 yr and eight younger adults aged 26-48 yr undergoing elective surgical procedures under nitrous oxide-fentanyl anesthesia were studied." | 3.68 | Distribution, elimination, and action of vecuronium in the elderly. ( Diaz, J; Lien, CA; Matteo, RS; Ornstein, E; Schwartz, AE, 1991) |
| "We assessed the pharmacokinetics of fentanyl in 19 infants and children undergoing cardiac surgery for correction of tetralogy of Fallot, A-V-canal and transposition of the great arteries." | 3.67 | Unexpected alterations in fentanyl pharmacokinetics in children undergoing cardiac surgery: age related or disease related? ( Crean, P; Goresky, G; Klein, J; Koren, G; MacLeod, SM, 1986) |
| "Effects of age on the pharmacodynamics of alfentanil, as a supplement to nitrous oxide anesthesia, were studied in younger (31-52 years; n = 14) and older (56-86 years; n = 14) women undergoing curative surgery for primary breast cancer." | 3.67 | Age has no effect on the pharmacodynamics of alfentanil. ( Bovill, JG; Burm, AG; Hennis, PJ; Lemmens, HJ, 1988) |
| "Fentanyl was administered i." | 2.80 | Effects of age on the pharmacokinetics and selected pharmacodynamics of intravenously administered fentanyl in foals. ( Casbeer, HC; Knych, HK; Mitchell, MM; Steffey, EP, 2015) |
| " Pharmacokinetic parameters were determined for the fentanyl HCl PCTS, and results were analysed using ANOVA." | 2.71 | Effects of application site and subject demographics on the pharmacokinetics of fentanyl HCl patient-controlled transdermal system (PCTS). ( Gupta, SK; Hwang, S; Sathyan, G; Southam, M, 2005) |
| " The pharmacokinetic properties of fentanyl administered as a single 5 ug/kg intravenous infusion were evaluated in 18 healthy volunteers by use of SIM as well as with NPEM." | 2.70 | Population pharmacokinetics of fentanyl in healthy volunteers. ( Ariano, RE; Duke, PC; Sitar, DS, 2001) |
| "Midazolam pretreatment was associated with a significant reduction in propofol dose requirement in both younger and older patients." | 2.70 | Effect of midazolam pretreatment on induction dose requirements of propofol in combination with fentanyl in younger and older adults. ( Bhaskaran, NC; Claydon, P; Cressey, DM; Reilly, CS, 2001) |
| "Rapacuronium is an investigational nondepolarizing relaxant that also has a rapid onset and short duration and consequently should be compared with succinylcholine in its ability to facilitate rapid tracheal intubation." | 2.69 | Comparison of the intubation conditions provided by rapacuronium (ORG 9487) or succinylcholine in humans during anesthesia with fentanyl and propofol. ( Caldwell, JE; Chan, V; Chung, F; Cicutti, N; Fleming, NW; Gan, TJ; Glass, PS; Gronert, GA; Kirkegaard-Nielsen, H; Kitts, JB, 1999) |
| "Because hypothermia is associated with adverse clinical outcomes, it is important to recognize predictors of hypothermia and to monitor and control body temperature in patients at risk." | 2.69 | Predictors of hypothermia during spinal anesthesia. ( Barnes, RA; Cattaneo, CG; El-Rahmany, HK; Frank, SM, 2000) |
| "The propofol requirements were significantly less in the midazolam-fentanyl groups, regardless of age, and among the premedicated patients older than 60 yr compared with the other age groups." | 2.69 | The combined effect of age and premedication on the propofol requirements for induction by target-controlled infusion. ( Ballester, JA; Elizalde, JL; Escobar, A; Olmos, M; Vidarte, MA, 2000) |
| " The dosage was calculated from the infusion time (time from start of infusion until specific clinical event)." | 2.68 | [Age-related correlation between EEG parameters and depth of anesthesia under propofol. Effect of fentanyl]. ( Eckert, O; Lehmkuhl, P; Neulinger, A; Pichlmayr, I; Werry, C, 1996) |
| "Fentanyl was administered at predicted plasma concentrations of 1 and 2 ng mg-1 using a computer-controlled continuous infusion and plasma concentrations of fentanyl were measured at the time of MAC-awake measurements." | 2.67 | Effect of fentanyl on awakening concentration of sevoflurane. ( Ikeda, K; Katoh, T; Uchiyama, T, 1994) |
| "Alfentanil has the most rapid analgesic onset and time to peak effect as well as the shortest distribution and elimination half-lives." | 2.39 | Clinical pharmacokinetics of alfentanil, fentanyl and sufentanil. An update. ( Scholz, J; Schulz, M; Steinfath, M, 1996) |
| "For propofol, there was a significantly lower dosing for older patients: 17% for patients aged 65-79 and 29% for those aged >80, which was still in less than the recommendations." | 1.43 | Does intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice. ( Akhtar, S; Burg, MM; Dai, F; Heng, J; Liu, J; Schonberger, RB, 2016) |
| "The reversal of opioid-induced respiratory depression and sedation by befiradol in adult rats was robust, whereas involved mechanisms are unclear." | 1.42 | 5-HT1A receptor agonist Befiradol reduces fentanyl-induced respiratory depression, analgesia, and sedation in rats. ( Ding, X; Greer, JJ; Ren, J, 2015) |
| "We demonstrate that fentanyl permeates the skin of young individuals in greater amounts and at a higher absorption rate than in middle-aged and old individuals in vitro." | 1.39 | Chronological age affects the permeation of fentanyl through human skin in vitro. ( Benfeldt, E; Holmgaard, R; Nielsen, JB; Sorensen, JA, 2013) |
| "This study describes a pharmacodynamic model during general anaesthesia in children relating the bispectral index (BIS) response to the anaesthetic dosing of propofol, fentanyl, and remifentanil." | 1.35 | Pharmacodynamic modelling of the bispectral index response to propofol-based anaesthesia during general surgery in children. ( Ammon, C; Fechner, J; Ihmsen, H; Jeleazcov, C; Schmidt, J; Schüttler, J; Schwilden, H, 2008) |
| " Statistically significant multivariate predictors of hypotension 0-10 min after anesthetic induction included: ASA III-V, baseline MAP <70 mm Hg, age > or =50 yr, the use of propofol for induction of anesthesia, and increasing induction dosage of fentanyl." | 1.33 | Predictors of hypotension after induction of general anesthesia. ( Baez, B; Bernstein, A; Bodian, CA; Hossain, S; Krol, M; Patel, P; Reich, DL, 2005) |
| "The risk of respiratory depression increased with age." | 1.32 | Side effects of opioids during short-term administration: effect of age, gender, and race. ( Baumgarten, M; Boston, R; Carr, DB; Cepeda, MS; Farrar, JT; Strom, BL, 2003) |
| " No change in OTF dosing in the elderly would appear necessary because of altered pharmacokinetics." | 1.32 | Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate. ( Hoffer, C; Kharasch, ED; Whittington, D, 2004) |
| "The effects of age on the pharmacokinetic and pharmacodynamic responses to rocuronium (Org 9426) were studied in 20 elderly (> 70 yr) and 20 younger control patients (< 60 yr) during N2O/O2, fentanyl anesthesia." | 1.29 | Pharmacokinetics and pharmacodynamics of rocuronium (Org 9426) in elderly surgical patients. ( Matteo, RS; Ornstein, E; Ostapkovich, N; Schwartz, AE; Stone, JG, 1993) |
| " Pharmacokinetic variables were calculated from the derived compartmental models." | 1.28 | Pharmacokinetics of sufentanil in the elderly surgical patient. ( Chang, WJ; Matteo, RS; Ornstein, E; Schwartz, AE; Young, WL, 1990) |
| " Dose-response curves of pancuronium were parallel in all age-groups." | 1.28 | Dose-response characteristics of pancuronium in neonates, infants and children. ( Luosto, T; Meretoja, OA, 1990) |
| " The elderly can show greater sensitivity to opioid drugs which may be related to pharmacokinetic differences." | 1.27 | The pharmacokinetics and clinical effects of a low dose of alfentanil in elderly patients. ( Bower, S; Dodson, ME; Kent, AP, 1988) |
| " The pharmacokinetic and pharmacodynamic components of each patient's dose-response relationship were evaluated simultaneously." | 1.27 | Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation. ( Scott, JC; Stanski, DR, 1987) |
| " Pharmacokinetic values were independent of dose." | 1.27 | The pharmacokinetics of alfentanil in children. ( Goresky, GV; Koren, G; Sabourin, MA; Sale, JP; Strunin, L, 1987) |
| "Alfentanil has a different pharmacokinetic and pharmacodynamic profile compared to fentanyl." | 1.27 | The clinical pharmacology of alfentanil. ( Stanski, DR, 1987) |
| " Plasma concentration versus time data were fitted to two- and three-compartment pharmacokinetic models, and clearance, volume of distribution at steady-state (Vdss), and elimination half-life were determined." | 1.27 | Pharmacokinetics of fentanyl in neonatal humans and lambs: effects of age. ( Fisher, DM; Gauntlett, IS; Hertzka, RE; Kuhls, E; Rudolph, C; Spellman, MJ, 1988) |
| " Pharmacokinetic variables were determined by non-compartmental techniques." | 1.27 | Pharmacokinetics of fentanyl in the elderly. ( Fisher, DM; Rosen, JI; Singleton, MA, 1988) |
| " It is suggested that individual dosing of fentanyl rather than continuous infusion should be preferred in routine neuroleptanalgesia." | 1.26 | ["Analgesic" fentanyl blood concentrations during neuroleptanalgesia]. ( Daub, D; Gensior, J; Lehmann, KA, 1982) |
| " This was reflected by a prolonged terminal elimination half-life in the elderly compared with the younger patients (945 versus 265 minutes, respectively, p less than 0." | 1.26 | Age and fentanyl pharmacokinetics. ( Bentley, JB; Borel, JD; Gillespie, TJ; Nenad, RE, 1982) |
Research
Studies (67)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (32.84) | 18.7374 |
| 1990's | 14 (20.90) | 18.2507 |
| 2000's | 19 (28.36) | 29.6817 |
| 2010's | 11 (16.42) | 24.3611 |
| 2020's | 1 (1.49) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Kantonen, T | 1 |
| Karjalainen, T | 1 |
| Isojärvi, J | 1 |
| Nuutila, P | 1 |
| Tuisku, J | 1 |
| Rinne, J | 1 |
| Hietala, J | 2 |
| Kaasinen, V | 1 |
| Kalliokoski, K | 1 |
| Scheinin, H | 1 |
| Hirvonen, J | 2 |
| Vehtari, A | 1 |
| Nummenmaa, L | 1 |
| Holmgaard, R | 1 |
| Benfeldt, E | 1 |
| Sorensen, JA | 1 |
| Nielsen, JB | 1 |
| Czwornog, J | 1 |
| Austin, GL | 1 |
| Mitzelfelt, JD | 2 |
| Carter, CS | 2 |
| Morgan, D | 2 |
| Takeuchi, Y | 1 |
| Knych, HK | 1 |
| Steffey, EP | 1 |
| Mitchell, MM | 1 |
| Casbeer, HC | 1 |
| Ren, J | 1 |
| Ding, X | 1 |
| Greer, JJ | 1 |
| Sidhu, SK | 1 |
| Weavil, JC | 1 |
| Venturelli, M | 1 |
| Rossman, MJ | 1 |
| Gmelch, BS | 1 |
| Bledsoe, AD | 1 |
| Richardson, RS | 1 |
| Amann, M | 1 |
| Akhtar, S | 1 |
| Liu, J | 1 |
| Heng, J | 1 |
| Dai, F | 1 |
| Schonberger, RB | 1 |
| Burg, MM | 1 |
| Apiliogullari, S | 1 |
| Duman, A | 1 |
| Gok, F | 1 |
| Dupree, JP | 1 |
| Seo, DO | 1 |
| Yucel, A | 1 |
| Gulhas, N | 1 |
| Aydogan, MS | 1 |
| Erdogan, MA | 1 |
| Beytur, A | 1 |
| Tasdemir, C | 1 |
| Ersoy, MO | 1 |
| Tuominen, L | 1 |
| Salo, J | 1 |
| Någren, K | 1 |
| Laine, P | 1 |
| Melartin, T | 1 |
| Isometsä, E | 1 |
| Viikari, J | 1 |
| Raitakari, O | 1 |
| Keltikangas-Järvinen, L | 1 |
| Cepeda, MS | 1 |
| Farrar, JT | 1 |
| Baumgarten, M | 1 |
| Boston, R | 1 |
| Carr, DB | 1 |
| Strom, BL | 1 |
| Okamura, K | 1 |
| Sanuki, M | 1 |
| Kinoshita, H | 1 |
| Fujii, K | 1 |
| Matsunaga, A | 1 |
| Bencherif, B | 1 |
| Stumpf, MJ | 1 |
| Links, JM | 1 |
| Frost, JJ | 1 |
| Kharasch, ED | 1 |
| Hoffer, C | 1 |
| Whittington, D | 1 |
| Laferrière, A | 1 |
| Colin-Durand, J | 1 |
| Moss, IR | 1 |
| Reich, DL | 1 |
| Hossain, S | 1 |
| Krol, M | 1 |
| Baez, B | 1 |
| Patel, P | 1 |
| Bernstein, A | 1 |
| Bodian, CA | 1 |
| Gupta, SK | 1 |
| Hwang, S | 1 |
| Southam, M | 1 |
| Sathyan, G | 1 |
| Janczewski, WA | 1 |
| Feldman, JL | 1 |
| Kuczkowski, KM | 1 |
| Kalso, E | 1 |
| Simpson, KH | 1 |
| Slappendel, R | 1 |
| Dejonckheere, J | 1 |
| Richarz, U | 1 |
| Jeleazcov, C | 1 |
| Ihmsen, H | 1 |
| Schmidt, J | 1 |
| Ammon, C | 1 |
| Schwilden, H | 1 |
| Schüttler, J | 1 |
| Fechner, J | 1 |
| d'Hollander, AA | 1 |
| Nevelsteen, M | 1 |
| Barvais, L | 1 |
| Baurain, M | 1 |
| Van Peer, A | 1 |
| Levron, JC | 2 |
| Noorduin, H | 1 |
| Heykants, J | 1 |
| Bentley, JB | 1 |
| Borel, JD | 1 |
| Nenad, RE | 1 |
| Gillespie, TJ | 1 |
| Lehmann, KA | 1 |
| Gensior, J | 1 |
| Daub, D | 1 |
| Danel, V | 1 |
| Gonod, E | 1 |
| Pomet, D | 1 |
| Kurth, CD | 1 |
| Steven, JM | 1 |
| Nicolson, SC | 1 |
| Katoh, T | 1 |
| Uchiyama, T | 1 |
| Ikeda, K | 1 |
| Holdsworth, MT | 1 |
| Forman, WB | 1 |
| Killilea, TA | 1 |
| Nystrom, KM | 1 |
| Paul, R | 1 |
| Brand, SC | 1 |
| Reynolds, R | 1 |
| Matteo, RS | 3 |
| Ornstein, E | 3 |
| Schwartz, AE | 3 |
| Ostapkovich, N | 1 |
| Stone, JG | 1 |
| Huang, FY | 1 |
| Wang, MJ | 1 |
| Huang, HH | 1 |
| Scholz, J | 1 |
| Steinfath, M | 1 |
| Schulz, M | 1 |
| Werry, C | 1 |
| Neulinger, A | 1 |
| Eckert, O | 1 |
| Lehmkuhl, P | 1 |
| Pichlmayr, I | 1 |
| Woodhouse, A | 1 |
| Mather, LE | 1 |
| Fleming, NW | 1 |
| Chung, F | 1 |
| Glass, PS | 1 |
| Kitts, JB | 1 |
| Kirkegaard-Nielsen, H | 1 |
| Gronert, GA | 1 |
| Chan, V | 1 |
| Gan, TJ | 1 |
| Cicutti, N | 1 |
| Caldwell, JE | 1 |
| Frank, SM | 1 |
| El-Rahmany, HK | 1 |
| Cattaneo, CG | 1 |
| Barnes, RA | 1 |
| Olmos, M | 1 |
| Ballester, JA | 1 |
| Vidarte, MA | 1 |
| Elizalde, JL | 1 |
| Escobar, A | 1 |
| Cressey, DM | 1 |
| Claydon, P | 1 |
| Bhaskaran, NC | 1 |
| Reilly, CS | 1 |
| Mathew, JP | 1 |
| Weatherwax, KJ | 1 |
| East, CJ | 1 |
| White, WD | 1 |
| Reves, JG | 1 |
| Ariano, RE | 1 |
| Duke, PC | 2 |
| Sitar, DS | 2 |
| Klein, LC | 1 |
| Kudoh, A | 1 |
| Katagai, H | 1 |
| Takazawa, T | 1 |
| Matsuki, A | 1 |
| Lien, CA | 1 |
| Diaz, J | 1 |
| Meistelman, C | 1 |
| Benhamou, D | 1 |
| Barre, J | 1 |
| Mahe, V | 1 |
| Mazoit, X | 1 |
| Ecoffey, C | 1 |
| Young, WL | 1 |
| Chang, WJ | 1 |
| Lampe, GH | 1 |
| Donegan, JH | 1 |
| Rupp, SM | 1 |
| Wauk, LZ | 1 |
| Whitendale, P | 1 |
| Fouts, KE | 1 |
| Rose, BM | 1 |
| Litt, LL | 1 |
| Rampil, IJ | 1 |
| Wilson, CB | 1 |
| Meretoja, OA | 1 |
| Luosto, T | 1 |
| Benthuysen, JL | 1 |
| Sanford, TJ | 1 |
| Smith, NT | 1 |
| Kent, AP | 1 |
| Dodson, ME | 1 |
| Bower, S | 1 |
| Cook, DR | 1 |
| Halliburton, JR | 1 |
| Wagner, HN | 1 |
| Scott, JC | 1 |
| Stanski, DR | 2 |
| Goresky, GV | 1 |
| Koren, G | 2 |
| Sabourin, MA | 1 |
| Sale, JP | 1 |
| Strunin, L | 1 |
| Lemmens, HJ | 1 |
| Bovill, JG | 1 |
| Hennis, PJ | 1 |
| Burm, AG | 1 |
| Gauntlett, IS | 1 |
| Fisher, DM | 3 |
| Hertzka, RE | 1 |
| Kuhls, E | 1 |
| Spellman, MJ | 1 |
| Rudolph, C | 1 |
| Singleton, MA | 2 |
| Rosen, JI | 2 |
| Bailey, CC | 1 |
| Kitchen, I | 1 |
| Baughman, VL | 1 |
| Hoffman, WE | 1 |
| Albrecht, RF | 1 |
| Miletich, DJ | 1 |
| Goresky, G | 1 |
| Crean, P | 1 |
| Klein, J | 1 |
| MacLeod, SM | 1 |
| Gemperle, M | 1 |
| Mosher, GL | 1 |
| Robinson, RH | 1 |
Clinical Trials (15)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Premature Fatigue in Veterans With Heart Failure: Neuronal Influences[NCT02209610] | Early Phase 1 | 32 participants (Actual) | Interventional | 2015-07-01 | Completed | ||
| Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461] | 137 participants (Actual) | Observational | 2009-07-31 | Completed | |||
| Comparison of the Effect of a Single Shot Saphenous Block With Plain Bupivacaine vs. Protracted Bupivacaine Mixture as a Supplement to Continuous Sciatic Catheter After Major Ankle and Foot Surgery[NCT02346110] | Phase 4 | 40 participants (Actual) | Interventional | 2015-04-30 | Completed | ||
| Fentanyl Effect on Blood Pressure in Elderly Patients After Induction of General Anesthesia[NCT02489019] | Phase 2/Phase 3 | 105 participants (Anticipated) | Interventional | 2018-02-19 | Recruiting | ||
| Focussed Echocardiography to Detect Preoperative Hypovolemia and Left Ventricular Dysfunction as a Predictor of Post-Induction Hypotension[NCT02944266] | 150 participants (Anticipated) | Observational | 2016-01-31 | Recruiting | |||
| Perfusion Index as a Predictor of Hypotension Following Propofol Induction of General Anesthesia in Geriatric Patients - A Prospective Observational Study.[NCT04682717] | 30 participants (Actual) | Observational | 2020-12-01 | Completed | |||
| Comparison of Leg Elevation and Leg Wrapping in the Prevention of Propofol Induced Hypotension: A Prospective Randomised Controlled Study[NCT02845921] | 150 participants (Anticipated) | Interventional | 2016-01-31 | Recruiting | |||
| Effect of the Pneumatic Compression of Lower Leg on Post-induction Hypotension in Elderly Patients Undergoing Robot Assisted Laparoscopic Prostatectomy: a Double Blined Randomized Controlled Trial[NCT05343689] | 100 participants (Actual) | Interventional | 2022-05-04 | Completed | |||
| "PGDT With the Hypotension Prediction Index to Reduce the Number and Duration of Intraoperative Hypotension and the Incidence of Renal Failure in Patients Undergoing Lung Surgery"[NCT04149314] | 142 participants (Actual) | Interventional | 2019-11-20 | Completed | |||
| Compare the Side Effects and Differences Awake Level of Propofol by Using Three TCI Formula of Anesthesia in TVOR Patients[NCT00760253] | 118 participants (Actual) | Observational | 2008-09-30 | Completed | |||
| Near Infrared Spectroscopy Monitoring of Cerebral Oxygen Saturation in Neonatal Cardiac Surgery - Comparison With Common Methods of Estimating Adequate Systemic Perfusion[NCT00166101] | 25 participants (Actual) | Observational | 2002-08-31 | Completed | |||
| Efficacy of a Thermal Insulation System in Inadvertent Hypothermia and Perioperative Comfort[NCT05131568] | 124 participants (Actual) | Interventional | 2018-10-15 | Completed | |||
| Neuromodulation With Percutaneous Electrical Nerve Field Stimulation for Adults With COVID-19[NCT04514627] | 100 participants (Anticipated) | Interventional | 2020-07-13 | Recruiting | |||
| A Hydromorphone High Resolution Pharmacokinetic-Pharmacodynamic Fingerprint as the Basis for Identifying Sex Differences in Opioid Pharmacokinetics and Pharmacodynamics[NCT01123486] | 0 participants (Actual) | Interventional | 2015-01-31 | Withdrawn (stopped due to PI relocated to new university) | |||
| Influence of Aging on Perioperative Methadone Dosing[NCT04526236] | Phase 4 | 60 participants (Actual) | Interventional | 2019-09-03 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Maximal Voluntary Quadriceps Force [% Change From Baseline]
Following dynamic single leg knee extension exercise for a given duration (4-8 min), the decline in maximal voluntary contraction force will be measured. (NCT02209610)
Timeframe: 1 minute after exercise on study day
| Intervention | percentage change (Mean) |
|---|---|
| Patients With Heart Failure: Neuromuscular Abnormalities | -30 |
| Health Control Subjects and Neuromuscular Function | -5 |
Muscle Afferent Affect
Corticospinal responsiveness will be quantified before and after exercise. (NCT02209610)
Timeframe: 1 minute after exercise on study day
| Intervention | percent change (Mean) |
|---|---|
| Patients With Heart Failure: Neuromuscular Abnormalities | -30 |
| Health Control Subjects and Neuromuscular Function | 10 |
Quadriceps Twitch Force and Voluntary Activation (% Change From Baseline)
During a 2-min maximal voluntary quadriceps contraction, central and peripheral fatigue will develop progressively and significantly more in HF vs. CTRLs. (NCT02209610)
Timeframe: During (20 second intervals) and 1 minute after exercise on study day
| Intervention | percentage change (Mean) | |
|---|---|---|
| Twitch force | Voluntary activation [VA] | |
| Health Control Subjects and Neuromuscular Function | -35 | -20 |
| Patients With Heart Failure: Neuromuscular Abnormalities | -60 | -25 |
Reviews
3 reviews available for fentanyl and Aging
| Article | Year |
|---|---|
Clinical pharmacokinetics of alfentanil, fentanyl and sufentanil. An update.
Topics: Aging; Alfentanil; Analgesics, Opioid; Fentanyl; Half-Life; Humans; Obesity; Sufentanil | 1996 |
Newborn anaesthesia: pharmacological considerations.
Topics: Aging; Anesthesia; Anesthesia, Inhalation; Cardiovascular Diseases; Dose-Response Relationship, Drug | 1986 |
The pharmacokinetics of fentanyl, sufentanil and alfentanil: a comparative review.
Topics: Aging; Alfentanil; Anesthetics; Chemical Phenomena; Chemistry, Physical; Fentanyl; Humans; Sufentani | 1988 |
Trials
15 trials available for fentanyl and Aging
| Article | Year |
|---|---|
Effects of age on the pharmacokinetics and selected pharmacodynamics of intravenously administered fentanyl in foals.
Topics: Aging; Analgesics, Opioid; Animals; Area Under Curve; Female; Fentanyl; Half-Life; Horses; Male | 2015 |
Single intrathecal fentanyl for combined spinal epidural anesthesia confers no advantage over hemodynamic effects in elderly patients.
Topics: Aged; Aged, 80 and over; Aging; Anesthesia, Epidural; Anesthesia, Spinal; Anesthetics, Intravenous; | 2012 |
Application of MRI-based partial-volume correction to the analysis of PET images of mu-opioid receptors using statistical parametric mapping.
Topics: Adult; Aged; Aging; Algorithms; Brain; Brain Mapping; Carbon Radioisotopes; Fentanyl; Humans; Image | 2004 |
Effects of application site and subject demographics on the pharmacokinetics of fentanyl HCl patient-controlled transdermal system (PCTS).
Topics: Administration, Cutaneous; Adolescent; Adult; Aging; Analgesics, Opioid; Area Under Curve; Body Weig | 2005 |
Predicting long-term response to strong opioids in patients with low back pain: findings from a randomized, controlled trial of transdermal fentanyl and morphine.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Dose-Response | 2007 |
Effect of fentanyl on awakening concentration of sevoflurane.
Topics: Adult; Aging; Anesthesia Recovery Period; Anesthesia, General; Anesthetics; Awareness; Dose-Response | 1994 |
[Age-related correlation between EEG parameters and depth of anesthesia under propofol. Effect of fentanyl].
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aging; Anesthetics, Combined; Anesthetics, Intravenous; El | 1996 |
The influence of age upon opioid analgesic use in the patient-controlled analgesia (PCA) environment.
Topics: Adult; Aged; Aging; Analgesia, Patient-Controlled; Analgesics, Opioid; Double-Blind Method; Drug Adm | 1997 |
Comparison of the intubation conditions provided by rapacuronium (ORG 9487) or succinylcholine in humans during anesthesia with fentanyl and propofol.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Combined; Anesthetics, Intravenous; | 1999 |
Predictors of hypothermia during spinal anesthesia.
Topics: Aged; Aging; Analysis of Variance; Anesthesia, Spinal; Anesthetics, Intravenous; Anesthetics, Local; | 2000 |
The combined effect of age and premedication on the propofol requirements for induction by target-controlled infusion.
Topics: Adjuvants, Anesthesia; Adult; Aged; Aging; Analgesics, Opioid; Anesthetics, Intravenous; Blood Press | 2000 |
Effect of midazolam pretreatment on induction dose requirements of propofol in combination with fentanyl in younger and older adults.
Topics: Adjuvants, Anesthesia; Adolescent; Adult; Aged; Aging; Analysis of Variance; Anesthetics, Intravenou | 2001 |
Bispectral analysis during cardiopulmonary bypass: the effect of hypothermia on the hypnotic state.
Topics: Adjuvants, Anesthesia; Aged; Aging; Analgesics, Opioid; Anesthesia, General; Anesthetics, Inhalation | 2001 |
Population pharmacokinetics of fentanyl in healthy volunteers.
Topics: Adult; Age Distribution; Aged; Aging; Analysis of Variance; Female; Fentanyl; Humans; Infusions, Int | 2001 |
Nitrous oxide and epinephrine-induced arrhythmias.
Topics: Adult; Aging; Anesthesia, Inhalation; Arrhythmias, Cardiac; Electrocardiography; Epinephrine; Female | 1990 |
Other Studies
49 other studies available for fentanyl and Aging
| Article | Year |
|---|---|
Interindividual variability and lateralization of μ-opioid receptors in the human brain.
Topics: Adult; Aging; Analgesics, Opioid; Body Mass Index; Brain Chemistry; Female; Fentanyl; Functional Lat | 2020 |
Chronological age affects the permeation of fentanyl through human skin in vitro.
Topics: Adult; Aged; Aging; Analgesics, Opioid; Female; Fentanyl; Humans; In Vitro Techniques; Middle Aged; | 2013 |
Body mass index, age, and gender affect prep quality, sedation use, and procedure time during screening colonoscopy.
Topics: Aging; Anesthetics, Intravenous; Body Mass Index; Colonoscopy; Female; Fentanyl; Humans; Male; Midaz | 2013 |
Thermal sensitivity across ages and during chronic fentanyl administration in rats.
Topics: Aging; Analgesics, Opioid; Animals; Body Weight; Chronic Pain; Data Interpretation, Statistical; Fen | 2014 |
Screening colonoscopy: still the best choice, but for how long?
Topics: Aging; Body Mass Index; Colonoscopy; Female; Fentanyl; Humans; Male; Midazolam | 2013 |
5-HT1A receptor agonist Befiradol reduces fentanyl-induced respiratory depression, analgesia, and sedation in rats.
Topics: Aging; Analgesia; Anesthetics, Intravenous; Animals; Arousal; Behavior, Animal; Brain Stem; Consciou | 2015 |
Aging alters muscle reflex control of autonomic cardiovascular responses to rhythmic contractions in humans.
Topics: Adult; Aged; Aging; Analgesics, Opioid; Arterial Pressure; Autonomic Nervous System; Cardiac Output; | 2015 |
Does intravenous induction dosing among patients undergoing gastrointestinal surgical procedures follow current recommendations: a study of contemporary practice.
Topics: Adult; Aged; Aged, 80 and over; Aging; Algorithms; Anesthesia, Intravenous; Anesthetics, Intravenous | 2016 |
Do infants need higher intrathecal fentanyl doses than older children?
Topics: Aging; Anesthesia, Spinal; Anesthetics, Intravenous; Child; Dose-Response Relationship, Drug; Fentan | 2008 |
Effects of chronic fentanyl administration on physical performance of aged rats.
Topics: Aging; Analgesics, Opioid; Animals; Behavior, Animal; Body Composition; Body Weight; Drug Evaluation | 2011 |
Temperament trait Harm Avoidance associates with μ-opioid receptor availability in frontal cortex: a PET study using [(11)C]carfentanil.
Topics: Adult; Aging; Analgesics, Opioid; Anxiety; Brain Mapping; Carbon Radioisotopes; Fear; Female; Fentan | 2012 |
Side effects of opioids during short-term administration: effect of age, gender, and race.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta | 2003 |
Side effects of opioids during short-term administration: effect of age, gender, and race.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta | 2003 |
Side effects of opioids during short-term administration: effect of age, gender, and race.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta | 2003 |
Side effects of opioids during short-term administration: effect of age, gender, and race.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Analgesics, Opioid; Cohort Studies; Female; Fenta | 2003 |
[Study of nausea and vomiting accompanying intravenous patient-controlled analgesia with fentanyl after cervical spine surgery].
Topics: Aged; Aging; Analgesia, Patient-Controlled; Antiemetics; Cervical Vertebrae; Female; Fentanyl; Human | 2003 |
Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate.
Topics: Administration, Oral; Aged; Aging; Analgesics, Opioid; Area Under Curve; Chromatography, High Pressu | 2004 |
Ontogeny of respiratory sensitivity and tolerance to the mu-opioid agonist fentanyl in rat.
Topics: Age Factors; Aging; Analgesics, Opioid; Analysis of Variance; Animals; Animals, Newborn; Dose-Respon | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Predictors of hypotension after induction of general anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Blood Pr | 2005 |
Distinct rhythm generators for inspiration and expiration in the juvenile rat.
Topics: Aging; Animals; Biological Clocks; Decerebrate State; Exhalation; Female; Fentanyl; Inhalation; Lung | 2006 |
Anesthetic implications of botulinum toxin type A (Botox) injections for the treatment of 'the aging face' in the parturient.
Topics: Adult; Aging; Anesthesia Recovery Period; Anesthesia, General; Anesthesia, Obstetrical; Anesthetics, | 2007 |
Pharmacodynamic modelling of the bispectral index response to propofol-based anaesthesia during general surgery in children.
Topics: Adolescent; Aging; Anesthesia, Intravenous; Anesthetics, Combined; Anesthetics, Intravenous; Blood P | 2008 |
Effect of age on the establishment of muscle paralysis induced in anaesthetized adult subjects by ORG NC 45.
Topics: Adolescent; Adult; Aged; Aging; Anesthesia; Fentanyl; Humans; Methohexital; Middle Aged; Pancuronium | 1983 |
Overview of the clinical pharmacokinetics of alfentanil.
Topics: Adolescent; Adult; Aged; Aging; Alfentanil; Analgesics; Child; Child, Preschool; Fentanyl; Half-Life | 1984 |
Age and fentanyl pharmacokinetics.
Topics: Adult; Aged; Aging; Female; Fentanyl; Half-Life; Humans; Kinetics; Middle Aged; Models, Biological | 1982 |
["Analgesic" fentanyl blood concentrations during neuroleptanalgesia].
Topics: Adult; Aging; Analgesics; Female; Fentanyl; Humans; Male; Middle Aged; Neuroleptanalgesia; Sex Facto | 1982 |
[Anaesthesia by administration at a constant rate of fentanyl and methohexitone (300 patients). Clinical study (author's transl)].
Topics: Aging; Analgesia; Anesthesia, General; Body Weight; Bone and Bones; Female; Fentanyl; Humans; Male; | 1980 |
Cerebral oxygenation during pediatric cardiac surgery using deep hypothermic circulatory arrest.
Topics: Aging; Anesthesia; Brain; Cardiac Surgical Procedures; Child, Preschool; Fentanyl; Hemodynamics; Hum | 1995 |
Transdermal fentanyl disposition in elderly subjects.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Aging; Female; Fentanyl; Humans; Male; Me | 1994 |
Pharmacokinetics and pharmacodynamics of rocuronium (Org 9426) in elderly surgical patients.
Topics: Adult; Aged; Aging; Androstanols; Anesthesia, Inhalation; Anesthesia, Intravenous; Female; Fentanyl; | 1993 |
Differences in temperature changes between pediatric and adult patients after cardiopulmonary bypass.
Topics: Adult; Aging; Anesthesia, Intravenous; Body Temperature; Cardiac Surgical Procedures; Cardiopulmonar | 1993 |
Effects of adolescent nicotine exposure on opioid consumption and neuroendocrine responses in adult male and female rats.
Topics: Adrenocorticotropic Hormone; Aging; Analgesics, Opioid; Animals; Body Weight; Corticosterone; Drinki | 2001 |
Plasma proinflammatory cytokine response to surgical stress in elderly patients.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Anesthetics, Inhalation; Anesthetics, Intravenou | 2001 |
Distribution, elimination, and action of vecuronium in the elderly.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthesia; Fentanyl; Humans; Middle Aged; Nitrous Oxide; Sur | 1991 |
Effects of age on plasma protein binding of sufentanil.
Topics: Adult; Aging; Anesthetics; Blood Proteins; Child; Child, Preschool; Fentanyl; Humans; Infant; Infant | 1990 |
Pharmacokinetics of sufentanil in the elderly surgical patient.
Topics: Adult; Aged; Aging; Anesthesia, Intravenous; Anesthetics; Carbon Dioxide; Endarterectomy; Female; Fe | 1990 |
Dose-response characteristics of pancuronium in neonates, infants and children.
Topics: Adolescent; Aging; Anesthesia Recovery Period; Anesthesia, Intravenous; Child; Child, Preschool; Dos | 1990 |
Aging and alfentanil disposition in healthy volunteers and surgical patients.
Topics: Adult; Aged; Aging; Alfentanil; Female; Fentanyl; Humans; Male; Middle Aged; Smoking; Stress, Physio | 1989 |
The pharmacokinetics and clinical effects of a low dose of alfentanil in elderly patients.
Topics: Aged; Aged, 80 and over; Aging; Alfentanil; Analgesics, Opioid; Anesthesia, Inhalation; Female; Fent | 1988 |
Radiolabeled drugs as probes of central nervous system neurons.
Topics: Adult; Aged; Aging; Brain; Brain Chemistry; Female; Fentanyl; Forecasting; Humans; Isotope Labeling; | 1985 |
Decreased fentanyl and alfentanil dose requirements with age. A simultaneous pharmacokinetic and pharmacodynamic evaluation.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alfentanil; Dose-Response Relationship, Drug; Electroencephal | 1987 |
The pharmacokinetics of alfentanil in children.
Topics: Adolescent; Aging; Alfentanil; Anesthesia, Intravenous; Anesthetics; Body Weight; Child; Child, Pres | 1987 |
The clinical pharmacology of alfentanil.
Topics: Aging; Alfentanil; Anesthetics; Electroencephalography; Fentanyl; Half-Life; Humans | 1987 |
Age has no effect on the pharmacodynamics of alfentanil.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alfentanil; Anesthesia; Dose-Response Relationship, Drug; Fem | 1988 |
Pharmacokinetics of fentanyl in neonatal humans and lambs: effects of age.
Topics: Aging; Animals; Animals, Newborn; Fentanyl; Humans; Infant; Infant, Newborn; Sheep | 1988 |
Pharmacokinetics of fentanyl in the elderly.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anesthesia, General; Fentanyl; Humans; Infusions, Intravenous | 1988 |
Developmental responses to opioids reveals a lack of effect on stress-induced corticosterone levels in neonatal rats.
Topics: Aging; Animals; Animals, Newborn; Buprenorphine; Corticosterone; Female; Fentanyl; Male; Morphine; N | 1987 |
Cerebral vascular and metabolic effects of fentanyl and midazolam in young and aged rats.
Topics: Aging; Animals; Cerebral Cortex; Cerebrovascular Circulation; Depression, Chemical; Electroencephalo | 1987 |
Unexpected alterations in fentanyl pharmacokinetics in children undergoing cardiac surgery: age related or disease related?
Topics: Adolescent; Aging; Child; Child, Preschool; Endocardial Cushion Defects; Fentanyl; Half-Life; Heart | 1986 |
Plasma concentrations of fentanyl in infants, children and adults.
Topics: Adolescent; Adult; Aging; Child; Child, Preschool; Fentanyl; Humans; Infant | 1987 |
[Neuroleptoanalgesia].
Topics: Aged; Aging; Animals; Cardiac Surgical Procedures; Cardiovascular System; Catecholamines; Central Ne | 1970 |
Anesthesia for fractured hips. Innovar versus halothane.
Topics: Adult; Aged; Aging; Benperidol; Drug Combinations; Female; Fentanyl; Fractures, Bone; Halothane; Hip | 1972 |