fenretinide and Scleroderma--Systemic

fenretinide has been researched along with Scleroderma--Systemic* in 1 studies

Other Studies

1 other study(ies) available for fenretinide and Scleroderma--Systemic

Article	Year
The synthetic retinoid (4-hydroxyphenyl)retinamide decreases collagen expression in vitro and in the tight-skin mouse. Arthritis and rheumatism, 1993, Volume: 36, Issue:7 We documented the effect of the retinoid (4-hydroxyphenyl)retinamide on collagen expression in a tissue culture and in an animal model of scleroderma.. We used RNA analysis, chloramphenicol acetyltransferase assays, organ culture, and histologic evaluation.. We showed that (4-hydroxyphenyl)retinamide decreases alpha 1(I) collagen messenger RNA and transcription in cultured cells, and decreases collagen levels in the dermis of tight-skin mice.. These results provide a basis for further experiments to address the efficacy of (4-hydroxyphenyl)retinamide in the treatment of scleroderma. Topics: Animals; Cell Division; Collagen; Disease Models, Animal; Fenretinide; Fibroblasts; Gene Expression; Humans; Male; Mice; Mice, Mutant Strains; RNA, Messenger; Scleroderma, Systemic; Skin; Transforming Growth Factor beta	1993

Article

Year

The synthetic retinoid (4-hydroxyphenyl)retinamide decreases collagen expression in vitro and in the tight-skin mouse.

Arthritis and rheumatism, 1993, Volume: 36, Issue:7

We documented the effect of the retinoid (4-hydroxyphenyl)retinamide on collagen expression in a tissue culture and in an animal model of scleroderma.. We used RNA analysis, chloramphenicol acetyltransferase assays, organ culture, and histologic evaluation.. We showed that (4-hydroxyphenyl)retinamide decreases alpha 1(I) collagen messenger RNA and transcription in cultured cells, and decreases collagen levels in the dermis of tight-skin mice.. These results provide a basis for further experiments to address the efficacy of (4-hydroxyphenyl)retinamide in the treatment of scleroderma.

Topics: Animals; Cell Division; Collagen; Disease Models, Animal; Fenretinide; Fibroblasts; Gene Expression; Humans; Male; Mice; Mice, Mutant Strains; RNA, Messenger; Scleroderma, Systemic; Skin; Transforming Growth Factor beta

1993