fenretinide has been researched along with Bronchial-Diseases* in 1 studies
1 other study(ies) available for fenretinide and Bronchial-Diseases
Article | Year |
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Involvement of mitochondrial and Akt signaling pathways in augmented apoptosis induced by a combination of low doses of celecoxib and N-(4-hydroxyphenyl) retinamide in premalignant human bronchial epithelial cells.
Celecoxib is being evaluated as a chemopreventive agent. However, its mechanism of action is not clear because high doses were used for in vitro studies to obtain antitumor effects. We found that celecoxib inhibited the growth of premalignant and malignant human bronchial epithelial cells with IC(50) values between 8.9 and 32.7 micromol/L, irrespective of cyclooxygenase-2 (COX-2) expression. Normal human bronchial epithelial cells were less sensitive to celecoxib. Because these concentrations were higher than those attainable in vivo ( Topics: Anticarcinogenic Agents; Apoptosis; Bronchi; Bronchial Diseases; Celecoxib; Cell Line, Tumor; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Drug Screening Assays, Antitumor; Drug Synergism; Epithelial Cells; Fenretinide; Humans; Lung Neoplasms; Mitochondria; Phosphorylation; Precancerous Conditions; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Pyrazoles; Recombinant Fusion Proteins; Sulfonamides | 2006 |