fenprostalene and Ovarian-Cysts

Of 170 cows with ovarian cysts which were detected by palpation of the ovaries per rectum, 88 cows (51.8%) were diagnosed as having follicular cysts on the basis of milk progesterone concentrations. Eighty-three of the 88 cows were used for treatment trials. A group of 56 cows injected subcutaneously with fenprostalene, prostaglandin F2 alpha analog, 14 days after treatment with fertirelin, an analog of gonadotropin-releasing hormone, compared with another 27 cows treated only with fertirelin (controls), showed a higher pregnancy rate within 100 days after the initial treatment (66.1 vs 48.1%) and shorter intervals from the treatment to conception (30 +/- 21 vs 43 +/- 27 days). It was concluded that the administration of fenprostalene following fertirelin treatment is effective in shortening the interval from treatment to conception in cows with follicular cysts.

Topics: Abortifacient Agents, Nonsteroidal; Animals; Biomarkers; Cattle; Cattle Diseases; Clinical Trials as Topic; Drug Therapy, Combination; Estrus; Female; Gonadotropin-Releasing Hormone; Hormones; Milk; Ovarian Cysts; Ovarian Follicle; Pregnancy; Pregnancy, Animal; Progesterone; Prostaglandins F, Synthetic; Rectum