Page last updated: 2024-10-27

fenoprofen and Rheumatoid Arthritis

fenoprofen has been researched along with Rheumatoid Arthritis in 36 studies

Fenoprofen: A propionic acid derivative that is used as a non-steroidal anti-inflammatory agent.
fenoprofen : A monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 2 is substituted by a 3-phenoxyphenyl group. A non-steroidal anti-inflammatory drug, the dihydrate form of the calcium salt is used for the management of mild to moderate pain and for the relief of pain and inflammation associated with disorders such as arthritis. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.

Research Excerpts

ExcerptRelevanceReference
"In doses of 1,200 mg/day or more, ibuprofen is as effective as aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of rheumatoid arthritis."10.15Update on ibuprofen for rheumatoid arthritis. ( Ward, JR, 1984)
"To investigate the influence of rheumatoid arthritis on the stereoselective disposition of fenoprofen administered as a racemic mixture, eight patients with rheumatoid arthritis receiving calcium rac-fenoprofen (200 mg/8 h) and 7 healthy volunteers given single oral dose (600 mg) were investigated."9.11Influence of rheumatoid arthritis in the enantioselective disposition of fenoprofen. ( Barissa, GR; Donadi, EA; Dos Reis, ML; Lanchote, VL; Poggi, JC, 2004)
" Fourteen patients with rheumatoid arthritis received equivalent therapeutic doses of the antinflammatory drugs aspirin, 4 gm/day, and fenoprofen calcium, 2."9.04Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers. ( Craig, RM; Culic, DD; Falk, J; Loebl, DH; Ridolfo, AS; Schmid, FR, 1977)
"Fenoprofen1 (dl-2-[3-phenoxyphenyl]propionic acid) is a new non-steroidal anti-inflammatory, antipyretic, analgesic agent advocated for use in rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and gout."9.04Fenoprofen: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases. ( Avery, GS; Brogden, RN; Pinder, RM; Speight, TM, 1977)
"9% of a group of 18 patients with rheumatoid arthritis participating in an open-label study with fenoprofen calcium (Nalfon), there was observed a mean titre decrease in level of rheumatoid factor as compared to baseline levels."9.04The effect of fenoprofen calcium (Nalfon) on levels of rheumatoid factor in patients with rheumatoid arthritis. ( Duff, IF; Himes, JE, 1977)
"Fenoprofen calcium (FC) was compared to aspirin (ASA) in 20 patients with rheumatoid arthritis in a double-blind parallel study."9.04Fenoprofen calcium therapy in rheumatoid arthritis. ( Auclair, RJ; Zuckner, J, 1976)
"The pooled data of a multi-clinic, double-blind, crossover study (16 weeks' duration), comparing fenoprofen and aspirin in 116 patients with active rheumatoid arthritis are reported."9.04Fenoprofen in rheumatoid arthritis: a controlled crossover multi-centre study. ( Gum, OB, 1976)
"Thirty patients with active definite or classic rheumatoid arthritis (RA), participated in a double-blind crossover study comparing fenoprofen calcium with placebo."9.04Fenoprofen in patients with rheumatoid arthritis receiving maintenance gold therapy. ( Duff, IF; Himes, JE; Neukom, JE, 1976)
"Twenty-one patients with active rheumatoid arthritis on maintenance corticosteroids were studied during a double-blind, crossover trial with fenoprofen."9.04Fenoprofen calcium in steroid treated rheumatoid arthritis: efficacy, safety, and steroid-sparing effect. ( Blechman, WJ; Zane, S, 1976)
"Fenoprofen, a new antirheumatic agent, was evaluated in 45 patients with rheumatoid arthritis in an open study design to simulate the conditions under which the drug will be used."9.04Longterm fenoprofen therapy in patients with rheumatoid arthritis. ( Englund, DW; Harris, BK; Roth, SH, 1976)
"Fenoprofen calcium was compared with acetylsalicylic acid in the treatment of 27 patients with definite or classic rheumatoid arthritis, over a period of one year."9.04Some problems in the interpretation of clinical trials: longterm parallel study of fenoprofen in rheumatoid arthritis. ( Britton, MC; Fries, JF, 1976)
"Aspirin was associated with significantly higher mean serum glutamic oxaloacetic transaminase (SGOT) levels than fenoprofen, but only among patients undergoing gold induction."6.64Fenoprofen, aspirin, and gold induction in rheumatoid arthritis. ( Collins, RL; Davis, JD; Kaufmann, JS; Ruchte, IR; Turner, RA, 1977)
"In doses of 1,200 mg/day or more, ibuprofen is as effective as aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of rheumatoid arthritis."6.15Update on ibuprofen for rheumatoid arthritis. ( Ward, JR, 1984)
"To investigate the influence of rheumatoid arthritis on the stereoselective disposition of fenoprofen administered as a racemic mixture, eight patients with rheumatoid arthritis receiving calcium rac-fenoprofen (200 mg/8 h) and 7 healthy volunteers given single oral dose (600 mg) were investigated."5.11Influence of rheumatoid arthritis in the enantioselective disposition of fenoprofen. ( Barissa, GR; Donadi, EA; Dos Reis, ML; Lanchote, VL; Poggi, JC, 2004)
" Fourteen patients with rheumatoid arthritis received equivalent therapeutic doses of the antinflammatory drugs aspirin, 4 gm/day, and fenoprofen calcium, 2."5.04Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers. ( Craig, RM; Culic, DD; Falk, J; Loebl, DH; Ridolfo, AS; Schmid, FR, 1977)
"Fenoprofen1 (dl-2-[3-phenoxyphenyl]propionic acid) is a new non-steroidal anti-inflammatory, antipyretic, analgesic agent advocated for use in rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and gout."5.04Fenoprofen: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases. ( Avery, GS; Brogden, RN; Pinder, RM; Speight, TM, 1977)
"9% of a group of 18 patients with rheumatoid arthritis participating in an open-label study with fenoprofen calcium (Nalfon), there was observed a mean titre decrease in level of rheumatoid factor as compared to baseline levels."5.04The effect of fenoprofen calcium (Nalfon) on levels of rheumatoid factor in patients with rheumatoid arthritis. ( Duff, IF; Himes, JE, 1977)
"Ninety patients with rheumatoid arthritis completed a double-blind crossover trial comparing fenoprofen, ibuprofen, ketoprofen, and naproxen."5.04Four new anti-inflammatory drugs: responses and variations. ( Balme, HW; Franklin, S; Huskisson, EC; Scott, J; Woolf, DL, 1976)
"Fenoprofen calcium (FC) was compared to aspirin (ASA) in 20 patients with rheumatoid arthritis in a double-blind parallel study."5.04Fenoprofen calcium therapy in rheumatoid arthritis. ( Auclair, RJ; Zuckner, J, 1976)
"The pooled data of a multi-clinic, double-blind, crossover study (16 weeks' duration), comparing fenoprofen and aspirin in 116 patients with active rheumatoid arthritis are reported."5.04Fenoprofen in rheumatoid arthritis: a controlled crossover multi-centre study. ( Gum, OB, 1976)
"Thirty patients with active definite or classic rheumatoid arthritis (RA), participated in a double-blind crossover study comparing fenoprofen calcium with placebo."5.04Fenoprofen in patients with rheumatoid arthritis receiving maintenance gold therapy. ( Duff, IF; Himes, JE; Neukom, JE, 1976)
"Twenty-one patients with active rheumatoid arthritis on maintenance corticosteroids were studied during a double-blind, crossover trial with fenoprofen."5.04Fenoprofen calcium in steroid treated rheumatoid arthritis: efficacy, safety, and steroid-sparing effect. ( Blechman, WJ; Zane, S, 1976)
"Fenoprofen, a new antirheumatic agent, was evaluated in 45 patients with rheumatoid arthritis in an open study design to simulate the conditions under which the drug will be used."5.04Longterm fenoprofen therapy in patients with rheumatoid arthritis. ( Englund, DW; Harris, BK; Roth, SH, 1976)
"Fenoprofen calcium was compared with acetylsalicylic acid in the treatment of 27 patients with definite or classic rheumatoid arthritis, over a period of one year."5.04Some problems in the interpretation of clinical trials: longterm parallel study of fenoprofen in rheumatoid arthritis. ( Britton, MC; Fries, JF, 1976)
"We know from adult randomised controlled trials that some NSAIDs, such as ibuprofen, naproxen, and aspirin, can be effective in certain chronic pain conditions."4.95Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. ( Anderson, B; Cooper, TE; Eccleston, C; Fisher, E; Wilkinson, NM, 2017)
"Fenoprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID) against rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis and gout."4.31Carborane Analogues of Fenoprofen Exhibit Improved Antitumor Activity. ( Hey-Hawkins, E; Laube, M; Lönnecke, P; Maksimović-Ivanić, D; Mijatović, S; Mojić, M; Pietzsch, J; Useini, L, 2023)
"The new antirheumatic agents, fenoprofen calcium, naproxen, and tolmetin sodium, are effective in the management of rheumatoid arthritis."3.65New antirheumatic agents: Fenoprofen calcium (Nalfon), naproxen (Naprosyn), and tolmetin sodium (Tolectin). ( Lewis, JR, 1977)
"Aspirin was associated with significantly higher mean serum glutamic oxaloacetic transaminase (SGOT) levels than fenoprofen, but only among patients undergoing gold induction."2.64Fenoprofen, aspirin, and gold induction in rheumatoid arthritis. ( Collins, RL; Davis, JD; Kaufmann, JS; Ruchte, IR; Turner, RA, 1977)
"Treatment of rheumatoid arthritis is often frustrating for patient and physician alike because of its chronic nature and our lack of knowledge about precise cause."2.35Treatment of rheumatoid arthritis: a review including newer and experimental anti-inflammatory agents. ( Kaye, RL; Pemberton, RE, 1976)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199031 (86.11)18.7374
1990's1 (2.78)18.2507
2000's2 (5.56)29.6817
2010's1 (2.78)24.3611
2020's1 (2.78)2.80

Authors

AuthorsStudies
Useini, L1
Mojić, M1
Laube, M1
Lönnecke, P1
Mijatović, S1
Maksimović-Ivanić, D1
Pietzsch, J1
Hey-Hawkins, E1
Eccleston, C1
Cooper, TE1
Fisher, E1
Anderson, B1
Wilkinson, NM1
Barissa, GR2
Poggi, JC1
Donadi, EA2
Dos Reis, ML1
Lanchote, VL2
De Miranda Silva, C1
Marques, MP1
Da Silva, LM1
Ward, JR1
Thomsen, BS1
From, A1
Jacobsen, IA1
Starklint, H1
Pedersen, PC1
Zizic, TM1
Simon, LS1
Mills, JA1
Dieppe, P1
Doyle, D1
Jacoby, R1
Nash, DP1
James, MF1
Heald, G1
Shorter, JH1
Turner, RA2
Lipsmeyer, EA1
Kilpatrick, FW1
Hadler, NM1
Loebl, DH1
Craig, RM1
Culic, DD1
Ridolfo, AS2
Falk, J1
Schmid, FR1
Lewis, JR1
Brogden, RN1
Pinder, RM1
Speight, TM1
Avery, GS1
Reinicke, C1
Himes, JE2
Duff, IF2
Pemberton, RE2
Strand, LJ1
Davis, JD1
Collins, RL1
Ruchte, IR1
Kaufmann, JS1
Franke, M1
Manz, G1
Scherbel, AL1
Huskisson, EC1
Woolf, DL1
Balme, HW1
Scott, J1
Franklin, S1
Zuckner, J1
Auclair, RJ1
Gum, OB1
Neukom, JE1
Blechman, WJ1
Zane, S1
Roth, SH1
Englund, DW1
Harris, BK1
Sigler, JW1
Bluhm, GB1
Fries, JF1
Britton, MC1
Kaye, RL1
Turner, R1
Zarro, VJ1
Marcolongo, R1
Camarri, E1
Tocca, M1
Fanteria, E1

Reviews

5 reviews available for fenoprofen and Rheumatoid Arthritis

ArticleYear
Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents.
    The Cochrane database of systematic reviews, 2017, 08-02, Volume: 8

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Arthritis, Rheumatoid; Asp

2017
Update on ibuprofen for rheumatoid arthritis.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Tolerance;

1984
Nonsteroidal antiinflammatory drugs (second of two parts).
    The New England journal of medicine, 1980, May-29, Volume: 302, Issue:22

    Topics: Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Fenoprofen; Humans; Ibuprofen; Mefenamic

1980
[Nonsteroid antirheumatic agents].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1977, Jul-15, Volume: 32, Issue:14

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Fenoprofen; Flufenamic Acid; Humans; Indomethacin;

1977
Treatment of rheumatoid arthritis: a review including newer and experimental anti-inflammatory agents.
    Archives of internal medicine, 1976, Volume: 136, Issue:9

    Topics: Activities of Daily Living; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Arthri

1976

Trials

19 trials available for fenoprofen and Rheumatoid Arthritis

ArticleYear
Influence of rheumatoid arthritis in the enantioselective disposition of fenoprofen.
    Chirality, 2004, Volume: 16, Issue:9

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Arthritis, Rheumatoid; Female; Fen

2004
Homoeopathy.
    Lancet (London, England), 1983, Feb-26, Volume: 1, Issue:8322

    Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Fenoprofen; Homeopathy; Humans; Phytotherapy; Plant

1983
Update on ibuprofen for rheumatoid arthritis.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Tolerance;

1984
Arthritis: anti-inflammatory drugs in practice.
    The Practitioner, 1981, Volume: 225, Issue:1353

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Apazone; Arthritis, Rheumatoid; As

1981
Gastrointestinal blood loss. Effect of aspirin, fenoprofen, and acetaminophen in rheumatoid arthritis as determined by sequential gastroscopy and radioactive fecal markers.
    JAMA, 1977, Mar-07, Volume: 237, Issue:10

    Topics: Acetaminophen; Aged; Arthritis, Rheumatoid; Aspirin; Autoradiography; Blood Specimen Collection; Fem

1977
Fenoprofen: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases.
    Drugs, 1977, Volume: 13, Issue:4

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Blood Platelets; Clinical Tria

1977
The effect of fenoprofen calcium (Nalfon) on levels of rheumatoid factor in patients with rheumatoid arthritis.
    The Journal of international medical research, 1977, Volume: 5, Issue:6

    Topics: Arthritis, Rheumatoid; Calcium; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Feno

1977
A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents.
    Digestive diseases and sciences, 1979, Volume: 24, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as

1979
Fenoprofen, aspirin, and gold induction in rheumatoid arthritis.
    Clinical pharmacology and therapeutics, 1977, Volume: 21, Issue:1

    Topics: Adult; Arthritis, Rheumatoid; Aspartate Aminotransferases; Aspirin; Clinical Trials as Topic; Drug T

1977
Comparison of fenoprofen and oxyphenbutazone in patients with rheumatoid arthritis.
    Current therapeutic research, clinical and experimental, 1977, Volume: 21, Issue:1

    Topics: Adult; Aged; Alkaline Phosphatase; Arthritis, Rheumatoid; Blood Sedimentation; Clinical Trials as To

1977
Four new anti-inflammatory drugs: responses and variations.
    British medical journal, 1976, May-01, Volume: 1, Issue:6017

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Fenoprofen; Gastrointesti

1976
Fenoprofen calcium therapy in rheumatoid arthritis.
    The Journal of rheumatology, 1976, Volume: 2

    Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Fenoprofen; Humans; Middle Ag

1976
Fenoprofen in rheumatoid arthritis: a controlled crossover multi-centre study.
    The Journal of rheumatology, 1976, Volume: 2

    Topics: Adolescent; Adult; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Female; Fenoprofen; Hum

1976
Fenoprofen in patients with rheumatoid arthritis receiving maintenance gold therapy.
    The Journal of rheumatology, 1976, Volume: 2

    Topics: Adult; Aged; Arthritis, Rheumatoid; Calcium; Clinical Trials as Topic; Fenoprofen; Gold; Humans; Mid

1976
Fenoprofen calcium in steroid treated rheumatoid arthritis: efficacy, safety, and steroid-sparing effect.
    The Journal of rheumatology, 1976, Volume: 2

    Topics: Adrenal Cortex Hormones; Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Fenop

1976
Longterm fenoprofen therapy in patients with rheumatoid arthritis.
    The Journal of rheumatology, 1976, Volume: 2

    Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Fenoprofen; Gastrointestinal D

1976
Comparison of benefit-to-risk ratios of aspirin and fenoprofen: controlled multicentre study in rheumatoid arthritis.
    The Journal of rheumatology, 1976, Volume: 2

    Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Female; Fenoprofe

1976
Some problems in the interpretation of clinical trials: longterm parallel study of fenoprofen in rheumatoid arthritis.
    The Journal of rheumatology, 1976, Volume: 2

    Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Fenoprofen; Humans; Phenylpropionates

1976
Fenoprofen.
    Drug and therapeutics bulletin, 1974, Jun-21, Volume: 12, Issue:13

    Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Fenoprofen; Humans; Male; Osteoarthritis;

1974

Other Studies

13 other studies available for fenoprofen and Rheumatoid Arthritis

ArticleYear
Carborane Analogues of Fenoprofen Exhibit Improved Antitumor Activity.
    ChemMedChem, 2023, 03-01, Volume: 18, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Boranes; Cyclooxygenase 2; Cyclooxyg

2023
Stereoselective disposition of fenoprofen in plasma and synovial fluid of patients with rheumatoid arthritis.
    Chirality, 2007, May-05, Volume: 19, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Arthritis, Rheumatoid; Chromatography, Li

2007
Acute renal failure possibly associated with fenoprofen therapy.
    Arthritis and rheumatism, 1983, Volume: 26, Issue:2

    Topics: Acute Kidney Injury; Aged; Arthritis, Rheumatoid; Female; Fenoprofen; Humans; Phenylpropionates

1983
Rheumatoid arthritis IV: non-steroidal anti-inflammatory agents use in treatment.
    Maryland state medical journal, 1982, Volume: 31, Issue:7

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Hu

1982
Current review and comparison of the new nonsteroidal anti-inflammatory agents.
    The Journal of foot surgery, 1980,Winter, Volume: 19, Issue:4

    Topics: Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Drug Administration Schedule; Fenoprofen

1980
Joint space measurement in hand radiographs using computerized image analysis.
    Arthritis and rheumatism, 1995, Volume: 38, Issue:7

    Topics: Adult; Aged; Aging; Arthritis, Rheumatoid; Aspirin; Female; Fenoprofen; Finger Joint; Hand; Humans;

1995
The new anti-inflammatory agents: phenylalkanoic acids.
    The Journal of the Arkansas Medical Society, 1976, Volume: 73, Issue:3

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Fenoprofen; Ibuprofen; Naproxen; Phenylpropionates

1976
New non-steroidal anti-inflammatory drugs.
    North Carolina medical journal, 1977, Volume: 38, Issue:3

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Fenoprofen; Humans; Ibuprofen; Naproxen; Penicillam

1977
New antirheumatic agents: Fenoprofen calcium (Nalfon), naproxen (Naprosyn), and tolmetin sodium (Tolectin).
    JAMA, 1977, Mar-21, Volume: 237, Issue:12

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Gastrointestinal Hemorrhage; H

1977
Nonsteroidal antiinflammatory drugs: new alternatives for rheumatic disease.
    Postgraduate medicine, 1978, Volume: 63, Issue:3

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Fenoprofen; Humans; Ibup

1978
Aspirin and newer anti-inflammatory agents in rheumatoid arthritis.
    American family physician, 1977, Volume: 16, Issue:1

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Humans; Ibuprofen; Indomethaci

1977
New nonsteroidal anti-inflammatory drugs.
    American family physician, 1976, Volume: 14, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Humans; Ibuprofen; Na

1976
[Prolonged use of dl-2(3-phenoxyphenyl)propionic acid in rheumatoid arthritis].
    La Clinica terapeutica, 1975, Dec-15, Volume: 75, Issue:5

    Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Evaluation; Female; Fenoprofen; Humans; Male; Middle Aged;

1975