fenoldopam has been researched along with Postoperative Complications in 26 studies
Fenoldopam: A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.
Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Among patients with acute kidney injury after cardiac surgery, fenoldopam infusion, compared with placebo, did not reduce the need for renal replacement therapy or risk of 30-day mortality but was associated with an increased rate of hypotension." | 9.19 | Effect of fenoldopam on use of renal replacement therapy among patients with acute kidney injury after cardiac surgery: a randomized clinical trial. ( Alvaro, G; Amantea, B; Baldassarri, R; Bellomo, R; Bove, T; Calabrò, MG; Camata, A; Caramelli, F; Cariello, C; Comis, M; Conte, M; Dal Checco, E; Faita, L; Frontini, M; Galdieri, N; Guarracino, F; Landoni, G; Lembo, R; Maglioni, E; Martinez, B; Pala, G; Pappalardo, F; Pasero, DC; Paternoster, G; Persi, B; Pinelli, F; Pisano, A; Renzini, M; Saleh, O; Scandroglio, AM; Verdecchia, C; Zangrillo, A; Zucchetti, MC, 2014) |
| "Among patients with acute kidney injury after cardiac surgery, fenoldopam infusion, compared with placebo, did not reduce the need for renal replacement therapy or risk of 30-day mortality but was associated with an increased rate of hypotension." | 5.19 | Effect of fenoldopam on use of renal replacement therapy among patients with acute kidney injury after cardiac surgery: a randomized clinical trial. ( Alvaro, G; Amantea, B; Baldassarri, R; Bellomo, R; Bove, T; Calabrò, MG; Camata, A; Caramelli, F; Cariello, C; Comis, M; Conte, M; Dal Checco, E; Faita, L; Frontini, M; Galdieri, N; Guarracino, F; Landoni, G; Lembo, R; Maglioni, E; Martinez, B; Pala, G; Pappalardo, F; Pasero, DC; Paternoster, G; Persi, B; Pinelli, F; Pisano, A; Renzini, M; Saleh, O; Scandroglio, AM; Verdecchia, C; Zangrillo, A; Zucchetti, MC, 2014) |
| "1 microg/kg/min of fenoldopam, unilateral renal ischemia (1 hour, left renal artery cross-clamping) followed by 4 hours of reperfusion, and unilateral renal I/R with fenoldopam infusion." | 3.73 | Fenoldopam inhibits nuclear translocation of nuclear factor kappa B in a rat model of surgical ischemic acute renal failure. ( Aravindan, N; Natarajan, M; Shaw, AD, 2006) |
| "Fenoldopam mesylate is a short-acting dopamine-1 agonist that has been suggested to be a possible reno-protective agent in patients undergoing cardiac surgery." | 2.75 | Effects of fenoldopam infusion in complex cardiac surgical operations: a prospective, randomized, double-blind, placebo-controlled study. ( Ballotta, A; Bianchini, C; Castelvecchio, S; De Benedetti, D; Frigiola, A; Menicanti, L; Ranucci, M, 2010) |
| "Fenoldopam prophylaxis was significantly associated with a reduction in acute renal failure incidence (from 22% to 11%, p = 0." | 2.71 | Fenoldopam prophylaxis of postoperative acute renal failure in high-risk cardiac surgery patients. ( Barzaghi, N; Bove, T; Giordano, G; Juliano, G; Locatelli, A; Manzato, A; Melchiorri, C; Ranucci, M; Soro, G; Uslenghi, MF; Vavassori, A, 2004) |
| "Fenoldopam is a dopamine receptor alpha1-specific agonist that increases renal blood flow in patients with kidney failure." | 2.71 | Fenoldopam mesylate in early acute tubular necrosis: a randomized, double-blind, placebo-controlled clinical trial. ( Cotsonis, G; Finkel, KW; Murray, PT; Samuels, J; Shaw, AD; Tumlin, JA, 2005) |
| "Fenoldopam mesylate is a novel, highly selective dopamine type-1 agonist that preferentially dilates the renal and splanchnic vasculature, but has not been investigated in patients undergoing prolonged aortic clamping for whom adverse renal outcomes should be more likely." | 2.70 | Fenoldopam infusion associated with preserving renal function after aortic cross-clamping for aneurysm repair. ( Benjamin, ME; Flinn, WR; Gilbert, TB; Hasnain, JU; Lilly, MP, 2001) |
| "Perioperative hypertension is commonly encountered in patients that undergo surgery." | 2.44 | Perioperative hypertension management. ( Marik, PE; Varon, J, 2008) |
| "Fenoldopam has no dopamine-2, alpha or beta-adrenergic activity and is 3." | 2.41 | [Fenoldopam: potential clinical applications in heart surgery]. ( Shorten, GD, 2001) |
| "Fenoldopam is a direct-acting vasodilator that acts at the postsynaptic dopamine 1 receptors in renal, coronary, cerebral, and splanchnic vasculature resulting in arterial dilation and a lowering of the mean arterial pressure (MAP)." | 2.40 | Initial experience with fenoldopam in children. ( Pruitt, RD; Strauser, LM; Tobias, JD, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 14 (53.85) | 29.6817 |
| 2010's | 11 (42.31) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, H | 1 |
| Xie, Q | 1 |
| Peng, Z | 1 |
| Bove, T | 2 |
| Zangrillo, A | 1 |
| Guarracino, F | 1 |
| Alvaro, G | 1 |
| Persi, B | 1 |
| Maglioni, E | 1 |
| Galdieri, N | 1 |
| Comis, M | 1 |
| Caramelli, F | 1 |
| Pasero, DC | 1 |
| Pala, G | 1 |
| Renzini, M | 1 |
| Conte, M | 1 |
| Paternoster, G | 1 |
| Martinez, B | 1 |
| Pinelli, F | 1 |
| Frontini, M | 1 |
| Zucchetti, MC | 1 |
| Pappalardo, F | 1 |
| Amantea, B | 1 |
| Camata, A | 1 |
| Pisano, A | 1 |
| Verdecchia, C | 1 |
| Dal Checco, E | 1 |
| Cariello, C | 1 |
| Faita, L | 1 |
| Baldassarri, R | 1 |
| Scandroglio, AM | 1 |
| Saleh, O | 1 |
| Lembo, R | 1 |
| Calabrò, MG | 1 |
| Bellomo, R | 1 |
| Landoni, G | 1 |
| O'Neal, JB | 1 |
| Shaw, AD | 3 |
| Billings, FT | 1 |
| Mas-Font, S | 1 |
| Ros-Martinez, J | 1 |
| Pérez-Calvo, C | 1 |
| Villa-Díaz, P | 1 |
| Aldunate-Calvo, S | 1 |
| Moreno-Clari, E | 1 |
| Varon, J | 1 |
| Marik, PE | 1 |
| Ranucci, M | 3 |
| De Benedetti, D | 1 |
| Bianchini, C | 1 |
| Castelvecchio, S | 1 |
| Ballotta, A | 1 |
| Frigiola, A | 1 |
| Menicanti, L | 1 |
| Brienza, N | 1 |
| Giglio, MT | 1 |
| Marucci, M | 1 |
| Coleman, MD | 1 |
| Shaefi, S | 1 |
| Sladen, RN | 1 |
| Ricci, Z | 1 |
| Luciano, R | 1 |
| Favia, I | 1 |
| Garisto, C | 1 |
| Muraca, M | 1 |
| Morelli, S | 1 |
| Di Chiara, L | 1 |
| Cogo, P | 1 |
| Picardo, S | 1 |
| Goldstein, SL | 1 |
| Arora, P | 1 |
| Kolli, H | 1 |
| Nainani, N | 1 |
| Nader, N | 1 |
| Lohr, J | 1 |
| Caporelli, S | 1 |
| Loggi, S | 1 |
| Zompanti, V | 1 |
| Romano, R | 1 |
| Carbonari, L | 1 |
| Alò, F | 1 |
| Antognini, M | 1 |
| Pelaia, P | 1 |
| Leung, N | 1 |
| Textor, SC | 1 |
| Biancofiore, G | 1 |
| Della Rocca, G | 1 |
| Bindi, L | 1 |
| Romanelli, A | 1 |
| Esposito, M | 1 |
| Meacci, L | 1 |
| Urbani, L | 1 |
| Filipponi, F | 1 |
| Mosca, F | 1 |
| Soro, G | 1 |
| Barzaghi, N | 1 |
| Locatelli, A | 1 |
| Giordano, G | 1 |
| Vavassori, A | 1 |
| Manzato, A | 1 |
| Melchiorri, C | 1 |
| Juliano, G | 1 |
| Uslenghi, MF | 1 |
| Rocca, GD | 1 |
| Pompei, L | 1 |
| Costa, MG | 1 |
| Coccia, C | 1 |
| Scudeller, L | 1 |
| Marco, PD | 1 |
| Monaco, S | 1 |
| Pietropaoli, P | 1 |
| Tumlin, JA | 1 |
| Finkel, KW | 1 |
| Murray, PT | 1 |
| Samuels, J | 1 |
| Cotsonis, G | 1 |
| Laake, JH | 1 |
| Bugge, JF | 1 |
| Aravindan, N | 1 |
| Natarajan, M | 1 |
| Barr, LF | 1 |
| Kolodner, K | 1 |
| Jones, DR | 1 |
| Lee, HT | 1 |
| Strauser, LM | 1 |
| Pruitt, RD | 1 |
| Tobias, JD | 1 |
| Gilbert, TB | 1 |
| Hasnain, JU | 1 |
| Flinn, WR | 1 |
| Lilly, MP | 1 |
| Benjamin, ME | 1 |
| Shorten, GD | 2 |
| Halpenny, M | 1 |
| Rushe, C | 1 |
| Breen, P | 1 |
| Cunningham, AJ | 1 |
| Boucher-Hayes, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Fenoldopam in Reducing the Need for Renal Replacement Therapy After Cardiac Surgery. A Randomized Controlled Study.[NCT00621790] | Phase 3 | 667 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| Role of Mitochondrial Dysfunction in the Occurrence of Acute Kidney Injury(AKI) in Postoperative Cardiac Surgery[NCT04125069] | 27 participants (Actual) | Observational | 2019-10-02 | Completed | |||
| Fenoldopam Prophylaxis of Splanchnic Organs Underperfusion During Cardiopulmonary Bypass: a Randomized, Controlled Trial.[NCT00747331] | Phase 4 | 80 participants (Anticipated) | Interventional | 2008-09-30 | Completed | ||
| Impact of Intraoperative Hypotension on Risk of Acute Kidney Injury After Off-pump Coronary Artery Bypass Grafting Surgery: A Retrospective Cohort Study[NCT03889730] | 821 participants (Actual) | Observational | 2019-03-03 | Completed | |||
| Lithium in Cardiac Surgery Related Acute Kidney Injury: A Pilot Study[NCT03056248] | Phase 4 | 50 participants (Anticipated) | Interventional | 2017-04-01 | Not yet recruiting | ||
| Intraoperative Fenoldopam Infusion in Children Requiring Cardiopulmonary Bypass During Cardiac Surgery[NCT00982527] | Phase 3 | 80 participants (Actual) | Interventional | 2009-09-30 | Completed | ||
| Effect of Remote Ischemic Preconditioning on the Incidence of Acute Kidney Injury in Patients Undergoing Coronary Artery Bypass Graft Surgery: A Randomized Controlled Trial[NCT02981680] | 180 participants (Actual) | Interventional | 2013-11-30 | Completed | |||
| Combination Fenoldopam Mesylate and Intravenous MESNA (2-mercaptoethane Sulphonate)in Early Acute Kidney Injury (AKD): A Randomized, Double-Blind Placebo Controlled Clinical Trial[NCT00286403] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2008-08-31 | Withdrawn (stopped due to The study was terminated due to logistics at a local hospital.) | ||
| N-acetylcysteine and Fenoldopam Protect the Renal Function of Patients With Chronic Renal Insufficiency Undergoing Cardiac Surgery.[NCT00122018] | Phase 2 | 80 participants | Interventional | 2002-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 reviews available for fenoldopam and Postoperative Complications
| Article | Year |
|---|---|
Does Fenoldopam Protect Kidney in Cardiac Surgery? A Systemic Review and Meta-Analysis With Trial Sequential Analysis.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Fenoldopam; Hospital Mortality; Humans; Kidney; Po | 2019 |
Acute kidney injury following cardiac surgery: current understanding and future directions.
Topics: Acute Kidney Injury; Antihypertensive Agents; Biomarkers; Cardiac Surgical Procedures; Creatinine; F | 2016 |
Prevention of acute kidney injury in Intensive Care Units.
Topics: Acute Kidney Injury; Contrast Media; Critical Care; Diuretics; Fenoldopam; Fluid Therapy; Hemodynami | 2017 |
Perioperative hypertension management.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Enalaprilat; Fenoldopam; Hemodynamics; Humans; | 2008 |
Preventing acute kidney injury after noncardiac surgery.
Topics: Acute Disease; Acute Kidney Injury; Atrial Natriuretic Factor; Cardiac Output; Fenoldopam; Hemodynam | 2010 |
Preventing acute kidney injury after cardiac surgery.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Coronary Artery Bypass, Off-Pump; Early Diagnosis; | 2011 |
Preventing acute kidney injury after cardiac surgery.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Coronary Artery Bypass, Off-Pump; Early Diagnosis; | 2011 |
Preventing acute kidney injury after cardiac surgery.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Coronary Artery Bypass, Off-Pump; Early Diagnosis; | 2011 |
Preventing acute kidney injury after cardiac surgery.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Coronary Artery Bypass, Off-Pump; Early Diagnosis; | 2011 |
Preventable risk factors for acute kidney injury in patients undergoing cardiac surgery.
Topics: Acute Kidney Injury; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Asp | 2012 |
Perioperative renal protection.
Topics: Acute Kidney Injury; Anesthesiology; Biomarkers; Creatinine; Dopamine Agonists; Fenoldopam; Humans; | 2008 |
Initial experience with fenoldopam in children.
Topics: Age Factors; Antihypertensive Agents; Body Weight; Brain Neoplasms; Child; Dopamine Agonists; Emerge | 1999 |
[Fenoldopam: potential clinical applications in heart surgery].
Topics: Acute Kidney Injury; Antihypertensive Agents; Coronary Artery Bypass; Diuretics; Dopamine Agonists; | 2001 |
10 trials available for fenoldopam and Postoperative Complications
| Article | Year |
|---|---|
Effect of fenoldopam on use of renal replacement therapy among patients with acute kidney injury after cardiac surgery: a randomized clinical trial.
Topics: Acute Kidney Injury; Aged; Cardiac Surgical Procedures; Creatinine; Critical Illness; Double-Blind M | 2014 |
Effects of fenoldopam infusion in complex cardiac surgical operations: a prospective, randomized, double-blind, placebo-controlled study.
Topics: Aged; Cardiopulmonary Bypass; Double-Blind Method; Female; Fenoldopam; Humans; Infusions, Intravenou | 2010 |
High-dose fenoldopam reduces postoperative neutrophil gelatinase-associated lipocaline and cystatin C levels in pediatric cardiac surgery.
Topics: Acute Kidney Injury; Acute-Phase Proteins; Biomarkers; Cardiac Surgical Procedures; Cystatin C; Doub | 2011 |
Use of fenoldopam to control renal dysfunction early after liver transplantation.
Topics: Adult; Antibodies, Monoclonal; Basiliximab; Creatinine; Cyclosporine; Dopamine; Dopamine Agonists; D | 2004 |
Fenoldopam prophylaxis of postoperative acute renal failure in high-risk cardiac surgery patients.
Topics: Acute Kidney Injury; Aged; Biomarkers; Cardiac Surgical Procedures; Cohort Studies; Creatinine; Dopa | 2004 |
Fenoldopam prophylaxis of postoperative acute renal failure in high-risk cardiac surgery patients.
Topics: Acute Kidney Injury; Aged; Biomarkers; Cardiac Surgical Procedures; Cohort Studies; Creatinine; Dopa | 2004 |
Fenoldopam prophylaxis of postoperative acute renal failure in high-risk cardiac surgery patients.
Topics: Acute Kidney Injury; Aged; Biomarkers; Cardiac Surgical Procedures; Cohort Studies; Creatinine; Dopa | 2004 |
Fenoldopam prophylaxis of postoperative acute renal failure in high-risk cardiac surgery patients.
Topics: Acute Kidney Injury; Aged; Biomarkers; Cardiac Surgical Procedures; Cohort Studies; Creatinine; Dopa | 2004 |
Fenoldopam mesylate and renal function in patients undergoing liver transplantation: a randomized, controlled pilot trial.
Topics: Acute Kidney Injury; Adult; Aged; Blood Urea Nitrogen; Blood Volume; Cyclosporine; Diuretics; Dopami | 2004 |
Fenoldopam mesylate in early acute tubular necrosis: a randomized, double-blind, placebo-controlled clinical trial.
Topics: Creatinine; Diabetes Complications; Disease Progression; Dopamine Agonists; Double-Blind Method; Ear | 2005 |
N-acetylcysteine and fenoldopam protect the renal function of patients with chronic renal insufficiency undergoing cardiac surgery.
Topics: Acetylcysteine; Aged; Cardiac Surgical Procedures; Dopamine Agonists; Double-Blind Method; Female; F | 2008 |
Fenoldopam infusion associated with preserving renal function after aortic cross-clamping for aneurysm repair.
Topics: Adult; Age Factors; Aged; Aorta; Aortic Aneurysm, Abdominal; Cardiovascular Surgical Procedures; Dop | 2001 |
The effects of fenoldopam on renal function in patients undergoing elective aortic surgery.
Topics: Aged; Analysis of Variance; Antihypertensive Agents; Aorta; Blood Pressure; Double-Blind Method; Ele | 2002 |
6 other studies available for fenoldopam and Postoperative Complications
| Article | Year |
|---|---|
Invited commentary.
Topics: Acute Kidney Injury; Blood Flow Velocity; Cardiopulmonary Bypass; Coronary Artery Bypass; Dose-Respo | 2010 |
A novel use for novel acute kidney injury biomarkers: fenoldopam's effect on neutrophil gelatinase-associated lipocalin and cystatin C.
Topics: Acute-Phase Proteins; Cardiac Surgical Procedures; Cystatin C; Fenoldopam; Humans; Lipocalins; Posto | 2011 |
[Fenoldopam and kidney function in a case of abdominal aortic pseudoaneurysm with supra-renal clamping in an emergency protocol].
Topics: Acute Kidney Injury; Aneurysm, False; Aorta, Abdominal; Aortic Rupture; Constriction; Dopamine Agoni | 2003 |
Acute renal failure after liver transplantation: the role of dopamine and fenoldopam.
Topics: Acute Kidney Injury; Dopamine; Dopamine Agents; Fenoldopam; Glomerular Filtration Rate; Humans; Live | 2004 |
Prevention of acute renal failure--first do no harm!
Topics: Acute Kidney Injury; Atrial Natriuretic Factor; Blood Pressure; Cardiotonic Agents; Diuretics; Diure | 2006 |
Fenoldopam inhibits nuclear translocation of nuclear factor kappa B in a rat model of surgical ischemic acute renal failure.
Topics: Acute Kidney Injury; Animals; Disease Models, Animal; DNA; Fenoldopam; Follow-Up Studies; Gene Expre | 2006 |