Page last updated: 2024-10-27

fenofibrate and Pregnancy

fenofibrate has been researched along with Pregnancy in 23 studies

Pharmavit: a polyvitamin product, comprising vitamins A, D2, B1, B2, B6, C, E, nicotinamide, & calcium pantothene; may be a promising agent for application to human populations exposed to carcinogenic and genetic hazards of ionizing radiation; RN from CHEMLINE

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
" Prenatal fenofibrate administration attenuated detrimental effects induced by MIA on both the schizophrenia-like behavioral phenotype and dopamine transmission in male offspring."7.91The PPARα agonist fenofibrate attenuates disruption of dopamine function in a maternal immune activation rat model of schizophrenia. ( Aroni, S; De Felice, M; Devoto, P; Fanni, S; Frau, R; Melis, M; Muntoni, AL; Pistis, M, 2019)
" Valproic acid (VPA) is an anticonvulsant drug in both human and rodents with teratogenic effects during pregnancy."7.91Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats. ( Mirza, R; Sharma, B, 2019)
"To describe a successful pregnancy in a patient who used fenofibrate during the first trimester."7.78Use of fenofibrate during the first trimester of unplanned pregnancy in a patient with hypertriglyceridemia. ( Aytemir, K; Canpolat, U; Sahiner, L; Sunman, H, 2012)
"Fenofibrate was used safely and successfully during pregnancy in this case of hypertriglyceridemia-associated pancreatitis refractory to conservative measures."7.77Hyperlipidemia-associated pancreatitis in pregnancy managed with fenofibrate. ( Lorenz, RP; Smith, JM; Whitten, AE, 2011)
"The social motivational theory of autism spectrum disorder (ASD) focuses on social anhedonia as key causal feature of the impaired peer relationships that characterize ASD patients."5.56Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences. ( Braccagni, G; De Montis, MG; Gambarana, C; Guzzi, F; Parenti, M; Scheggi, S, 2020)
"Bexarotene is a synthetic retinoid from the subclass of retinoids called rexinoids which selectively activate retinoid X receptors."5.39U.K. consensus statement on safe clinical prescribing of bexarotene for patients with cutaneous T-cell lymphoma. ( Azurdia, R; Cowan, R; Eagle, M; Gallop-Evans, E; Graham-Brown, R; Illidge, T; Morris, S; Parry, E; Scarisbrick, JJ; Soran, H; Wachsmuth, R; Wain, EM; Whittaker, S; Wierzbicki, AS, 2013)
" Prenatal fenofibrate administration attenuated detrimental effects induced by MIA on both the schizophrenia-like behavioral phenotype and dopamine transmission in male offspring."3.91The PPARα agonist fenofibrate attenuates disruption of dopamine function in a maternal immune activation rat model of schizophrenia. ( Aroni, S; De Felice, M; Devoto, P; Fanni, S; Frau, R; Melis, M; Muntoni, AL; Pistis, M, 2019)
" Valproic acid (VPA) is an anticonvulsant drug in both human and rodents with teratogenic effects during pregnancy."3.91Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats. ( Mirza, R; Sharma, B, 2019)
"Fenofibrate was used safely and successfully during pregnancy in this case of hypertriglyceridemia-associated pancreatitis refractory to conservative measures."3.77Hyperlipidemia-associated pancreatitis in pregnancy managed with fenofibrate. ( Lorenz, RP; Smith, JM; Whitten, AE, 2011)
"A fenofibrate was proposed but declined due to our patient's wish to breastfeed."1.72Hypertriglyceridaemia in pregnancy: an unexpected diagnosis and its management. ( Barclay, K; Kaplan, F; Koysombat, K; Padmagirison, R, 2022)
"The social motivational theory of autism spectrum disorder (ASD) focuses on social anhedonia as key causal feature of the impaired peer relationships that characterize ASD patients."1.56Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences. ( Braccagni, G; De Montis, MG; Gambarana, C; Guzzi, F; Parenti, M; Scheggi, S, 2020)
"Bexarotene is a synthetic retinoid from the subclass of retinoids called rexinoids which selectively activate retinoid X receptors."1.39U.K. consensus statement on safe clinical prescribing of bexarotene for patients with cutaneous T-cell lymphoma. ( Azurdia, R; Cowan, R; Eagle, M; Gallop-Evans, E; Graham-Brown, R; Illidge, T; Morris, S; Parry, E; Scarisbrick, JJ; Soran, H; Wachsmuth, R; Wain, EM; Whittaker, S; Wierzbicki, AS, 2013)
"Fenofibrate treatment did not modify plasma free fatty acid (FFA) concentration in virgin rats, it greatly increased it in pregnant animals."1.35Fenofibrate reduces adiposity in pregnant and virgin rats but through different mechanisms. ( Bocos, C; Gonzalez, MC; Herrera, E; Vidal, H, 2009)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.70)18.7374
1990's1 (4.35)18.2507
2000's8 (34.78)29.6817
2010's8 (34.78)24.3611
2020's4 (17.39)2.80

Authors

AuthorsStudies
Singh, S1
Dhar, R1
Karmakar, S1
Barclay, K1
Koysombat, K1
Padmagirison, R1
Kaplan, F1
Grady, J1
Clifford, C1
Treadwell, MC1
Parikh, ND1
Satishchandran, A1
Scheggi, S1
Guzzi, F1
Braccagni, G1
De Montis, MG1
Parenti, M1
Gambarana, C1
Strassburg, CP1
De Felice, M1
Melis, M1
Aroni, S1
Muntoni, AL1
Fanni, S1
Frau, R1
Devoto, P1
Pistis, M1
Mirza, R1
Sharma, B1
Savas, Ü1
Machemer, DEW1
Hsu, MH1
Gaynor, P1
Lasker, JM1
Tukey, RH1
Johnson, EF1
González, MC2
Corton, JC1
Cattley, RC1
Herrera, E4
Bocos, C4
Vidal, H2
Marche, K1
Danel, T1
Bordet, R1
Whitten, AE1
Lorenz, RP1
Smith, JM1
Moustafa, T1
Fickert, P1
Magnes, C1
Guelly, C1
Thueringer, A1
Frank, S1
Kratky, D1
Sattler, W1
Reicher, H1
Sinner, F1
Gumhold, J1
Silbert, D1
Fauler, G1
Höfler, G1
Lass, A1
Zechner, R1
Trauner, M1
Sunman, H1
Canpolat, U1
Sahiner, L1
Aytemir, K1
Scarisbrick, JJ1
Morris, S1
Azurdia, R1
Illidge, T1
Parry, E1
Graham-Brown, R1
Cowan, R1
Gallop-Evans, E1
Wachsmuth, R1
Eagle, M1
Wierzbicki, AS2
Soran, H1
Whittaker, S1
Wain, EM1
Mikhailidis, DP1
Wray, R1
Soria, A2
González, Mdel C1
Vickers, MH1
Hofman, PL1
Gluckman, PD1
Lobie, PE1
Cutfield, WS1
Blane, GF1
Pinaroli, F1
Staels, B1
Vu-Dac, N1
Kosykh, VA1
Saladin, R1
Fruchart, JC1
Dallongeville, J1
Auwerx, J1
Caroli-Bosc, FX1
Le Gall, P1
Pugliese, P1
Delabre, B1
Caroli-Bosc, C1
Demarquay, JF1
Delmont, JP1
Rampal, P1
Montet, JC1
Ujházy, E1
Onderová, E1
Horáková, M1
Bencová, E1
Durisová, M1
Nosál, R1
Balonová, T1
Zeljenková, D1

Reviews

2 reviews available for fenofibrate and Pregnancy

ArticleYear
[Modern treatment of primary biliary cholangitis].
    Der Internist, 2018, Volume: 59, Issue:1

    Topics: Bezafibrate; Budesonide; Chenodeoxycholic Acid; Cohort Studies; Female; Fenofibrate; Humans; Liver C

2018
Drug treatment of combined hyperlipidemia.
    American journal of cardiovascular drugs : drugs, devices, and other interventions, 2001, Volume: 1, Issue:5

    Topics: Acute Disease; Clofibric Acid; Diabetes Mellitus, Type 2; Female; Fenofibrate; Humans; Hydroxymethyl

2001

Other Studies

21 other studies available for fenofibrate and Pregnancy

ArticleYear
Fenofibrate mediated activation of PPARα negatively regulates trophoblast invasion.
    Placenta, 2022, Volume: 126

    Topics: Cell Movement; Female; Fenofibrate; Humans; Ligands; Placenta; PPAR alpha; Pregnancy; Trophoblasts

2022
Hypertriglyceridaemia in pregnancy: an unexpected diagnosis and its management.
    BMJ case reports, 2022, Aug-29, Volume: 15, Issue:8

    Topics: Diet, Fat-Restricted; Female; Fenofibrate; Humans; Hyperlipidemias; Hypertriglyceridemia; Pregnancy

2022
Use of fenofibrate for intrahepatic cholestasis of pregnancy.
    Journal of hepatology, 2023, Volume: 79, Issue:2

    Topics: Cholestasis, Intrahepatic; Female; Fenofibrate; Humans; Pregnancy; Pregnancy Complications

2023
Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences.
    Molecular autism, 2020, 07-27, Volume: 11, Issue:1

    Topics: Animals; Anxiety; Autistic Disorder; Behavior, Animal; Biomarkers; Disease Models, Animal; Female; F

2020
The PPARα agonist fenofibrate attenuates disruption of dopamine function in a maternal immune activation rat model of schizophrenia.
    CNS neuroscience & therapeutics, 2019, Volume: 25, Issue:5

    Topics: Animals; Disease Models, Animal; Dopamine; Female; Fenofibrate; Male; Neuroimmunomodulation; Neurons

2019
Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats.
    Brain research bulletin, 2019, Volume: 147

    Topics: Animals; Anticonvulsants; Anxiety; Autism Spectrum Disorder; Autistic Disorder; Behavior, Animal; Br

2019
Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model.
    The Journal of biological chemistry, 2009, Jun-12, Volume: 284, Issue:24

    Topics: Animals; Clofibric Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Fasting; Female; Fe

2009
Peroxisome proliferator-activated receptor alpha (PPARalpha) agonists down-regulate alpha2-macroglobulin expression by a PPARalpha-dependent mechanism.
    Biochimie, 2009, Volume: 91, Issue:8

    Topics: alpha-Macroglobulins; Animals; Down-Regulation; Female; Fenofibrate; Male; Mice; PPAR alpha; Pregnan

2009
Fenofibrate reduces adiposity in pregnant and virgin rats but through different mechanisms.
    BMB reports, 2009, Oct-31, Volume: 42, Issue:10

    Topics: Adipocytes; Adipose Tissue, White; Adiposity; Animals; Biomarkers; Fatty Acids; Female; Fenofibrate;

2009
Fetal alcohol-induced hyperactivity is reversed by treatment with the PPARα agonist fenofibrate in a rat model.
    Psychopharmacology, 2011, Volume: 214, Issue:1

    Topics: Animals; Disease Models, Animal; Female; Fenofibrate; Fetal Alcohol Spectrum Disorders; Hyperkinesis

2011
Hyperlipidemia-associated pancreatitis in pregnancy managed with fenofibrate.
    Obstetrics and gynecology, 2011, Volume: 117, Issue:2 Pt 2

    Topics: Adult; Blood Glucose; Female; Fenofibrate; Humans; Hypertriglyceridemia; Hypolipidemic Agents; Infan

2011
Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury.
    Gastroenterology, 2012, Volume: 142, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4;

2012
Use of fenofibrate during the first trimester of unplanned pregnancy in a patient with hypertriglyceridemia.
    The Annals of pharmacotherapy, 2012, Volume: 46, Issue:2

    Topics: Adult; Female; Fenofibrate; Fetal Development; Humans; Hypertriglyceridemia; Hypolipidemic Agents; I

2012
U.K. consensus statement on safe clinical prescribing of bexarotene for patients with cutaneous T-cell lymphoma.
    The British journal of dermatology, 2013, Volume: 168, Issue:1

    Topics: Adult; Amylases; Anticarcinogenic Agents; Bexarotene; Blood Cell Count; Blood Glucose; Cholesterol,

2013
Triglyceridemia and peroxisome proliferator-activated receptor-alpha expression are not connected in fenofibrate-treated pregnant rats.
    Molecular and cellular biochemistry, 2005, Volume: 273, Issue:1-2

    Topics: Acyl-CoA Oxidase; Animals; Carnitine O-Palmitoyltransferase; Female; Fenofibrate; Gene Expression; H

2005
Combination therapy with acipimox enhances the effect of growth hormone treatment on linear body growth in the normal and small-for-gestational-age rat.
    American journal of physiology. Endocrinology and metabolism, 2006, Volume: 291, Issue:6

    Topics: Animals; Birth Weight; Blood Pressure; Bone Development; Fatty Acids, Nonesterified; Female; Fenofib

2006
[Fenofibrate: animal toxicology in relation to side-effects in man (author's transl)].
    La Nouvelle presse medicale, 1980, Dec-22, Volume: 9, Issue:49

    Topics: Abnormalities, Drug-Induced; Animals; Biopsy; Clofibrate; Cricetinae; Dogs; Female; Fenofibrate; Hum

1980
Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates.
    The Journal of clinical investigation, 1995, Volume: 95, Issue:2

    Topics: Acyl-CoA Oxidase; Aging; Animals; Apolipoprotein C-III; Apolipoproteins C; Base Sequence; Cells, Cul

1995
Role of fibrates and HMG-CoA reductase inhibitors in gallstone formation: epidemiological study in an unselected population.
    Digestive diseases and sciences, 2001, Volume: 46, Issue:3

    Topics: Anticholesteremic Agents; Cholelithiasis; Double-Blind Method; Female; Fenofibrate; Humans; Hydroxym

2001
Opposite metabolic response to fenofibrate treatment in pregnant and virgin rats.
    Journal of lipid research, 2002, Volume: 43, Issue:1

    Topics: Adipose Tissue; Animals; Cholesterol; Cholesterol, VLDL; Female; Fenofibrate; Fetus; Hypolipidemic A

2002
Teratological study of the hypolipidaemic drugs etofylline clofibrate (VULM) and fenofibrate in Swiss mice.
    Pharmacology & toxicology, 1989, Volume: 64, Issue:3

    Topics: Animals; Body Weight; Clofibrate; Female; Fenofibrate; Fetus; Gestational Age; Hypolipidemic Agents;

1989