fenofibrate has been researched along with Neuronal Ceroid-Lipofuscinoses in 3 studies
Pharmavit: a polyvitamin product, comprising vitamins A, D2, B1, B2, B6, C, E, nicotinamide, & calcium pantothene; may be a promising agent for application to human populations exposed to carcinogenic and genetic hazards of ionizing radiation; RN from CHEMLINE
Neuronal Ceroid-Lipofuscinoses: A group of severe neurodegenerative diseases characterized by intracellular accumulation of autofluorescent wax-like lipid materials (CEROID; LIPOFUSCIN) in neurons. There are several subtypes based on mutations of the various genes, time of disease onset, and severity of the neurological defects such as progressive DEMENTIA; SEIZURES; and visual failure.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Batten disease (BD; also known as juvenile neuronal ceroid lipofuscinosis) is a genetic disorder inherited as an autosomal recessive trait and is characterized by blindness, seizures, cognitive decline, and early death resulting from the inherited mutation of the CLN3 gene." | 1.43 | Fibrates inhibit the apoptosis of Batten disease lymphoblast cells via autophagy recovery and regulation of mitochondrial membrane potential. ( Heo, TH; Hong, M; Jun, HS; Kim, SJ; Lee, HK; Lee, YS; Song, KD; Yi, S, 2016) |
| "The classical late infantile neuronal ceroid lipofuscinosis (LINCLs) is an autosomal recessive disease, where the defective gene is Cln2, encoding tripeptidyl-peptidase I (TPP1)." | 1.38 | Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor α: implications for late infantile Batten disease therapy. ( Corbett, GT; Ghosh, A; Gonzalez, FJ; Pahan, K, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lojewski, X | 1 |
| Staropoli, JF | 1 |
| Biswas-Legrand, S | 1 |
| Simas, AM | 1 |
| Haliw, L | 1 |
| Selig, MK | 1 |
| Coppel, SH | 1 |
| Goss, KA | 1 |
| Petcherski, A | 1 |
| Chandrachud, U | 1 |
| Sheridan, SD | 1 |
| Lucente, D | 1 |
| Sims, KB | 1 |
| Gusella, JF | 1 |
| Sondhi, D | 1 |
| Crystal, RG | 1 |
| Reinhardt, P | 1 |
| Sterneckert, J | 1 |
| Schöler, H | 1 |
| Haggarty, SJ | 1 |
| Storch, A | 1 |
| Hermann, A | 1 |
| Cotman, SL | 1 |
| Hong, M | 1 |
| Song, KD | 1 |
| Lee, HK | 1 |
| Yi, S | 1 |
| Lee, YS | 1 |
| Heo, TH | 1 |
| Jun, HS | 1 |
| Kim, SJ | 1 |
| Ghosh, A | 1 |
| Corbett, GT | 1 |
| Gonzalez, FJ | 1 |
| Pahan, K | 1 |
3 other studies available for fenofibrate and Neuronal Ceroid-Lipofuscinoses
| Article | Year |
|---|---|
Human iPSC models of neuronal ceroid lipofuscinosis capture distinct effects of TPP1 and CLN3 mutations on the endocytic pathway.
Topics: Aminopeptidases; Blotting, Western; Case-Control Studies; Cell Proliferation; Cells, Cultured; Dipep | 2014 |
Fibrates inhibit the apoptosis of Batten disease lymphoblast cells via autophagy recovery and regulation of mitochondrial membrane potential.
Topics: Apoptosis; Autophagy; Bezafibrate; Cells, Cultured; Fenofibrate; Gemfibrozil; Humans; Lymphocytes; M | 2016 |
Gemfibrozil and fenofibrate, Food and Drug Administration-approved lipid-lowering drugs, up-regulate tripeptidyl-peptidase 1 in brain cells via peroxisome proliferator-activated receptor α: implications for late infantile Batten disease therapy.
Topics: Aminopeptidases; Animals; Astrocytes; Brain; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Fenof | 2012 |