fenofibrate has been researched along with Muscular Dystrophy, Duchenne in 2 studies
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Muscular Dystrophy, Duchenne: An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fenofibrate treatment returned myofibre function by inhibiting the expressions of myostatin, MuRF1, and atrogin-1 protein in the gastrocnemius muscle and diaphragm, while leaving the mRNA level of myostatin unaffected." | 1.72 | A new therapeutic effect of fenofibrate in Duchenne muscular dystrophy: The promotion of myostatin degradation. ( Huang, X; Jiang, Z; Li, C; Li, S; Li, X; Liu, B; Sun, L; Sun, Z; Xu, D; Zhang, L; Zhao, L, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, Z | 1 |
| Xu, D | 1 |
| Zhao, L | 1 |
| Li, X | 1 |
| Li, S | 1 |
| Huang, X | 1 |
| Li, C | 1 |
| Sun, L | 1 |
| Liu, B | 1 |
| Jiang, Z | 1 |
| Zhang, L | 1 |
| Sun, C | 1 |
| Choi, IY | 1 |
| Rovira Gonzalez, YI | 1 |
| Andersen, P | 1 |
| Talbot, CC | 1 |
| Iyer, SR | 1 |
| Lovering, RM | 1 |
| Wagner, KR | 1 |
| Lee, G | 1 |
2 other studies available for fenofibrate and Muscular Dystrophy, Duchenne
| Article | Year |
|---|---|
A new therapeutic effect of fenofibrate in Duchenne muscular dystrophy: The promotion of myostatin degradation.
Topics: Animals; Fenofibrate; Humans; Male; Mice; Mice, Inbred mdx; Muscle, Skeletal; Muscular Dystrophy, Du | 2022 |
Duchenne muscular dystrophy hiPSC-derived myoblast drug screen identifies compounds that ameliorate disease in mdx mice.
Topics: Animals; Drug Evaluation, Preclinical; Fenofibrate; Ginsenosides; Humans; Induced Pluripotent Stem C | 2020 |