fenofibrate has been researched along with Hypertrophy in 5 studies
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Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "By analysis of the data from the Toxicogenomics Database (TG-GATEs), histidine decarboxylase gene (Hdc) was identified as largely and commonly upregulated by three fibrates, clofibrate, fenofibrate, and WY-14,643, which are known to induce hepatocellular hypertrophy and proliferation via stimulation of peroxisome proliferator-activated receptor α (PPARα) in rodents." | 3.96 | Peroxisome proliferator-activated receptor α agonist-induced histidine decarboxylase gene expression in the rat and mouse liver. ( Amagase, Y; Mizukawa, Y; Urushidani, T, 2020) |
| "Endothelin-1 (ET-1) is synthesized and secreted by cardiomyocytes and induces cardiac hypertrophy." | 3.72 | Activation of peroxisome proliferator-activated receptor-alpha decreases endothelin-1-induced p38 mitogen-activated protein kinase activation in cardiomyocytes. ( Goto, K; Irukayama-Tomobe, Y; Kasuya, Y; Miyauchi, T; Sakai, S; Yamaguchi, I, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amagase, Y | 1 |
| Mizukawa, Y | 1 |
| Urushidani, T | 1 |
| Jen, HL | 1 |
| Liu, PL | 1 |
| Chen, YH | 1 |
| Yin, WH | 1 |
| Chen, JW | 1 |
| Lin, SJ | 1 |
| Liang, F | 1 |
| Wang, F | 1 |
| Zhang, S | 1 |
| Gardner, DG | 1 |
| Irukayama-Tomobe, Y | 1 |
| Miyauchi, T | 1 |
| Kasuya, Y | 1 |
| Sakai, S | 1 |
| Goto, K | 1 |
| Yamaguchi, I | 1 |
| Zhao, X | 1 |
| Li, LY | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study to Evaluate the Possible Safety and Efficacy of Fenofibrate in the Prophylaxis of Doxorubicin Induced Cardiotoxicity in Breast Cancer Patients[NCT06155331] | Phase 4 | 44 participants (Anticipated) | Interventional | 2023-12-31 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for fenofibrate and Hypertrophy
| Article | Year |
|---|---|
Peroxisome proliferator-activated receptor α agonist-induced histidine decarboxylase gene expression in the rat and mouse liver.
Topics: Animals; Cell Proliferation; Cells, Cultured; Clofibrate; Databases, Genetic; Fenofibrate; Gene Expr | 2020 |
Peroxisome Proliferator-Activated Receptor
Topics: Adiponectin; Blotting, Western; Cells, Cultured; Electrophoretic Mobility Shift Assay; Endothelin-1; | 2016 |
Peroxisome proliferator activated receptor (PPAR)alpha agonists inhibit hypertrophy of neonatal rat cardiac myocytes.
Topics: Animals; Animals, Newborn; Base Sequence; Cell Size; Cells, Cultured; Fenofibrate; Gene Expression; | 2003 |
Activation of peroxisome proliferator-activated receptor-alpha decreases endothelin-1-induced p38 mitogen-activated protein kinase activation in cardiomyocytes.
Topics: Animals; Animals, Newborn; Cell Size; Cells, Cultured; Endothelin-1; Fenofibrate; Hypertrophy; Myocy | 2004 |
PPAR-alpha agonist fenofibrate induces renal CYP enzymes and reduces blood pressure and glomerular hypertrophy in Zucker diabetic fatty rats.
Topics: Actins; Animals; Blood Pressure; Blotting, Western; Collagen Type IV; Cyclin D1; Cytochrome P-450 CY | 2008 |