fenofibrate has been researched along with Glioma in 3 studies
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Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Then, we explored the molecular mechanism by which lncRNA HOTAIR regulates PPARα in cell lines in vitro and in a nude mouse glioma model in vivo and explored the effect of the combined application of HOTAIR knockdown and fenofibrate treatment on glioma invasion." | 8.02 | The lipid-lowering drug fenofibrate combined with si-HOTAIR can effectively inhibit the proliferation of gliomas. ( Dai, X; Huang, B; Ni, S; Nyalali, AMK; Sun, J; Xu, F; Zhang, K; Zhao, H; Zhu, W, 2021) |
| "The effects of fenofibrate on Glioma cell motility, IGF-I receptor (IGF-IR) signaling, PPARalpha activity, reactive oxygen species (ROS) metabolism, mitochondrial potential, and ATP production were analyzed in human glioma cell lines." | 7.76 | ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARalpha -mediated inhibition of glioma cell motility in vitro. ( Del Valle, L; Drukala, J; Grabacka, M; Madeja, Z; Reiss, K; Urbanska, K; Wilk, A; Wybieralska, E, 2010) |
| "Fenofibrate treatment of HGG cells robustly diminished the expression of key signaling pathways, including NF-κB and cyclin D1." | 5.40 | Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade gliomas and anti-invasive effects on glioma stem cells. ( Binello, E; Emdad, L; Germano, IM; Kothari, H; Mormone, E, 2014) |
| " Then, we explored the molecular mechanism by which lncRNA HOTAIR regulates PPARα in cell lines in vitro and in a nude mouse glioma model in vivo and explored the effect of the combined application of HOTAIR knockdown and fenofibrate treatment on glioma invasion." | 4.02 | The lipid-lowering drug fenofibrate combined with si-HOTAIR can effectively inhibit the proliferation of gliomas. ( Dai, X; Huang, B; Ni, S; Nyalali, AMK; Sun, J; Xu, F; Zhang, K; Zhao, H; Zhu, W, 2021) |
| "The effects of fenofibrate on Glioma cell motility, IGF-I receptor (IGF-IR) signaling, PPARalpha activity, reactive oxygen species (ROS) metabolism, mitochondrial potential, and ATP production were analyzed in human glioma cell lines." | 3.76 | ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARalpha -mediated inhibition of glioma cell motility in vitro. ( Del Valle, L; Drukala, J; Grabacka, M; Madeja, Z; Reiss, K; Urbanska, K; Wilk, A; Wybieralska, E, 2010) |
| "Fenofibrate treatment of HGG cells robustly diminished the expression of key signaling pathways, including NF-κB and cyclin D1." | 1.40 | Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade gliomas and anti-invasive effects on glioma stem cells. ( Binello, E; Emdad, L; Germano, IM; Kothari, H; Mormone, E, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, W | 1 |
| Zhao, H | 1 |
| Xu, F | 1 |
| Huang, B | 1 |
| Dai, X | 1 |
| Sun, J | 1 |
| Nyalali, AMK | 1 |
| Zhang, K | 1 |
| Ni, S | 1 |
| Binello, E | 1 |
| Mormone, E | 1 |
| Emdad, L | 1 |
| Kothari, H | 1 |
| Germano, IM | 1 |
| Drukala, J | 1 |
| Urbanska, K | 1 |
| Wilk, A | 1 |
| Grabacka, M | 1 |
| Wybieralska, E | 1 |
| Del Valle, L | 1 |
| Madeja, Z | 1 |
| Reiss, K | 1 |
3 other studies available for fenofibrate and Glioma
| Article | Year |
|---|---|
The lipid-lowering drug fenofibrate combined with si-HOTAIR can effectively inhibit the proliferation of gliomas.
Topics: Adult; Aged; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromatin Immuno | 2021 |
Characterization of fenofibrate-mediated anti-proliferative pro-apoptotic effects on high-grade gliomas and anti-invasive effects on glioma stem cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Proliferation; Fenofibrate; Flow Cytometry | 2014 |
ROS accumulation and IGF-IR inhibition contribute to fenofibrate/PPARalpha -mediated inhibition of glioma cell motility in vitro.
Topics: Adenosine Triphosphate; Base Sequence; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Fenofibrate | 2010 |