fenofibrate has been researched along with Alzheimer Disease in 6 studies
Pharmavit: a polyvitamin product, comprising vitamins A, D2, B1, B2, B6, C, E, nicotinamide, & calcium pantothene; may be a promising agent for application to human populations exposed to carcinogenic and genetic hazards of ionizing radiation; RN from CHEMLINE
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with fenofibrate, pioglitazone and their combination resulted in a significant improvement in the behavioural and neurochemical changes induced by βA injection." | 1.56 | Neuroprotective effect of PPAR alpha and gamma agonists in a mouse model of amyloidogenesis through modulation of the Wnt/beta catenin pathway via targeting alpha- and beta-secretases. ( Assaf, N; El Sayed, NS; El-Shamarka, ME; Khadrawy, YA; Salem, NA, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Necula, M | 1 |
| Kayed, R | 1 |
| Milton, S | 1 |
| Glabe, CG | 1 |
| Assaf, N | 1 |
| El-Shamarka, ME | 1 |
| Salem, NA | 1 |
| Khadrawy, YA | 1 |
| El Sayed, NS | 1 |
| Wójtowicz, S | 1 |
| Strosznajder, AK | 1 |
| Jeżyna, M | 1 |
| Strosznajder, JB | 1 |
| Baumann, S | 1 |
| Höttecke, N | 2 |
| Schubenel, R | 2 |
| Baumann, K | 2 |
| Schmidt, B | 2 |
| Zall, A | 1 |
| Kieser, D | 1 |
| Naumann, EC | 1 |
| Thomaszewski, B | 1 |
| Schneider, K | 1 |
| Steinbacher, DT | 1 |
| Masur, S | 1 |
| Kukar, T | 1 |
| Murphy, MP | 1 |
| Eriksen, JL | 1 |
| Sagi, SA | 1 |
| Weggen, S | 1 |
| Smith, TE | 1 |
| Ladd, T | 1 |
| Khan, MA | 1 |
| Kache, R | 1 |
| Beard, J | 1 |
| Dodson, M | 1 |
| Merit, S | 1 |
| Ozols, VV | 1 |
| Anastasiadis, PZ | 1 |
| Das, P | 1 |
| Fauq, A | 1 |
| Koo, EH | 1 |
| Golde, TE | 1 |
1 review available for fenofibrate and Alzheimer Disease
| Article | Year |
|---|---|
The Novel Role of PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer's Disease and Other Neurodegenerative Disorders.
Topics: Alzheimer Disease; Animals; Brain; Drug Delivery Systems; Fenofibrate; Humans; Neurodegenerative Dis | 2020 |
5 other studies available for fenofibrate and Alzheimer Disease
| Article | Year |
|---|---|
Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Humans; Plaque, Amyloid; Protein Structu | 2007 |
Neuroprotective effect of PPAR alpha and gamma agonists in a mouse model of amyloidogenesis through modulation of the Wnt/beta catenin pathway via targeting alpha- and beta-secretases.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Cognitive D | 2020 |
NSAID-derived gamma-secretase modulators. Part III: Membrane anchoring.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Anti-Inflammatory Ag | 2009 |
NSAID-derived γ-secretase modulation requires an acidic moiety on the carbazole scaffold.
Topics: Acids; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor P | 2011 |
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Anti-Inflammatory Ag | 2005 |