Page last updated: 2024-10-27

fenfluramine and Xerostomia

fenfluramine has been researched along with Xerostomia in 3 studies

Fenfluramine: A centrally active drug that apparently both blocks serotonin uptake and provokes transport-mediated serotonin release.
fenfluramine : A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension.

Xerostomia: Decreased salivary flow.

Research Excerpts

ExcerptRelevanceReference
"Serotonin reuptake inhibitors, such as fluoxetine, fenfluramine, and dexfenfluramine, are frequently used to treat obesity, depression, and bulimia."3.69Nutritional implications of xerostomia and rampant caries caused by serotonin reuptake inhibitors: a case study. ( Boyd, LD; Dwyer, JT; Papas, A, 1997)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19902 (66.67)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brownell, KD1
Stunkard, AJ1
Boyd, LD1
Dwyer, JT1
Papas, A1
Abdel-Kader, MM1
Mashaly, M1
Abdel-Aziz, MT1

Trials

1 trial available for fenfluramine and Xerostomia

ArticleYear
The double-blind in danger: untoward consequences of informed consent.
    The American journal of psychiatry, 1982, Volume: 139, Issue:11

    Topics: Adult; Aged; Body Weight; Clinical Trials as Topic; Dizziness; Double-Blind Method; Fatigue; Female;

1982

Other Studies

2 other studies available for fenfluramine and Xerostomia

ArticleYear
Nutritional implications of xerostomia and rampant caries caused by serotonin reuptake inhibitors: a case study.
    Nutrition reviews, 1997, Volume: 55, Issue:10

    Topics: Adult; Antidepressive Agents; Dental Caries; Diet; Female; Fenfluramine; Fluoxetine; Humans; Obesity

1997
Clinical and biochemical studies on obese subjects using fenfluramine.
    The Journal of the Egyptian Medical Association, 1974, Volume: 57, Issue:9-10

    Topics: Anorexia Nervosa; Blood Pressure; Diarrhea; Fatigue; Female; Fenfluramine; Glucose Tolerance Test; H

1974
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